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| 1 | Dietary polyphenols and colorectal cancer risk:The Fukuoka colorectal cancer study显示文摘AIM:To investigate the associations between dietary intake of polyphenols and colorectal cancer. METHODS:The study subjects were derived from the Fukuoka colorectal cancer study, a community-based case-control study. The study subjects were 816 cases of colorectal cancer and 815 community-based controls. The consumption of 148 food items was assessed by a computer-assisted interview. We used the consumption of 97 food items to estimate dietary intakes of total, tea and coffee polyphenols. The Phenol-Explorer database was used for 92 food items. Of the 5 foods which were not listed in the Phenol-Explorer Database, polyphenol contents of 3 foods (sweet potatoes, satoimo and daikon) were based on a Japanese study and 2 foods (soybeans and fried potatoes) were estimated by ORAC-based polyphenol contents in the United States Department of Agriculture Database. Odds ratios (OR) and 95%CI of colorectal cancer risk according to quintile categories of intake were obtained by using logistic regression models with adjustment for age, sex, residential area, parental history of colorectal cancer, smoking, alcohol consumption, body mass index 10 years before, type of job, leisure-time physical activity and dietary intakes of calcium and n-3 polyunsaturated fatty acids.RESULTS:There was no measurable difference in total or tea polyphenol intake between cases and controls, but intake of coffee polyphenols was lower in cases than in controls. The multivariate-adjusted OR of colorectal cancer according to quintile categories of coffee polyphenols (from the first to top quintile) were 1.00 (referent), 0.81 (95%CI:0.60-1.10), 0.65 (95%CI:0.47-0.89), 0.65 (95%CI:0.46-0.89) and 0.82 (95%CI:0.60-1.10), respectively (P trend = 0.07). Similar, but less pronounced, decreases in the OR were also noted for the third and fourth quintiles of total polyphenol intake. Tea polyphenols and non-coffee polyphenols showed no association with colorectal cancer risk. The sitespecific analysis, based on 463 colon cancer cases and 340 rectal cancer cases, showed an inverse association between coffee polyphenols and colon cancer. The multivariate-adjusted OR of colon cancer for the first to top quintiles of coffee polyphenols were 1.00 (referent), 0.92 (95%CI:0.64-1.31), 0.75 (95%CI:0.52-1.08), 0.69 (95%CI:0.47-1.01), and 0.68 (95%CI:0.46-1.00), respectively (P trend = 0.02). Distal colon cancer showed a more evident inverse association with coffee polyphenols than proximal colon cancer. The association between coffee polyphenols and rectal cancer risk was U -shaped, with significant decreases in the OR at the second to fourth quintile categories. There was also a tendency that the OR of colon and rectal cancer decreased in the intermediate categories of total polyphenols. The decrease in the OR in the intermediate categories of total polyphenols was most pronounced for distal colon cancer. Intake of tea polyphenols was not associated with either colon or rectal cancer. The associations of coffee consumption with colorectal, colon and rectal cancers were almost the same as observed for coffee polyphenols. The trend of the association between coffee consumption and colorectal cancer was statistically significant. CONCLUSION:The present findings suggest a decreased risk of colorectal cancer associated with coffee consumption. | Zhen-Jie Wang Keizo Ohnaka Makiko Morita Kengo Toyomura Suminori Kono Takashi Ueki Masao Tanaka Yoshihiro Kakeji Yoshihiko Maehara Takeshi Okamura Koji Ikejiri Kitaroh Futami Takafumi Maekawa Yohichi Yasunami Kenji Takenaka Hitoshi Ichimiya Reiji Terasaka | 2013 | World Journal of Gastroenterology2013，19，17： | 12 |
| 2 | Ion chromatography for determination of nitrite and nitrate in seawater using monolithic ODS columns显示文摘 | Kazuaki Ito Yohichi Takayama Nobuyuki Makabe Ryo Mitsui Takeshi Hirokawa | 2005 | Journal of Chromatography A2005，，1： | 2 |
| 3 | Ion chromatography for determination of nitrite and nitrate in seawater using monolithic ODS columns 显示文摘 | Kazuaki It o Yohichi Takayama Nobuyuki Makabe Ryo Mitsui Takeshi Hirokawa | 2005 | Journal of Chromatography A2005，，1083： | 1 |
| 4 | Dorsal root gan- glia rnorphologie features in patients with herniation of the nucleus pulposus: assessment using magnetic resonance myelography and clinical correlation显示文摘 | Yohichi Aota Katsuhiro Onari Howard S | 2001 | Spine2001，26，19： | 1 |
| 5 | Perioperative changes in plasma brain natriuretic peptide concentrations in patients undergoing cardiac surgery显示文摘 | Keisuke Morimoto Tohru Mori Shingo Ishiguro Naruto Matsuda Yohichi Hara Hiroaki Kuroda | 1998 | Surgery Today1998，，1： | 1 |
| 6 | Soy food and isoflavone intake and colorectal cancer risk: The Fukuoka Colorectal Cancer Study显示文摘 | Sanjeev Budhathoki Amit Man Joshi Keizo Ohnaka Guang Yin Kengo Toyomura Suminori Kono Ryuichi Mibu Masao Tanaka Yoshihiro Kakeji Yoshihiko Maehara Takeshi Okamura Koji Ikejiri Kitaroh Futami Takafumi Maekawa Yohichi Yasunami Kenji Takenaka Hitoshi Ichimiy | 2011 | Scandinavian Journal of Gastroenterology2011，，2： | 1 |
| 7 | Photocatalytic convertion of NOx on AgCI/AI2O3 catalyst显示文摘 | Yohichi Yamashita Naoko Aoyama Nobutaune Takezawa | 1999 | Journal of Molecular Catalysis A:Chemical1999，150，： | 1 |
| 8 | Transmission system using self- oscillating multi- phase liquid membrane system 显示文摘 | Hiroshi Y Kazuo M Yohichi G | 1997 | Chemistry Letters1997，10，： | 1 |
| 9 | Hepatocellular carcinoma associated with autoimmune hepatitis显示文摘 | Raisuke Nishiyama Toshikazu Kanai Jinro Abe Ryuhei Hara Yohichi Watahiki Takanori Sakaguchi Satoshi Nakamura | 2004 | Journal of Hepato - Biliary - Pancreatic Surgery2004，，3： | 1 |
| 10 | Preparation and properties of glycerol-based double or triple chain surfactants with two hydrophilic ionic groups显示文摘 | ZHU YUN-PENG ARAKI MASUYAMA YOHICHI KIRITO | 1992 | J Am Oil Chem Soc1992，7，69： | 1 |
| 11 | Develop- ment of cam-drive type proportional valve for water hy- draulics显示文摘 | Kenji Suzuki Sho Akazawa Yohichi Nakao | 2012 | Int J Automat Technol2012，6，4： | 1 |
| 12 | A Japanese Lung Cancer Registry Study: Prognosis of 13,010 Resected Lung Cancers显示文摘 | Hisao Asamura Tomoyuki Goya Yoshihiko Koshiishi Yasunori Sohara Kenji Eguchi Masaki Mori Yohichi Nakanishi Ryosuke Tsuchiya Kaoru Shimokata Hiroshi Inoue Toshihiro Nukiwa Etsuo Miyaoka | 2008 | Journal of Thoracic Oncology2008，，1： | 1 |
| 13 | 显示文摘 | Masuyama Araki Kirito Yohichi | 1992 | JAOCS1992，69，7： | 1 |
| 14 | Photocatalytic conversion of NOx on AgCI/A12O3 catalyst显示文摘 | Yohichi Y Naoko A Nobutsune T | 1999 | J Mol Catal A: Chem1999，150，12： | 1 |
| 15 | Photo-catalytic conversion of NOr on AgCl/Al2 03 catalyst 显示文摘 | Yohichi Ya Naoko Aoyama Nobustsune T | 1999 | JMol Catal A: Chem1999，150，： | 1 |
| 16 | A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo显示文摘 | Craig W. Day Ralph Baric Sui Xiong Cai Matt Frieman Yohichi Kumaki John D. Morrey Donald F. Smee Dale L. Barnard | 2009 | Virology2009，，2： | 1 |
| 17 | Co-integration, co-expression and co - segregation of an unlinked selectable marker gene and NtFAD3 gene in transgenie rice plants produced by particle bombardment 显示文摘 | Yohichi W Motoyasu O Koh l | 1998 | Genes Genet Syst1998，73，： | 1 |
| 18 | Synthesis of NiO-loaded KTiNbO5 photocatalysts by a novel polymerizable complex method 显示文摘 | Hiroyuki Takahashi Masato Kakihana Yohichi Yamashita | 1999 | Journal of Alloys and Compounds1999，285，12： | 1 |
| 19 | A basic analysis of pulsed photoacoustic signals using the finite elements method显示文摘 | Masanobu Kasai Sei Fukushima Yohichi Gohshi | 1988 | J Appl Phys1988，64，3： | 1 |
| 20 | Preparation and properties of glycerol-based double or triple chain surfactants with two hydrophilic ionic groups显示文摘 | Zhu Yunpeng Masuyama A Kirito Yohichi | 1992 | J Am OilChem Soc1992，69，7： | 1 |
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