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| 1 | 4-Hydroxybenzyl-substituted amino acid derivatives from Gastrodia elata显示文摘Seven new 4-hydroxybenzyl-substituted amino acid derivatives(1-7), together with 11 known compounds, were isolated from an aqueous extract of the rhizomes of Gastrodia elata Blume.Their structures were determined by spectroscopic and chemical methods. Compounds 1-3 are pyroglutamate derivatives containing 4-hydroxybenzyl units at the N atom and 4-7 are the first examples of natural products with the 4-hydroxybenzyl unit linked via a thioether bond to 2-hydroxy-3-mercaptopropanoic acid(4-6) and 2-hydroxy-4-mercaptobutanoic acid(7), which would be biogenetically derived from cysteine and homocysteine, respectively. The structures of 1 and 2 were verified by synthesis, while the absolute configurations of 4, 5 and 7 were assigned using Mosher's method based on the MPA determination rule of ΔδRS values. The known compound 4-(hydroxymethyl)-5-nitrobenzene-1,2-diol(8) exhibited activity against Fe^(2+)-cysteine induced rat liver microsomal lipid peroxidation with IC_(50) values of 9.99×10^(-6) mol/L. | Qinglan Guo Yanan Wang Sheng Lin Chenggen Zhu Minghua Chen Zhibo Jiang Chengbo Xu Dan Zhang Huailing Wei Jiangong Shi | 2015 | Acta Pharmaceutica Sinica B2015，5，4： | 18 |
| 2 | Changes of main secondary metabolites in leaves of Ginkgo biloba in response to ozone fumigation显示文摘To investigate the effect of elevated O3 on the accumulation of main secondary metabolites in leaves of Ginkgo biloba L.,four-year-old trees were exposed in open-top chambers with ambient air and the air with twice ambient O3 concentration in Shenyang in 2006.Elevated O3 increased the concentrations of terpenes,but decreased the concentrations of phenolics in G.biloba leaves.The results showed that secondary compounds from G.biloba leaves responded to the elevated O3 exposure in a different way when compared to previous studies which showed elevated O3 increased the concentrations of phenolics but had no effect on the terpenes in leaves of other deciduous trees.Furthermore,reduced synthesis of phenolics may decrease the resistance of G.biloba to O3 and other environmental factors.On the other hand,the induced synthesis of terpenes may enhance the antioxidant abilities in G.biloba leaves at the end of O3 fumigation. | HE Xingyuan HUANG Wei CHEN Wei DONG Tian LIU Changbing CHEN Zhenju XU Sheng RUAN Yanan | 2009 | Journal of Environmental Sciences2009，21，2： | 8 |
| 3 | Genetic dissection of rice appearance quality and cooked rice elongation by genome-wide association study显示文摘Appearance and cooked rice elongation are key quality traits of rice. Although some QTL for these traits have been identified, understanding of the genetic relationship between them remains limited. In the present study, large phenotypic variation was observed in 760 accessions from the 3 K Rice Genomes Project for both appearance quality and cooked rice elongation. Most component traits of appearance quality and cooked rice elongation showed significant pairwise correlations, but a low correlation was found between appearance quality and cooked rice elongation. A genome-wide association study identified 74 QTL distributed on all 12 chromosomes for grain length, grain width, length to width ratio, degree of endosperm with chalkiness, rice elongation difference, and elongation index. Thirteen regions containing QTL stably expressed in multiple environments and/or exerting pleiotropic effects on multiple traits were detected. By gene-based association analysis and haplotype analysis, 46 candidate genes, including five cloned genes, and 49 favorable alleles were identified for these 13 QTL. The effect of the candidate gene Wx on rice elongation difference was validated by a transgenic strategy. These results shed light on the genetic bases of appearance quality and cooked rice elongation and provide gene resources for improving rice quality by molecular breeding. | Xianjin Qiu Jing Yang Fan Zhang Yanan Niu Xiuqing Zhao Congcong Shen Kai Chen Sheng Teng Jianlong Xu | 2021 | The Crop Journal2021，9，6： | 5 |
| 4 | Complications and risk factors for complications of implanted subcutaneous ports for intraperitoneal chemotherapy in gastric cancer with peritoneal metastasis显示文摘Objective:Intraperitoneal(IP)chemotherapy through subcutaneous port is an effective treatment for gastric cancer(GC)patients with peritoneal metastasis(PM).The objective of this study is to assess the port complications and risk factors for complications in GC patients with PM.Methods:In retrospective screening of 301 patients with subcutaneous ports implantation,249 GC patients with PM who received IP chemotherapy were screened out for analysis.Port complications and risk factors for complications were analyzed.Results:Of the 249 analyzed patients,57(22.9%)experienced port complications.Subcutaneous liquid accumulation(42.1%)and infection(28.1%)were the main complications,and other complications included port rotation(14.1%),wound dehiscence(12.3%),inflow obstruction(1.7%)and subcutaneous metastasis(1.7%).The median interval between port implantation and occurrence of complications was 3.0 months.Eastern Cooperative Oncology Group(ECOG)performance status[odds ratio(OR),1.74;95%confidence interval(95%CI),1.12-2.69],albumin(OR,3.67;95%CI,1.96-6.86),implantation procedure optimization(OR,0.33;95%CI,0.18-0.61)and implantation groups(OR,0.37;95%CI,0.20-0.69)were independent risk factors for port complications(P<0.05).ECOG performance status was the only factor that related to the grades of port complications(P=0.016).Conclusions:Port complications in GC patients who received IP chemotherapy are manageable.ECOG performance status,albumin,implantation procedure and implantation group are independent risk factors for port complications in GC patients with PM. | Zhongyin Yang Chen Li Wentao Liu Yanan Zheng Zhenglun Zhu Ziehen Hua Zhentian Ni Sheng Lu Min Yan Chao Yan Zhenggang Zhu | 2020 | Chinese Journal of Cancer Research2020，32，4： | 5 |
| 5 | Dual-metal atoms embedded into two-dimensional covalent organic framework as efficient electrocatalysts for oxygen evolution reaction:A DFT study显示文摘The electrochemical oxygen evolution reaction(OER)is a half-reaction of water-splitting for hydrogen generation,yet suffers from its sluggish kinetics and large overpotential.It is highly desirable to develop efficient and stable OER electrocatalysts for the advancement of water-splitting.Herein,by means of density functional theory(DFT)calculations,we systematically investigated a series of two-dimensional(2D)dual-atom catalysts(DACs)on a novel synthesized covalent organic framework(COF)material as potential efficient catalysts toward the OER.The designed 6 homonuclear(2TM-COF)and 15 heteronuclear(TM1TM2-COF)DACs all exhibit good stability.There is a strong scaling relationship between the adsorption Gibbs free energies of HO*and HOO*intermediates,and the OER overpotential(η^(OER))volcano curve can be plotted as a function ofΔGO*−ΔGHO*.RhIr-COF shows the best OER catalytic activity with aη^(OER)value of 0.29 V,followed by CoNi-COF(0.33 V),RuRh-COF(0.34 V),and NiIrCOF(0.37 V).These four OER DACs exhibit lower onset potential and higher current density than that of the IrO2(110)benchmark catalyst.Aided by the descriptor identification study,the Bader charge that correlated with the Pauling electronegativity of the embedded dual-metal atoms was found to be the most important factor governing the catalytic activity of the OER.Our work highlights a potentially efficient class of 2D COF-based DACs toward the OER. | Yanan Zhou Lanlan Chen Li Sheng Qiquan Luo Wenhua Zhang Jinlong Yang | 2022 | Nano Research2022，15，9： | 2 |
| 6 | Grain boundary character and stress corrosion cracking behavior of Co-Cr alloy fabricated by selective laser melting显示文摘In this work,we used the selective laser melting(SLM)fabricated Co-Cr alloy with prominent residual strain,extremely non-equilibrium microstructures,and low stacking fault energy as a precursor to fabricate materials with the optimal grain boundary character distribution.The grain boundary engineering(GBE)of the Co-Cr alloy was achieved by a simple heat treatment of the SLM-fabricated Co-Cr alloy.The obtained GBE Co-Cr alloy exhibited 81.47%of special grain boundaries(∑3^(n)n=1,2,3),while it substantially disrupted the connectivity of the random high-angle boundaries,successfully reducing the propensity of intergranular degradation.Slow strain rate tests(SSRTs)showed that the GBE Co-Cr alloy possessed lower stress corrosion cracking(SCC)susceptibility and higher ductility in the corrosive environment(0.9%Na Cl solution)than in the air.The high fraction of special boundaries,coupled with the stress-induced martensitic transformation(SIMT)in the GBE Co-Cr alloy yielded these results,which unique and rarely simultaneously satisfied for common structural materials.The current'SLM induced GBE strategy'offers a novel approach towards customized GBE materials with high SCC resistance and ductility in the corrosive environment,shedding new light on developing high-performance structural materials. | Xin Dong Ning Li Yanan Zhou Huabei Peng Yuntao Qu Qi Sun Haojiang Shi Rui Li Sheng Xu Jiazhen Yan | 2021 | Journal of Materials Science & Technology2021，，34： | 1 |
| 7 | Reservoir Characteristics of Fine-grained Sedimentary Rocks in Saline Lakes in the Cenozoic Upper Ganchaigou Formation,Southwestern Qaidam Basin,NW China显示文摘Cenozoic fine-grained sedimentary rocks in the southwestern Qaidam Basin,as typical salinized lacustrine sediments,are significantly different from those in other freshwater lakes under the impact of the high salinity in the lake.Many fine-grained sedimentary rock samples were selected from the lower member of Neogene(N_(1))in the Gaskule Oilfield,Qaidam Basin,northwest China,with the aim to analyze and test their petrology,pore structure,and organic geochemical characteristics and determine its genesis and geological significance.Based on previous results,a new genesis of mixed sedimentary rocks is proposed.The Cenozoic lacustrine fine-grained sedimentary rocks in SW Qaidam Basin belong to mixed sedimentary rocks,which can be divided into three types,including carbonate and terrigenous clastic-bearing mudstone,carbonate-bearing to terrigenous clastic mixed sedimentary rocks,and carbonate-terrigenous clastic mixed sedimentary rocks.The geneses of mixing are quite different from that of mixed marine rocks.According to the sedimentary characteristics of the salinized lakes,three new geneses of mixed deposits are proposed:syn-sedimentary mixing,varve interbedded mixing,and biogenic mixing.The reservoir spaces of the Cenozoic lacustrine fine-grained sedimentary rocks in SW Qaidam Basin include residual intergranular pores,intercrystalline pores,microfractures,and minor dissolved pores.The reservoirs have super-low porosity and ultra-low permeability,with a porosity of 1.82%-21.04%,averaging 7.71%,and permeability of(0.0028-254.86)×10^(−3)μm^(2),averaging 2.82×10^(−3)μm^(2).The test results of total organic carbon(TOC)content show that the highest content of organic carbon reached 1.41%,and those of vitrinite reflectance show that Ro ranges from 0.525%-0.824%,with an average of 0.806%.The organic geochemical characteristics show that the fine-grained mixed sedimentary rocks of SW Qaidam Basin have the potential for self-generation and self-storage.As an unconventional reservoir,it has potential industrial value.This is the first study of fine-grained sedimentary rocks in the Qaidam Basin,which offers certain theoretical and practical values. | SHENG Jun LIU Jincheng LI Yunlong ZOU Haiyan LONG Anlin WANG Lin LI Jiyong QI Qingshan YANG Xiaojing LI Yanan | 2022 | Acta Geologica Sinica(English Edition)2022，96，3： | 1 |
| 8 | (+)/(-)-Yanhusuosines A and B, two dimeric benzylisoquinoline-protoberberine alkaloid atropo-enantiomers featuring polycyclic skeletons from Corydalis yanhusuo显示文摘(+)/(-)-Yanhusuosines A(1) and B(2), two pairs of trace benzylisoquinoline-protoberberine atropoenantiomeric homodimers featuring an unprecedented 6/7/6/6/6/6 hexacyclic skeleton, were isolated from the tubers of Corydalis yanhusuo. The structures of(+)/(-)-1 and(+)/(-)-2 were elucidated using spectroscopic and quantum-chemical calculation approaches.(+)/(-)-Yanhusuosines A(1) and B(2)represent a new class of alkaloid dimers biogenetically constructed by a molecule of benzylisoquinoline with a unit of protoberberine via an intermolecular [4 + 3] cycloaddition. Their plausible biosynthetic pathways are discussed, and compound 2 exerted moderate inhibitory activity of NO formation in LPS induced RAW264.7 macrophages. | Guiyang Xia Biaobing Xiao Lingyan Wang Huan Xia Yuzhuo Wu Yanan Wang Hongcai Shang Sheng Lin | 2023 | Chinese Chemical Letters2023，34，7： | 1 |
| 9 | CRISPR/Cas12a Technology Combined with RT-ERA for Rapid and Portable SARS-CoV-2 Detection显示文摘Dear Editor,The outbreak and rapid spread of the new coronavirus,severe acute respiratory syndrome coronavirus 2(SARSCo V-2),have resulted in more than 120 million confirmed infections and 2 million deaths worldwide as of March2021.The statistical data were from WHO COVID-19Explorer(https://worldhealthorg.shinyapps.io/covid/).The virus is also responsible for billions of US dollars in economic losses and has attracted great concern about public health safety worldwide.Generally. | Sihua Liu Mengqian Huang Yanan Xu Jun Kang Sheng Ye Si Liu Zhiyun Wang Hongyun Liu Jibin Yu Kongxin Hu Tao Wang | 2021 | Virologica Sinica2021，36，5： | 1 |
| 10 | Recent progress in copper catalyzed asymmetric Henry reaction显示文摘Henry reaction is one of the most classical reactions to construct synthetically useful product nitro alcohol, which as a privileged skeleton is widely distributed in various pharmaceuticals. This review summarizes the recent progress of copper-catalyzed asymmetric Henry reaction from 2011 to 2016. The significant progress that has been made in this area will be highlighted and some of challenges that the author believes may be hindering further progress will be revealed. | Sheng Zhang Yanan Li Youguo Xu Zhiyong Wang | 2018 | Chinese Chemical Letters2018，29，6： | 1 |
| 11 | Unbiased transcriptomic analyses reveal distinet effects of immune deficiency in CNS function with and without injury显示文摘The mammalian central nervous system (CNS) is considered an immune privileged system as it is separated from the periphery by the blood brain barrier (BBB). Yet, immune functions have been postulated to heavily influence the functional state of the CNS, especially after injury or during neurodegeneration. There is controversy regarding whether adaptive immune responses are beneficial or detrimental to CNS injury repair. In this study, we utilized immunocompromised SCID mice and subjected them to spinal cord injury (SCI). We analyzed motor function, electrophysiology, histochemistry, and performed unbiased RNA-sequencing. SCID mice displayed improved CNS functional recovery compared to WT mice after SCI. Weighted gene-coexpression network analysis (WGCNA) of spinal cord transcriptomes revealed that SCID mice had reduced expression of immune function-related genes and heightened expression of neural transmission-related genes after SCI, which was confirmed by immunohistochemical analysis and was consistent with better functional recovery. Transcriptomic analyses also indicated heightened expression of neurotransmission-related genes before injury in SCID mice, suggesting that a steady state of immune-deficiency potentially led to CNS hyper-connectivity. Consequently, SCID mice without injury demonstrated worse performance in Morris water maze test. Taken together, not only reduced inflammation after injury but also dampened steady-state immune function without injury heightened the neurotransmission program, resulting in better or worse behavioral outcomes respectively. This study revealed the intricate relationship between immune and nervous systems, raising the possibility for therapeutic manipulation of neural function via immune modulation. | Dandan Luo Weihong Ge Xiao Hu Chen Li Chia-Ming Lee Liqiang Zhou Zhourui Wu Juehua Yu Sheng Lin Jing Yu Wei Xu Lei Chen Chong Zhang Kun Jiang Xingfei Zhu Haotian Li Xinpei Gao Yanan Geng Bo Jing Zhen Wang Changhong Zheng Rongrong Zhu Qiao Yan Quan Lin Keqiang Ye Yi E. Sun Liming Cheng | 2019 | Protein & Cell2019，10，8： | 1 |
| 12 | (+)/(-)-Yanhusamides A-C,three pairs of unprecedented benzylisoquinoline-pyrrole hetero-dimeric alkaloid enantiomers from Corydalis yanhusuo显示文摘A chemical investigation on the aqueous extract of Corydalis yanhusuo tubers led to the isolation and structural elucidation of three pairs of trace enantiomeric hetero-dimeric alkaloids,(+)/(-)-yanhusamides A-C(1-3),featuring an unprecedented 3,8-diazatricylco[5.2.2.0^(2,6)]undecane-8,10-diene bridged system.Their structures were exhaustively characterized by X-ray diffraction,comprehensive spectroscopic data analysis,and computational methods.Guided by the hypothetical biosynthetic pathway for 1-3,a gram-scale biomimetic synthesis of(±)-1 was achieved in 3 steps using photoenolization/Diels-Alder(PEDA)[4+2]cycloaddition.Compounds 1-3 exhibited potent inhibition of NO production induced by LPS in RAW264.7 macrophages.The in vivo assay showed that oral administration of 30 mg/kg of(±)-1 attenuated the severity of rat adjuvant-induced arthritis(AIA).Additionally,(±)-1 induced a dose-dependent antinociceptive effect in the acetic acid-induced mice writhing assay. | Lingyan Wang Guiyang Xia Huan Xia Xiaohong Wei Yanan Wang Sheng Lin | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 0 |
| 13 | ESTIMATION OF FUNCTION APPROXIMATION USING DITZIAN-TOTIK'S CONTINUOUS MODEL显示文摘Ditzian-Totik’scotinuous modulus of ωφ(f,t) andωφ(f,t), are used to extimate approximation of functions by their F-T series in C-space and Lp-space. | Sheng Shuyun(Hangzhou University, China)Xu Yanan(Shaoxing College of Arts and Science, China) | 1999 | Analysis in Theory and Applications1999，15，2： | 0 |
| 14 | A new sesquiterpenoidal glucoside from the roots of Paeonia lactiflora显示文摘Objective:To study the chemical constituents of the roots of Paeonia lactiflora.Materials and methods:The isolation and purification were carried out by column chromatography on macroporous adsorbent resin,MCI gel,silica gel,and Sephadex LH-20,as well as semi-preparative RP-HPLC.The structures were elucidated on the basis of physicochemical properties and spectroscopic analysis,as well as the ECD quantum chemical computation methods.Results:A sesquiterpenoidal glucoside(1)along with two sesquiterpenoids(2-3)were isolated from the roots of Paeonia lactiflora,and their structures were identified as(+)-(1R,2R,4S,5S,10R)-2-α-D-glucopyranosyloxy-2-hydroxy-cadin-6,12-dien-15-oic acid(1),drim-7-en-3β,11,12-triol(2),and 3β-hydroxy-11,12-O-isopropylidenedrimene(3),respectively.Conclusion:Compound 1 was identified as a new sesquiterpenoidal glucoside. | Wanchao Zhong Guiyang Xia Huan Xia Jingfang Zhang Yanan Wang Sheng Lin | 2020 | TMR Modern Herbal Medicine2020，3，4： | 0 |
| 15 | Circularly polarized luminescence of talarolactones(+)/(-)-A and(+)/(-)-C:The application of CPL-calculation in stereochemical assignment显示文摘Two pairs of fluorescent natural products,talarolactones(+)/(−)-A and(+)/(−)-C[(+)/(−)-1 and(+)/(−)-2],were discovered and characterized as a new family of circularly polarized luminescence-active small organic molecules(CPL-SOMs)with high fluorescence efficiency and fascinating CPL properties.The CPL(|glum|)levels of enantiomerically pure(+)/(−)-1 and(+)/(−)-2 in solution falls into the usual range(10−5−10−3)considering their pure organic nature,but the sign of CPL were found to be closely related to the absolute configuration of C-8.The high agreement of the measured CPL spectra of(+)/(−)-1 and(+)/(−)-2 with the time-dependent density functional theory(TDDFT)calculated ones demonstrated the usefulness of CPL-calculation as a unique method for stereochemical assignment.This study may open up a new perspective for the stereochemical studies and the future development of CPL materials. | Guiyang Xia Lingyan Wang Huan Xia Yuzhuo Wu Yanan Wang Haiyu Hu Sheng Lin | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
| 16 | Apoferritin nanoparticle based dual-antigen influenza conjugate vaccine with potential cross-protective efficacy against heterosubtypic influenza virus显示文摘Ferritin nanoparticles with self-assembling properties have been widely explored as vaccine carrier by displaying foreign antigens through genetic fusion strategy.In the present work,an apoferritin(AFt)nanoparticle was tested as influenza vaccine carrier by chemically conjugating a matrix protein 2 ectodomain(M2e)antigen peptide or/and the full-length hemagglutinin(HA)antigen on the outer surface of the AFt,with heterobifunctional sSMCC or SM(PEG)_(24) containing PEG chain as linkers.To each AFt nanoparticle,about 30-32 M2e or 1.8 HA antigen could be coupled.The AFt-(PEG)24-M2e,in which the M2e was coupled through SM(PEG)_(24) containing PEG chain,conferred higher protective efficacy in immunized mice than AFt-M2e did,but was less effective than AFt-(PEG)_(24)-HA.When both M2e and HA were coupled,the synthesized dual-antigen vaccine candidate AFt-(PEG)_(24)-M2e/HA elicited high level of M2e and HA antigen-specific antibodies and conferred 100%protection against lethal infection of homologous PR8 HI N1 virus strain and 70%protection against a heterologous A/FM/1/47(FM1,H1N1)strain,which was more effective than the M2e or HA single antigen vaccine candidates.The potential cross-protective effect of the dual-antigen vaccine was further demonstrated by significant specific hemagglutination inhibition(HAI)titers in serum of the immunized mice against three other heterologous viral strains including A/Singapore/GPl908/2015(IVR-180)H1N1,A/Anhui/1/2005 H5N1,and A/Hong Kong H3N2. | Yanan Sheng Jiangxue Wei Zhengjun Li Zhiguo Su Guanghui Ma Songping Zhang | 2022 | Particuology2022，20，5： | 0 |
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