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| 1 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 2 | Insights into low fish mercury bioaccumulation in a mercury-contaminated reservoir, Guizhou, China显示文摘 | Bian Liu Haiyu Yan Cuiping Wang Qiuhua Li Stéphane Guédron Jorge E. Spangenberg Xinbin Feng Janusz Dominik | 2011 | Environmental Pollution2011，，： | 1 |
| 3 | The blood-brain barrier penetra- tion and distribution of PEGylated fluorescein-doped magnetic sil- ica nanoparticles in rat brain显示文摘 | Ku ST Yan F Wang Y | 2010 | Biochem Biophys Res Commun2010，394，4： | 1 |
| 4 | Tip30-induced apoptosis requires translocation of Bax and involves mitochondrial release of cytochromec and Smac/DIABLO in hepatocellular carcinoma cells 显示文摘 | Shi M Yan SG Xie ST | 2008 | Biochimica Biophysica Acta2008，1783，： | 1 |
| 5 | Tip30-indueed apoptosis requires translocation of Bax and involves mitochondrial release of cytochrome c and Smac/DIABLO in hepatoeeliular carcinoma cells显示文摘 | Shi M Yan SG Xie ST | 2008 | Bioehim Biophys Aeta2008，1783，2： | 1 |
| 6 | Floating photoeatalysts of flyash cenospheres supported Ag Cl/TiO2 films with enhanced Rhodamine B photedecomposition activity 显示文摘 | Huo PW Yan YS Li ST | 2010 | Desalination2010，256，13： | 1 |
| 7 | Preparation of poly-o-phenylenediamine/TiO2/flyash cenospheres and its photo-degradation property on antibiotics 显示文摘 | Huo PW Yan YS Li ST | 2010 | Applied Surface Science2010，256，11： | 1 |
| 8 | Clinical Pharmacokinetics of the Nicotinic Channel Modulator Dexmecamylamine (TC-5214) in Subjects with Various Degrees of Renal Impairment显示文摘 | Sofie Alverlind Stéphane Barassin Per Dalén Yan Li Steven Toler Hans Eriksson Raj Tummala | 2014 | Clinical Drug Investigation2014，，7： | 1 |
| 9 | Protective effects from carnosine and histidine on acetaminophen-induced liver injury显示文摘 | Yan SL Wu ST Yin MC | 2009 | J Food Sci2009，74，： | 1 |
| 10 | Tip30-induced apoptosis requires translocation of Bax and involves mitochondrial release of cytochrome e and Smac/DIABLO in hepatocellular carcinoma cells 显示文摘 | Shi M Yan SG Xie ST | 2008 | Biochim Biophys Acta2008，1783，2： | 1 |
| 11 | Effects of salicylic acid (SA), ultraviolet radiation (UV-B and UV-C) on trans-resveratrol inducement in the skin of harvested grape berries 显示文摘 | Li XD Zheng XB Yan ST Li SH | 2008 | Frontiers of Agriculture in China2008，2，1： | 1 |
| 12 | Volvariella volvocea and its life history显示文摘 | Chang ST Yan CK | 1971 | American Journal of Botany1971，58，6： | 1 |
| 13 | Protective effects from carnosine and histidine on acetaminophen-induced liver in- jury显示文摘 | Yan SL Wu ST Yin MC | 2009 | J Food Sci2009，74，8： | 1 |
| 14 | Enteric dysbiosis associated with a mouse model of alcoholic liver disease显示文摘 | Arthur W. Yan Derrick E. Fouts Johannes Brandl Peter St?rkel Manolito Torralba Eckart Schott Hide Tsukamoto Karen E. Nelson David A. Brenner Bernd Schnabl | 2011 | Hepatology2011，，： | 1 |
| 15 | Tip30-induced apoptosis requires transloeation of Bax and involves mitochondrial release of cytochrome c and Smac/DIABLO in hepatocellular carcinoma cells 显示文摘 | Shi M Yan SG Xie ST | 2008 | Bioehim Biophys Aeta2008，1783，2： | 1 |
| 16 | TIP30-induced apoptosis requires translocation of Bax and involves mitochondrial release of cytochrome Cand Smac/DIABLO in hepatocelhlar carcinoma cells 显示文摘 | Shi M Yan SG Xie ST | 2008 | Biochim Biophys Aeta2008，1783，2： | 1 |
| 17 | An eight-year study of epidemiologic features of enterovirus 71 in Taiwan显示文摘 | Chen SC Chang HL Yan ST | | 0，，01： | 1 |
| 18 | Retinoic acid inhibits expression of TNF--alpha and iNOS in activated rat mlcroglia显示文摘 | Dheen ST Y J un Z Yan | 2005 | Glia2005，50，1： | 1 |
| 19 | Retinoic acid inhibits expression of TNF-al- pha and iNOS in activated rat microglia显示文摘 | Dheen ST Jun Y Yan Z | 2005 | Glia2005，50，1： | 1 |
| 20 | Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines显示文摘 | Yan SL Huang CY Wu ST | 2010 | Toxicol In Vitro2010，24，3： | 1 |
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