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| 1 | Recurrence or metastasis of HCC:predictors,early detection and experimental antiangiogenic therapy显示文摘AIM To investigate the predictors forrecurrence or metastasis of HCC,and toevaluate the effect of antiangiogenic therapy onthe growth of transplantable human HCC in nudemice.METHODS RT-PCR was used to measure theexpression of matrix metalloproteinase-9(MMP-9)and vascular endothelial growth factor(VEGF)in 56 pairs of nontumorous liver andtumor samples.Sixty blood samples from humanHCC were examined by nested RT-PCR to find outAFP mRNA.Recombinant human endostatin andpolyclonal antibody against VEGF wereadministered to treat human HCC transplanted innude mice.RESULTS Thirty of 56 HCC samples showedstronger expression of MMP-9 in tumoroustissues than in nontumorous tissues.Fifteen ofthe 26 patients with relative expression level ofMMP-9 more than 0.34 developed tumorrecurrence or metastasis,whereas only 7 of 30patients with relative expression level less than0.34 developed tumor recurrence(P<0.05).There was no significant difference in therelative expression level of VEGF betweenpatients with postoperative recurrence ormetastasis and those without recurrence.AFPmRNA was detectable in 53.3% of patients withHCC.The sensitivity and specificity of AFPmRNA as a marker to detect hematogenousdissemination of HCC cells was 81.8% and84.4%,respectively.Recombinant human endostatin and polyclonal antibody against VEGFinhibited the growth of transplantable HCC innude mice by 52.2% and 45.7%,respectively.CONCLUSION MMP-9 expression in HCCcorrelates with the postoperative recurrence ormetastasis of HCC.Patients with high level ofMMP-9 expression in HCC are susceptible tometastasis.AFP mRNA could serve as anindicator of hematogenous spreading of HCCcells in circulation and a predictor of recurrenceor metastasis of HCC.Antiangiogenesis may bean adjuvant therapy for HCC. | Jiang YF Yang ZH Hu JQ | 2000 | World Journal of Gastroenterology2000，6，1： | 57 |
| 2 | Can the rat donor liver tolerate prolonged warm ischemia?显示文摘INTRODUCTIONThe last two decades of the twentieth century havewitnessed increasingly successful rates of livertransplantation.The number of liver transplantations hasincreased steadily while the number of organ donors | Yan JQ Li HW Cai WY Zhang MJ Yang WP | 2000 | World Journal of Gastroenterology2000，6，4： | 3 |
| 3 | EPIMEDOKOREANONE A FROM THE AERIAL PARTS O FEPIMEDIUM KOREANUM NAKAI显示文摘EPIMEDOKOREANONEAFROMTHEAERIALPARTSOFEPIMEDIUMKOREANUMNAKAIWenKuiLI;JunShanYANG;PeiGenXIAO(InstituteofMedicinalPlantDevelopme... | Li, WK Yang, JS Xiao, PG Pan, JQ Lu, MJ Zhang, RY | 1996 | Chinese Chemical Letters1996，7，1： | 2 |
| 4 | Frequency of cytochrome P450 2(29 allelic variants in the Chinese and French populations显示文摘 | Yang JQ Morin S Verstuyft C | 2003 | Fundam Clin Pharmacol2003，17，3： | 1 |
| 5 | Comparative analysis of a large dataset indicates that internal transcribed spacer(ITS)should be incorporated into the core barcode for seed plants显示文摘 | Li DZ Gao LM Li H Wang H Ge X J Liu JQ Chen ZD Zhou SL Chen SL Yang JB | | 0，，： | 1 |
| 6 | Composition and structure of bacterial communities in waste water of aquatic products processing factories显示文摘 | Wang ZH Yang JQ Zhang D J | 2014 | Research Journal of Biotechnology2014，9，2： | 1 |
| 7 | State estimation and simultaneous unknown input and measurement noise reconstruction based on associated observers显示文摘 | Yang JQ Zhu FL Sun X | 2013 | International Journal of Adaptive Control Signal Processing[ISSN 1099-1115]2013，27，10： | 1 |
| 8 | Hypertension and insulin resistance are not directly related in obese dogs 显示文摘 | Rocchini AP Yang JQ Gokee A | 2004 | Hypertension2004，43，： | 1 |
| 9 | Reference value of semen quality in Chinese young men显示文摘 | Wu JQ Yang QY Tao JG | | 0，，： | 1 |
| 10 | Technique of the ground penetrating radar used in coal mining engineering 显示文摘 | Liu CX Yang YJ Jiang JQ | 1998 | Chinese Journal of Geotechnical Engineering1998，20，6： | 1 |
| 11 | TFF3 mediated induction of VEGF via hypoxia in human gastric cancer SGC-7901 cells显示文摘 | Guleng B Han J Yang JQ | 2012 | Mol Biol Rep2012，39，4： | 1 |
| 12 | Variation in the ratio of nucleotide substitution and indel rates across genomes in mammals and bacteria 显示文摘 | Chen JQ Wu Y Yang H | 2009 | Molecular Biology and Evolution2009，26，7： | 1 |
| 13 | Charaterization of unilateral polycystic ovary compared with polycystic ovary syndrome显示文摘 | Yao LQ Kuang JQ Yang DZ | | 0，，： | 1 |
| 14 | SATBI is overexptssed in metastatic prostate cancer and promotesprostate cancer cell growth and invasion显示文摘 | MAO LJ YANG CH WANG JQ | 2013 | Transl Med2013，，： | 1 |
| 15 | Lung-targeting microspheres of carboplatin显示文摘 | Lu B Zhang JQ Yang H | 2003 | Int J Pharm2003，265，12： | 1 |
| 16 | Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model 显示文摘 | Yang JQ Wen X Liu H Folayan G Dong X Zhou M Van Kaer L Singh RR | 2007 | Arthritis Rheum2007，56，4： | 1 |
| 17 | Intestinal epithelial cell secretion of RELM-β protects against gastrointestinal worm infection显示文摘 | Herbert DR Yang JQ Hogan SP | | 0，，13： | 1 |
| 18 | Posterior corneal surface topographicchanges after in situ kemtomileusis are related to residual corneal bed thickness显示文摘 | Wang Z Chen JQ Yang B | 1999 | Ophthalmology1999，106，2： | 1 |
| 19 | Effects of cardiotrophin - 1 onhemodynamics and cardiomyecyte apoptosis in rats with acute myocardial infarction显示文摘 | Yin RX Yang DZ Li JQ | 2004 | J Med Invest2004，51，12： | 1 |
| 20 | The characteristics of verapamil-sensitive idiopathic left ventricular taehycardia combined with a left accessory pathway and the effect of radiofrequency catheter ablation 显示文摘 | Hu JQ Ma J Yang Q | 2011 | Europace2011，10，： | 1 |
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