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| 1 | Transplantation of bone marrow mesenchymal stem cells improves cognitive deficits and alleviates neuropathology in animal models of Alzheimer’s disease: a meta-analytic review on potential mechanisms显示文摘Background Alzheimer’s disease is a neurodegenerative disorder.Therapeutically,a transplantation of bone marrow mesenchymal stem cells(BMMSCs)can play a beneficial role in animal models of Alzheimer’s disease.However,the relevant mechanism remains to be fully elucidated.Main body Subsequent to the transplantation of BMMSCs,memory loss and cognitive impairment were significantly improved in animal models with Alzheimer’s disease(AD).Potential mechanisms involved neurogenesis,apoptosis,angiogenesis,inflammation,immunomodulation,etc.The above mechanisms might play different roles at certain stages.It was revealed that the transplantation of BMMSCs could alter some gene levels.Moreover,the differential expression of representative genes was responsible for neuropathological phenotypes in Alzheimer’s disease,which could be used to construct gene-specific patterns.Conclusions Multiple signal pathways involve therapeutic mechanisms by which the transplantation of BMMSCs improves cognitive and behavioral deficits in AD models.Gene expression profile can be utilized to establish statistical regression model for the evaluation of therapeutic effect.The transplantation of autologous BMMSCs maybe a prospective therapy for patients with Alzheimer’s disease. | Chuan Qin Yalan Lu Kewei Wang Lin Bai Guiying Shi Yiying Huang Yongning Li | 2020 | Translational Neurodegeneration2020，9，2： | 9 |
| 2 | E3 ligase UHRF2 stabilizes the acetyltransferase TIP60 and regulates H3K9ac and H3K14ac via RING finger domain显示文摘UHRF2 是调整房间周期, genomic 稳定性和 epigenetics 的 ubiquitin 蛋白质 ligase E3。我们进行了 co-immunoprecipitation 试金并且发现 TIP60 和 HDAC1 与 UHRF2 交往。我们以前证明 UHRF2 在正常和癌症房间调整了 H3K9ac 和 H3K14ac 差别。然而,精确信号 transduction 机制不是清楚的。在这研究,我们发现 TIP60 UHRF2 下游地行动了调整 H3K9ac 和 H3K14ac 表示。TIP60 被 UHRF2 ubiquitination 在正常房间稳定。然而, TIP60 在癌症房间被使动摇。TIP60 的弄空或抑制破坏在 UHRF2, H3K9ac 和 H3K14ac 之间的规章的关系。在摘要,调查结果建议 UHRF2 调停了癌症的 histones 和开始和前进的 translational 以后修正。 | Shengyuan Zeng YangyangWang Ting Zhang Lu Bai Yalan Wang Changzhu Duan | 2017 | Protein & Cell2017，8，3： | 8 |
| 3 | The vicK gene of Streptococcus mutans mediates its cariogenicity via exopolysaccharides metabolism显示文摘Streptococcus mutans(S.mutans)is generally regarded as a major contributor to dental caries because of its ability to synthesize extracellular polysaccharides(EPS)that aid in the formation of plaque biofilm.The VicRKX system of S.mutans plays an important role in biofilm formation.The aim of this study was to investigate the effects of vicK gene on specific characteristics of EPS in S.mutans biofilm.We constructed single-species biofilms formed by different mutants of vicK gene.Production and distribution of EPS were detected through atomic force microscopy,scanning electron microscopy and confocal laser scanning microscopy.Microcosmic structures of EPS were analyzed by gel permeation chromatography and gas chromatography-mass spectrometry.Cariogenicity of the vicK mutant was assessed in a specific pathogen-free rat model.Transcriptional levels of cariogenicityassociated genes were confirmed by quantitative real-time polymerase chain reaction.The results showed that deletion of vicK gene suppressed biofilm formation as well as EPS production,and EPS were synthesized mostly around the cells.Molecular weight and monosaccharide components underwent evident alterations.Biofilms formed in vivo were sparse and contributed a decreased degree of caries.Moreover,expressional levels of genes related to EPS synthesis were down-regulated,except for gtfB.Our report demonstrates that vicK gene enhances biofilm formation and subsequent caries development.And this may due to its regulations on EPS metabolism,like synthesis or microcosmic features of EPS.This study suggests that vicK gene and EPS can be considered as promising targets to modulate dental caries. | Yalan Deng Yingming Yang Bin Zhang Hong Chen Yangyu Lu Shirui Ren Lei Lei Tao Hu | 2021 | International Journal of Oral Science2021，13，4： | 2 |
| 4 | Structure-design and theoretical-calculation for ultrasmall Co_(3)O_(4) anchored into ionic liquid modified graphene as anode of flexible lithium-ion batteries显示文摘Cobalt oxide(Co_(3)O_(4))is currently suitable in energy storage applications because of its high capacity based on the conversion reaction mechanism.However,unmodified Co_(3)O_(4)suffers from distinctly inferior rate capability and poor cycling stability.On the basis of the aforementioned considerations and density functional theory(DFT)simulations,the three-dimensional hierarchical porous structure(HPS)ultrasmall Co_(3)O_(4)anchored into ionic liquid(IL)modified graphene oxide(GO)has been successfully prepared(ultrasmall/Co_(3)O_(4)-GA-IL).The ultrasmall/Co_(3)O_(4)-GA-IL consists of Co_(3)O_(4)co-assembled with IL modified GO to generate the HPS which can facilitate ion transfer channels through reduction of the electron and ion transportation path and transmission impedance.In addition,N-doping graphene can enhance the inherent electrical conductivity of Co_(3)O_(4),which is proved by the DFT calculations.By virtue of the novel superstructure,the ultrasmall/Co_(3)O_(4)-GA-IL electrode demonstrates a high reversible capacity of 1,304 mAh·g^(−1),an enhanced high-rate capability(715 mAh·g^(−1)at 5 C),and a capacity retention of 98.4%even after 500 cycles at 5 C rate,which corresponds to 0.0003%capacity loss per cycle.Pouch cells based on the cathode are further fabricated and demonstrate excellent mechanical and electrochemical properties under bent and folded state,highlighting the practical application of our deliberately designed electrode in wearable electronics. | Longda Cong Shichao Zhang Hengyao Zhu Weixin Chen Xueyan Huang Yalan Xing Jun Xia Puheng Yang Xia Lu | 2022 | Nano Research2022，15，3： | 1 |
| 5 | Dual interfacial engineering for efficient Cs_(2)AgBiBr_(6) based solar cells显示文摘The emerging lead-free halide double perovskite solar cells have attracted widespread attentions due to their long-term stability and non-toxicity, but suffer from the low device performance. One efficiencylimiting factor is the improper contacts between the halide double perovskite and anode/cathode electrodes. Here, we improve the efficiency and stability of the bismuth-halide double perovskite based solar cells by a synergistic interface design for both electron and hole transport layers(ETL/HTL). The results show that the modification of the TiO_2 ETL with a thin hydrophobic C60 layer and replacement of the lithium-doped small molecule HTL with an un-doped conjugated polymer lead to higher surface quality of perovskite film and better energy-level alignment at the contacts. As a result, the optimized device shows reduced trap density, suppressed charge recombination and enhanced charge extraction, leading to an increase of 69% in device efficiency. In addition, the device also exhibits superior stability in ambient environment, heat stress and light bias after interface optimization. This work provides an efficient strategy for the device optimization of the emerging lead-free perovskite solar cells. | Tao Luo Yalan Zhang Xiaoming Chang Junjie Fang Tianqi Niu Jing Lu Yuanyuan Fan Zicheng Ding Kui Zhao Shengzhong(Frank)Liu | 2021 | Journal of Energy Chemistry2021，30，2： | 1 |
| 6 | DC-SIGN promotes Japanese encephalitis virus transmission from dendritic cells to T cells via virological synapses显示文摘Skin-resident dendritic cells(DCs) likely encounter incoming viruses in the first place, and their migration to lymph nodes following virus capture may promote viral replication. However, the molecular mechanisms underlying these processes remain unclear. In the present study, we found that compared to cell-free viruses, DC-bound viruses showed enhanced capture of JEV by T cells.Additionally, JEV infection was increased by co-culturing DCs and T cells. Blocking the C-type lectin receptor DC-specific intercellular adhesion molecule-3-grabbing non-integrin(DC-SIGN) with neutralizing antibodies or antagonists blocked JEV transmission to T cells. Live-cell imaging revealed that DCs captured and transferred JEV viral particles to T cells via virological synapses formed at DC-T cell junctions. These findings indicate that DC-SIGN plays an important role in JEV transmission from DCs to T cells and provide insight into how JEV exploits the migratory and antigen-presenting capabilities of DCs to gain access to lymph nodes for dissemination and persistence in the host. | Ping Wang Mei Li Wei Lu Di Zhang Qinxue Hu Yalan Liu | 2017 | Virologica Sinica2017，32，6： | 1 |
| 7 | RING finger 138 deregulation distorts NF-κB signaling and facilities colitis switch to aggressive malignancy显示文摘Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling transduction.Here,we discovered the critical role of RING finger 138(RNF138)in CRC tumorigenesis through regulating the NF-кB signaling,which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage response.RNF138^(−/−) mice were hyper-susceptible to the switch from colitis to aggressive malignancy,which coincided with sustained aberrant NF-кB signaling in the colonic cells.Furthermore,RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein(NIBP)to the cytoplasm,which requires the ubiquitin interaction motif(UIM)domain.More importantly,we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings,raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB signaling.Using the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients,we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor growth.Overall,our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression,and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation. | Yalan Lu Rong Huang Jianming Ying Xingchen Li Tao Jiao Lei Guo Haitao Zhou Han Wang Amannisa Tuersuntuoheti Jianmei Liu Qichen Chen Yanhong Wang Luying Su Changyuan Guo Fu Xu Ziyi Wang Yan Lu Kai Li Junbo Liang Zhen Huang Xiao Chen Jinjie Yao Hanjie Hu Xiaowen Cheng Yufeng Wan Xinyan Chen Ning Zhang Shiying Miao Jianqiang Cai Linfang Wang Changzheng Liu Wei Song Hong Zhao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 8 | The molecular regulation of autophagy in antimicrobial immunity显示文摘Autophagy is a catabolic process that can degrade worn-out organelles and invading pathogens.The activation of autophagy regulates innate and adaptive immunity,playing a key role in the response to microbial invasion.Microbial infection may cause different consequences such as the elimination of invaders through autophagy or xenophagy,host cell death,and symbiotic relationships.Pathogens adapt to the autophagy mechanism and further relieve intracellular stress,which is conducive to host cell survival and microbial growth.The regulation of autophagy forms a complex network through which host immunity is modulated,resulting in a variety of pathophysiological manifestations.Modification of the autophagic pathway is an essential target for the development of antimicrobial drugs. | Chuan Qin Yalan Lu Lin Bai Kewei Wang | 2022 | Journal of Molecular Cell Biology2022，14，4： | 0 |
| 9 | In vitro Antioxidant Activity of Extracts from Eleutherine plicata Herb by Different Extraction Methods显示文摘[Objectives] To study in vitro antioxidant activity of extracts from Eleutherine plicata Herb by different extraction methods.[Methods]1,1-diphenyl-2-picrylhydrazyl( DPPH) free radical scavenging method,2,2'-Azinobis( 3-ehtylbenzothiazolin-6-sulfnic acid) diammonium salt( ABTS) free radical scavenging method,and iron ion reduction ability determination method were applied to measure the extracts of Eleutherine plicata Herb by ethanol extraction,water extraction,and ethanol extraction after water extraction,and comparison was made with positive control Vc( vitamin C). [Results]The ethanol extract,water extract,and ethanol extract after water extraction of Eleutherine plicata Herb had a high DPPH free radical,ABTS free radical scavenging activity,and reducing activity. [Conclusions]E. plicata Herb is a natural antioxidant with high potential. | Yalan LUO Yuan LIU Luyang LU Jizhong ZHANG Shanshan MA | 2017 | Medicinal Plant2017，8，6： | 0 |
| 10 | Pharmacognosy Identification of Yi Medicinal Material Campanula colorata显示文摘[Objectives] To study the original plant,traits and microscopic identification for Yi medicinal material Campanula colorata,and provide experimental data for its identification and medicinal use. [Methods] Plant identification,trait identification,powder identification and paraffin slice identification were adopted in the study. [Results]It was found that the original plant of Campanula colorata was characterized by stiff hairs,slightly thicker root than stem,serrated leaf margin,tubular bell-shaped corolla and blue-purple color; traits were featured by odorlessness,and bitter taste after slight sweetness; the microscopic identification characteristics were that the laticifer was sporadic,containing reddish brown or yellow brown materials,and the oil droplets and nonglandular hairs were common. [Conclusions] The original plant,trait and microscopic identification characteristics were obvious for Yi medicinal material Campanula colorata,which could provide a reference for developing quality standards and identifying the original plant of Campanula colorata,and provide the basis for further research and development. | Shanshan MA Kaishun WANG Yalan LUO Jizhong ZHANG Luyang LU | 2017 | Medicinal Plant2017，8，3： | 0 |
| 11 | Relationship between groundwater cadmium and vicinity resident urine cadmium levels in the non-ferrous metal smelting area,China显示文摘Cadmium(Cd)has received widespread attention owing to its persistent toxicity and non-degradability.Cd in the human body is mainly absorbed from the external environment and is usually assessed using urinary Cd.Hunan Province is the heartland of the Chinese non-ferrous mining area,where several serious Cd pollution events have occurred,including high levels of Cd in the urine of residents.However,the environmental factors influencing high urinary Cd levels(UCLs)in nearby residents remain unclear.Therefore,211 nearby residents’UCLs and the corresponding sociological characteristics from nine groundwater samples in this area were analyzed using statistical analysis models.Groundwater Cd concentration ranged from 0.02 to 1.15μg/L,aligning with class III of the national standard;the range of UCL of nearby residents was 0.37–36.60μg/L,exceeding the national guideline of 0–2.5μg/L.Groundwater Cd levels were positively correlated with the UCL(P<0.001,correlation coefficient 95%CI=9.68,R^(2)=0.06).In addition,sociological characteristics,such as smoking status and education level,also affect UCL.All results indicate that local governments should strengthen the prevention and abatement of groundwater Cd pollution.This study is the first to systematically evaluate the relationship between groundwater Cd and UCL using internal and external environmental exposure data.These findings provide essential bases for relevant departments to reduce Cd exposure in regions where the heavy metal industry is globally prevalent. | Yujie Pan Yalan Li Hongxia Peng Yiping Yang Min Zeng Yang Xie Yao Lu Hong Yuan | 2023 | Frontiers of Environmental Science & Engineering2023，17，5： | 0 |
| 12 | Development of a dual-fluorescence reporter system for high-throughput screening of L-aspartate-a-decarboxylase显示文摘β-Alanine (3-am inopropionic acid)holds great potential in industrial application.It can be obtained through a chemical synthesis route,which is hazardous to the environm ent.It is w ell known that L-aspartate-a-decarboxylase(ADC)can convert L-aspartate to β-alanine in bacteria.However,due to the low activity of ADC,industrial production of β-alanine through the green biological route remains unclear.Thus,im proving the activity of ADC is critical to reduce the cost of p-alanine production.In this study,we established a dual-fluorescence high-throughput system fo r efficient ADC screening.By measuring the am ount of β-alanine and the expression level of ADC using two different fluorescence markers,we can rapidly quantify the relative activity of ADC variants.From a mutagenesis library containing 2000 ADC variants,we obtained am utant w ith 33%increased activity.Further analysis revealed that m utations o f K43R and P103Q in ADC significantly improved the yield of β-alanine produced by the whole-cell biocatalysis.Compared with the previous singlefluorescence method,our system can not only quantify the amount of β-alanine but also measure the expression level of ADC with different fluorescence,making it able to effectively screen out ADC variants with im proved relative activity.The dual-fluorescence high-throughput system for rapid screening of ADC provides a good strategy fo r industrial production of β-alanine via the biological conversion route in the future. | Mingyue Fei Xudan Mao Yiyang Chen Yalan Lu Lin Wang Jie Yang Juanping Qiu Dongchang Sun | 2020 | Acta Biochimica et Biophysica Sinica2020，52，12： | 0 |
| 13 | MiR-743a-5p regulates differentiation of myoblast by targeting Mob1b in skeletal muscle development and regeneration显示文摘The microRNAs (miRNAs) play an important role in regulating myogenesis by targeting mRNA. However, the understanding of miRNAs in skeletal muscle development and diseases is unclear. In this study, we firstly performed the transcriptome profiling in differentiating C2C12 myoblast cells. Totally, we identified 187 miRNAs and 4260 mRNAs significantly differentially expressed that were involved in myoblast differentiation. We carried out validation of microarray data based on 5 mRNAs and 5 miRNAs differentially expressed and got a consistent result. Then we constructed and validated the significantly up- and down-regulated mRNA-miRNA interaction networks. Four interaction pairs (miR-145a-5p-Fscn1, miR-200c-5p-Tmigd1, miR-27a-5p-Sln and miR-743a-5p-Mob1b) with targeted relationships in differentiated myoblast cells were demonstrated. They are all closely related to myoblast development. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated cell cycle signals important for exploring skeletal muscle development and disease. Functionally, we discovered that miR-743a targeting gene Mps One Binder Kinase Activator-Like 1B (Mob1b) gene in differentiated C2C12. The up-regulated miR-743a can promote the differentiation of C2C12 myoblast. While the down-regulated Mob1b plays a negative role in differentiation. In addition, the expression profile of miR-743a and Mob1b are consistent with skeletal muscle recovery after Cardiotoxin (CTX) injury. Our study revealed that miR-743a-5p regulates myoblast differentiation by targeting Mob1b involved in skeletal muscle development and regeneration. Our findings made a further exploration for mechanisms in myogenesis and might provide potential possible miRNA-based target therapies for skeletal muscle regeneration and disease in the near future. | YongSheng Zhang YiLong Yao ZiShuai Wang Dan Lu YuanYuan Zhang Adeyinka Abiola Adetula SiYuan Liu Min Zhu YaLan Yang XinHao Fan MuYa Chen YiJie Tang Yun Chen YuWen Liu GuoQiang Yi ZhongLin Tang | 2022 | Genes & Diseases2022，9，4： | 0 |
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