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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Herlyn-Wemer-Wunderlich syndrome, obsrtueted hemivagina, uterus didelphys, unilateral renal agenesis显示文摘 | Doron K Yaara A Yael H | 2013 | IMAGing2013，15，： | 1 |
| 3 | Alternative splicing regulation at tandem 3 ' splice sites 显示文摘 | Martin A Yael M | 2006 | Nucleic Acids Research2006，34，1： | 1 |
| 4 | The E2 ubiquitin-conjugating enzymes Direct polyubiquitination to preferred lysines显示文摘 | Yael D Tamar Z Arie A | 2010 | J Biol Chem2010，285，： | 1 |
| 5 | typical amyoplasia congenita in an infant with Leigh syndrome:a mitochondrial cause of severe contractures显示文摘 | Wilnai Yael Seaver Laurie H Enns Gregory M A | 2012 | Am J Med Genet A2012，158，9： | 1 |
| 6 | SOCIAL CONSEQUENCES OF BORDERLINE PERSONALITY DISORDER SYMPTOMS IN A POPULATION-BASED SURVEY: MARITAL DISTRESS, MARITAL VIOLENCE, AND MARITAL DISRUPTION显示文摘 | Whisman Mark A Schonbrun Yael Chatav | 2009 | Journal of Personality Disorders2009，，4： | 1 |
| 7 | Carbamate Insecticides:Removal from Water by Chlorination and Ozonation显示文摘 | Yael M Ehud C Chaim R A | 1990 | Water Research1990，24，1： | 1 |
| 8 | Characterization of water distribution in bread during storage using magnetic resonance imaging显示文摘 | ALESSIA L AMIR M A YAEL V | 2007 | Magn Resort Imaging2007，25，10： | 1 |
| 9 | Face recognition:the problem of compensating for changes in illumination direction显示文摘 | Yael A Yael M Shimon U | 1997 | IEEE Transactions on Pattern Analysis and Machine Intelligence1997，19，7： | 1 |
| 10 | Self-rated oral health as an inde- pendent predictor of self-general health, self-esteem and life satisfac- tion 显示文摘 | Yael B Howard Lh Elaine A | 2004 | Social Science & Medicine2004，59，5： | 1 |
| 11 | Characterization of water distri- bution in bread during storage using magnetic resonance imaging 显示文摘 | Alessia L Amir M A Yael V | 2007 | Magnetic Resonance Imaging2007，25，10： | 1 |
| 12 | Self-rated oral health as an independent predictor of self-rated general health, self-esteem and life satisfaction显示文摘 | Yael Benyamini Howard Leventhal Elaine A Leventhal | 2003 | Social Science & Medicine2003，，5： | 1 |
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