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| 1 | Scope and Mechanism on Iridium-f-Amphamide Catalyzed Asymmetric Hydrogenation of Ketones显示文摘 | Zhiqin Liang Tilong Yang Guoxian Gu Li Dang Xumu Zhang | 2018 | Chinese Journal of Chemistry2018，36，9： | 3 |
| 2 | New chiral phosphorus ligands for enantioselective hydrogen显示文摘 | Tang Wenjun Zhang Xumu | 2003 | Chem Rev2003，103，8： | 1 |
| 3 | An ortho-substituted BIPHEP ligand and its applications in Rh-catalyzed hydrogenation of cyclic enamides显示文摘 | Wenjun Tang Yongxiang Chi Xumu Zhang | 2002 | Org Lett2002，4，10： | 1 |
| 4 | Synthesis of novel chiral bisoxazoline ligands with a spiro[4,4]-1,6-nonadiene skeleton显示文摘A new type of chiral bisoxazoline ligands 1 based on spiro[4,4]-1,6-nonadiene backbone was easily prepared in six steps from racemic spiro[4,4]-nonane-1,6-dione,with the Pd-catalyzed coupling of the enol triflates with CO and amino alcohols as the key steps for the construction of the oxazoline moiety. The structure of the ligand (R,S,S)-1b was unambiguously established by X-ray crystallographic analysis. The chiral Cu(II) complex generated in situ from the combination of spiro bisoxazoline ligand (S,S,S)-1c and Cu(OTf)2 was effective in the catalysis of asymmetric chlorination of the β-ketoester,methyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate,affording the corresponding chlorinated derivative in 99% yield with 17% ee. | HAN ZhaoBin WANG Zheng ZHANG XuMu DING KuiLing | 2010 | Chinese Science Bulletin2010，55，25： | 1 |
| 5 | Synthesis and Application of a New Triphosphorus Ligand for Regioselective Linear Hydroformylation:A Potential Way for the Stepwise Replacement of PPh3 for Industrial Use显示文摘 | Chen Caiyou LüHui Zhang Xumu | 2014 | Org Chem Fron2014，1，8： | 1 |
| 6 | New Chiral Phosphorus Ligands for Enantioselective Hydrogenation显示文摘 | TANG W J XUMU ZHANG | 2003 | Chem Rev2003，103，： | 1 |
| 7 | Highly Enantioselective Hydrogenation of β,β‐Disubstituted Nitroalkenes显示文摘 | Shengkun Li Kexuan Huang Bonan Cao Jiwen Zhang Wenjun Wu Xumu Zhang | 2012 | Angew Chem Int Ed2012，，34： | 1 |
| 8 | Enantioselective addition of diethylzinc to aldehydes catalyzed by a titanium complex with a chiral tetradentate ligand显示文摘 | Guo Cheng Zhang Xumu | 1997 | J Org Chem1997，62，： | 1 |
| 9 | Synthesis of a new type of P,N-ligand with a spiro skeleton for Ir-catalyzed asymmetric hydrogenations显示文摘 | Zhaobin Han Zheng Wang Xumu Zhang Kuiling Ding | 2010 | Tetrahedron: Asymmetry2010，，11： | 1 |
| 10 | 显示文摘 | Tang Wenjun Zhang Xumu | 2003 | Chem Rev2003，103，8： | 1 |
| 11 | Highly Enantioselective Hydrogenation of tetra-and tri-Substitutedα,β-Unsaturated Carboxylic Acids with oxa-Spiro Diphosphine Ligands显示文摘We herein present the design and synthesis of a structurally unique oxa-spirocyclic diphosphine ligand,termed as O-SDP.The diphosphine ligand O-SDP derived from oxa-spirocyclic diphenols(O-SPINOL)has a relatively larger bite angle compared with that of SDP,and O-SDP has been successfully applied in the ruthenium-catalyzed asymmetric hydrogenation ofα,β-unsaturated carboxylic acids under mild reaction conditions.High yields and enantioselectivities were generally achieved for a wide range of substrates(up to 99%yield and>99%ee),and many of the resulting products are key intermediates of important drugs such as Sacubitril,Artemisinin,and Paroxetine. | Gen-Qiang Chen Jia-Ming Huang Bi-Jin Lin Chuan Shi Ling-Yu Zhao Bao-De Ma Xiao-Bing Ding Qin Yin Xumu Zhang | 2020 | CCS Chemistry2020，2，6： | 1 |
| 12 | A Tetraphos- phorus Ligand for Highly Regioselective Isomerization-Hydro- formylation of Internal Olefins 显示文摘 | Yan Yongjun Zhang Xiaowei Zhang Xumu | 2006 | JAm Chem Soc2006，128，16： | 1 |
| 13 | novel chiral binaphthyl phosphorus ligands and their applications in Rh-catalyzed asymmetric hydrogenation 显示文摘 | YONGXIANG CHI XUMU ZHANG Synthesis of | 2002 | Tetrahedron Letters2002，43，27： | 1 |
| 14 | Preclinical characterization and anti-SARS-CoV-2 efficacy of ATV014:an oral cyclohexanecarboxylate prodrug of 1′-CN-4-aza-7,9-dideazaadenosine C-nucleoside显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of the global pandemic coronavirus disease 2019(COVID-19),has proven itself to be a highly virulent respiratory pathogen with an unpredictable evolutionary capacity,posing a persistent threat to mankind.At the time of this manuscript’s publication. | Qifan Zhou Sidi Yang Liu Cao Yang Yang Tiefeng Xu Qishu Chen Hongzhou Lu Yingjun Li Deyin Guo Xumu Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 15 | Facile access to chiral 4-substituted chromanes through Rh-catalyzed asymmetric hydrogenation显示文摘Rh/ZhaoPhos-catalyzed asymmetric hydroge nation of a series of(E)-2-(chro man-4-ylidene)acetates was successfully developed to prepare various chiral 4-substituted chromanes with high yields and excellent enantioselectivities(up to 99%yield,98%ee).Moreover,the gram-scale hydrogenation could be performed well in the presence of 0.02 mol%catalyst loading(TON=5000),the hydrogenation product was easily converted to access other important compounds,which demonstrated the synthetic utility of this asymmetric catalytic methodology. | Lin Tao Qingyang Zhao Xumu Zhang Xiu-Qin Dong | 2020 | Chinese Chemical Letters2020，31，7： | 0 |
| 16 | Enantioselective Hydrogenation of Endocyclic Enones:the Solution to a Historical Problem显示文摘Main observation and conclusion The enantioselective hydrogenation of endocyclic enones has been a historical problem for homogeneous catalysis.We herein report an efficient method to reduce endocyclic enones with molecular hydrogen.Catalyzed by a rhodium/Zhaophos complex,a variety of enones with five-,six-or seven-member ring were hydrogenated with high enantioselectivity(92%-99%ee).Excellent chemo-and enantioselectivity demonstrated this method was successfully applied in the enantioselective hydrogenation of citral to produce enantio-enriched citronellal. | Qiwei Lang Huaxin Yang Guoxian Gu Qiang Feng Jialin Wen Xumu Zhang | 2021 | Chinese Journal of Chemistry2021，39，4： | 0 |
| 17 | Developing a Practical Chiral Toolbox for Asymmetric Catalytic Reactions显示文摘Chiral Quest's Toolbox Approach: During the last several decades, chemists have made major progress in discovering man-made catalysts to perform challenging asymmetric transformations. However, there is no universal chiral ligand or catalyst for solving problems in enantioselective transformations. The focus of Chiral Quest's research is to develop a useful chiral toolbox for strategically important asymmetric catalytic reactions by inventing a diverse set of novel chiral ligands and combining them with transition metals as effective enantioselective catalysts. The toolbox approach addresses significant problems in organic stereochemistry and has resulted in practical methods for the synthesis of chiral pharmaceuticals and | ZHANG XuMu | 2001 | Chemical Research in Chinese Universities2001，17，z1： | 0 |
| 18 | Ir-Catalyzed Asymmetric Hydrogenation of Unprotected Indoles:Scope Investigations and Mechanistic Studies显示文摘Transition metal-catalyzed asymmetric hydrogenation(AH)of unprotected indoles has mainly been applied to alkyl substituted unprotected indoles.However,the challenging aryl substituted unprotected indoles with poor reactivity and enantioselectivity(≤42%ee)could not be hydrogenated well.In this work,a highly efficient Ir/bisphosphine-thiourea ligand ZhaoPhos catalytic system for the AH of challenging aryl substituted unprotected indoles has been successfully developed for the first time with high reactivity and excellent stereoselective control.Moreover,a series of 2-alkyl-substituted and 2,3-disubstituted unprotected indoles were also well tolerated in this catalytic system.A wide variety of chiral indoline derivatives were obtained in good to high yields with excellent stereoselectivities(75–99%yields,>20:1 dr,and 86–99%ee).The anion-binding activation strategy played an important role in accessing both high reactivity and excellent stereoselectivity,which was formed between the catalyst and unprotected indoles in situ-generating iminium ion with the assistance of Brønsted acid.A possible catalytic mechanism was proposed for this Ir-catalyzed AH according to density functional theory calculations and control experiment results.Readily available substrates,a broad range of substrate tolerance,an efficient chiral catalytic system,and a gram-scale protocol further demonstrated the potential practicality of this methodology. | Gongyi Liu Lini Zheng Kui Tian Haifeng Wang Lung Wa Chung Xumu Zhang Xiu-Qin Dong | 2023 | CCS Chemistry2023，5，6： | 0 |
| 19 | Assessing Dual Rh/Ru Cascade Catalysts in One-Pot Homogeneous Synthesis of Ethanol from Syngas and Methanol显示文摘The direct conversion of cheap syngas into value-added ethanol at an industrial scale is in high demand.Herein we disclose a one-pot homogeneous homologation of methanol to ethanol with syngas via a rhodium/ruthenium bimetallic catalytic approach.By introducing a catalytic amount of methyl iodide,methanol can be converted to ethanol with high selectivity(>91%ethanol).A syngas ratio of H_(2)/CO=4:1 was found to be optimal.Among various phosphine ligands tested,Rh-dppp catalyst gave the highest aldehyde pathway selectivity,thus providing an effective route for the synthesis of ethanol upon coupling with a Ru hydrogenation catalyst.The bite angle of the bisphosphine ligands dramatically influences the selectivity of the dual Rh/Ru metallic cascade catalysts.In line with the experimental findings,theoretical calculations predicted a rational trend of the selectivity of different bisphosphine ligands via varying bite angle properties. | Ji-Shu Zhang Ya-Fei Jiang Fanfu Guan Shaoke Zhang Cong-Qiao Xu Shao-Tao Bai Jialin Wen Jun Li Xumu Zhang | 2023 | CCS Chemistry2023，5，7： | 0 |
| 20 | Examination of Milstein Ru-PNN and Rh-Tribi/Tetrabi dual metal catalyst for isomerization-linear-hydroformylation of C4 raffinate and internal olefins显示文摘Isomerization-linear-hydroformylation is demanding,however,not an addressed issue,for the production of value-added linear aldehydes by converting cheap and abundant internal alkenes available from bio-&petrochemical industry.In this paper,a dual metal catalysis system combining a Ru-isomerization catalyst and a Rh-linear-hydroformylation catalyst satisfying the“4S”criterions was reported for isomerization-linear-hydroformylation of C4 raffinate(mixed butenes)and internal olefins.The optimized dual metal catalyst system hydroformylated Raffinate II feed to valuable valeraldehyde in 98%linear selectivity(n:i=49),80%conversion and high activity of 1069 h^(−1)TOF whereas 96%linear selectivity(n:i=24),71%conversion and 948 h^(−1)TOF were observed using only the Rh-hydroformylation catalyst.Notably,valeraldehyde are produced in million tons scale annually for making non-toxic plasticizer DPHP.Various 2-olefins were also converted to linear aldehydes in>98%linear selectivity(n:i>49),78%-82%conversion and high activity of 802-851 h^(−1)TOF. | Runtong Zhang Xin Yan Shao-Tao Bai Caiyou Chen Bozhao Nan Baode Ma Jialin Wen Xumu Zhang | 2022 | Green Synthesis and Catalysis2022，3，1： | 0 |
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