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| 1 | Novel drug-delivery approaches to the blood-brain barrier显示文摘The blood-brain barrier(BBB) maintains homeostasis by blocking toxic molecules from the circulation, but drugs are blocked at the same time. When the dose is increased to enhance the drug concentration in the central nervous system, there are side-effects on peripheral organs. In recent years, genetic therapeutic agents and small molecules have been used in various strategies to penetrate the BBB while minimizing the damage to systemic organs. In this review, we describe several representative methods to circumvent or cross the BBB, including chemical and physical strategies. | Xiaoqing Wang Xiaowen Yu William Vaughan Mingyuan Liu Yangtai Guan | 2015 | Neuroscience Bulletin2015，31，2： | 2 |
| 2 | Communication-delay-distribution-dependent networked control for a class of T-S fuzzy systems显示文摘 | Chen Peng Cheng Yangtai | 2010 | IEEE Transactions on Fuzzy Systems2010，18，2： | 1 |
| 3 | Mode superposition analysis of viscously damped nonlinear structural systems using an incremental algorithm显示文摘 | Lin Yangtai Sun Techang | 1993 | Journal of Vibration and Acoustics1993，115，： | 1 |
| 4 | Experimental polyneuropathy produced in guinea - pigs immunized against sulfatide 显示文摘 | Zhen Qin Yangtai Guan | 1997 | Neuroreport1997，8，13： | 1 |
| 5 | 显示文摘 | ZhangYanghuan(张羊换) CaiYing(蔡颖) YangTai(杨泰)etal | 2013 | 稀有金属材料与工程2013，4201，： | 1 |
| 6 | Evaluation of Bone Marrow- and Brain-Derived Neural Stem Cells in Therapy of Central Nervous System Autoimmunity显示文摘 | Jingxian Yang Yaping Yan Bogoljub Ciric Shuo Yu Yangtai Guan Hui Xu Abdolmohamad Rostami Guang-Xian Zhang | 2010 | The American Journal of Pathology2010，，4： | 1 |
| 7 | Correlation between human seizure-related gene 6 variants and idiopathic generalized epilepsy in a Southern Chinese Han population显示文摘This study sought to analyze the genotype and gene mutations of human seizure-related gene 6 in 98 patients with idiopathic generalized epilepsy (non-febrile seizures), who were selected from three generations of the Chinese Han population living in Shanghai, Zhejiang Province, Wuxi of Jiangsu Province, and Jiangxi Province of Southern China. Twenty-six patients' parents were available as a first-degree relatives group and 100 biologically unrelated healthy controls were collected as the control group. Based on the age of onset and seizure type, the patients were divided into six subgroups. Polymerase chain reaction and DNA direct sequencing analysis showed that the most frequent mutations c.1249dupC (p.Gly418Argfx31) and c.1636A > G (p.Thr546Ala) were detected in some idiopathic generalized epilepsy patients and their asymptomatic first-degree relatives (30.6% vs. 19.2% and 11.2% vs. 26.9%). A novel mutation c.1807G > A (p.Val603Met) was found in a patient with late-onset idiopathic generalized epilepsy. There was no significant difference in the incidence of these three mutations among the different subgroups of idiopathic generalized epilepsy and controls. Thus, further analysis of a larger population is needed to confirm the assumption that human seizure-related gene 6 is a susceptibility gene for idiopathic generalized epilepsy with various sub-syndromes. | Jianming Jiang Xiao ling Chen Wenting Liu Yan Zhao Yangtai Guan Yan Han FengWang Jiajun Lu Zhiliang Yu Zhenfang Du Xianning Zhang | 2012 | Neural Regeneration Research2012，7，2： | 0 |
| 8 | Case report of rabies-induced persistent mental symptoms显示文摘 | Xiaoqing WANG Xiaowen YU Yangtai GUAN | 2015 | 上海精神医学2015，27，1： | 0 |
| 9 | Glia Connect Inflammation and Neurodegeneration in Multiple Sclerosis显示文摘Multiple sclerosis(MS)is regarded as a chronic inflammatory disease that leads to demyelination and eventually to neurodegeneration.Activation of innate immune cells and other inflammatory cells in the brain and spinal cord of people with MS has been well described.However,with the innovation of technology in glial cell research,we have a deep understanding of the mechanisms of glial cells connecting inflammation and neurodegeneration in MS.In this review,we focus on the role of glial cells,including microglia,astrocytes,and oligodendrocytes,in the pathogenesis of MS.We mainly focus on the connection between glial cells and immune cells in the process of axonal damage and demyelinating neuron loss. | Ye Sun Haojun Yu Yangtai Guan | 2023 | Neuroscience Bulletin2023，39，3： | 0 |
| 10 | Seizure-related 6,a brain-specific expression gene,is highly expressed in the human cerebellum显示文摘Epilepsy is a complex, Mendelian disease, and most cases are sporadic. Genomic comparisons of tissue from identified monogenic epilepsies with multigenic and acquired syndromes could ultimately reveal crucial molecular neuropathology for an epileptic phenotype. In the present study, a novel gene, human seizure-related (hSEZ)-6, was isolated from a human brain cDNA library. hSEZ-6 comprises 17 exons and spans a region of at least 55.6 kb, which was localized to 17q12 by radiation hybridization. hSEZ-6 exhibits two isoform types, hSEZ-6A and hSEZ-6B, which encode 996 and 995 amino acids, respectively. The two putative hSEZ-6 proteins contain similar motifs and share 82% and 84% identity with mouse SEZ-6A protein, whose expression level increased in mouse cerebral cortex-derived cells treated with a convulsant drug, pentylentetrazole. Northern blot analysis demonstrated that hSEZ-6 is expressed highly in the cerebellum and in nucleus of the extrapyramidal system, such as the caudate nucleus and putamen. Reverse transcription polymerase chain reaction revealed that hSEZ-6 is expressed in neurons rather than gliocytes, which suggests that hSEZ-6 is a seizure-related gene. | Jianming Jiang Long Yu Yangtai Guan Zhiliang Yu Xinghua Huang Xiaosong Chen LishaTang Xianning Zhang | 2010 | Neural Regeneration Research2010，5，16： | 0 |
| 11 | Establishment of probabilistic model for Salmonella Enteritidis growth and inactivation under acid and osmotic pressure显示文摘The growth and survival characteristic of Salmonella Enteritidis under acidic and osmotic conditions were studied.Meanwhile,a probabilistic model based on the theory of cell division and mortality was established to predict the growth or inactivation of S.Enteritidis.The experimental results demonstrated that the growth curves of planktonic and detached cells showed a significant difference(p<0.05)under four conditions,including pH5.0+0.0%NaCl,pH7.0+4.0%NaCl,pH6.0+4.0%NaCl,and pH5.0+4.0%NaCl.And the established primary and secondary models could describe the growth of S.enteritis well by estimating four mathematics evaluation indexes,including determination coefficient(R2),root mean square error(RMSE),accuracy factor(Af)and bias factor(Bf).Moreover,sequential treatment of 15%NaCl stress followed by pH 4.5 stress was the best condition to inactivate S.Enteritidis in 10 h at 25◦C.The probabilistic model with Logistical or Weibullian form could also predict the inactivation of S.Enteritidis well,thus realize the unification of predictive model to some extent or generalization of inactivation model.Furthermore,the primary 4-parameter probabilistic model or generalized inactivation model had slightly higher applicability and reliability to describe the growth or inactivation of S.Enteritidis than Baranyi model or exponential inactivation model within the experimental range in this study. | Yujiao Shi Hong Liu Baozhang Luo Yangtai Liu Siyuan Yue Qing Liu Qingli Dong | 2017 | Food Science and Human Wellness2017，6，4： | 0 |
| 12 | Optical non-destructive techniques for small berry fruits: A review显示文摘Small berries including strawberry and blueberry are extensively consumed fruits with great economic values due to their characteristic flavor and appearance as well as potential health benefits.This review elaborated the optical non-destructive techniques viz.Vis-NIR spectroscopy,computer vision system,hyperspectral imaging,multispectral imaging,laser-induced method and thermal imaging,and their applications for quality and safety control of small berry fruits.The discussion regarding the photoacoustic technique,X-ray technique,Terahertz spectroscopy,odor imaging,micro-destructive testing and smart mobile terminal-based analyzer was also presented.Furthermore,we proposed our personal understanding of the technical challenges and further trends for these optical non-destructive techniques:1)owing to the relatively low detection limit,the so-called micro-destructive techniques may be alternative to the traditional non-destructive techniques in both practical and fundamental research;2)we suggest that the research articles like“collecting data first,and then modeling the relevant properties of agricultural products by machine learning”should be less produced in related fields.That's because such research methods are likely to be suspected of“cheating”.It is recommended that some modeling competitions can be carried out in the agricultural engineering field to avoid or reduce the“cheating”model. | Shuping Li Hongpei Luo Menghan Hu Miao Zhang Jianlin Feng Yangtai Liu Qingli Dong Baolin Liu | 2019 | Artificial Intelligence in Agriculture2019，，2： | 0 |
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