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| 1 | Slip rate of the seismogenic fault of the 2021 Maduo earthquake in western China inferred from GPS observations显示文摘Seismic and field observations indicate that the Mw7.4 Maduo earthquake ruptured the Jiangcuo fault,which is a secondary fault~85 km south of the northern boundary of the Bayan Hor block in western China.The kinematic characteristics of the Jiangcuo fault can shed lights on the seismogenic mechanism of this earthquake.Slip rate is one of the key parameters to describe the kinematic features of a fault,which can also provide quantitative evidences for regional seismic hazard assessments.However,due to lack of effective observations,the slip rate of the Jiangcuo fault has not been studied quantitatively.In this study,we consider the interaction between the Jiangcuo fault and the eastern Kunlun fault,and estimate the slip rates of the two faults using the interseismic GPS observations across the seismogenic region.The inferred results show that the slip rates of the Jiangcuo fault and the Tuosuo Lake segment of the Kunlun fault are 1.2±0.8 and 5.4±0.3 mm a^(-1),respectively.Combining the slip rate with the average slip inferred from the coseismic slip model,the earthquake recurrence interval of the Jiangcuo fault is estimated to be 1800700+3700 years(1100–5500 years).Based on the results derived from previous studies,as well as calculations in this study,we infer that the slip rate of the Kunlun fault may decrease gradually from the Tuosuo Lake segment to the eastern tip.The Jiangcuo fault and its adjacent parallel secondary faults may have absorbed the relative motion of blocks together with the Kunlun fault. | Yage ZHU Faqi DIAO Yuchao FU Chengli LIU Xiong XIONG | 2021 | Science China Earth Sciences2021，64，8： | 3 |
| 2 | A Meta-Analysis of Pension Models for Patients with Mental Disorders显示文摘Objective:To analyze the pension models available for patients with mental disorders and design a more suitable one.Methods:A total of 135 pieces of literature in the database of China National Knowledge Infrastructure(CNKI)published from August 11,1970,to November 17,2022,were classified and analyzed.A knowledge map was drawn and the research context was sorted out from the aspects of temporal distribution,spatial distribution,research hotspots,and evolutionary trend,so as to reveal the research status and development trend in the field of pension for patients with mental disorders.Results:The temporal distribution of the literature in this review involved 20 disciplines,41 papers,2 information articles,40 authors,13 research levels,and 20 research institutions.In terms of research hotspots and evolutionary trends,the keywords“disability pension,”“pension institutions,”and“patients with mental disorders”play a fundamental role in the dynamic evolution and diversification of research topics in the field of the mental disorder pension model.Conclusion:There has been not much research on elderly care for patients with mental disorders,and it is still in the exploratory stage without a sustainable and stable research theme.In recent years,keywords such as“the combination of medical care,”“community care for the elderly,”and“intelligent care”for the elderly have become prominent and the number of related studies has increased,and the research quality in this field has also improved.Intelligent medical care for elderly patients with mental disorders will become the trend of future research. | Yage Zhu Liangmei Chen | 2023 | Journal of Clinical and Nursing Research2023，7，6： | 0 |
| 3 | Bi-FoRe:an efficient bidirectional knockin strategy to generate pairwise conditional alleles with fluorescent indicators显示文摘Gene expression labeling and conditional manipulation of gene function are important for elaborate dissection of gene function.However,contemporary generation of pairwise dual-function knockin alleles to achieve both conditional and geno-tagging effects with a single donor has not been reported.Here we first developed a strategy based on a flipping donor named FoRe to generate conditional knockout alleles coupled with fluorescent allele-labeling through NHEJ-mediated unidirectional targeted insertion in zebrafish facilitated by the CRISPR/Cas system.We demonstrated the feasibility of this strategy at sox10 and isl1 loci,and successfully achieved Cre-induced conditional knockout of target gene function and simultaneous switch of the fluorescent reporter,allowing generation of genetic mosaics for lineage tracing.We then improved the donor design enabling efficient one-step bidirectional knockin to generate paired positive and negative conditional alleles,both tagged with two different fluorescent reporters.By introducing Cre recombinase,these alleles could be used to achieve both conditional knockout and conditional gene restoration in parallel;furthermore,differential fluorescent labeling of the positive and negative alleles enables simple,early and efficient realtime discrimination of individual live embryos bearing different genotypes prior to the emergence of morphologically visible phenotypes.We named our improved donor as Bi-FoRe and demonstrated its feasibility at the sox10 locus.Furthermore,we eliminated the undesirable bacterial backbone in the donor using minicircle DNA technology.Our system could easily be expanded for other applications or to other organisms,and coupling fluorescent labeling of gene expression and conditional manipulation of gene function will provide unique opportunities to fully reveal the power of emerging single-cell sequencing technologies. | Bingzhou Han Yage Zhang Xuetong Bi Yang Zhou Christopher JKrueger Xinli Hu Zuoyan Zhu Xiangjun Tong Bo Zhang | 2021 | Protein & Cell2021，12，1： | 0 |
| 4 | A regeneration process-matching scaffold with appropriate dynamic mechanical properties and spatial adaptability for ligament reconstruction显示文摘Ligament regeneration is a complicated process that requires dynamic mechanical properties and allowable space to regulate collagen remodeling.Poor strength and limited space of currently available grafts hinder tissue regeneration,yielding a disappointing success rate in ligament reconstruction.Matching the scaffold retreat rate with the mechanical and spatial properties of the regeneration process remains challenging.Herein,a scaffold matching the regeneration process was designed via regulating the trajectories of fibers with different degradation rates to provide dynamic mechanical properties and spatial adaptability for collagen infiltration.This core-shell structured scaffold exhibited biomimetic fiber orientation,having tri-phasic mechanical behavior and excellent strength.Besides,by the sequential material degradation,the available space of the scaffold increased from day 6 and remained stable on day 24,consistent with the proliferation and deposition phase of the native ligament regeneration process.Furthermore,mature collagen infiltration and increased bone integration in vivo confirmed the promotion of tissue regeneration by the adaptive space,maintaining an excellent failure load of 67.65%of the native ligament at 16 weeks.This study proved the synergistic effects of dynamic strength and adaptive space.The scaffold matching the regeneration process is expected to open new approaches in ligament reconstruction. | Xiaojing Xie Junjie Xu Jing Lin Jia Jiang Yunfan Huang Jun Lu Yuhao Kang Yage Hu Jiangyu Cai Fujun Wang Tonghe Zhu Jinzhong Zhao Lu Wang | 2022 | Bioactive Materials2022，7，7： | 0 |
| 5 | Probing the interseismic locking state of the Xianshuihe fault based on a viscoelastic deformation model显示文摘The interseismic locking state of tectonic faults is essential for regional seismic hazard assessments.However,it is challenging to obtain this parameter reliably due to the weak deformation and complex model configurations.To better probe the fault locking state,more reliable physical models and well-covered observations are required.Here we investigate the locking state of the Xianshuihe fault based on a new-developed viscoelastic deformation model.Meanwhile,we combine GPS velocities from 13 new near-field stations and existing stations in this region to improve the spatial resolution.Similar to the theoretical predictions,our results indicate that the elastic model will clearly overestimate the fault locking depth and seismic moment accumulation rate,and the fault slip rate inferred from the elastic model is slightly lower than that from the viscoelastic model.Relying on the locking distribution inferred from the viscoelastic model,we identify four potential asperities on the Xianshuihe fault.More importantly,we find a clear spatial correlation between the fault locking distribution and the rupture extent of historical earthquakes,which indicates that the fault locking state may control the rupture extent and thus the magnitude of earthquakes.In addition,our results show that the 2022 M6.8 Luding earthquake only ruptured the south part of a potential asperity,and the accumulated energy in the northern unruptured area is equivalent to an Mw6.9 earthquake,where the seismic hazard deserves special attention. | Yage ZHU Faqi DIAO Fei CHEN Yuebing WANG Zhigang SHAO Rongjiang WANG Xiong XIONG | 2024 | Science China Earth Sciences2024，67，1： | 0 |
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