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| 1 | Drawdown mechanism of light particles in baffled stirred tank for the KR desulphurization process显示文摘To improve the efficiency of the desulfurization process, the drawdown mechanism of light particles in stirred tank is studied in this paper. For both up and down pumping modes, the just drawdown speeds(Njd) of floating particles in transformative Kanbara Reactor(KR) are measured in one and four baffled stirred tanks experimentally. Then numerical simulations with standard k-ε model coupled with volume of fluid model(VOF) and discrete phase model(DPM) are conducted to analyze the flow field at the just drawdown speed Njd. The torques on the impeller obtained from experiments and simulations agree well with each other, which indicates the validity of our numerical simulations. Based on the simulations, three main drawdown mechanisms for floating particles, the axial circulation, turbulent fluctuation and largescale eddies, are analyzed. It's found that the axial circulation dominates the drawdown process at small submergence(S = 1/4 T and 1/3 T) and the large-scale eddies play a major role at large submergence(S = 2/3 T and 3/4 T). Besides, the turbulent fluctuation affects the drawdown process significantly for up pumping mode at small submergence(S = 1/4 T and 1/3 T) and for down pumping mode at large submergence(S = 2/3 T and 3/4 T). This paper helps to provide a more comprehensive understanding of the KR desulphurizer drawdown process in the baffled stirred tank. | Meng Li Yangbo Tan Jianglong Sun De Xie Zeng Liu | 2019 | Chinese Journal of Chemical Engineering2019，27，2： | 8 |
| 2 | Colour modulation and enhancement of upconversion emissions in K_(2)NaScF_(6):Yb/Ln(Ln=Er,Ho,Tm) nanocrystals显示文摘Effective colour modulation of upconversion emissions in lanthanide-doped nanomaterials becomes even more important for fundamental and applied research.Herein,on the one hand,by raising the content of doped Yb^(3+)from 10 mol%to 50 mol%,a significant increase of the red/green emission ratio from 4.0 to 68.2 is observed in K_(2)NaScF_(6):Yb/Er nanocrystals.This yellow to red colour change is attributed to the increased cross relaxation between Er^(3+)and Yb^(3+)caused by the increased Yb^(3+)amount,^(4) S_(3/2)(Er^(3+))^(+2) F7/2(Yb^(3+))→4 I13/2(Er^(3+))^(+2) F5/2(Yb^(3+)).On the other hand,the upconversion green and red emission of K_(2)NaScF_(6):Yb/Er(20/2 mol%)nanocrystals are intensified 10.6 and 8.8 folds,respectively,after an active shell(K_(2)NaScF_(6):Yb)is epitaxially grown,which are more effective than the7.4-and 6.4-fold enhancement from an inert shell(K_(2)NaScF_(6))growth.Moreover,the shell thickness from2.85 to 9.5 nm through controlling the molar ratio of shell-precursor to core from 1:2 to 3:1 can be easily realized.This study will provide more opportunities for the application of K_(2)NaScF_(6):Yb/Ln nanoparticles in varied fields such as theranostics,photovoltaics,and photocatalysis. | Yangbo Wang Huaiyong Li Hui Ma Ling Huang | 2021 | Journal of Rare Earths2021，39，12： | 3 |
| 3 | Clinical study of IL-18 and NANOG gene polymorphisms in prostate cancer patients显示文摘Objective Recent studies have shown abnormal expression of NANOG and IL-18 to be related to cancer. However, the molecular mechanism by which IL-18 and NANOG gene polymorphisms are associated with prostate cancer is unclear. In this study, we examined whether IL-18 and NANOG gene polymorphisms and their interaction with prostate cancer-related risk factor are associated with the susceptibility to and clinicopathological development of prostate cancer among Chinese men.Methods Polymorphisms in the NANOG and IL-18 genes were evaluated for susceptibility in 120 patients with prostate cancer. The control group consisted of 125 samples from Chinese men. Genotyping was conducted using Taq Man allelic discrimination assays. Statistical analysis was performed using SPSS software. Results No association of NANOG and IL-18 gene polymorphisms and overall prostate cancer susceptibility was detected. The IL-18-607 CC genotype was significantly associated with a higher tumor grade(P = 0.025) and stage(P =0.001). The IL-18-137 GG genotype correlated with a higher tumor grade(P = 0.028) and stage(P = 0.008). The IL-18-137 G allele was significantly more frequent in patients with lymph node metastasis(P = 0.035). The IL-18-607 CC genotype was associated with distant metastasis(P = 0.025). However, no significant association was observed between NANOG polymorphisms and any clinicopathological feature. The Cox proportional hazard model showed that tumor grade and stage grouping were independent prognostic factors in IL-18, while IL-18 polymorphism was not. Polymorphism variants in the IL-18(IL-18-607 and IL-18-137) and NANOG(genotypes AC) genes might be associated with a worse prognosis of patients with prostate cancer.Conclusion NANOG may be associated with the early stages of prostate cancer carcinogenesis. IL-18 and NANOG gene polymorphisms may play a major role in the growth, invasion, and metastasis of prostate cancer. | Shaojun Nong Yangbo Guan Zhiwei Wang Zhongqing Wei Yueping Zhang Jian Ni Chongsheng He Limin Ma Shujun Zhou Wenguang Li | 2018 | Oncology and Translational Medicine2018，4，6： | 2 |
| 4 | Significant association between IL-18 and OCT4 gene polymorphisms in susceptibility and clinical characteristics of prostate cancer显示文摘Objective Recent studies have shown abnormal expression of octamer-binding transcription factor 4(OCT4) and interleukin-18(IL-18) to be related to cancer. However, the molecular mechanisms by which the IL-18 and OCT4 gene polymorphisms are associated with prostate cancer remain unclear. In this study, we aimed to determine whether the presence of IL-18 and OCT4 polymorphisms were associated with size, grade, tumor, nodes and metastasis(TNM) stage, or survival in patients with prostate cancer.Methods Polymorphisms in OCT4 and IL-18 genes were evaluated to determine susceptibility to prostate cancer in 120 patients. A control group consisted of 125 Chinese participants. Genotyping was performed using TaqMan allelic discrimination assays, and statistical analysis was performed using SPSS. Results No association was found between OCT4 and IL-18 gene polymorphisms and prostate cancer susceptibility. For OCT4 AA and IL-18-607 CC genotypes, there was a significant association with higher tumor grade(P = 0.03 and P = 0.025) and stage(P = 0.04 and P = 0.001). The OCT4 and IL-18-137 GG genotype was correlated with higher tumor grade(P = 0.028) and stage(P = 0.008). Furthermore, OCT4 AA was significantly more frequent in patients with lymph node metastasis(P = 0.02) and distant metastasis(P = 0.01). The Cox proportional hazard model showed that tumor grade and stage grouping were independent prognostic factors but IL-18 and OCT4 polymorphisms were not. Conclusion The OCT4 gene may have a profound effect on prostate cancer risk. Polymorphism variants in the IL-18(IL-18-607 and IL-18-137) and OCT4 genes may be associated with poor prognoses for individuals with prostate cancer. | Shaojun Nong Yangbo Guan Zhiwei Wang Zhongqing Wei Yueping Zhang Jian Ni Chongsheng He Limin Ma Shujun Zhou Wenguang Li | 2019 | Oncology and Translational Medicine2019，5，3： | 2 |
| 5 | Selective TBK1/IKKi dual inhibitors with anticancer potency显示文摘 | Jijia Li Jingjia Huang Ji‐Hak Jeong Sun‐Jin Park Rui Wei Jieying Peng Zhiyong Luo Yen Ting Chen Yangbo Feng Jun‐Li Luo | 2014 | Int. J. Cancer2014，，： | 1 |
| 6 | Modeling and Parameters Extraction Technique for the MOSFETs at Liquid Nitrogen Temperature显示文摘 | YI Yangbo GE Zhe LI Haisong SUN Weifeng SHI Longxing | 2009 | Chinese Journal of Electronics2009，18，2： | 1 |
| 7 | Membrane bioreactors for hospital wastewater treatment: recent advancements in membranes and processes显示文摘Discharged hospital wastewater contains various pathogenic microorganisms,antibiotic groups,toxic organic compounds,radioactive elements,and ionic pollutants.These contaminants harm the environment and human health causing the spread of disease.Thus,effective treatment of hospital wastewater is an urgent task for sustainable development.Membranes,with controllable porous and nonporous structures,have been rapidly developed for molecular separations.In particular,membrane bioreactor(MBR)technology demonstrated high removal efficiency toward organic compounds and low waste sludge production.To further enhance the separation efficiency and achieve material recovery from hospital waste streams,novel concepts of MBRs and their applications are rapidly evolved through hybridizing novel membranes(non hydrophilic ultrafiltration/microfiltration)into the MBR units(hybrid MBRs)or the MBR as a pretreatment step and integrating other membrane processes as subsequent secondary purification step(integrated MBR-membrane systems).However,there is a lack of reviews on the latest advancement in MBR technologies for hospital wastewater treatment,and analysis on its major challenges and future trends.This review started with an overview of main pollutants in common hospital wastewater,followed by an understanding on the key performance indicators/criteria in MBR membranes(i.e.,solute selectivity)and processes(e.g.,fouling).Then,an in-depth analysis was provided into the recent development of hybrid MBR and integrated MBR-membrane system concepts,and applications correlated with wastewater sources,with a particular focus on hospital wastewaters.It is anticipated that this review will shed light on the knowledge gaps in the field,highlighting the potential contribution of hybrid MBRs and integrated MBRmembrane systems toward global epidemic prevention. | Yan Zhao Yangbo Qiu Natalie Mamrol Longfei Ren Xin Li Jiahui Shao Xing Yang Bart van der Bruggen | 2022 | Frontiers of Chemical Science and Engineering2022，16，5： | 0 |
| 8 | Effects of surface vortex on the drawdown and dispersion of floating particles in stirred tanks显示文摘The effects of surface vortex on the drawdown and dispersion of floating particles in stirred tanks were investigated.Particle distribution and power consumption were analyzed by experiments and numerical simulations in both baffled and unbaffled tanks agitated by a Rushton impeller.In unbaffled tanks,a non-aggregation rule was applied and the average dispersion index was found to serve as a reasonable prediction of the full drawdown of floating particles.The critical impeller speeds in an unbaffled tank were higher than those in a tank with vertical baffles.At each immersion depth in a baffled tank,particles distributed more uniformly and more power was consumed.Comparison of snapshots of the baffled and unbaffled tanks shows that the surface vortex increases the drawdown speed while it decreases the particle distribution uniformity and power consumption.Therefore,the use of baffles to suppress the surface vortex provides for a more uniform particle distribution in stirred tanks. | Wentao Xu Yangbo Tan Meng Li Jianglong Sun De Xie Zeng Liu | 2020 | Particuology2020，18，2： | 0 |
| 9 | A Novel Maximum Resolved Shear Stress Gradient Criterion and Its Application for Crack Deflection Behavior in Polycrystalline Silicon Materials显示文摘In this paper,a development of new resolved shear stress gradient criteria is performed for the study of crack propagation behavior in polycrystalline materials with an emphasis on the effect of slip plane and slip direction.The prediction of crack deflection behavior by the maximum resolved shear stress gradient criterion shows good agreement with the experimental results.Comparison study for the prediction of crack propagation behavior in poly crystalline materials by other criteria demonstrates that the maximum resolved shear stress gradient criterion is superior to other fracture criteria.This suggests that the new criterion could be further applied for predicting the crack deflection behavior in other polycrystalline materials. | Yangbo Zhang Qida Liu Qun Li Yangdong Ni Yuanjie Yu Jean-Nicolas Jaubert Eric Lajoie-Mazenc Emmanuel Boyere Metais Thomas Hong Zuo | 2022 | Acta Mechanica Solida Sinica2022，35，3： | 0 |
| 10 | Reduced-Order Observer-Based Leader-Following Formation Control for Discrete-Time Linear Multi-Agent Systems显示文摘Formation control of discrete-time linear multi-agent systems using directed switching topology is considered in this work via a reduced-order observer, in which a formation control protocol is proposed under the assumption that each directed communication topology has a directed spanning tree. By utilizing the relative outputs of neighboring agents, a reduced-order observer is designed for each following agent. A multi-step control algorithm is established based on the Lyapunov method and the modified discrete-time algebraic Riccati equation. A sufficient condition is given to ensure that the discrete-time linear multi-agent system can achieve the expected leader-following formation.Finally, numerical examples are provided so as to demonstrate the effectiveness of the obtained results. | Zhongxin Liu Yangbo Li Fuyong Wang Zengqiang Chen | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，10： | 0 |
| 11 | Improving fatigue strength of bainite/martensite dual-phase steels in very high cycle fatigue regime by refining microstructures显示文摘Very high cycle fatigue behaviors of two bainite/martensite dual-phase steels were investigated.One of the steels was cyclic rapid heat treated and its microstructures were refined. Fatigue strength of the steel is 225 MPa higher than that without refining.Observation of fracture surfaces show that the fatigue cracks initiate at bainites for non-refined steel and at non-metallic inclusions for the refined steel.The size of inclusions is much smaller than that of bainites which results in the improvement of fatigue strength. | Yangbo Liu Shouxin Li Zhengou Yang Jingyu Cui Jialin Gu Bingzhe Bai | 2012 | Theoretical & Applied Mechanics Letters2012，2，3： | 0 |
| 12 | Impact of IL-18 gene promoter polymorphisms on renal cell carcinoma occurrence and prognosis in Chinese Han population显示文摘Objective Genetic polymorphisms in various inflammatory cytokines have been associated with the risk and growth or invasiveness of renal cell carcinoma(RCC).However,the molecular basis of RCC pathogenesis is unclear.The aim of this study was to explore a possible association between two IL-18 gene promoter polymorphisms,-137G/C and -607 C/A,and RCC occurrence and prognosis in a Chinese Han population.Methods Chinese Han patients with RCC(n=175) and age-matched healthy controls(n=200) were analyzed by single nucleotide polymorphism genotyping during follow-up.Results IL-18-137G allele frequency was significantly higher in patients with lymph node metastasis(Odds ratio [OR],3.52;95% confidence interval [CI],0.97-16.17;P=0.045).The IL-18-607 CC genotype was associated with distant metastasis(OR,2.81;95% CI,1.35-6.24;P=0.025).The IL-18-137G allele was correlated with more advanced tumor stage(OR,1.83;95% CI,1.05-3.72;P=0.026) and higher tumor grade(OR,2.23;95% CI,0.78-4.12;P=0.041).The IL-18-607 CC genotype frequency was significantly higher in patients with more advanced cancer stage(OR,2.92;95% CI,1.80-6.87;P=0.001) and higher tumor grade(OR,2.21;95% CI,1.25-12.25;P=0.035).The IL-18-607 allele was associated with more advanced cancer stage(OR,2.47;95% CI,1.38-3.83;P=0.002).Carriers of the GG genotype with the -137G/C polymorphism had a 2.165-times higher risk of RCC progression than carriers of the GC genotype(Hazard ratio=2.15,95% CI,1.270-3.687).Conclusion The IL-18-137G allele was correlated with more advanced stage,higher tumor grade,and lymph node metastasis.IL-18 gene promoter polymorphism -137G/C may thus influence the prognosis of RCC patients. | Shaojun Nong Yangbo Guan Zhongqing Wei Yueping Zhang Bin Cheng Chongsheng He Limin Ma Shujun Zhou Wenguang Li Jian Ni Zhiwei Wang | 2019 | Oncology and Translational Medicine2019，5，6： | 0 |
| 13 | Trigger System for γ-ray Total Absorption BaF2 Facility显示文摘The γ-ray total absorption facility(GTAF)is designed to measure the cross-sections of theneutron radioactive capture reactions by online method,in which the data acquisition system is developed based on the flash analog-to-digital converter(FADC).The digital total waveform acquisition method is used.The trigger | HE Guozhu PENG Meng SHI Bin ZHANG Qiwei LUO Hong BAO Jie LI Xia RUAN Xichao NIE Yangbo HUANG Hanxiong REN Jie ZHOU Zuying TANG Hongqing | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 14 | Electric modulation of conduction in MAPbBr_(3) single crystals显示文摘The resistive switching(RS)mechanism of hybrid organic–inorganic perovskites has not been clearly understood until now.A switchable diode-like RS behavior in MAPbBr3 single crystals using Au(or Pt)symmetric electrodes is reported.Both the high resistance state(HRS)and low resistance state(LRS)are electrode-area dependent and light responsive.We propose an electric-fielddriven inner p–n junction accompanied by a trap-controlled space-charge-limited conduction(SCLC)conduction mechanism to explain this switchable diode-like RS behavior in MAPbBr_(3) single crystals. | Shanming Ke Shangyu Luo Jinhui Gong Liwen Qiu Renhong Liang Yangbo Zhou Bingcheng Luo Baochang Cheng Li Wang Longlong Shu | 2021 | Journal of Advanced Ceramics2021，10，2： | 0 |
| 15 | Pore-level numerical simulation of methane-air combustion in a simplified two-layer porous burner显示文摘A simplified two-dimensional model of two-layer porous burner based on pore level is developed.The heat transfer of solid phase in porous burner is seen as the synergistic effects of conduction through connecting bridges and surface radiation between the solid particles in the model.A numerical simulation study on the characteristics of flow,combustion and heat transfer in the two-layer porous burner is carried out using the pore level model,and the effects of the control parameters such as the inlet velocity and solid thermal conductivity on thermal non-equilibrium are investigated.The results show that the flame structure is highly two-dimensional based on pore level.Obvious thermal non-equilibrium in the burner for the two phases and solid phase are observed,the largest temperature difference between the gas and solid phases is observed in combustion zone,while the temperature difference inside the solid particles is largest near the flame front.The results also reveal that thermal non-equilibrium of porous burner is much affected by the inlet velocity and solid thermal conductivity. | Yang Liu Yangbo Deng Junrui Shi Rujie Xiao Houping Li | 2021 | Chinese Journal of Chemical Engineering2021，34，6： | 0 |
| 16 | Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation显示文摘Excessive inflammatory responses contribute to the pathogenesis and lethality of highly pathogenic human coronaviruses,but the underlying mechanism remains unclear.In this study,the N proteins of highly pathogenic human coronaviruses,including severe acute respiratory syndrome coronavirus(SARS-CoV),middle east respiratory syndrome coronavirus(MERS-CoV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),were found to bind MASP-2,a key serine protease in the lectin pathway of complement activation,resulting in excessive complement activation by potentiating MBL-dependent MASP-2 activation,and the deposition of MASP-2,C4b,activated C3 and C5b-9.Aggravated inflammatory lung injury was observed in mice infected with adenovirus expressing the N protein.Complement hyperactivation was also observed in SARS-CoV-2-infected patients.Either blocking the N protein:MASP-2 interaction,MASP-2 depletion or suppressing complement activation can significantly alleviate N protein-induced complement hyperactivation and lung injury in vitro and in vivo.Altogether,these data suggested that complement suppression may represent a novel therapeutic approach for pneumonia induced by these highly pathogenic coronaviruses. | Ting Gao Lin Zhu Hainan Liu Xiaopeng Zhang Tingting Wang Yangbo Fu Hongzhen Li Qincai Dong Yong Hu Zhang Zhang Jing Jin Zijing Liu Weihong Yang Yaoning Liu Yanwen Jin Kaitong Li Yongjiu Xiao Junli Liu Huailong Zhao Yue Liu Ping Li Jibo Song Lu Zhang Yuwei Gao Sisi Kang Shoudeng Chen Qingjun Ma Xiuwu Bian Wei Chen Xuan Liu Qing Mao Cheng Cao | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 0 |
| 17 | Remodeling of the osteoimmune microenvironment after biomaterials implantation in murine tibia: Single-cell transcriptome analysis显示文摘Osseointegration seems to be a foreign body reaction equilibrium due to the complicated interactions between the immune and skeletal systems.The heterogeneity of the osteoimmune microenvironment in the osseointegration of implant materials remains elusive.Here,a single-cell study involving 40043 cells is conducted,and a total of 10 distinct cell clusters are identified from five different groups.A preliminary description of the osteoimmune microenvironment revealed the diverse cellular heterogeneity and dynamic changes modulated by implant properties.The increased immature neutrophils,Ly6C+CCR2hi monocytes,and S100a8hi macrophages induce an aggressive inflammatory response and eventually lead to the formation of fibrous capsule around the stainless steel implant.The enrichment of mature neutrophils,FcgR1hi and differentiated immunomodulatory macrophages around the titanium implant indicates favorable osseointegration under moderate immune response.Neutrophil-depletion mice are conducted to explore the role of neutrophils in osseointegration.Neutrophils may improve bone formation by enhancing the recruitment of BMSCs via the CXCL12/CXCR3 signal axis.These findings contribute to a better knowledge of osteoimmunology and are valuable for the design and modification of‘osteoimmune-smart’biomaterials in the bone regeneration field. | Jia Li Congrui Zhao Yangbo Xu Lu Song Yanqi Chen Yuzi Xu Yang Ma Siyuan Wang Antian Xu Fuming He | 2023 | Bioactive Materials2023，，4： | 0 |
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