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| 1 | Dietary polyphenols and colorectal cancer risk:The Fukuoka colorectal cancer study显示文摘AIM:To investigate the associations between dietary intake of polyphenols and colorectal cancer. METHODS:The study subjects were derived from the Fukuoka colorectal cancer study, a community-based case-control study. The study subjects were 816 cases of colorectal cancer and 815 community-based controls. The consumption of 148 food items was assessed by a computer-assisted interview. We used the consumption of 97 food items to estimate dietary intakes of total, tea and coffee polyphenols. The Phenol-Explorer database was used for 92 food items. Of the 5 foods which were not listed in the Phenol-Explorer Database, polyphenol contents of 3 foods (sweet potatoes, satoimo and daikon) were based on a Japanese study and 2 foods (soybeans and fried potatoes) were estimated by ORAC-based polyphenol contents in the United States Department of Agriculture Database. Odds ratios (OR) and 95%CI of colorectal cancer risk according to quintile categories of intake were obtained by using logistic regression models with adjustment for age, sex, residential area, parental history of colorectal cancer, smoking, alcohol consumption, body mass index 10 years before, type of job, leisure-time physical activity and dietary intakes of calcium and n-3 polyunsaturated fatty acids.RESULTS:There was no measurable difference in total or tea polyphenol intake between cases and controls, but intake of coffee polyphenols was lower in cases than in controls. The multivariate-adjusted OR of colorectal cancer according to quintile categories of coffee polyphenols (from the first to top quintile) were 1.00 (referent), 0.81 (95%CI:0.60-1.10), 0.65 (95%CI:0.47-0.89), 0.65 (95%CI:0.46-0.89) and 0.82 (95%CI:0.60-1.10), respectively (P trend = 0.07). Similar, but less pronounced, decreases in the OR were also noted for the third and fourth quintiles of total polyphenol intake. Tea polyphenols and non-coffee polyphenols showed no association with colorectal cancer risk. The sitespecific analysis, based on 463 colon cancer cases and 340 rectal cancer cases, showed an inverse association between coffee polyphenols and colon cancer. The multivariate-adjusted OR of colon cancer for the first to top quintiles of coffee polyphenols were 1.00 (referent), 0.92 (95%CI:0.64-1.31), 0.75 (95%CI:0.52-1.08), 0.69 (95%CI:0.47-1.01), and 0.68 (95%CI:0.46-1.00), respectively (P trend = 0.02). Distal colon cancer showed a more evident inverse association with coffee polyphenols than proximal colon cancer. The association between coffee polyphenols and rectal cancer risk was U -shaped, with significant decreases in the OR at the second to fourth quintile categories. There was also a tendency that the OR of colon and rectal cancer decreased in the intermediate categories of total polyphenols. The decrease in the OR in the intermediate categories of total polyphenols was most pronounced for distal colon cancer. Intake of tea polyphenols was not associated with either colon or rectal cancer. The associations of coffee consumption with colorectal, colon and rectal cancers were almost the same as observed for coffee polyphenols. The trend of the association between coffee consumption and colorectal cancer was statistically significant. CONCLUSION:The present findings suggest a decreased risk of colorectal cancer associated with coffee consumption. | Zhen-Jie Wang Keizo Ohnaka Makiko Morita Kengo Toyomura Suminori Kono Takashi Ueki Masao Tanaka Yoshihiro Kakeji Yoshihiko Maehara Takeshi Okamura Koji Ikejiri Kitaroh Futami Takafumi Maekawa Yohichi Yasunami Kenji Takenaka Hitoshi Ichimiya Reiji Terasaka | 2013 | World Journal of Gastroenterology2013，19，17： | 12 |
| 2 | 通过水溶液还原法用抗坏血酸制备纳米铜颗粒(英文)显示文摘通过水溶液还原法用抗坏血酸还原Cu2+制备纳米铜颗粒,并研究溶液pH和Cu2O平均粒径对纳米铜颗粒制备的影响。在溶液pH值为3、5和7时,可制得铜颗粒,并且在pH=7时制得的铜颗粒粒径最小。在溶液pH为9和11时无法制得铜颗粒。Cu2O的平均粒径能影响铜粉的粒径。Cu2O的平均粒径越大,得到的铜颗粒越大。通过对反应过程中不同时间点收集的样品进行XRD分析,可探索出反应的进程。在反应过程中,Cu(OH)2首先作为前驱体出现,然后被还原为Cu2O,最后被还原为铜颗粒。 | 刘清明 Takehiro YASUNAMI Kensuke KURUDA Masazumi OKIDO | 2012 | Transactions of Nonferrous Metals Society of China2012，22，9： | 6 |
| 3 | Role of diffusion-weighted imaging in evaluating therapeutic efficacyafter transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘 | Kei Kubota Tomoaki Yamanishi Satoshi Itoh Yoriko Murata Kana Miyatake Hiroaki Yasunami Kazuo Morio Norihiko Hamada Akihito Nishioka Yasuhiro Ogawa | 2010 | Oncology Reports2010，，3： | 3 |
| 4 | Current diagnosis and treatment of early pancreatic cancer显示文摘 | Ryu S Maeshiro K Yasunami Y | 1996 | Nippon Rinsho1996，，54： | 1 |
| 5 | 显示文摘 | Tsuji Y Mitsuo M Yasunami R | 2000 | J Reprod Immunol2000，46，1： | 1 |
| 6 | HLA-DPB1 0202 is associated with a predictor of good prognosis of Graves' disease in the Japanese显示文摘 | Takahashi M Yasunami M Kubota S | 2006 | Hum ImmunoI2006，67，12： | 1 |
| 7 | Beneficial effects of costimulatory blockade with anti-inducible costimulator antibody in conjunction with CTL A4Ig on prevention of islet xenograft rejection from rat to mouse显示文摘 | Nabeyana K Yasunami Y Toyofuku A | 2004 | Transplantation2004，78，11： | 1 |
| 8 | 查看详情显示文摘 | Kunitake T Okahata Y Shimomura M Yasunami S Takarabe K | | 0，，： | 1 |
| 9 | Soy food and isoflavone intake and colorectal cancer risk: The Fukuoka Colorectal Cancer Study显示文摘 | Sanjeev Budhathoki Amit Man Joshi Keizo Ohnaka Guang Yin Kengo Toyomura Suminori Kono Ryuichi Mibu Masao Tanaka Yoshihiro Kakeji Yoshihiko Maehara Takeshi Okamura Koji Ikejiri Kitaroh Futami Takafumi Maekawa Yohichi Yasunami Kenji Takenaka Hitoshi Ichimiy | 2011 | Scandinavian Journal of Gastroenterology2011，，2： | 1 |
| 10 | Preparation of Cu nanopartic1es with ascorbic acid by aqueous solution reduction method显示文摘 | LIU Q M YASUNAMI T KURUDA K OKIDO M | 2012 | Transactions of Nonferrous Metal Society of China2012，22，9： | 1 |
| 11 | Multidrug resistance protein expression of adult T-cell leukemia/lymphoma显示文摘 | Yasunami T Wang YH Tsuji K | 2007 | Leuk Res2007，31，4： | 1 |
| 12 | Diagnosis of mucin-producing tumor of the pancreas by balloon- catheter endoscopic retrograde pancreatography - compression study显示文摘 | Maeshiro K Nakayama Y Yasunami Y | 1998 | Hepatogastroenterology1998，45，24： | 1 |
| 13 | Balloon-catheter endoscopic retrograde pancreatography-compression study for diagnosis of early-stage pancreatitis 显示文摘 | Maeshiro K Ikeda S Yasunami Y | 2007 | Gastroenterol2007，4217，： | 1 |
| 14 | Hepatocyte growth factor is es-sential for amelioration of hyperglycemia in streptozotocin-induced di-abetic mice receiving a marginal mass of intrahepatic islet grafts显示文摘 | Nakano M Yasunami Y Maki T | 2000 | Transplantation2000，69，： | 1 |
| 15 | Digestion and lymphatictransport of eicosapentaenoic and docosahexaenoic acids given in Cheform of triacylglycerol,free acid and ethyl ester in rats显示文摘 | IKEDA I SASAKI E YASUNAMI H | 1995 | Biochimicaet Biophysica Acta1995，1259，3： | 1 |
| 16 | CDZ valphal4 natural killer T cellsare essential for acceptance of rat islet xenograft in mice 显示文摘 | Zkehara Y Yasunami Y Kodama S | 2000 | JClin Invest2000，105，12： | 1 |
| 17 | Identification of adipophilin as a potential plasma biomarker for colorectal cancer using label-free quantitative mass spectrometry and protein microarray显示文摘 | Matsubara J Honda K Ono M Sekine S Tanaka Y Kobayashi M Jung G Sakuma T Nakamori S Sata N Nagai H Ioka T Okusaka T Kosuge T Tsuchida A Shimahara M Yasunami Y Chiba T Yamada T | | 0，，10： | 1 |
| 18 | Antibacterial activity of pectin hydrolyzates显示文摘 | Takenaka T Muto O Yasunami K | 1994 | J Soc Food Sci Technol1994，41，： | 1 |
| 19 | Beneficial effects of COS-timulatory blockade with anti inducible costimulator antibody in conjunction with CTLA4-Ig on prevention of islet xenograft rejection from rat to mouse显示文摘 | Nabeyama K Yasunami Y Toyofuku A | 2004 | Transplantation2004，78，： | 1 |
| 20 | Beneficial effects of costimulatory blockade with anti-inducible costimulator antibody in conjunction with CTLA4Ig on prevention of islet xenograft rejection from rat to mouse 显示文摘 | Nabeyama K Yasunami Y Toyofuku A | 2004 | Transplantation2004，78，11： | 1 |
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