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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Characterization of water distribution in bread duringstorage using magnetic resonance imaging显示文摘 | Alessia Lodi Amir M Abduljalilb Yael Vodovotz | 2007 | MagneticResonance Imaging2007，25，10： | 1 |
| 3 | Extracelluar matrix production and calcium carbonate precipitation by coral cells in vitro 显示文摘 | Yael Helman Frank Natale Robert M | 2008 | PNAS2008，105，1： | 1 |
| 4 | Phosphoenolpyruvate Carboxykinase Revisited显示文摘 | Colleen M Croniger Yael Olswang | 2002 | Biochemistry and Molecular Biology Education2002，30，1： | 1 |
| 5 | Alternative splicing regulation at tandem 3 ' splice sites 显示文摘 | Martin A Yael M | 2006 | Nucleic Acids Research2006，34，1： | 1 |
| 6 | How taxonomic diversity,commu nitystructure,and sample size determine the reliability of higher taxon surrogates 显示文摘 | Thomas MN ItaiVR Yael M | 2013 | Ecological Applications2013，23，： | 1 |
| 7 | Bioehar impact on de- velopment and productivity of pepper and tomato grown in ferti- gated soilless media 显示文摘 | Ellen R G Yael M H Max K | 2010 | Plant Soil2010，337，： | 1 |
| 8 | Involvement of a short interspersed element in epigenetic transcriptional silencing of the amoebapore gene in Entamoeba histolytica显示文摘 | Anbar M Bracha R Yael Nuchamowitz | 2005 | Eukaryotic Cell2005，4，： | 1 |
| 9 | Phosphoenolpyruvate carboxykinase revisited insights into its metabolic role显示文摘 | Colleen M Croniger Yael Olswang Lea Reshef | 2002 | Biochem Mol Biol Edu2002，30，1： | 1 |
| 10 | Biochar impact on de- velopment and productivity of pepper and tomato grown in fertigated soilless media 显示文摘 | ELLEN R G YAEL M I-I MAX K | 2010 | Plant Soil2010，337，： | 1 |
| 11 | Char- aeterization of water distribution in bread during storage using magnetic resonance imaging显示文摘 | ALESSIA Lodi AMIR M Abduljalil YAEL Vodovotz | 2007 | Magnetie Resonance Imaging2007，，25： | 1 |
| 12 | typical amyoplasia congenita in an infant with Leigh syndrome:a mitochondrial cause of severe contractures显示文摘 | Wilnai Yael Seaver Laurie H Enns Gregory M A | 2012 | Am J Med Genet A2012，158，9： | 1 |
| 13 | Characterization of water distribution in bread during storage using magnetic resonance imaging显示文摘 | Alessia Lodi Amir M Abduljalil Yael Vodovotz | | 0，，： | 1 |
| 14 | Carbamate Insecticides:Removal from Water by Chlorination and Ozonation显示文摘 | Yael M Ehud C Chaim R A | 1990 | Water Research1990，24，1： | 1 |
| 15 | Phosphoenolpyruvate carboxykina revisited显示文摘 | Colleen M Croniger Yael Olswang Lea Reshef | 2002 | Biochemi Mol Biol Education2002，30，1： | 1 |
| 16 | Characterization of water distribution in bread during storage using magnetic resonance imaging显示文摘 | ALESSIA L AMIR M A YAEL V | 2007 | Magn Resort Imaging2007，25，10： | 1 |
| 17 | Detection of Eharlichia canis by PCR in different tissues obtained during necropsy from dogs surveyed for naturally occurring canine monoeytic ehrlichiosis 显示文摘 | Arnon G Emmanuel L Yael Y M | 2008 | Vet J2008，，175： | 1 |
| 18 | DNA isolation and AFLP fingerprinting of nectarine and peach varieties (Prunus persica)显示文摘 | AUGUSTO M SERGIO L YAEL J MANUEL T ROSA M MANUEL L DANIELA S | 1999 | Plant Molecular Biology Reporter1999，17，： | 1 |
| 19 | Face recognition:the problem of compensating for changes in illumination direction显示文摘 | Yael A Yael M Shimon U | 1997 | IEEE Transactions on Pattern Analysis and Machine Intelligence1997，19，7： | 1 |
| 20 | Phosphoenolpyruvate carboxykinase revisited 显示文摘 | Colleen M Croniger Yael Olswang | 2002 | Biochemistry and Molecular Biology Education2002，30，1： | 1 |
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