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| 1 | The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance显示文摘 | Zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong Han, Yuanhuai Li, Yan Cao, Yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan Liu, Longlong Zhou, Jianping Nan, Chenghu Qin, Yongjun Wang, Jun Cui, Lin Liu, Huimin Liang, Chengzhi Qiao, Zhijun | 2017 | Molecular Plant2017，10，9： | 53 |
| 2 | Geochemical characteristics of soil selenium and evaluation of Serich land resources in the central area of Guiyang City,China显示文摘Based on the results of multipurpose regional geochemical surveys of the Guizhou Province, geochemical characteristics of soil Se and Se-rich land resources in the central area of Guiyang City were studied and evaluated.Major conclusions are as follows:(1) the Se content in surface soil of the central area of Guiyang City was 0.17–2.89 mg kg^(-1), and the average was 0.78 mg kg^(-1), which were respectively 2.6 and 3.9 times of the national background value of soil and the world background value of soil.The Se content in deep soil was 0.11–1.48 mg kg^(-1), and the average was 0.44 mg kg^(-1), which were respectively 1.5 and2.2 times of the national background value of soil and the world background value of soil. The soil Se content decreased with the increase in the soil depth on the vertical profile, and the surface soil had a higher Se content.(2)Distribution of Se content was mainly affected by parent material, physicochemical properties of soil and other components, soil type, and land use type. Parent material played a key role, as the soil Se content was mainly originated from parent rock and increased with the background value of Se in parent rock, physicochemical properties of soil and other components had certain influences upon the Se content. Se was shown to have a significant linear positive correlation with S and organic carbon but no significant correlation with p H value. Se content varied with different types of soil as follows: skeleton soil > yellow soil > paddy soil > limestone soil > purple soil. Land use type also hadcertain influences upon the soil Se content as follows: dry land > construction land > garden plot > grassland =garden plot > forest land.(3) Taking 0.4 mg kg^(-1)B x(Se) <3.0 mg kg^(-1) as the standard for Se-rich soil, Se-rich soil of the study area covered an area of 2224 km^2 and 92.5% of the total area; the remaining is general soil. The study area had no Se-excess soil. Therefore, the central area of Guiyang City has a high proportion of Se-rich land, a large area of Serich land resources, and a moderate selenium enrichment strength, which have been rarely seen anywhere and provide advantageous resources for the development of Se-rich featured agriculture. | Ziping Pan Shaolin He Chaojin Li Wei Men Chengzhi Yan Fang Wang | 2017 | Acta Geochimica2017，36，2： | 8 |
| 3 | Cu(II)-Catalyzed Ligand-Free Oxidation of Diarylmethanes and Second Alcohols in Water显示文摘我们开发了催化的简单、有效的 Cu (II ) 用水里的 70%tert 丁基 hydroperoxide (TBHP ) 的 diarylmethanes 和第二等的白酒的 ligand 免费的氧化。一系列 diarylmethanes 直接在 67%-98% 收益被氧化进 diaryl 酉同类。另外,各种各样的第二等的白酒也在 48%-98% 收益被转变成需要的产品。重要地,当任何器官的溶剂,表面活化剂,或阶段转移代理人不在时的催化系统,为各种各样的功能的组有一个宽底层范围和高忍耐。 | Jianglong Wu Yan Liu Xiaowei Ma Ping Liu Chengzhi Gu Bin Dai | 2017 | Chinese Journal of Chemistry2017，35，9： | 5 |
| 4 | Preferential binding between intracellular organic matters and Al_(13) polymer to enhance coagulation performance显示文摘Coagulation is the best available method for removing intracellular organic matter(IOM),which is released from algae cells and is an important precursor to disinfection by-products in drinking water treatment. To gain insight into the best strategy to optimize IOM removal, the coagulation performance of two Al salts, i.e., aluminum chloride(AlCl_3) and polyaluminum chloride(PACl, containing 81.2% Al_(13)), was investigated to illuminate the effect of Al species distribution on IOM removal. PACl showed better removal efficiency than AlCl_3 with regard to the removal of turbidity and dissolved organic carbon(DOC), owing to the higher charge neutralization effect and greater stability of pre-formed Al_(13) species. High pressure size exclusion chromatography analysis indicated that the superiority of PACl in DOC removal could be ascribed to the higher binding affinity between Al_(13) polymer and the low and medium molecular weight(MW) fractions of IOM. The results of differential log-transformed absorbance at 254 and 350 nm indicated more significant formation of complexes between AlCl_3 and IOM, which benefits the removal of tryptophan-like proteins thereafter. Additionally,PACl showed more significant superiority compared to AlCl_3 in the removal of <5 kD a and hydrophilic fractions, which are widely viewed as the most difficult to remove by coagulation.This study provides insight into the interactions between Al species and IOM, and advances the optimization of coagulation for the removal of IOM in eutrophic water. | Ruiping Liu Tingting Guo Min Ma Mingquan Yan Jing Qi Chengzhi Hu Gang Liu Huijuan Liu Jiuhui Qu Walter van der Meer | 2019 | Journal of Environmental Sciences2019，31，2： | 5 |
| 5 | Development of Public Participation in Regulatory Planning in China:A Comparative Study Based on National Regulations | YIN Chengzhi, XIONG Yan School of Public Policy & Management, Tsinghua University China Architectural Design & Research Group | 2011 | China City Planning Review2011，20，4： | 4 |
| 6 | Gold nanoparticles based digital color analysis for quinidine detection显示文摘In this contribution,we developed a novel digital color analysis of gold nanoparticles(AuNPs) for pharmaceutical detection by choosing quinidine as an example.It was found that the color of AuNPs colloid solution changed from red to blue in the presence of different concentrations of quinidine,and the color information of each solution could be digitalized with tricolor(RGB) system.Under the optimum conditions,the R value of the solution was found to be linear with the natural logarithm of concentration of quinidine in the range of 112 384 nmol/L.This method has the advantages of rapid,economical and simple,and can serve as a potential alternative to traditional spectrophotometry for practical use. | ZOU BoZhou LIU Yue YAN XiaoLi HUANG ChengZhi | 2013 | Chinese Science Bulletin2013，58，18： | 2 |
| 7 | Genomic decoding of breeding history to guide breeding-by-design in rice显示文摘Deciphering the intrinsic molecular logic of empirical crop breeding from a genomic perspective is a decisive prerequisite for breeding-by-design(BbD),but remains not well established.Here,we decoded the historical features of past rice breeding by phenotyping and haplotyping 546 accessions covering the majority of cultivars bred in the history of Northeast China(NEC).We revealed that three groups founded the genetic diversities in NEC rice with distinct evolution patterns and traced and verified the breeding footprints to known or genome-wide association study(GWAS)-detected quantitative trait loci(QTLs),or introgressions from indica sub-species with chronological changes in allele frequencies.Then we summarized a rice breeding trend/principle in NEC,and combined with the successful example in breeding and application of Zhongkefa5 to demonstrate the guiding value of our conclusion for BbD in practice.Our study provides a paradigm for decoding the breeding history of a specific crop to guide BbD,which may have implications in different crop breeding. | Zhuo Chen Qingyun Bu Guifu Liu Maoqing Wang Hongru Wang Huazhao Liu Xiufeng Li Hong Li Jun Fang Yan Liang Zhenfeng Teng Sai Kang Hong Yu Zhukuan Cheng Yongbiao Xue Chengzhi Liang Jiuyou Tang Jiayang Li Chengcai Chu | 2023 | National Science Review2023，10，5： | 1 |
| 8 | Downward shift of gas hydrate stability zone due to seafloor erosion in the eastern Dongsha Island,South China Sea显示文摘New acquired and reprocessed three-dimensional(3D)seismic data were used to delineate the distribution and characterization of bottom simulating reflections(BSRs)in the Chaoshan Sag,in the eastern part of Dongsha Island,South China Sea.Three submarine canyons with different scales were interpreted from the 3D seismic data,displaying three stages of canyon development and are related with the variation of BSR.Abundant faults were identified from the coherence and ant-tracing attributions extracted from 3D seismic data,which provide the evidence for fluid migration from deeper sediments to the gas hydrate stability zone(GHSZ).The uplift of Dongsha Island created a large number of faults and leads to the increased seafloor erosion.The erosion caused the cooling of the seafloor sediments and deepening of the base of the gas hydrate stability zone,which is attributed to the presence of paleo-BSR and BSR downward shift in the study area.Hence,methane gas may be released during the BSR resetting and gas hydrate dissociation related with seafloor erosion. | JIN Jiapeng WANG Xiujuan HE Min LI Jie YAN Chengzhi LI Yuanping ZHOU Jilin QIAN Jin | 2020 | Journal of Oceanology and Limnology2020，38，4： | 1 |
| 9 | HPLC-DAD-Q- TOF-MS/MS analysis and HPLC quantitati0n of chemical constit- uents iN traditional Chinese medicinal formula Ge-Gen Decoction 显示文摘 | Yao yan Chai Chengzhi Wang Dawei | 2013 | J Pharm Biomed Anal2013，80，192： | 1 |
| 10 | Genome-wide signatures of the geographic expansion and breeding of soybean显示文摘Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We analyzed the genome sequences of 2,214 soybeans and proposed a soybean evolutionary route, i.e., the expansion of annual wild soybean(Glycine soja Sieb. & Zucc.) from southern China and its domestication in central China, followed by the expansion and local breeding selection of its landraces(G. max(L.) Merr.). We observed that the genetic introgression in soybean landraces was mostly derived from sympatric rather than allopatric wild populations during the geographic expansion. Soybean expansion and breeding were accompanied by the positive selection of flowering time genes, including GmSPA3c. Our study sheds light on the evolutionary history of soybean and provides valuable genetic resources for its future breeding. | Ying-Hui Li Chao Qin Li Wang Chengzhi Jiao Huilong Hong Yu Tian Yanfei Li Guangnan Xing Jun Wang Yongzhe Gu Xingpeng Gao Delin Li Hongyu Li Zhangxiong Liu Xin Jing Beibei Feng Tao Zhao Rongxia Guan Yong Guo Jun Liu Zhe Yan Lijuan Zhang Tianli Ge Xiangkong Li Xiaobo Wang Hongmei Qiu Wanhai Zhang Xiaoyan Luan Yingpeng Han Dezhi Han Ruzhen Chang Yalong Guo Jochen C.Reif Scott A.Jackson Bin Liu Shilin Tian Li-juan Qiu | 2023 | Science China(Life Sciences)2023，66，2： | 1 |
| 11 | Rapidgrafting of azido - labeled oligo ( ethyl-ene glycol ) s onto an alkynyl - termina-ted monolayer on nonoxidized silicon viamicrowave - assisted “ Click,’ reaction显示文摘 | Li Yan Wang Jun Cai Chengzhi | 2011 | Langmuir2011，27，6： | 1 |
| 12 | HPLC-DAD-QTOF-MS/MS analysis and HPLC quantitation of chemical constituents in traditional Chinese medicinal formula Ge-Gen Decoction显示文摘 | Yan Yan Chai Chengzhi Wang Dawei | 2013 | J Pharm Biomed Anal2013，80，： | 1 |
| 13 | New candidate proteins for benzo(a)pyrene-induced spatial learning and memory deficits显示文摘 | Chengzhi C Yan T Shuqun C | 2011 | J Toxicol Sci2011，36，2： | 1 |
| 14 | Nuclear PKM2 expression predicts poor prognosis in patients with esophageal squamous cell carcinoma显示文摘 | Xuelin Zhang Chengzhi He Chunya He Baofu Chen Yanxia Liu Min Kong Chunguo Wang Lizhong Lin Yan Dong Haihui Sheng | 2013 | Pathology - Research and Practice2013，，： | 1 |
| 15 | Targeted Degradation of DNA/RNA Binding Proteins via Covalent Hydrophobic Tagging显示文摘Targeted protein degradation(TPD)holds great promise for biological inquiry and therapeutic development.However,it still remains elusive to destruct DNA/RNA binding proteins(DBPs/RBPs)previously deemed undruggable.Herein,we report ligandassisted covalent hydrophobic tagging(LACHT)as a modular strategy for TPD of these difficult-totarget proteins.Guided by a noncovalent protein ligand,LACHT leverages a reactive N-acyl-N-alkyl sulfonamide group to covalently label the protein target with a hydrophobic adamantane,which further engages the cellular quality control mechanism to induce proteolytic degradation.Using a smallmolecule ligand,we demonstrated that LACHT allowed TPD of a DBP,bromodomain-containing protein 4,in human leukemia cells with high efficiency.Mechanistic studies revealed that LACHT-mediated TPD dependent on ligand-directed irreversible tagging and the covalently labeled proteins underwent polyubiquitination before removal through both the proteasome and the lysosome.Furthermore,when an RNA ligand was employed,we showed that LACHT also enabled TPD of an RBP,Lin28a,leading to upregulation of its downstream let-7 miRNA.This study thus provides a generalizable platform to expand the TPD toolbox for biomedical applications. | Yan Wang Jingzi Zhang Jiafang Deng Chengzhi Wang Lei Fang Yan Zhang Jinbo Li | 2023 | CCS Chemistry2023，5，10： | 0 |
| 16 | Evidence for Expensive Tissue Hypothesis in the Asian Common Toad(Duttaphrynus melanostictus)显示文摘Dear Editor,Phenotypic plasticity of an organism by modifying morphological and physiological traits responding to diverse environments is widely recognized across animal taxa(Muñoz-Muñoz et al.,2021;Donihue et al.,2021;Giacomini et al.,2022;Zamora-Camacho et al.,2022;Jiang et al.,2022;Chen et al.,2023).The brain,as a critical phenotypic trait,displays a significant variation in size among different species(Striedter,2006). | Li ZHAO Ying JIANG Duojing QIU Long JIN Chengzhi YAN Li ZHAO Wenbo LIAO | 2023 | Asian Herpetological Research2023，14，4： | 0 |
| 17 | Synergistic drug combinations prediction by integrating pharmacological data显示文摘There is compelling evidence that synergistic drug combinations have become promising strategies for combating complex diseases,and they have evident predominance comparing to traditional one drug-one disease approaches.In this paper,we develop a computational method,namely SyFFM,that takes pharmacological data into consideration and applies field-aware factorization machines to analyze and predict potential synergistic drug combinations.Firstly,features of drug pairs are constructed based on associations between drugs and target,and enzymes,and indication areas.Then,the synergistic scores of drug combinations are obtained by implementing field-aware factorization machines on latent vector space of these features.Finally,synergistic combinations can be predicted by introducing a threshold.We applied SyFFM to predict pairwise synergistic combinations and three-drug synergistic combinations,and the performance is good in terms of cross-validation.Besides,more than 90%combinations of the top ranked predictions are proved by literature and the analysis of parameters in model shows that our method can help to investigate and explain synergistic mechanisms underlying combinatorial therapy. | Chengzhi Zhang Guiying Yan | 2019 | Synthetic and Systems Biotechnology2019，4，1： | 0 |
| 18 | Use of copper-cysteamine nanoparticles to simultaneously enable radiotherapy,oxidative therapy and immunotherapy for melanoma treatment显示文摘Dear Editor,Melanoma,squamous cell carcinoma(SCC),and basal cell carcinoma(BCC)are three major types of skin cancer.Among them,melanoma is the most severe form and accounts for~4%of all newly diagnosed cancers annually in the United States.It is estimated that approximately 9500 people are diagnosed with skin cancer every day,and more than 1 million Americans are living with melanoma.Melanoma treatment is still a major challenge in the clinic.Photodynamic therapy(PDT)is composed of targeted ablation and immune activation,is less invasive than other therapies and has been widely used in the treatment of various cancers. | Qi Zhang Xiangdong Guo Yingnan Cheng Lalit Chudal Nil Kanatha Pandey Jieyou Zhang Lun Ma Qing Xi Guangze Yang Ying Chen Xin Ran Chengzhi Wang Jingyi Zhao Yan Li Li Liu Zhi Yao Wei Chen Yuping Ran Rongxin Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 19 | Effects of iron oxide on crystallization behavior and spatial distribution of spinel in stainless steel slag显示文摘Chromium plays a vital role in stainless steel due to its ability to improve the corrosion resistance of the latter.However,the re-lease of chromium from stainless steel slag(SSS)during SSS stockpiling causes detrimental environmental issues.To prevent chromium pollution,the effects of iron oxide on crystallization behavior and spatial distribution of spinel were investigated in this work.The results revealed that FeO was more conducive to the growth of spinels compared with Fe2O3 and Fe3O4.Spinels were found to be mainly distrib-uted at the top and bottom of slag.The amount of spinel phase at the bottom decreased with the increasing FeO content,while that at the top increased.The average particle size of spinel in the slag with 18wt%FeO content was 12.8μm.Meanwhile,no notable structural changes were observed with a further increase in FeO content.In other words,the spatial distribution of spinel changed when the content of iron oxide varied in the range of 8wt%to 18wt%.Finally,less spinel was found at the bottom of slag with a FeO content of 23wt%. | Zihang Yan Qing Zhao Chengzhi Han Xiaohui Mei Chengjun Liu Maofa Jiang | 2024 | International Journal of Minerals,Metallurgy and Materials2024，31，2： | 0 |
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