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| 1 | Plate tectonic control on the formation and tectonic migration of Cenozoic basins in northern margin of the South China Sea显示文摘The tectonic evolution history of the South China Sea(SCS) is important for understanding the interaction between the Pacific Tectonic Domain and the Tethyan Tectonic Domain,as well as the regional tectonics and geodynamics during the multi-plate convergence in the Cenozoic.Several Cenozoic basins formed in the northern margin of the SCS,which preserve the sedimentary tectonic records of the opening of the SCS.Due to the spatial non-uniformity among different basins,a systematic study on the various basins in the northern margin of the SCS constituting the Northern Cenozoic Basin Group(NCBG) is essential.Here we present results from a detailed evaluation of the spatial-temporal migration of the boundary faults and primary unconformities to unravel the mechanism of formation of the NCBG.The NCBG is composed of the Beibu Gulf Basin(BBGB),Qiongdongnan Basin(QDNB),Pearl River Mouth Basin(PRMB) and Taixinan Basin(TXNB).Based on seismic profiles and gravity-magnetic anomalies,we confirm that the NE-striking onshore boundary faults propagated into the northern margin of the SCS.Combining the fault slip rate,fault combination and a comparison of the unconformities in different basins,we identify NE-striking rift composed of two-stage rifting events in the NCBG:an early-stage rifting(from the Paleocene to the Early Oligocene) and a late-stage rifting(from the Late Eocene to the beginning of the Miocene).Spatially only the late-stage faults occurs in the western part of the NCBG(the BBGB,the QDNB and the western PRMB),but the early-stage rifting is distributed in the whole NCBG.Temporally,the early-stage rifting can be subdivided into three phases which show an eastward migration,resulting in the same trend of the primary unconformities and peak faulting within the NCBG.The late-stage rifting is subdivided into two phases,which took place simultaneously in different basins.The first and second phase of the early-stage rifting is related to back-arc extension of the Pacific subduction retreat system.The third phase of the earlystage rifting resulted from the joint effect of slab-pull force due to southward subduction of the proto-SCS and the back-arc extension of the Pacific subduction retreat system.In addition,the first phase of the late-stage faulting corresponds with the combined effect of the post-collision extension along the Red River Fault and slab-pull force of the proto-SCS subduction.The second phase of the late-stage faulting fits well with the sinistral faulting of the Red River Fault in response to the Indochina Block escape tectonics and the slab-pull force of the proto-SCS. | Pengcheng Wang Sanzhong Li Yanhui Suo Lingli Guo Guangzeng Wang Gege Hui M.Santosh Ian D.Somerville Xianzhi Cao Yang Li | 2020 | Geoscience Frontiers2020，11，4： | 10 |
| 2 | Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo显示文摘多重骨髓瘤(公里) 是第二很经常的恶意的 hematological 疾病。Dihydrocelastrol (DHCE ) 被 hydrogenated celastrol 综合,从中国药用的植物 Tripterygium regelii 孤立的 treterpene。在这研究,我们首先在公里房间上报导了 DHCE 的反肿瘤活动。我们发现 DHCE 能禁止房间增长并且在 vitro 通过 caspase 依赖的方法支持 apoptosis。另外, DHCE 能使 interleukin (IL ) 的表达式失去活性 -6 和 downregulate 细胞外的调整蛋白质 kinases (ERK1/2 ) 和信号变换器和在公里的抄写 3 的使活跃之物(STAT3 ) 的 phosphorylation。它也面对 IL-6 对公里房间线保留了它的活动。而且,有 DHCE 的公里房间的处理在房间周期的 G 0/G1 阶段导致了房间的累积。尤其是, DHCE 减少了 4 和 6 在公里房间衬里的 cyclin D1 和 cyclin 依赖的 kinases 的表示。另外,它向 MM 房间线的功效能与 histone deacetylase 禁止者 panobinostat (LBH589 ) 在联合被提高,它在公里作为潜在的治疗学的策略暗示了 DHCE 和 LBH589 的联合处理的可能性。另外,有 DHCE 的 NCI-H929 忍受肿瘤的裸体老鼠的处理(10 mg/kg/d, i.p, 1-14 天) 在 vivo 导致了肿瘤生长的 73% 抑制。一起拿,我们的现在的学习的结果显示 DHCE 能禁止细胞的增长并且在骨髓瘤房间导致房间 apoptosis 通过不同机制调停了,可能通过禁止 IL-6/STAT3 和 ERK1/2 小径。并且它可以为公里病人提供一种新治疗学的选择。 | Liangning Hu Huiqun Wu Bo Li Dongliang Song Guang Yang Gege Chen Bingqian Xie Zhijian Xu Yong Zhang Dandan Yu Jun Hou Wenqin Xiao Xi Sun Gaomei Chang Yiwen Zhang Lu Gao Bojie Dai Yi Tao Jumei Shi Weiliang Zhu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 5 |
| 3 | Antitumor effect of dobutamine on multiple myeloma via mitogen-activated protein kinase pathway in vitro显示文摘多重骨髓瘤(公里) 是最恶意的癌症之一并且被房间, monoclonal 免疫球蛋白的分泌物和 osteolytic 损害,和它的发生在中年、老的病人正在增加的血浆被骨头髓的渗入描绘[1 ] 。作为公里房间异构并且药抵抗、起始的公里通常进行到 relapsed/refractory 阶段。尽管象镇静药, bortezomib,和 lenalidomide 那样的存在治疗能延长公里病人的幸存,公里是是仍然考虑了医不好。因此,建立新有效治疗对待 relapsed/refractory 公里是必要的。 | Bingqian Xie Zhijian Xu Guang Yang Gege Chen Bo Li Liangning Hu Wenqin Xiao Xi Sun Minjie Gao Lu Gao Xiaosong Wu Yi Tao Weiliang Zhu Jumei Shi | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 1 |
| 4 | 显示文摘 | Yu Jie Yang Gege Pan Yuanpei | 2014 | Plasma Science and Technology2014，16，8： | 1 |
| 5 | Distributed implantation of a flexible microelectrode array for neural recording显示文摘Flexible multichannel electrode arrays(fMEAs)with multiple flaments can be flexibly implanted in various patterns.It is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording demands.This study proposed a strategy for reducing the microelectrode volume with integrated packaging.An implantation system was developed specifically for semiautomatic distributed implantation.The feasibility and convenience of the fMEA and implantation platform were verified in rodents.The acute and chronic recording results provied the effectiveness of the packaging and implantation methods.These methods could provide a novel strategy for developing fMEAs with more flaments and recording sites to measure functional interactions across multiple brain regions. | Chunrong Wei Yang Wang Weihua Pei Xinyong Han Longnian Lin Zhiduo Liu Gege Ming Ruru Chen Pingping Wu Xiaowei Yang Li Zheng Yijun Wang | 2022 | Microsystems & Nanoengineering2022，8，3： | 1 |
| 6 | Inffuence of the near field of secondary source and the elasticity of pipe wall on active noise control performance of liquid-filled pipe显示文摘The numerical models of liquid-filled straight pipe system with active silencers are established. The inffuence of the near field of secondary source in the active silencers and the elasticity of pipe wall on active noise control performance under sound excitation is analyzed.The results show that the near field of secondary source is non-uniform, and the active control effect of some frequencies is poor or even the sound pressure level will increase when the error points are located in this region. The noise reduction can be increased by more than 10 d B when the error points are in the region of uniform sound field. The noise reduction of most frequencies can be increased by more than 5 d B by increasing the number of error points. The coupling between secondary source and pipe wall is strong because of the elasticity of pipe wall. Asymmetrically distributed secondary sources tend to excite the pipe wall vibration,which causes the troughs of control effect. The symmetrically distributed secondary sources can significantly improve the control effect. Increasing the number of secondary sources can improve the active-passive hybrid control effect of the system. However, it makes the sound field in the pipe more complex, and the active silencing effect of the models with multiple secondary sources decreases with increasing frequency. | GUO Gege SUN Hongling SUN Luyang CAO Shengnan YANG Jun | 2023 | Chinese Journal of Acoustics2023，42，4： | 0 |
| 7 | Rh/CeO_(2) composites prepared by combining dealloying with calcination as an efficient catalyst for CO oxidation and CH4 combustion显示文摘In this paper,a series of Rh/CeO_(2) catalysts with three-dimensional porous nanorod frameworks and large specific surface area were prepared by chemical dealloying Al–Ce–Rh precursor alloys and then calcining in pure O_(2).The effects of the Rh content and calcination temperature on CO oxidation and CH_(4) combustion were studied,and the results reveal that the Rh/CeO_(2) catalysts produced by dealloying melt-spun Al_(91.3)Ce_(8)Rh_(0.7) alloy ribbons and then calcining at 500℃ exhibit the best catalytic activity,the reaction temperatures for the complete conversion of CO and CH_(4) are as low as 90 and 400℃,respectively.Furthermore,after 150 h of continuous testing at high concentrations of H2O and CO_(2),the nature of the catalyst is not irreversibly destroyed and can still return to its initial level of activity.This excellent catalytic activity is attributed to a portion of Rh being uniformly distributed on the CeO_(2) nanorod surface in the form of nanoparticles,forming strong Rh–CeO_(2) interfacial synergy.Another portion of Rh permeated into the CeO_(2) lattice,which results in a significant increase in the number of oxygen vacancies in CeO_(2),thus allowing more surface active oxygen to be adsorbed and converted from the gas phase.Moreover,the catalytic reaction can proceed even in an oxygen-free environment due to the excellent oxygen storage performance of the Rh/CeO_(2) catalyst. | Dong Duan Chunxi Hao Gege He Yang Wen Zhanbo Sun | 2022 | Journal of Rare Earths2022，40，4： | 0 |
| 8 | Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation显示文摘Multiple myeloma(MM)is characterized by excessive aggregation of B-cell-derived malignant plasma cells in the hematopoietic system of bone marrow.Previously,we synthesized an innovative molecule named dihydrocelastrol(DHCE)from celastrol,a triterpene purified from medicinal plant Tripterygium wilfordii.Herein,we explore the therapeutic properties and latent signal transduction mechanism of DHCE action in bortezomib(BTZ)-resistant(BTZ-R)MM cells.In this study,we first report that DHCE shows antitumor activities in vitro and in vivo and exerts stronger inhibitory effects than celastrol on BTZ-R cells.We find that DHCE inhibits BTZ-R cell viability by promoting apoptosis via extrinsic and intrinsic pathways and suppresses BTZ-R MM cell proliferation by inducing G0/G1 phase cell cycle arrest.In addition,inactivation of JAK2/STAT3 and PI3K/Akt pathways are involved in the DHCE-mediated antitumor effect.Simultaneously,DHCE acts synergistically with BTZ on BTZ-R cells.PSMB5,a molecular target of BTZ,is overexpressed in BTZ-R MM cells compared with BTZ-S MM cells and is demonstrated to be a target of STAT3.Moreover,DHCE downregulates PSMB5 overexpression in BTZ-R MM cells,which illustrates that DHCE overcomes BTZ resistance through increasing the sensitivity of BTZ in resistant MM via inhibiting STAT3-dependent PSMB5 regulation.Overall,our findings imply that DHCE may become a potential therapeutic option that warrants clinical evaluation for BTZ-R MM. | Shuhan Jin Bo Li Bibo Zhang Xuejie Gao Xinyan Jia Li Xu Shuaikang Chang Ke Hu Guanli Wang Zhijian Xu Ting Zhang Dongliang Song Guang Yang Xiaosong Wu Huabin Zhu Cheng Huang Yumeng Lu Jumei Shi Weiliang Zhu Gege Chen | 2023 | Acta Biochimica et Biophysica Sinica2023，55，12： | 0 |
| 9 | Quantifying spatial distribution of interrill and rill erosion in a loess at different slopes using structure from motion(SfM)photogrammetry显示文摘The spatial distribution of interrill and rill erosion is essential for unravelling soil erosion principles and the application of soil and water conservation practices.To quantify interrill and rill erosion and their spatial development,four 30-min rainfalls at 90 mm h^(-1)intensity were consecutively simulated on runoff plots packed with a loess at six slopes of 10°,15°,20°,25°,30°and 35°.The soil surface was measured using the structure from motion(SfM)photogrammetry upon each simulation run,and the runoff and sediment samples were collected and measured at every 10 min.Rills did not develop until the third simulation run.During the initial two runs,the lower third section was more severely eroded than the upper and middle thirds along the slope direction,yet the interrill erosion was statistically uniform from left to right.Rills tended to emerge by both sidewalls and in the lower portion in the third run.The corresponding rill erosion increased with slope from 10°to 20°and then decreased for the slopes steeper,which was consistent with the slope trend of the sediment yield directly measured.The rills expanded substantially primarily via head retreat and to a lesser extent via sideward erosion after receiving another 30-min rainfall.Rill erosion contributed 69.3%of the total erosion loss,and shifted the critical slope corresponding to the maximum loss from 20°to 25°.These findings demonstrate the significance of rill erosion not only in total soil loss but also in its relation to slope,as well as the effectiveness of SfM photogrammetry in quantifying interrill and rill erosion. | Tao He Yang Yang Yangzi Shi Xiaozhen Liang Suhua Fu Gege Xie Baoyuan Liu Yingna Liu | 2022 | International Soil and Water Conservation Research2022，10，3： | 0 |
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