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| 1 | Highly efficient green InP-based quantum dot light-emitting diodes regulated by inner alloyed shell component显示文摘InP-based quantum dot light-emitting diodes(QLEDs),as less toxic than Cd-free and Pb-free optoelectronic devices,have become the most promising benign alternatives for the next generation lighting and display.However,the development of green-emitting InP-based QLEDs still remains a great challenge to the environmental preparation of InP quantum dots(QDs)and superior device performance.Herein,we reported the highly efficient green-emitting InP-based QLEDs regulated by the inner alloyed shell components.Based on the environmental phosphorus tris(dimethylamino)phosphine((DMA)3P),we obtained highly efficient InP-based QDs with the narrowest full width at half maximum(~35 nm)and highest quantum yield(~97%)by inserting the gradient inner shell layer ZnSe_(x)S_(1-x)without further post-treatment.More importantly,we concretely discussed the effect and physical mechanism of ZnSe_(x)S_(1-x)layer on the performance of QDs and QLEDs through the characterization of structure,luminescence,femtosecond transient absorption,and ultraviolet photoelectron spectroscopy.We demonstrated that the insert inner alloyed shell ZnSe_(x)S_(1-x)provided bifunctionality,which diminished the interface defects upon balancing the lattice mismatch and tailored the energy levels of InP-based QDs which could promote the balanced carrier injection.The resulting QLEDs applying the InP/ZnSe_(0.7)S_(0.3)/ZnS QDs as an emitter layer exhibited a maximum external quantum efficiency of 15.2%with the electroluminescence peak of 532 nm,which was almost the highest record of InP-based pure green-emitting QLEDs.These results demonstrated the applicability and processability of inner shell component engineering in the preparation of high-quallity InP-based QLEDs. | Peng Yu Sheng Cao Yuliang Shan Yuhe Bi Yaqi Hu Ruosheng Zeng Bingsuo Zou Yunjun Wang Jialong Zhao | 2022 | Light(Science & Applications)2022，11，7： | 1 |
| 2 | An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC) has a high mortality rate. To determine the molecular basis of ESCC development, this study sought to identify characteristic genome-wide alterations in ESCC, including exonic mutations and structural alterations. The clinical implications of these genetic alterations were also analyzed. Exome sequencing and verification were performed for nine pairs of ESCC and the matched blood samples, followed by validation with additional samples using Sanger sequencing. Whole-genome SNP arrays were employed to detect copy number alteration(CNA) and loss of heterozygosity(LOH) in 55 cases, including the nine ESCC samples subjected to exome sequencing. A total of 108 non-synonymous somatic mutations(NSSMs) in102 genes were verified in nine patients. The chromatin modification process was found to be enriched in our gene ontology(GO) analysis. Tumor genomes with TP53 mutations were significantly more unstable than those without TP53 mutations. In terms of the landscape of genomic alterations, deletion of 9p21.3 covering CDKN2A/2B(30.9%), amplification of 11q13.3 covering CCND1(30.9%), and TP53 point mutation(50.9%) occurred in two-thirds of the cases. These results suggest that the deregulation of the G1 phase during the cell cycle is a key event in ESCC.Furthermore, six minimal common regions were found to be significantly altered in ESCC samples and three of them, 9p21.3, 7p11.2, and 3p12.1, were associated with lymph node metastasis. With the high correlation of TP53 mutation and genomic instability in ESCC, the amplification of CCND1, the deletion of CDKN2A/2B, and the somatic mutation of TP53 appear to play pivotal roles via G1 deregulation and therefore helps to classify this cancer into different genomic subtypes.These findings provide clinical significance that could be useful in future molecular diagnoses and therapeutic targeting. | Qiyan Wang Jian Bai Amir Abliz Ying Liu Kenan Gong Jingjing Li Wenjie Shi Yaqi Pan Fangfang Liu Shujuan Lai Haijun Yang Changdong Lu Lixin Zhang Wei Chen Ruiping Xu Hong Cai Yang Ke Changqing Zeng | 2015 | Genomics, Proteomics & Bioinformatics2015，13，4： | 1 |
| 3 | Electronic nose with a new feature reduction method and a multi-linear classifier for Chinese liquor classification显示文摘 | Yaqi Jing Qinghao Meng Peifeng Qi Ming Zeng Wei Li and Shugen Ma | 2014 | Review Of Scientific Instruments2014，，： | 1 |
| 4 | Advantages of nasogastric tube feeding during neoadjuvant concurrent chemoradiotherapy for esophageal cancer:A retrospective study显示文摘ObjectiveTo compare the effects of oral intake and nasogastric tube(NG)feeding on nutritional status,complications and survival during neoadjuvant chemoradiotherapy for esophageal squamous-cell carcinoma(ESCC)patients.MethodsA total of 61 ESCC cases treated with neoadjuvant chemoradiotherapy from December 2018 to March 2020 were enrolled,including(38 in oral intake group,and 22 in NG feeding group.Disease characteristics and baseline nutritional markers were collected in both groups.Nutritional status,complication and completion rate of chemoradiotherapy in both groups were evaluated.ResultsCompared with the oral intake group,patients in the NG feeding group had a later T stage(P=0.027)and clinical stage(P=0.014).The levels of energy intake(P=0.033),serum prealbumin(P<0.001),albumin(P=0.017)and hemoglobin(P=0.015)before treatment in NG group were significantly lower than those in oral intake group.Furthermore,patient-generated subjective global assessment(PG-SGA)score(P=0.016)and the levels of serum C-reactive protein(P=0.014)of NG feeding group were significantly higher than those of oral intake group.However,at the end of treatment,PG-SGA scores were increased in oral intake group and decreased in NG feeding group.In addition,the NG feeding group had a lower incidence of grade≥2 esophagitis(P=0.037),and higher completion rate of chemotherapy compared with oral intake group(P=0.034).Meanwhile,the proportion of parenteral nutrition(P=0.008)and anti-inflammatory(P=0.022)treatment in NG feeding group was significantly lower than that in oral intake group.Although patients in the NG feeding group had a worse prognosis,there were no statistically significant differences in overall survival(OS)and progression-free survival(PFS)between the two groups(P>0.05).ConclusionsAs a safe and effective enteral nutrition approach to improving nutrition,nasogastric tube feeding could increase treatment completion rate and reduce the incidence of≥grade 2 esophagitis reaction during neoadjuvant chemoradiotherapy. | Jie Dong Qingwu Du Tian Zhang Xi Chen Wencheng Zhang Yajun Chen Yaqi Zeng Chunlei Li Yueying Li Yujie Wang Kun Wang Qingsong Pang | 2023 | Radiation Medicine and Protection2023，4，2： | 0 |
| 5 | A disease-relevant mutation of SPOP highlights functional significance of ATM-mediated DNA damage response显示文摘Dear Editor,Accumulating evidence supports that,as a critical genome guardian mechanism,the DNA damage response(DDR)is a barrier to early tumorigenesis.As a crucial DDR pathway,Ataxia Telangiectasia Mutated(ATM)-mediated phosphorylation of downstream targets is essential for activation of cell cycle checkpoints,DNA repair,and programed cell death in the presence of DNA damage.Despite extensive biochemical and cellular studies on ATM phosphorylation,these phosphorylation sites are rarely mutated in cancers,challenging the pathophysio-logical relevance of ATM-mediated phosphorylation in the disease setting. | Mingming Xiao Joshua S.Fried Jinlu Ma Yang Su Rebecca J.Boohaker Qinghua Zeng Yaqi Mo Fanbiao Meng Rong Xiang Bo Xu | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 0 |
| 6 | Electrochemical detection of amino acids based on cucurbit[7]uril-mediated three-dimensional gold nanoassemblies显示文摘In this paper, cucurbit[7]uril(CB[7])-mediated three-dimensional gold nanoassemblies were successfully prepared to increase the loaded amount of CB[7] and enhance the electrochemical detection of amino acids. Particle sizes of gold nanoparticles(Au NPs) significantly affect stability and detection sensitivity of nanoassemblies. The volume of gold nanoassemblies first increased and then decreased with the increase of CB[7] concentration. The 3D gold nanoassemblies composed of 16 nm Au NPs and 100 μmol/L CB[7]had excellent stability and maximum volume, exhibiting more sensitive detection for a variety of amino acids. And the detection limits of aromatic amino acids are lower in virtue of the higher binding constant between aromatic amino acids and CB[7]. This study will develop and deepen our understanding of molecular recognition in amino acids detection. | Shimi Liu Hao Zhang Yaqi Wang Yan Zeng Sobhan Chatterjee Feng Liang | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
| 7 | Ocean Response to a Climate Change Heat-Flux Perturbation in an Ocean Model and Its Corresponding Coupled Model显示文摘State-of-the-art coupled general circulation models(CGCMs)are used to predict ocean heat uptake(OHU)and sealevel change under global warming.However,the projections of different models vary,resulting in high uncertainty.Much of the inter-model spread is driven by responses to surface heat perturbations.This study mainly focuses on the response of the ocean to a surface heat flux perturbation F,as prescribed by the Flux-Anomaly-Forced Model Intercomparison Project(FAFMIP).The results of ocean model were compared with those of a CGCM with the same ocean component.On the global scale,the changes in global mean temperature,ocean heat content(OHC),and steric sea level(SSL)simulated in the OGCM are generally consistent with CGCM simulations.Differences in changes in ocean temperature,OHC,and SSL between the two models primarily occur in the Arctic and Atlantic Oceans(AA)and the Southern Ocean(SO)basins.In addition to the differences in surface heat flux anomalies between the two models,differences in heat exchange between basins also play an important role in the inconsistencies in ocean climate changes in the AA and SO basins.These discrepancies are largely due to both the larger initial value and the greater weakening change of the Atlantic meridional overturning circulation(AMOC)in CGCM.The greater weakening of the AMOC in the CGCM is associated with the atmosphere–ocean feedback and the lack of a restoring salinity boundary condition.Furthermore,differences in surface salinity boundary conditions between the two models contribute to discrepancies in SSL changes. | Jiangbo JIN Xiao DONG Juanxiong HE Yi YU Hailong LIU Minghua ZHANG Qingcun ZENG He ZHANG Xin GAO Guangqing ZHOU Yaqi WANG | 2022 | Advances in Atmospheric Sciences2022，39，1： | 0 |
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