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| 1 | Laparoscopic Partial Nephrectomy With Segmental Renal Artery Clamping:Technique and Clinical Outcomes显示文摘Background:Warm ischemic injury is one of the most important factors affecting renal function in partial nephrectomy(PN).The technique of segmental renal artery clamping emerges as an alternative to conventional renal artery clamping for renal hilar control.Objective:To evaluate the feasibility and efficiency of laparoscopic PN(LPN) with segmental renal artery clamping in comparison with the conventional technique.Design,setting,and participants:A total of 75 patients underwent LPN from June 2007 to November 2009.All patients had T1a or T1b tumor in one kidney and a normal contralateral kidney.Thirty-seven patients underwent surgeries with main renal artery clamping,and 38 underwent surgeries with segmental artery clamping.Intervention:All procedures were performed by the same laparoscopic surgeon.Measurements:Blood loss,operation time,warm ischemia(WI) time,and complications affected renal function before and after operation were recorded.Results and limitations:All LPNs were completed without conversion to open surgery or nephrectomy.The novel technique slightly increased WI time(p < 0.001) and intraoperative blood loss(p = 0.006),while it provided better postoperative affected renal function(p < 0.001) compared with the conventional technique.The total complication rate was 12%.Among the 38 cases where segmental renal artery clamping was performed,7 had to convert to the conventional method.Tumor size and location influenced the number of clamped segmental arteries.Long-term postoperative renal function is still awaited.Conclusions:LPN with segmental artery clamping is safe and feasible in clinical practice.It minimizes the intraoperative WI injury and improves early postoperative affected renal function compared with main renal artery clamping.(C) 2010 European Association of Urology.Published by Elsevier B.V.All rights reserved. | Shao,P.F. Qin,C. Yin,C.J. Meng,X.X. Ju,X.B. Li,J. Lü,Q.A. Zhang,W. Xu,Z.Q.Shao,Pengfei Qin,Chao Yin,Changjun Meng,Xiaoxin Ju,Xiaobing Li,Jie Lü,Qiang Zhang,Wei Xu,Zhengquan] Nanjing Med Univ,Affiliated Hosp 1,Dept Urol,Nanjing,Peoples R China.Guangzhou Rd 300,Nanjing 210029,Peoples R China. | 2011 | 南京医科大学学报(自然科学版)2011，31，7： | 123 |
| 2 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 3 | 大斜度井和水平井地层评价中的经验、问题和发展方向显示文摘大斜度井和水平井(HA/HZ)测井组合的选择原则主要是指导地质导向钻井。有时(HA/HZ)井所穿过的地层或油藏某部分没有垂直评价井,只能用HA/HZ测井数据评价常规有效厚度/总厚度比、孔隙度和含水饱和度。对同一地层,HA/HZ测井响应与垂直井响应存在很大差异。研究表明,由于视倾角误差,孔隙度值偏差可达6P.u.,含水饱和度误差超过50%,大斜度井中真地层厚度偏差达到200%~300%。垂直井的常规地层评价方法不太适用于HA/HZ井地层和流体性质评价。HA/HZ井与垂直井测井响应差异的主要原因是很多测井仪器是专为探测垂直井地层而设计的,因此在HA/HZ井中,必须对解释方案进行修改,这时需考虑井眼附近地层的几何形状;测量方位;地层各向异性对电阻率、声波和核测井响应的影响;异常侵入剖面;重力引起的仪器偏心以及井眼底部聚积的岩屑。虽然井眼成像测井能有效地测量大斜度井相对地层倾角,但当井斜超过80°时地层倾角的测量仍存在很多问题。中子和密度测井响应又相当程度地受岩屑的影响。这种井的测井难度很大,将差质量测井响应与因几何形状、各向异性以及井眼影响引起的异常测井响应区分开来显得相当重要。HA/HZ井用于地质导向的定性标准测井难以满足未来地层评价的要求。许多地方不能钻垂直评价井,因此利用大位移井信息评价地层很关键。作业公司和测井服务公司必须相互协作,共同解决HA/HZ井仪器响应和数据解释问题,开发出能定量描述HA/HZ井的新仪器。 | Quinn R Passey H Yin C M Rendeiro D E Fitz 唐宇 王昌学 | 2006 | 测井技术2006，30，1： | 10 |
| 4 | Green fluorescent protein (GFP) transgenic pig produced by somatic cell nuclear transfer显示文摘Transgenic somatic cell nuclear transfer is a very promising route for producing transgenic farm ani-mals. Research on GFP transgenic pigs can provide useful information for breeding transgenic pigs, human disease models and human organ xenotransplantation. In this study, a liposomal transfection system was screened and transgenic embryos were reconstructed by nuclear transfer of GFP positive cells into enucleated in vitro matured oocytes. The development of reconstructed embryos both in vitro and in vivo was observed, and GFP expression was determined. The results showed that porcine fe-tal-derived fibroblast cells cultured with 4.0 μL/mL liposome and 1.6 μg/mL plasmid DNA for 6 h re-sulted in the highest transfection rate (3.6%). The percentage of GFP reconstructed embryos that de-veloped in vitro to the blastocyst stage was 10%. Of those the GFP positive percentage was 48%. Re-constructed transgenic embryos were transferred to 10 recipients. 5 of them were pregnant, and 3 de-livered 6 cloned piglets in which 4 piglets were transgenic for the GFP as verified by both GFP protein expression and GFP DNA sequence analysis. The percentage of reconstructed embryos that resulted in cloned piglets was 1.0%; while the percentage of piglets that were transgenic was 0.7%. This is the first group of transgenic cloned pigs born in China, marking a great progress in Chinese transgenic cloned pig research. | LIU ZhongHua SONG Jun WANG ZhenKun TIAN JiangTian KONG QingRan ZHENG Zhong YIN Zhi GAO Li MA HaiKun SUN Shuang LI YuTian WANG HongBin R S PRATHER | 2008 | Chinese Science Bulletin2008，53，7： | 8 |
| 5 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 6 | Glycogenic hepatopathy:A narrative review显示文摘Glycogenic hepatopathy(GH) is a rare complication of the poorly controlled diabetes mellitus characterized by the transient liver dysfunction with elevated liver enzymes and associated hepatomegaly caused by the reversible accumulation of excess glycogen in the hepatocytes. It is predominantly seen in patients with longstanding type 1 diabetes mellitus and rarely reported in association with type 2 diabetes mellitus. Although it was first observed in the pediatric population, since then, it has been reported in adolescents and adults with or without ketoacidosis. The association of GH with hyperglycemia in diabetes has not been well established. One of the essential elements in the pathophysiology of development of GH is the wide fluctuation in both glucose and insulin levels. GH and non-alcoholic fatty liver disease(NAFLD) are clinically indistinguishable, and latter is more prevalent in diabetic patients and can progress to advanced liver disease and cirrhosis. Gradient dual-echo MRI can distinguish GH from NAFLD; however, GH can reliably be diagnosed only by liver biopsy. Adequate glycemic control can result in complete remission of clinical, laboratory and histological abnormalities. There has been a recent report of varying degree of liver fibrosis identified in patients with GH. Future studies are required to understand the biochemical defects underlying GH, noninvasive, rapid diagnostic tests for GH, and to assess the consequence of the fibrosis identified as severe fibrosis may progress to cirrhosis. Awareness of this entity in the medical community including specialists is low. Here we briefly reviewed the English literature on pathogenesis involved, recent progress in the evaluation, differential diagnosis, and management. | Jagannath M Sherigar Joline De Castro Yong Mei Yin Debra Guss Smruti R Mohanty | 2018 | World Journal of Hepatology2018，10，2： | 7 |
| 7 | Hepatic stellate cells in liver development, regeneration, and cancer显示文摘 | Yin Chunyue Evason Kimberley J Asahina Kinji Stainier Didier Y R | 2013 | Journal of Clinical Investigation2013，，5： | 3 |
| 8 | Lime roasting of pyrite显示文摘 | Taylor P R Yin Z B Barrtlet R W | 1990 | Gold1990，6，： | 2 |
| 9 | Successful operation of a cooperative SLR station of China and Argentina in San Juan显示文摘We introduced the observations and researches using a Satellite Laser Ranging (SLR) system with high precision, which was designed and made in China and installed in the Observatory of San Juan Uni- versity, Argentina, the capability of the system and the achievement of the cooperative procedure be- tween China and Argentina. The SLR station in San Juan, set up by China and Argentina, is quite sig- nificant for improving the distribution of SLR stations and enhancing the orbital coverage of the whole earth. Since the SLR system started to work in the Observatory of San Juan University in the beginning of 2006, the operation is rather good, and rich data with high precision have been obtained. Further plan of the cooperation for the near future is also presented. | HAN YanBen LIU WeiDong E ACTIS R PODESTA WANG TanQiang GUO TangYong QU Feng A M PACHECO A A GONZALEZ E ALONSO XIANG QingGe HUANG DongPing YIN ZhiQiang | 2008 | Chinese Science Bulletin2008，53，16： | 2 |
| 10 | Self-inhibition of synthesis and antigen presentation by Epstein-Barr virus-encoded EBNA1显示文摘 | Yin Y Manoury B Fahraeus R | 2003 | Science2003，301，： | 2 |
| 11 | Metabolic alterations in cerebrospinal fluid from double hemorrhage model of dogs 显示文摘 | Yin W Tibbs R Aoki K | 2001 | Neurol Res2001，23，1： | 1 |
| 12 | Looking at upside down faces显示文摘 | Yin R | 1969 | J Exp Psychol1969，81，： | 1 |
| 13 | Optimal markdown pricing: Implications of inventory display formats in the presence of strategic customers显示文摘 | Yin R Aviv Y Pazgal A | 2009 | Management Science2009，55，8： | 1 |
| 14 | A Geochemical Method for Reconstruction of the Occupation History of Penguin Colony in the Maritime Antarctic显示文摘 | SUN L G ZHU R B YIN X B | 2004 | Polar Biology2004，27，： | 1 |
| 15 | Growth inhibition of prostate cancer cells by epigallocatechin gallate in the presence of Cu^2+显示文摘 | Yu H N Yin J J Shen S R | 2004 | J Agric Food Chem2004，52，3： | 1 |
| 16 | Response of silicon diode dosemeters to scattered radiation from megavoltage photon beams显示文摘 | YIN Z HUGTENBURG R P BEDDOE A H | 2002 | Radiat Prot Dosim2002，101，14： | 1 |
| 17 | Effect of dietary supplementation of chitosan and galacto-mannan-oligo- saecharides on serum parameters and the insulin-like growth factor-I mRNA expression in early weaned pig- lets显示文摘 | Tang Z R Yin Y L Nyachoti C M | 2005 | Domest Anim Endocrin2005，28，： | 1 |
| 18 | Prognostic interaction between thrombocytosis and JAK2V617F mutation in the WHO subcateories of melodysplastic/myeloproliferative disease-unclassifiable and refractory anemia with ringed sideroblasts and marked thrombocytosis Leukemia显示文摘 | Atallah E Nussenzveig R Yin CC | 2008 | 22 (6):1295-12982008，22，6： | 1 |
| 19 | Genetic profiling in graves'disease:further evidence for lack of a distinct genetic contribution tograves'ophthalmopathy显示文摘 | Yin X Latif R Bahn R | | 0，，07： | 1 |
| 20 | MicroRNA-145 suppresses lung adenocarcinoma-initiating cell proliferation by targeting OCT4显示文摘 | Yin R Zhang S Wu Y | 2011 | Oncol Rep2011，25，6： | 1 |
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