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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | Patients with Inflammatory Bowel Disease Have a Lower Response Rate to HBV Vaccination Compared to Controls显示文摘 | Mustafa Erhan Altun?z Ebubekir ?enate? Atakan Ye?il Turan ?alhan Ay?e Oya Kurda? ?vün? | 2012 | Digestive Diseases and Sciences2012，，4： | 3 |
| 4 | Current-source converter based STATCOM, Modeling and control显示文摘 | Ye Y Kazerani M Quintana V H | 2005 | IEEE Transactions on Power Delivery2005，20，2： | 1 |
| 5 | Structure and water sorption of polyurethane nanocomposites based on organic and inorganic components显示文摘 | Mamunya Ye P ShtompelV I Lebedev E V | 2004 | European Polym J2004，40，： | 1 |
| 6 | Recyclable Au, Agand Au-Ag nanocolloids for the chemoselective hydrogenation of t, 13-unsaturated aldehydes and ketones to allylic alcohols显示文摘 | PASCAL G N M PIETER V YE X P | 2009 | ApplCatalA: Genera2009，355，12： | 1 |
| 7 | Residential radon exposure and lung cancer risk in Misasa, Japan: a case-control study显示文摘 | SOBUE T LEE V S YE W | 2000 | J Radiat Res(Tokyo)2000，41，2： | 1 |
| 8 | A novel modeling and control method for three-phase PWM converters显示文摘 | Ye Y Kazerani M Quintana V H | 1999 | IEEE Transactions on Power Electronics1999，46，3： | 1 |
| 9 | Dynamics of placodal lineage development revealed by targeted transgene expression 显示文摘 | Hatini V Ye X Balas G | 1999 | Dev Dyn1999，215，： | 1 |
| 10 | Microplasma systems for creating coatings on aluminum alloys 显示文摘 | BUTYAGIN P I KHOKHRYAKOV YE V MAMAEV A I | 2003 | Materials Letters2003，57，11： | 1 |
| 11 | Magnetic properties of amorphous powders of Y-Co alloys produced by grinding显示文摘 | Yermakov A E Yurchikov Ye Ye Barinov V A | 1981 | Physics of Metals and Metallography1981，52，6： | 1 |
| 12 | Transapical transcatheter aortic valve implantation in humans: initial clinical experience显示文摘 | Lichtenstein S V Cheung A Ye J Thompson C R Carere R G Pasupati S | 2006 | Circulation2006，114，： | 1 |
| 13 | Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity 显示文摘 | Ye S Zhong H Yanamadala V | 2002 | Am J Hypertens2002，15，8： | 1 |
| 14 | Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promotedby cigarette smoke显示文摘 | Ye Y N Wu W K Shin V Y | 2005 | Carcinogenesis2005，26，4： | 1 |
| 15 | Contributory role of 5-1ipoxygen- ase and its association with angiogenesis in the promotion of inflam- mation-associated colonic tumorigenesis by cigarette smoking 显示文摘 | Ye Y N Liu E S Shin V Y | 2004 | Toxicology2004，203，13： | 1 |
| 16 | Azospirillum brasilense colonisation of wheat roots and the role of lectin-carbohydrate interactions in bacterial adsorption and root-hair deformation显示文摘 | Ye g o r e n k o v a I V K o n n o v a l S A S a c h u k V N e t a 1 | 2001 | Plant and soil2001，231，2： | 1 |
| 17 | Research on stem cells as candidates to be differentiated into hepatocytes 显示文摘 | Zhang L Ye JS Decot V | 2012 | Biomed Mater Eng2012，22，13： | 1 |
| 18 | Investigation of anti-islanding protection of power converter based distributed generators using frequency domain analysis 显示文摘 | JOHN V YE Z KOLWALKAR A | 2004 | IEEE Transactions on Power Electronics2004，19，5： | 1 |
| 19 | Nonenzymatic glucose detection using multi-walled carbon nanotube e- leetrodes显示文摘 | Ye J S Wen Y Zhang W V | 2004 | Electroehem Commun2004，，1： | 1 |
| 20 | Formation of the stress-induced mm2 phase at the ferroelastic-antiferroelectric 4 over bar 3m-4 over bar 2m phase transition in Cr-CI boracite 显示文摘 | Topolov V Yu Ye Z G | 1996 | Journal of Physics Condensed Matter1996，8，33： | 1 |
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