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| 1 | Hydrogen-rich saline attenuates neuronal ischemia reperfusion injury by protecting mitochondrial function in rats显示文摘 | Yaomei Cui Hao Zhang Muhuo Ji Min Jia Huixian Chen Jianjun Yang Manlin Duan | 2014 | Journal of Surgical Research2014，，： | 2 |
| 2 | Design and Implementation of Verification Code Identification Based on Anisotropic Heat Kernel显示文摘Many websites use verification codes to prevent users from using the machine automatically to register,login,malicious vote or irrigate but it brought great burden to the enterprises involved in internet marketing as entering the verification code manually.Improving the verification code security system needs the identification method as the corresponding testing system.We propose an anisotropic heat kernel equation group which can generate a heat source scale space during the kernel evolution based on infinite heat source axiom,design a multi-step anisotropic verification code identification algorithm which includes core procedure of building anisotropic heat kernel,settingwave energy information parameters,combing outverification codccharacters and corresponding peripheral procedure of gray scaling,binarizing,denoising,normalizing,segmenting and identifying,give out the detail criterion and parameter set.Actual test show the anisotropic heat kernel identification algorithm can be used on many kinds of verification code including text characters,mathematical,Chinese,voice,3D,programming,video,advertising,it has a higher rate of 25%and 50%than neural network and context matching algorithm separately for Yahoo site,49%and 60%for Captcha site,20%and 52%for Baidu site,60%and 65%for 3DTakers site,40%,and 51%.for MDP site. | LIU Lizhao LIU Jian DAI Yaomei XU Huarong YIN Huayi ZHU Shunzhi | 2016 | China Communications2016，13，1： | 2 |
| 3 | Engineering strategies to enhance oncolytic viruses in cancer immunotherapy显示文摘Oncolytic viruses(OVs)are emerging as potentially useful platforms in treatment methods for patients with tumors.They preferentially target and kill tumor cells,leaving healthy cells unharmed.In addition to direct oncolysis,the essential and attractive aspect of oncolytic virotherapy is based on the intrinsic induction of both innate and adaptive immune responses.To further augment this efficacious response,OVs have been genetically engineered to express immune regulators that enhance or restore antitumor immunity. | Yaomei Tian Daoyuan Xie Li Yang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
| 4 | Erythroblast island macrophages: recent discovery and future perspectives显示文摘Erythroblastic island(EBI),composed of a central macrophage surrounded by developing erythroid cells,is a structure found in hematopoietic tissues such as fetal liver and bone marrow.It is the first described hematopoietic niche that predominantly supports erythropoiesis.Although it is well accepted that EBIs and EBI macrophage play important roles during erythropoiesis,the mechanisms by which they support erythropoiesis remain largely unclear due to our inability to identify and isolate EBI macrophages.Earlier efforts to identify surface markers for EBI macrophages have focused on the adhesion molecules which are involved in macrophage’s interaction with erythroblasts.These include EMP,Vcam1,CD169,CD163,and aV integrin.Findings from these earlier studies suggested that combination of Vcam1,CD169,and mouse macrophage surface marker F4/80 can be used to define mouse EBI macrophage.We found that not all F4/80+Vcam1+CD169+macrophages are EBI macrophages.Instead,we discovered that EBI macrophages are characterized by the expression of Epor in both mouse and man.RNA-seq analyses of the newly identified EBI macrophages revealed that EBI macrophages have involved specialized function in supporting erythropoiesis.Our findings provide foundation for future studies.Here we will review current knowledge of EBI macrophages and discuss future perspectives. | Wei Li Yaomei Wang Lixiang Chen Xiuli An | 2019 | Blood Science2019，1，1： | 1 |
| 5 | Solvent Bar Microextraction with HPLC for Determination and Protein- Binding Characteristics of Oleanolic Acid and Ursolic Acid显示文摘 | Hao Yaomei Chen Xuan Hu Shuang | 2014 | Chromatographia2014，，77： | 1 |
| 6 | Parameters for evaluation water circulation environment显示文摘 | Yu Yiannian | 1988 | Hydrological Processes1988，2，： | 1 |
| 7 | 显示文摘 | YaoMei(姚枚) WangShengping(王声平) LiJinkui(李金魁)etal | 1993 | 金属学报1993，29，11： | 1 |
| 8 | Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy显示文摘Despite the remarkable success of immune checkpoint inhibitors(ICIs),primary resistance to ICIs causes only subsets of patients to achieve durable responses due to the complex tumor microenvironment(TME).Oncolytic viruses(OVs)can overcome the immunosuppressive TME and promote systemic antitumor immunity in hosts.Engineered OVs armed with ICIs would likely have improved effectiveness as a cancer therapy.According to the diverse immune cell landscapes among different types of tumors,we rationally and precisely generated three recombinant oncolytic adenoviruses(OAds):OAd-SIRPα-Fc,OAd-Siglec10-Fc and OAd-TIGIT-Fc.These viruses were designed to locally deliver SIRPα-Fc,Siglec10-Fc or TIGIT-Fc fusion proteins recognizing CD47,CD24 or CD155,respectively,in the TME to achieve enhanced antitumor effects.Our results suggested that OAd-SIRPα-Fc and OAd-Siglec10-Fc both showed outstanding efficacy in tumor suppression of macrophage-dominated tumors,while OAd-TIGIT-Fc showed the best antitumor immunity in CD8+T-cell-dominated tumors.Importantly,the recombinant OAds activated an inflammatory immune response and generated long-term antitumor memory.In addition,the combination of OAd-Siglec10-Fc with anti-PD-1 significantly enhanced the antitumor effect in a 4T1 tumor model by remodeling the TME.In summary,rationally designed OAds expressing ICIs tailored to the immune cell landscape in the TME can precisely achieve tumor-specific immunotherapy of cancer. | Daoyuan Xie Yaomei Tian Die Hu Yuanda Wang Yuling Yang Bailing Zhou Rui Zhang Zhixiang Ren Mohan Liu Jie Xu Chunyan Dong Binyan Zhao Li Yang | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 9 | Optimizing hairy root production from explants of Phyllanthus hainanensis,a shrub used for traditional herbal medicine显示文摘Phyllanthus hainanensis is a shrub that has been used in traditional herbal medicine.It has great pharmaceutical potential for treating diseases such as cancer and diabetes.As a prerequisite for propagation of this species on a large scale,hairy roots in P.hainanensis were induced using Rhizobium rhizogenes and various factors affecting hairy root induction and growth evaluated.Seven factors were tested:(1)type of explant,(2)type of culture medium,(3)duration of pre-culture,(4)R.rhizogenes inoculum cell density,(5)duration of infection,(6)acetosyringone concentration in the culture medium,and(7)duration of incubation.The optimal protocol for hairy root induction and growth was:young shoots,pre-cultured in Y1 for 2 d,inoculated with R.rhizogenes broth with an OD600 of 0.6 for 20 min,and incubated for 3 d.Putative transgenic hairy roots were initially identified by morphology and then confirmed by polymerase chain reaction.Successful and optimal production of hairy roots is a critical prerequisite for industrial scale clonal propagation of P.hainanensis.Being able to cultivate the plant on a large scale will provide rapid and ready supply of the plant materials that can be used in herbal medicine and in scientific and industrial exploitation. | Zhaogui YAN Shengyu LIU Junlian ZHANG Guan HUANG Lijun DUAN Yaomei YE | 2020 | Frontiers of Agricultural Science and Engineering2020，7，4： | 0 |
| 10 | MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling显示文摘The incidence of cutaneous melanoma(CM)has been increasing annually worldwide.In this study,we identify that MrgprF,a MAS related GPR family member,is decreased in cutaneous melanoma tissues and cell lines due to hypermethylation of its promoter region,and show that patients with CM expressing high levels of MrgprF exhibit an improved clinical outcome.We demonstrate that MrgprF forced expression inhibits tumor cell proliferation,migration,xenograft tumor growth,and metastasis.On the contrary,MrgprF knockdown promotes tumor cell proliferation and transformation of immortalized human keratinocyte-HaCaT cells,supporting the inhibitory role of MrgprF during tumor progression.Mechanistic studies reveal that MrgprF reduces the phosphoinositol‑3‑kinase(PI3K)complex formation between p101 and p110γsubunits,the critical step for phosphatidylinositol-(3,4)-P2(PIP2)conversion to phosphatidylinositol-(3,4,5)-P3(PIP3),and then reduces the activation of PI3K/Akt signaling.This effect can be reversed by Akt specific agonist SC79.In addition,AMG 706,a previously documented inhibitor for endothelial cell proliferation,is identified as a potential agonist for MrgprF,and can impede tumor growth both in vitro and in vivo.Taken together,our findings suggest that MrgprF,a novel tumor suppressor in cutaneous melanoma,may be useful as a therapeutic target in the future. | Qiushuo Shen Yanfei Han Kai Wu Yaomei He Xiulin Jiang Peishen Liu Cuifeng Xia Qiuxia Xiong Rui Liu Qianming Chen Yong Zhang Song Zhao Cuiping Yang Yongbin Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 0 |
| 11 | Study of transmission grating diffraction efficiencies for soft X-ray显示文摘Tansmission grating spectrometers are extensively used to measure absthlute X-ray spectra in a photon-energy range below 1000 eV. The transmission grating,as its dispersive element, must be calibrated to obtain its danaction efficiencies. Calibrations of absolute distraction efficiencies of the tlansmission grating at photon energyof 844eV have been carried out on Beliing Synchrotron mediation Facility. With theaid of grating model, all of the grating structure paraxneters have been determinedand the absolute dchaction efficiencies in a photon-energy range below 2000eV havealso been calculated and discussed. | YANG Jiamin DING Yaonan ZHENG Zhijian YI Rongqing SUN Kexu CUI Mingqi CUl Congwu ZHU Peiping CHEN Zhenlin LI Chaoguang WANG Yaomei (Insfifule of Nuclear Physics and Chetnisfry, CAEP, Chengdu 610003*Beijing institute of High Energy Physics, the Ch | 1999 | Nuclear Science and Techniques1999，10，2： | 0 |
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