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| 1 | Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients显示文摘Dear Editor,The ongoing coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus-2(SARSCoV-2)is a serious threat to global public health,and is imposing severe burdens on human society.Several candidate vaccines against SARS-CoV-2 are now undergoing clinical trials.The Spike(S)protein of SARS-CoV-2 is widely considered as a promising antigen.However. | Bao-zhong Zhang Ye-fan Hu Lin-lei Chen Thomas Yau Yi-gang Tong Jing-chu Hu Jian-piao Cai Kwok-Hung Chan Ying Dou Jian Deng Xiao-lei Wang Ivan Fan-Ngai Hung Kelvin Kai-Wang To Kwok Yung Yuen Jian-Dong Huang | 2020 | Cell Research2020，30，8： | 5 |
| 2 | Survival analysis of breast cancer liver metastasis treated by hepatectomy: A propensity score analysis for Chinese women in Hong Kong显示文摘Background: Survival of patients with breast cancer liver metastasis is very poor. This study aimed to analyze the survival outcome of hepatectomy for this patient population. Methods: From January 1995 to December 2014, 2522 patients with liver cancer received hepatectomy at our hospital. Twenty-one of them, all female, received the operation for breast cancer liver metastasis. Performance was compared with patients with colorectal liver metastasis treated with hepatectomy after propensity score analysis in a ratio of 1:3. Results: Twenty-one patients received hepatectomy for breast cancer. After propensity score matching, 63 patients who had hepatectomy for colorectal cancer were selected for comparison. There was no significant difference in immediate or short-term outcomes between the two groups of patients in terms of operative time, blood loss and surgical morbidities. All patients with breast cancer had R0 resection. No hospital death occurred. After hepatectomy, the 1-, 3- and 5-year overall survival rates were 100.0%, 58.9% and 58.9% respectively in patients with breast cancer. The 1-, 3- and 5-year overall survival rates were 95.0%, 57.2% and 39.7% respectively in patients with colorectal cancer (P = 0.572). On multivariate analysis, triple negative status was the only independent poor prognostic factor in breast cancer liver metastasis (OR = 6.411;95% CI: 1.351–30.435;P = 0.019). Conclusions: Hepatectomy is a safe and effective way of treating breast cancer liver metastasis at experienced centers where multidisciplinary adjuvant treatments are available. It can be considered more frequently as part of the multidisciplinary care for this patient population. | Tan To Cheung Kenneth SH Chok Albert CY Chan Simon HY Tsang Wing Chiu Dai Thomas CC Yau Ava Kwong Chung Mau Lo | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，5： | 3 |
| 3 | HDPR1,a novel inhibitor of the WNT/beta-catenin signaling,is frequently downregulated in hepatoceUular carcinoma:involvement of methylation-mediated gene silencing显示文摘 | Yau TO Chan CY Chan KL | 2004 | Oncogene2004，24，9： | 1 |
| 4 | Upregulation of the Wnt co-receptor LRP6 promotes hepatocarcinogenesis and enhances cell invasion显示文摘 | Tung EK Wong BY Yau TO | 2012 | PLoS One2012，7，36： | 1 |
| 5 | Evaluation of nuclear factor- kappa B, urokinase-type plasminogen activator, and HBx and their clinicopathologieal significance in hepato- cellular carcinoma 显示文摘 | Chan CF Yau TO Jin DY | 2004 | Clin Cancer Res2004，10，121： | 1 |
| 6 | Evaluation of nuclear factor-kappaB,urokinase-type plasminogen activator,and HBx and their clinicopathological significance in hepatocellular carcinoma显示文摘 | Chan CF Yau TO Jin DY | 2004 | Clin Cancer Res2004，10，12： | 1 |
| 7 | Upregulation of the Writ co-recep- tor LRP6 pxomotes hepatocarcinogenesis and enhances cell invasion 显示文摘 | Tung EK Wong BY Yau TO | 2012 | PLoS One2012，7，36： | 1 |
| 8 | 显示文摘 | Chart CF Yau TO Jin DY | 2004 | Clin Cancer Res2004，10，121： | 1 |
| 9 | Evaluation of nuclear factor- kappaB, urokinase-type plasminogen activator, and HBx and their clinicopathological significance in hepatocellular carcinoma 显示文摘 | Chan CF Yau TO Jin DY | 2004 | Clin Cancer Res2004，10，121： | 1 |
| 10 | Evaluation of Nuclear Factor-KB, Urokinase-Type Plasminogen Activator, and HBx and Their Clinicopathological Significance in Hepatocellular Carcinoma 显示文摘 | Chan CF Yau TO Jin DY | 2004 | Clin Cancer Res2004，10，12： | 1 |
| 11 | Evaluation of nuclear factor-kappaB, urokinase-type pIasminogen activator, and HBx and their clinieopathologieal significance in hepatoeenular carcinoma 显示文摘 | Chan CF Yau TO Jin DY et ol | 2004 | Clin Cancer Res2004，10，12： | 1 |
| 12 | The use of single‐agent sorafenib in the treatment of advanced hepatocellular carcinoma patients with underlying Child‐Pugh B liver cirrhosis显示文摘 | Joanne Chiu Yuen Fong Tang Tzy‐Jyun Yao Ashley Wong Hilda Wong Roland Leung Pierre Chan Tan To Cheung Albert C. Chan Roberta Pang Sheung‐Tat Fan Ronnie Poon Thomas Yau | 2012 | Cancer2012，，21： | 1 |
| 13 | Evaluation of nuclear factor-kappa B, urokinase-type plasminogen activator,and HBx and their clinicopathological significance in hepatocellular carcinoma显示文摘 | Chan CF Yau TO Jin DY | 2004 | Clin Cancer Res2004，10，121： | 1 |
| 14 | HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatoceilular carcinoma: involvement of methylation-mediated gene silencing显示文摘 | Yau TO Chan CY Chan KL | 2005 | Oncogene2005，24，： | 1 |
| 15 | 穴位的起源(英文)显示文摘探讨穴位的起源,认为穴位的起源与古人鬼神邪祟致病的理念有关。鬼神邪祟所藏之处即为穴位,在病变局部直接驱除鬼神邪祟便成为最主要的治病思路。《黄帝内经》中记载的'以痛为腧'形象地说明了早期穴位的确定方法和应用要点,而《黄帝内经》时代毫针刺法的广泛应用则促进了穴位理论和经脉理论的融合,使得穴位的结构和功能进一步深化,穴位也因此成为人体气血运行的关键部位。从穴位概念的产生到定型实际上展现了由巫术到医学的历史发展进程。 | Li Lei Yau To Yau Chuen-heung | 2012 | Journal of Acupuncture and Tuina Science2012，10，2： | 1 |
| 16 | HDPRI,a novel in- hibitor of the Wnt/β-catenin signaling,is frequently downregulated in hepatocellular carcinoma:involvement of methylation-mediated gene silencing 显示文摘 | Yau TO Chan CY Chan KL | 2005 | Oncogene2005，24，9： | 1 |
| 17 | HDPR1 , a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing显示文摘 | Yau TO Chan CY Chan KL | 2005 | Oneogene2005，24，9： | 1 |
| 18 | Evaluation of nuclear factor-kappaB, urokinase-type plasminogen activator, and HBx and their clinicopathological significance in hepatocellular carcinoma 显示文摘 | Chan CF Yau TO Jin DY Wong CM Fan ST Ng IOL | 2004 | Clin Cancer Res2004，10，12： | 1 |
| 19 | Evaluation of nuclear factor-kappa B,urokinase-type plasminogen activator,and HBx and their clinicopathological significance in hepatocellular carcinoma显示文摘 | Yau TO Jin DY | 2004 | Clin Cancer Res2004，10，12： | 1 |
| 20 | HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellu- lar carcinoma: involvement of methylation-mediated gene silencing 显示文摘 | Yau TO Chan CY Chan KL | 2005 | Oncogene2005，24，9： | 1 |
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