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| 1 | Mechanism studies of Xinfeng capsule on improving cardiovascular function though toll-like receptor 4/nuclear factor kappa B pathway in a rat model of adjuvant arthritis显示文摘OBJECTIVE: To observe the impact of Xinfeng capsule(XFC) on cardiovascular function in adjuvant arthritis(AA) model rats and investigate the mechanism though toll-like receptor 4(TLR4)/nuclear factor kappa B(NF-κB) signaling pathway.METHODS: Seventy rats were randomly divided into seven groups: normal control(NC), model control(MC), tripterygium glycosides tablet(TPT),methotrexate(MTX), high, moderate and low dose XFC group. The administration began from day 19 after modeling for 30 day. Paw swelling, arthritic in-dex(AI), cardiac function indexes and myocardial pathological pattern were detected. The expression of TLR4, myeloid differentiation factor(My D) 88, interleukin-1 receptor-associated kinase(IRAK) 1, tumor necrosis factor receptor associated factor(TRAF) 6, NF-κB, tumor necrosis factor-alpha(TNF-α) proteins in myocardial tissue were determined by western blot method.RESULTS: Paw swelling and AI in MC group increased in MC group(P < 0.01), and decreased in high and moderate dose XFC groups(P < 0.01 or P > 0.05). Left ventricular systolic pressure(LVSP),left ventricular end-diastolic pressure(LVEDP),heart rate(HR) were elevated in MC group(P <0.01), and ± dp/dtmax and CI were reduced(P <0.01); while LVSP, LVEDP and HR declined and ±dp/dtmax, CI improved in high dose XFC group(P <0.05 or P < 0.01). LVSP in high dose XFC group were reduced more than other treatment groups(P <0.05 or P < 0.01). The improvements on LVEDP, dp/dt-max were superior to MTX and low dose XFC group, and the improvement on CI was better than low dose XFC group(P < 0.05 or P < 0.01). Myocardial fibers arranged irregular in MC group with intracellular edema and mitochondria damage. The modifications on myocardial structural were shown in each treatment group, but more prominent in TPT, high and moderate dose XFC group. The proteins of TLR4, My D88, IRAK1, TRAF6, NF-κB, TNF-αwere highly expressed in MC group, and those proteins declined in high and moderate dose XFC group(P < 0.05 or P < 0.01). High dose XFC group was superior to MTX and low dose XFC group on reducing TLR4, NF-κB, TNF-α(P < 0.05).CONCLUSION: XFC can not only inhibit the excessive activation of TLR4/NF-κB signaling pathway and the increased inflammatory mediators, but also reduce the damage of myocardial tissue and cells. | Wang Yuan Liu Jian Huang Chuanbing Sun Yue Zhang Wandong Wan Lei Zong Ruikai Wang Yali | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 4 |
| 2 | Comparative study of mutation spectrums ofMT-RNR1m.1555A〉G, GJB2, and SLC26A4 between familial and sporadic patients with nonsyndromic sensorineural hearing loss in Chinese Han显示文摘 | Li Qian Ji Yubin Han Bing Zong Liang Lan Lan Zhao Yali Wang Hongyang Wang Dayong Wang Qiuju | 2014 | Chinese Medical Journal2014，，18： | 3 |
| 3 | Two-step Structural Design of Mesh Antennas for High Beam Pointing Accuracy显示文摘A well-designed reflector surface with high beam pointing accuracy in electromagnetic performance is of practical significance to the space application of cable mesh reflector antennas. As for space requirements, circular polarizations are widely used in spaceborne antennas,which usually lead to a beam shift for offset reflectors and influence the beam pointing accuracy. A two-step structural design procedure is proposed to overcome the beam squint phenomenon for high beam pointing accuracy design of circularly polarized offset cable mesh reflectors. A simple structural optimal design and an integrated structural electromagnetic optimization are combined to alleviate the beam squint effect of circular polarizations. It is implemented by cable pretension design and adjustment to shape the offset cable mesh surface. Besides, in order to increase the efficiency of integrated optimization, an update Broyden-Fletcher-Goldfarb-Shanno(BFGS) Hessian matrix is employed in the optimization iteration with sequential quadratic programming. A circularly polarized offset cable mesh reflector is utilized to show the feasibility and effectiveness of the proposed procedure. A high beam pointing accuracy in order of 0.0001o of electromagnetic performance is achieved. | Shuxin ZHANG Jingli DU Wei WANG Xinghua ZHANG Yali ZONG | 2017 | Chinese Journal of Mechanical Engineering2017，30，3： | 2 |
| 4 | The enhanced gas sensing behavior of porous nanocrystalline SnO 2 prepared by solid-state chemical reaction显示文摘 | Ying Zong Yali Cao Dianzeng Jia Pengfei Hu | 2009 | Sensors & Actuators: B Chemical2009，，1： | 1 |
| 5 | Clue to a New Deafness Gene:A Large Chinese Nonsyndromic Hearing Loss Family Linked to DFNA4显示文摘Hereditary hearing loss is one of the most common neurosensory defects in humans.Approximately 70%of cases are nonsyndromic and could be inherited in autosomal dominant, autosomal recessive,mitochondrial,X-linked,and Y-linked manners(Wang et al.,2004;Alford,2011).The autosomal dominant type,comprising 15%-20%of nonsyndromic hearing loss,is monogenic and genetically heterogeneous.Since the first dominant deafness | Liang Zong Chunye Lu Yali Zhao Qian Li Dongyi Han Weiyan Yang Yan Shen Qingyin Zheng Qiuju Wang | 2012 | Journal of Genetics and Genomics2012，39，12： | 0 |
| 6 | 肝胆肿瘤中肿瘤特异性CircRNA衍生抗原肽的鉴定显示文摘基于肿瘤抗原的免疫治疗的应用受到验证免疫原性肽稀缺性的阻碍。本研究旨在研究环状RNA(circRNA)在肝胆肿瘤类器官中作为肿瘤抗原肽新来源的潜力。使用RNA测序(RNA-seq)和基于算法的评分工具,预测3950个翻译的肿瘤特异性环状RNA在27个类器官中产生18971个抗原肽。从抗原格局来看,11个氨基酸长度(mer)肽和人白细胞抗原(HLA)-A结合肽具有最高的免疫原性相关评分。在分析的3/5类器官中,有13个预测抗原肽通过质谱(MS)免疫肽组学被直接确认为HLA-A、HLA-B和HLA-C(HLA-ABC)结合肽。在流式细胞术和酶联免疫吸附试验(ELISA)中,由HLA-ABC分子呈递的circRNA衍生的肿瘤特异性肽刺激CD8(CD8)T细胞,显示CD107a干扰素γ(IFNγ)共表达和IFNγ分泌增加。免疫原性环状RNA衍生肽诱导的靶向类器官的细胞毒性T细胞活性在杀伤实验中得到验证。值得注意的是,来自circTBC1D15的抗原肽YGFNEILKK不仅被认为是类器官的HLA-ABC呈递肽,而且还显著降低了肿瘤类器官的存活率。本研究的发现强调了产生肿瘤抗原的一个关键亚群,这对靶向肿瘤特异性circRNA具有重要意义。 | Wenwen Wang Lili Ma Zheng Xing Tinggan Yuan Jinxia Bao Yanjing Zhu Xiaofang Zhao Yan Zhao Yali Zong Yani Zhang Siyun Shen Xinyao Qiu Shuai Yang 王红阳 高栋 王鹏 陈磊 | 2023 | Engineering2023，，3： | 0 |
| 7 | Investigation of Reaction Mechanism of Amino Acids and Phosphorus Trichloride by 31P NMR and ESI-MS/MS显示文摘在 THF 的氨基酸和磷 trichloride 的反应被跟踪的 31P NMR 和 ESI-MS/MS 学习。一系列 hydridophoranes 和周期的 dipeptides 被获得。反应介绍了有趣的差异,反应机制被建议。机制建议那磷在氨基酸 hydridophorane 和周期的 dipeptides 的合成起一个重要作用。结果也证明 31P NMR 和 ESI-MS/MS 是为反应机制的调查的有用工具。 | Guo, Yanchun Cao Shuxia Xie, Yali Zong, Xiangkun Zhao, Yufen | 2011 | Chinese Journal of Chemistry2011，29，6： | 0 |
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