|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Correlation of E-selectin gene polymorphisms with risk of ischemic stroke A meta-analysis显示文摘OBJECTIVE: To investigate the association of E-selectin S128R polymorphisms with ischemic stroke. DATA SOURCES: A computer-based online search was conducted in PubMed, Elsevier, Ovid Database, the China National Knowledge Infrastructure, and Wanfang Database between January 1998 and December 2010. STUDY SELECTION: Case-controlled studies addressing the association of the E-selectin polymorphism and ischemic stroke were included in this review. The genotype distribution complied with the Hardy-Weinberg genetic equilibrium. The included reports were evaluated by two authors for strict quality screening. Meta-analysis software, REVMAN 5.1, was used to investigate heterogeneity, pooled odds ratio (OR) and 95% confidence interval (CI) in individual studies. MAIN OUTCOME MEASURES: Genotype and allele distributions at the E-selectin S128R site. RESULTS: Six case-controlled studies were included after screening and application of inclusion and exclusion criteria. There was no heterogeneity in the genotype and allele frequencies, and no publication bias was found. Meta-analysis of the pooled data showed that the OR value of the (AC+CC)/AA genotype was 1.93 (95% CI: 1.55-2.41, Z = 5.80, P < 0.000 01), and the OR for the C/A allele was 1.80 (95% CI: 1.47-2.22, Z = 5.59, P < 0.000 01) in the ischemic stroke group, compared with control group. Results of pooled data in Chinese subjects showed that the OR value of (AC+CC)/AA was 2.36 (95% CI: 1.68-3.31, Z = 4.99, P < 0.000 01), and the OR value of the C/A allele was 2.25 (95% CI: 1.63-3.12, Z = 4.89, P < 0.000 01). CONCLUSION: Polymorphism of E-selectin S128R was significantly associated with susceptibility to ischemic stroke; the AC and CC genotypes as well as the C allele may be factors associated with susceptibility to ischemic stroke. | Qingli Sun Yu Fu Aping Sun Yanhong Shou Mei Zheng Xiaogang Li Dongsheng Fan | 2011 | Neural Regeneration Research2011，6，22： | 46 |
| 2 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 3 | Microstructure and tribological properties of W-implanted PVD TiN coatings on 316L stainless steel显示文摘 | Bin Tian Wen Yue Zhiqiang Fu Yanhong Gu Chengbiao Wang Jiajun Liu | 2014 | Vacuum2014，，： | 3 |
| 4 | Impacts of Topographic Complexity on Modeling Moisture Transport and Precipitation over the Tibetan Plateau in Summer显示文摘The non-hydrostatic global variable resolution model(MPAS-atmosphere)is used to conduct the simulations for the South Asian Summer monsoon season(June,July,and August)in 2015 with a refinement over the Tibetan Plateau(TP)at the convection-permitting scale(4 km).Two experiments with different topographical datasets,complex(4-km)and smooth(60-km)topography,are designed to investigate the impacts of topographical complexity on moisture transport and precipitation.Compared with the observations and reanalysis data,the simulation can successfully capture the general features of key meteorological fields over the TP despite slightly underestimating the inflow through the southern TP.The results indicate that the complex topography can decrease the inward and outward moisture transport,ultimately increasing the total net moisture transport into the TP by~11%.The impacts of complex topography on precipitation are negligible over the TP,but the spatial distributions of precipitation over the Himalayas are significantly modulated.With the inclusion of complex topography,the sharper southern slopes of the Himalayas shift the lifted airflow and hence precipitation northward compared to the smooth topography.In addition,more small-scale valleys are resolved by the inclusion of complex topography,which serve as channels for moisture transport across the Himalayas,further favoring a northward shift of precipitation.Overall,the difference between the two experiments with different topography datasets is mainly attributed to their differing representation of the degree of the southern slopes of the Himalayas and the extent to which the valleys are resolved. | Gudongze LI Haoming CHEN Mingyue XU Chun ZHAO Lei ZHONG Rui LI Yunfei FU Yanhong GAO | 2022 | Advances in Atmospheric Sciences2022，39，7： | 3 |
| 5 | A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients显示文摘 | Cai-Hong Zeng Weibo Le Zhaohui Ni Minfang Zhang Lining Miao Ping Luo Rong Wang Zhimei Lv Jianghua Chen Jiong Tian Nan Chen Xiaoxia Pan Ping Fu Zhangxue Hu Lining Wang Qiuling Fan Hongguang Zheng Dewei Zhang Yaping Wang Yanhong Huo Hongli Lin Shuni Chen Sh | 2012 | American Journal of Kidney Diseases2012，，5： | 2 |
| 6 | Oxygen intercalation under hexagonal boron nitride(h-BN)on Pt(111)显示文摘The interface between a two-dimensional(2D)atomic crystal and a metal surface can be regarded as a nanoreactor, in which molecule adsorption and catalytic reactions may occur. In this work, we demonstrate that oxygen intercalation and desorption occur at the interface between hexagonal boron nitride(h-BN) overlayer and Pt(111) surface by using near-ambient pressure X-ray photoelectron spectroscopy(NAP-XPS), photoemission electron microscopy, and low-energy electron microscopy.Furthermore, CO oxidation under the h-BN cover was also observed by NAP-XPS. The present results indicate that the nanospace under the 2D cover can be used for surface reactions, in which novel surface chemistry may be induced by the nanoconfinement effect. | Yanhong Zhang Mingming Wei Qiang Fu Xinhe Bao | 2015 | Science Bulletin2015，60，18： | 2 |
| 7 | Detection and Prevention of Environmental Hormone显示文摘The sorts and detection methods of environmental hormone were analyzed firstly,and then the effects of environmental hormone on organisms and humanity were discussed. Finally the control measures of environmental hormone pollution,such as reducing the use of goods and pesticide and the study of new substitutes and degradation technology are advanced. | Qili Chen Ling Pan Yanhong Xv Xuan Fu Hongzhen Sun Hongyan Li Pingping Liu | 2013 | Meteorological and Environmental Research2013，4，12： | 1 |
| 8 | Development of a roll-bonded UNS N08825 alloy clad pipeline steel in Baosteel显示文摘In this study,a roll-bonded UNS N088225 alloy clad pipeline steel was investigated and developed in Baosteel. Based on the requirements of a number of potential projects,we performed a series of strict evaluations including mechanical and corrosion tests. The results show the mechanical properties and corrosion resistance of this clad steel to be excellent and to meet the requirements of all the design parameters. | LIANG Xiaojun MA Tianjun FU Yanhong JIAO Sihai DING Jianhua YUAN Xiangqian WANG Baosen ZHANG Qingfeng | 2017 | Baosteel Technical Research2017，11，1： | 1 |
| 9 | The activation and differential signalling of the growth hormone receptor induced by pGH or anti-idiotypic monoclonal antibodies in primary rat hepatocytes显示文摘 | Wei Li Hainan Lan Huimin Liu Zhiling Fu Yanhong Yang Weiwei Han Feng Guo Yu Liu Hui Zhang Jingsheng Liu Xin Zheng | 2013 | Molecular and Cellular Endocrinology (-)2013，，1： | 1 |
| 10 | Catalytic water dissociation using hyperbranched aliphatic polyester (Boltorn series) as the interface of a bipolar membrane显示文摘 | XUE Yanhong XU Tongwen FU Rongqiang | 2007 | Colloid and Interface Science2007，316，： | 1 |
| 11 | Organochlorinated Compounds in Waters of the Pearl River Delta Region显示文摘 | Yang Yanhong Sheng Guoying Fu Jimo Min Yushun | 1997 | Environmental Monitoring and Assessment (-)1997，，1： | 1 |
| 12 | Enhanced Reactivityof Graphene Wrinkles and Their Function as Nanosized GasInlets for Reactions Under Graphene显示文摘 | Zhang Yanhong Fu Qiang Cui Yi | 2013 | PCCP2013，15，19： | 1 |
| 13 | Co-activation for enhanced K-ion storage in battery anodes显示文摘The relative natural abundance of potassium and potentially high energy density has established potassium-ion batteries as a promising technology for future large-scale global energy storage.However,the anodes'low capacity and high dis charge platform lead to low energy density,which impedes their rapid development.Herein,we present a possible co-activation mechanism between bismuth(Bi)and tin(Sn)that enhances K-ion storage in battery anodes.The co-activated Bi-Sn anode delivered a high capacity of634 mAh g^(-1),with a discharge plateau as low as 0.35 V,and operated continuously for 500 cycles at a current density of 50 mA g^(-1),with a high Coulombic efficiency of 99.2%.This possible co-activation strategy for high potassium storage may be extended to other Na/Zn/Ca/Mg/Al ion battery technologies,thus providing insights into how to improve their energy storage ability. | Yanhong Feng Yawei Lv Hongwei Fu Mihir Parekh Apparao MRao He Wang Xiaolin Tai Xianhui Yi Yue Lin Jiang Zhou Bingan Lu | 2023 | National Science Review2023，10，7： | 0 |
| 14 | The high-quality sequencing of the Brassica rapa‘XiangQingCai’genome and exploration of genome evolution and genes related to volatile aroma显示文摘‘Vanilla’(XQC,brassica variety chinensis)is an important vegetable crop in the Brassica family,named for its strong volatile fragrance.In this study,we report the high-quality chromosome-level genome sequence of XQC.The assembled genome length was determined as 466.11 Mb,with an N50 scaffold of 46.20 Mb.A total of 59.50%repetitive sequences were detected in the XQC genome,including 47570 genes.Among all examined Brassicaceae species,XQC had the closest relationship with B.rapa QGC(‘QingGengCai’)and B.rapa Pakchoi.Two whole-genome duplication(WGD)events and one recent whole-genome triplication(WGT)event occurred in the XQC genome in addition to an ancient WGT event.The recent WGT was observed to occur during 21.59-24.40 Mya(after evolution rate corrections).Our findings indicate that XQC experienced gene losses and chromosome rearrangements during the genome evolution of XQC.The results of the integrated genomic and transcriptomic analyses revealed critical genes involved in the terpenoid biosynthesis pathway and terpene synthase(TPS)family genes.In summary,we determined a chromosome-level genome of B.rapa XQC and identified the key candidate genes involved in volatile fragrance synthesis.This work can act as a basis for the comparative and functional genomic analysis and molecular breeding of B.rapa in the future. | Zhaokun Liu Yanhong Fu Huan Wang Yanping Zhang Jianjun Han Yingying Wang Shaoqin Shen Chunjin Li Mingmin Jiang Xuemei Yang Xiaoming Song | 2023 | Horticulture Research2023，10，10： | 0 |
| 15 | RING finger 138 deregulation distorts NF-κB signaling and facilities colitis switch to aggressive malignancy显示文摘Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling transduction.Here,we discovered the critical role of RING finger 138(RNF138)in CRC tumorigenesis through regulating the NF-кB signaling,which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage response.RNF138^(−/−) mice were hyper-susceptible to the switch from colitis to aggressive malignancy,which coincided with sustained aberrant NF-кB signaling in the colonic cells.Furthermore,RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein(NIBP)to the cytoplasm,which requires the ubiquitin interaction motif(UIM)domain.More importantly,we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings,raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB signaling.Using the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients,we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor growth.Overall,our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression,and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation. | Yalan Lu Rong Huang Jianming Ying Xingchen Li Tao Jiao Lei Guo Haitao Zhou Han Wang Amannisa Tuersuntuoheti Jianmei Liu Qichen Chen Yanhong Wang Luying Su Changyuan Guo Fu Xu Ziyi Wang Yan Lu Kai Li Junbo Liang Zhen Huang Xiao Chen Jinjie Yao Hanjie Hu Xiaowen Cheng Yufeng Wan Xinyan Chen Ning Zhang Shiying Miao Jianqiang Cai Linfang Wang Changzheng Liu Wei Song Hong Zhao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 16 | The Future Challenges of Population Health in China:A Projection of the Major Health Problems and Life Expectancy——China,2015-2050显示文摘According to the Seventh National Population Census in 2020,the life expectancy of the Chinese population has been gradually rising in the past 10 years(1).With China’s industrialization,urbanization,and rapidly aging population,behavioral changes,and environmental factors have a growing impact on health.The strategy based on“curing disease”cannot meet the public’s health needs. | Jiangmei Liu Bo Jiang Yanhong Fu Zhuo Wang Min Liu Peng Yin Maigeng Zhou | 2022 | China CDC weekly2022，4，13： | 0 |
| 17 | Boron promoted Fe^(3+)/peracetic acid process for sulfamethazine degradation:Efficiency,role of boron,and identification of the reactive species显示文摘In this work,boron(B)was used to promote Fe^(3+)/peracetic acid(Fe^(3+)/PAA)for the degradation of sulfamethazine(SMT).An SMT degradation efficiency of 9.1%was observed in the Fe^(3+)/PAA system over 60 min,which was significantly increased to 99.3%in the B/Fe^(3+)/PAA system over 10 min.The B/Fe^(3+)/PAA process also exhibited superior resistance to natural substances,excellent adaptability to different harmful substances,and good removal of antibiotics in natural fresh water samples.The mechanism of action of boron for Fe^(3+)reduction was determined using scanning electron microscopy(SEM),X-ray photoelectron spectroscopy(XPS),Fourier transform infrared(FT-IR)spectroscopy,density functional theory(DFT)calculations,and electrochemical tests.The dominant role of^(·)OH was confirmed using quenching experiments,electron spin resonance(EPR)spectroscopy,and quantitative tests.Organic radicals(R-O^(·))and Fe(IV)also significantly contribute to the removal of SMT.DFT calculations on the reaction between Fe^(2+)and the PAA were conducted to further determine the contribution from ^(·)OH,R-O^(·),and Fe(IV)from the perspective of thermodynamics and the reaction pathways.Different boron dosages,Fe^(3+)dosages,and initial pH values were also investigated in the B/Fe^(3+)/PAA system to study their effect of SMT removal and the production of the reactive species.Fe(IV)production determined the k_(R-O·+Fe(IV))value suggesting that Fe(IV)may play a more important role than R-O^(·).A comparison of the results with other processes has also proved that the procedure described in this study(B/Fe^(3+)/PAA)is an effective method for the degradation of antibiotics. | Yanhong Zhang Guangbing Liu Yuzhu Xue Lichun Fu Yawei Qian Minhui Hou Xiang Li Chen Ling Ying Zhang Yuwei Pan | 2024 | Journal of Environmental Sciences2024，，1： | 0 |
| 18 | Hopf bifurcation of a tumor immune model with time delay显示文摘In this paper,a tumor immune model with time delay is studied.First,the stability of nonnegative equilibria is analyzed.Then the time delay τ is selected as a bifurcation parameter and the existence of Hopf bifurcation is proved.Finally,by using the canonical method and the central manifold theory,the criteria for judging the direction and stability of Hopf bifurcation are given. | Yanhong YANG Shengmao FU | 2022 | Frontiers of Mathematics in China2022，17，2： | 0 |
| 19 | Particle mixing behavior of fine coal in density control of gas-solid separation fluidized bed显示文摘In a gas-solid separation fluidized bed,mixing of fine coal is necessary to achieve a suitable bed density to enable effective separation of low rank coal.On the basis of a variety of mixture models,a gas-solid separation fluidized bed was judged,where fine coal particles of 0.6-1.0mm were uniformly mixed with magnetite powder.High-speed dynamic camera technology was combined with a slump-sampling method to study the mixing process of the fine coal in the fluidized bed.These results showed that limitations of the fluidized bed structure cause the mixing process to be dominated by lateral diffusion and supplemented by axial diffusion.Axial diffusion was mainly achieved through the ascension of bubbles,whereas lateral diffusion was determined by the bursting action of the gas bubbles at the surface of the bed and the undulating characteristics of the bed.The effective lateral diffusion coefficient increased exponentially with gas velocity but had no strong relationship with the bed height.As the feed point moved toward the center,fine coal began to diffuse to both sides,which shortened the time for the bed density stabilization from 20 to 5 min.The bed density of the layer was stabilized at approximately 1.75 g/cm3.The separation efficiency of the gas-solid separation fluidized bed containing binary mixtures was more obvious for 6-50 mm raw coal,with a probable error E of 0.16. | Bo Lv Zhenfu Luo Yanhong Fu Bo Zhang Xingzong Qin Xiangnan Zhu | 2020 | Particuology2020，18，3： | 0 |
| 20 | Associations between metabolic dysfunction-associated fatty liver disease and extrahepatic cancers:a cohort in China显示文摘Background:To evaluate the associations between a new definition of metabolic dysfunction-associated fatty liver disease(MAFLD)and extrahepatic cancers and compare with nonalcoholic fatty liver disease(NAFLD).Methods:We enrolled 151,391 Chinese participants in the Kailuan cohort.Hepatic steatosis was detected by abdominal ultrasound.Fine and Gray competing risk regression models were used to estimate hazard ratios(HRs)and 95%confidence interval(CI)between MAFLD and extrahepatic cancers.Results:MAFLD was associated with increased risk of prostate(HR=1.49,95%CI:1.07-2.08)and obesity-related cancers,including thyroid(HR=1.47,95%CI:1.01-2.12),kidney(HR=1.54,95%CI:1.18-2.00),colorectal(HR=1.15,95%CI:0.98-1.34)and breast cancer(HR=1.31,95%CI:1.04-1.66).The results were consistent in NAFLD vs.non-NAFLD and MAFLD-NAFLD vs.neither FLD.Compared with the neither FLD group,the NAFLD-only group had a higher risk of extrahepatic cancers(HR=1.57,95%CI:1.18-2.09),esophageal(HR=5.11,95%CI:2.25-11.62),and bladder cancer(HR=3.36,95%CI:1.23-9.17).The additional risk of extrahepatic cancers(HR=1.42,95%CI:1.17-1.73),esophageal(HR=4.37,95%CI:2.55-7.49),and breast cancer(HR=1.99,95%CI:1.01-3.92)was observed in MAFLD with metabolic dysregulation,and kidney(HR=1.83,95%CI:1.38-2.43),prostate(HR=1.46,95%CI:1.00-2.14)and breast cancer(HR=1.33,95%CI:1.02-1.74)was observed in MAFLD with overweight and metabolic dysregulation,as well as colorectal(HR=1.45,95%CI:1.07-1.96)and prostate cancer(HR=2.44,95%CI:1.42-4.21)in MAFLD with three risk factors.Additionally,MAFLD with excessive alcohol consumption would increase extrahepatic cancers(HR=1.14,95%CI:1.01-1.29)and breast cancer(HR=7.27,95%CI:2.33-22.69)risk.Conclusions:MAFLD and NAFLD shared similar excessive risks of obesity-related cancers,suggesting a driving role of FLD in these cancers.Metabolic dysregulation beyond obesity may play additional kidney,colorectal,and prostate cancer risks in MAFLD patients.It may be helpful in the clinic to relieve symptoms by treating metabolic disorders and preventing adverse outcomes of extrahepatic cancers. | Xiaojie Yuan Xiaomo Wang Shouling Wu Shuohua Chen Yanhong Wang Jierui Wang Ying Lu Yuanyuan Sun Qingjiang Fu Li Wang | 2023 | Hepatobiliary Surgery and Nutrition2023，12，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员