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| 1 | A DISLOCATION-MECHANICS-BASED CONSTITUTIVE MODEL FOR DYNAMIC STRAIN AGING显示文摘Dynamic strain aging(DSA)is an important phenomenon in solute hardened metals and seri-ously affects the mechanical properties of metals.DSA is generally induced by the interaction between themoving dislocations and the mobile solute atoms.In this paper,only the interaction between moving disloca-tions and mobile solute atoms in a dislocation core area(core atmosphere)will be taken into account.To es-rablish the constitutive model which can describe the DSA phenomenon,we improved the Zerilli-Armstrongdislocation-mechanics-based thermal viscoplastic constitutive relation,and added the effect of the interactionbetween the moving dislocations and core atmosphere.Because the constitutive relation estabhshed is basedon the Zerilh-Armstrong relation,it can describe not only the DSA phenomenon,but also the mechanical be-havior of metals over a broad range of temperatures(77K~1000K)and strain rate(10-4~104 s-1).Themodel prediction for tantalum fits well with the experimental data. | Guo Yangbo Tang Zhiping Cheng Jingyi | 2002 | Acta Mechanica Solida Sinica2002，15，2： | 1 |
| 2 | Dynamic synchronous motion accuracy measurement and estimation for a five-axis mirror milling system显示文摘A mirror milling system(MMS)comprises two face-to-face five-axis machine tools,one for the cutting spindle and the other for the support tool.Since it is essential to maintain the cutter and support coaxial during the cutting process,synchronous motion accuracy is the key index of the MMS.This paper proposed a novel method for measuring and estimating the synchronous motion accuracy of the dual five-axis machine tools.The method simultaneously detects errors in the tool center point(TCP)and tool axis direction(TAD)during synchronous motion.To implement the suggested method,a measurement device,with five high-precision displacement sensors was developed.A kinematic model was then developed to estimate the synchronous motion accuracy from the displacement sensor output.The screw theory was used to obtain the analytical expression of the inverse kinematic model,and the synchronous motion error was compensated and adjusted based on the inverse kinematic model of the dual five-axis machine tools.TCP and TAD quasi-static errors,such as geometric and backlash errors,were first compensated.By adjusting the servo parameters,the dynamic TCP and TAD errors,such as gain mismatch and reversal spike,were also reduced.The proposed method and device were tested in a large MMS,and the measured quasi-static and dynamic errors were all reduced when the compensation and adjustment method was used.Monte Carlo simulations were also used to estimate the uncertainty of the proposed scheme. | XU Kun TANG XinYu BI QingZhen YU YangBo QIAN DeHou JI YuLei | 2023 | Science China(Technological Sciences)2023，66，3： | 0 |
| 3 | Trigger System for γ-ray Total Absorption BaF2 Facility显示文摘The γ-ray total absorption facility(GTAF)is designed to measure the cross-sections of theneutron radioactive capture reactions by online method,in which the data acquisition system is developed based on the flash analog-to-digital converter(FADC).The digital total waveform acquisition method is used.The trigger | HE Guozhu PENG Meng SHI Bin ZHANG Qiwei LUO Hong BAO Jie LI Xia RUAN Xichao NIE Yangbo HUANG Hanxiong REN Jie ZHOU Zuying TANG Hongqing | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 4 | Study on Neutron Capture Reaction Cross-section Measurement显示文摘Theγ-ray total absorption BaF2facility was constructed to measure the neutron capture crosssection with high precision.An neutron source experimental condition of keV energy range was set up through the ~7Li(p,n)7Be reaction,based on the HI-13tandem accelerator providing the pulsed proton beam.The lithium target for | HE Guozhu SHI Bin ZHANG Qiwei RUAN Xichao NIE Yangbo HUANG Hanxiong REN Jie ZHOU Zuying TANG Hongqing | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 5 | SERPINE2 promotes liver cancer metastasis by inhibiting c-Cbl-mediated EGFR ubiquitination and degradation显示文摘Background:Liver cancer is a malignancy with high morbidity and mortality rates.Serpin family E member 2(SERPINE2)has been reported to play a key role in the metastasis of many tumors.In this study,we aimed to investigate the potential mechanism of SERPINE2 in liver cancer metastasis.Methods:The Cancer Genome Atlas database(TCGA),including DNA methy-lation and transcriptome sequencing data,was utilized to identify the crucial oncogene associated with DNA methylation and cancer progression in liver can-cer.Data from the TCGA and RNA sequencing for 94 pairs of liver cancer tissues were used to explore the correlation between SERPINE2 expression and clin-ical parameters of patients.DNA methylation sequencing was used to detect the DNA methylation levels in liver cancer tissues and cells.RNA sequencing,cytokine assays,immunoprecipitation(IP)and mass spectrometry(MS)assays,protein stability assays,and ubiquitination assays were performed to explore the regulatory mechanism of SERPINE2 in liver cancer metastasis.Patient-derived xenografts and tumor organoid models were established to determine the role of SERPINE2 in the treatment of liver cancer using sorafenib.Results:Based on the public database screening,SERPINE2 was identified as a tumor promoter regulated by DNA methylation.SERPINE2 expression was significantly higher in liver cancer tissues and was associated with the dismal prognosis in patients with liver cancer.SERPINE2 promoted liver cancer metas-tasis by enhancing cell pseudopodia formation,cell adhesion,cancer-associated fibroblast activation,extracellular matrix remodeling,and angiogenesis.IP/MS assays confirmed that SERPINE2 activated epidermal growth factor receptor(EGFR)and its downstream signaling pathways by interacting with EGFR.Mechanistically,SERPINE2 inhibited EGFR ubiquitination and maintained its protein stability by competing with the E3 ubiquitin ligase,c-Cbl.Additionally,EGFR was activated in liver cancer cells after sorafenib treatment,and SER-PINE2 knockdown-induced EGFR downregulation significantly enhanced the therapeutic efficacy of sorafenib against liver cancer.Furthermore,we found that SERPINE2 knockdown also had a sensitizing effect on lenvatinib treatment.Conclusions:SERPINE2 promoted liver cancer metastasis by preventing EGFR degradation via c-Cbl-mediated ubiquitination,suggesting that inhibition of the SERPINE2-EGFR axis may be a potential target for liver cancer treatment. | Shiyu Zhang Xing Jia Haojiang Dai Xingxin Zhu Wenfeng Song Suchen Bian Hao Wu Shinuo Chen Yangbo Tang Junran Chen Cheng Jin Mengqiao Zhou Haiyang Xie Shusen Zheng Penghong Song | 2024 | Cancer Communications2024，44，3： | 0 |
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