|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | Endoscopic retrograde cholangiopancreatography in cirrhosis-a systematic review and meta-analysis focused on adverse events显示文摘AIM To investigate indications and outcomes of endoscopic retrograde cholangiopancreatography(ERCP) in cirrhotics, especially adverse events. Patients with cirrhosis undergoing ERCP are believed to have increased risk. However, there is a paucity of literature describing the indications and outcomes of ERCP procedures in patients with cirrhosis, especially focusing on adverse events.METHODS We performed a systematic appraisal of major literature databases, including PubMed and EMBASE, with a manual search of literature from their inception until April 2017.RESULTS A total of 6,505 patients from 15 studies were analyzed(male ratio 59%, mean age 59 years), 11% with alcoholic and 89% with non-alcoholic cirrhosis, with 56.2% Child-Pugh class A, and 43.8% class B or C. Indications for ERCP included choledocholithiasis 60.9%, biliary strictures 26.2%, gallstone pancreatitis 21.1% and cholangitis 15.5%. Types of interventions included endoscopic sphincterotomy 52.7%, biliary stenting 16.7% and biliary dilation 4.6%. Individual adverse events included hemorrhage in 4.58%(95%CI: 2.77-6.75%, I^2 = 85.9%), post-ERCP pancreatitis(PEP) in 3.68%(95%CI: 1.83-6.00%, I^2 = 89.5%), cholangitis in 1.93%(95%CI: 0.63-3.71%, I^2 = 87.1%) and perforation in 0.00%(95%CI: 0.00-0.23%, I^2 = 37.8%). Six studies were used for comparison of ERCPrelated complications in cirrhosis vs non-cirrhosis, which showed higher overall rates of complications in cirrhosis patients with pooled OR of 1.63(95%CI: 1.27-2.09, I2 = 65%): higher rates of hemorrhage with OR of 2.05(95%CI: 1.62-2.58, I^2 = 2.1%) and PEP with OR of 1.33(95%CI: 1.04-1.70, I2=65%), but similar cholangitis rates with OR of 1.23(95%CI: 0.67-2.26, I^2 = 44.3%).CONCLUSION There is an overall higher rate of adverse events related to ERCP in patients with cirrhosis, especially hemorrhage and PEP. A thorough risk/benefit assessment should be performed prior to undertaking ERCP in patients with cirrhosis. | Shailender Singh Mashiana Amaninder Singh Dhaliwal Harlan Sayles Banreet Dhindsa Ji Won Yoo Qing Wu shailender singh Ali A Siddiqui Gordon Ohning Mohit Girotra Douglas G Adler | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，11： | 6 |
| 3 | Decellularization for whole organ bioengineering显示文摘 | J E Arenas-Herrera I K Ko A Atala J J Yoo | 2013 | Biomedical Materials2013，，1： | 2 |
| 4 | Stress and sleep quality in doctors working on-call shifts are associated with functional gastrointestinal disorders显示文摘AIM To investigate the role of sleep quality and psychosocial problems as predictors of functional gastrointestinal disorders(FGIDs) in doctors that work 24 hour-on-call shifts.METHODS In this cross-sectional observation study, using the Rome Ⅲ Questionnaire and Pittsburgh Sleep Quality Index(PSQI), we analyzed 170 doctors with 24 houron-call shifts. RESULTS Among the participants that had experienced a 24 hour-on-call shift within the last 6 mo, 48(28.2%) had FGIDs. Overall prevalence of irritable bowel syndrome(IBS) and functional dyspepsia(FD) were 16.5% and 17.1%, respectively, with 5.3% exhibiting both. Sleep scores(PSQI)(8.79 ± 2.71 vs 7.30 ± 3.43, P = 0.008), the presence of serious psychosocial alarm(83.3%vs 56.6%, P = 0.004), and the proportion of doctors who experienced over two months of recent on-call work(81.2% vs 68.9%, P = 0.044) were significantly different between individuals with or without FGIDs. Multivariate analysis revealed that presenting serious psychosocial alarm was an independent risk factor for prevalence of FD(OR = 5.47, 95%CI: 1.06-28.15, P = 0.042) and poor sleep quality(PSQI ≥ 6) was a predictor of IBS(OR = 4.17, 95%CI: 1.92-19.02, P = 0.016). CONCLUSION Physicians should recognize the role of sleep impairment and psychological stress in the development of FGIDs and a comprehensive approach should be considered to manage patients with FGIDs. | Soo-Kyung Lim Seung Jin Yoo Dae Lim Koo Chae A Park Han Jun Ryu Yong Jin Jung Ji Bong Jeong Byeong Gwan Kim Kook Lae Lee Seong-Joon Koh | 2017 | World Journal of Gastroenterology2017，23，18： | 2 |
| 5 | Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression显示文摘 | Yoo Byoung Kwon Emdad Luni Su Zao-zhong Villanueva Augusto Chiang Derek Y Mukhopadhyay Nitai D Mills Alan Scott Waxman Samuel Fisher Robert A Llovet Josep M Fisher Paul B Sarkar Devanand | 2009 | Journal of Clinical Investigation2009，，3： | 2 |
| 6 | On-line adaptive and nonlinear process monitoring of a pilot-scale sequencing batch reactor显示文摘 | YOO C K VANROLLEGHEM P A | 2006 | Environmental Monitoring and Assessment2006，119，： | 1 |
| 7 | Engineering of vaginal tissue in vivo显示文摘 | De Filippo RE Yoo JJ Atala A | 2003 | Tissue Eng2003，9，2： | 1 |
| 8 | Phylogeny and diversificatoin of B-function MADS-box genes in angiosperms: Evolutionary and functional implications of a 260-million-year-old duplication显示文摘 | Kim S Yoo M J Albert V A | 2004 | Am J Bot2004，91，： | 1 |
| 9 | On the optimality of multiantenna broadcast scheduling using zero- forcing beamforming 显示文摘 | Yoo T Goldsmith A | 2006 | IEEE Journal on Selected Areas in Communications2006，24，3： | 1 |
| 10 | Autologous penile corpora cavernosa replacement using tissue engineering techniques显示文摘 | Kwon TG Yoo JJ Atala A | 2002 | J Urol2002，168，42： | 1 |
| 11 | Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins显示文摘 | Yoo J Nichols A Mammen J | 2003 | Am J Physiol Cell Physiol2003，285，2： | 1 |
| 12 | Development of thermo- stable Candidaantarctica lipase B through novel in silico design of disulfidebridge显示文摘 | LE Q A T JOO J C YOO Y J | 2012 | Biotechnology and Bioengineering2012，109，4： | 1 |
| 13 | Urethral replacement using cell seeded tubularized collagen matrices显示文摘 | De Filippo RE Yoo JJ Atala A | | 0，，： | 1 |
| 14 | Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer’s disease显示文摘 | Liu Y Yoo MJ Savonenko A | 2008 | J Neurosci2008，28，13： | 1 |
| 15 | Role of endolaryngeal surgery (with or without laser) versus radiotherapy in the management of early (T1) glottic cancer: a systematic review显示文摘 | YOO J LACCHETTI C HAMMOND J A | 2014 | Head Neck2014，36，： | 1 |
| 16 | The control of neural cell-to-cell interactions through non- contact electrical field stimulation using graphene electrodes显示文摘 | Heo C Yoo J Lee S Jo A Jung S Yoo H Lee Y H Suh M | 2011 | Biomaterials2011，32，： | 1 |
| 17 | Immunomodulatory Effect of Arctigenin,a Lignan compound,on Tumor Necrosis Factor-αand Nit ric Oxide Production,and lymphocyte Proliferation显示文摘 | CHO J Y KIM A R YOO E S | 1999 | J Pharm Pharmacol1999，51，11： | 1 |
| 18 | Phase I study of subconjunctival ranibizumab in patients with primary pterygium undergoing pterygium surgery显示文摘 | Galor A Yoo SH Piccoli FV | | 0，，： | 1 |
| 19 | 查看详情显示文摘 | Fan W Snyder M A Kumar S Lee P S Yoo W C McCormick A V Penn R L Stein A Tsapatsis M | | 0，，： | 1 |
| 20 | On the optimality of multiantenna broadcast scheduling using zero-forcing beamforming显示文摘 | Yoo T Goldsmith A J | 2006 | IEEE Journal on Selected Areas in Communications2006，24，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员