| 1 | Probiotic mixture VSL#3 prevents ulcerative colitis-associated carcinogenesis in mice and cells by regulating the inflammatory and Wnt/β-catenin pathway显示文摘To the Editor:Increasing attention is being paid to preventing ulcerative colitis(UC)-associated carcinogenesis.The intestinal microbiota plays an important role in maintaining the intestinal barrier and immune function.Probiotic mixture VSL#3,that was bought from Sigma-Tau pharmaceuticals(De Simone Formulation)in May 2015,is a mixture of Lactobacillus casei,L.plantarum,L.acidophilus,L.delbrueckii subsp.bulgaricus,Bifidobacterium longum,B.breve,B.infantis and Streptococcus salivarius andcontains 4.5 billion live bacterialcolonies.i Previous studies have shown that VSL#3 can help induce and maintain UC remission.The effects of probiotics on UC-associated carcinogenesis are difficult to observe clinically;therefore,mouse models are often used to study this disease.Previous studies have shown that azoxymethane(AOM)combined with dextran sulfate sodium(DSS)can quickly induce a UC-associated carcinogenesis model. | Wenbin Li Yanan Wang Chunsaier Wang Hongying Wang Yiming Ma Hong Yang Xinhua Zhao Xiaomin Hu John Y.Kao Jiaming Qian Chung Owyang Jingnan Li | 2022 | Chinese Medical Journal2022，135，19： | 1 |
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