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| 1 | Midkine secretion protects Hep3B cells from cadmium induced cellular damage显示文摘AIM: To evaluate role of midkine secretion during Cadmium (Cd) exposure in the human hepatocyte cell line Hep3B cells. METHODS: Different dosages of Cd (0.5-1-5-10 μg/mL) were applied to Hep3B cells and their effects to apoptosis, lactate dehydrogenase (LDH) leakage and midkine secretion were evaluated as time dependent manner. Same experiments were repeated with exogenously applied midkine (250-5000 pg/mL) and/or 5 μg/mL Cd.RESULTS: Cd exposure induced prominent apoptosis and LDH leakage beginning from lower dosages at the 48th h. Cd induced midkine secretion with higher dosages (P < 0.001), (control, Cd 0.5-1-5-10 μg/mL respectively: 1123 ± 73, 1157 ± 63, 1242 ± 90, 1886 ± 175, 1712 ± 166 pg/mL). Exogenous 500-5000 pg/mL midkine application during 5 μg/mL Cd toxicity prevented caspase-3 activation (control, Cd toxicity, 250, 500, 1000, 2500, 5000 pg/mL midkine+ Cd toxicity, respectively: 374 ± 64, 1786 ± 156, 1545 ± 179, 1203 ± 113, 974 ± 116, 646 ± 56, 556 ± 63 cfu) LDH leakage and cell death in Hep3B cells (P < 0.001). CONCLUSION: Our results showed that midkine secretion from Hep3B cells during Cd exposure protects liver cells from Cd induced cellular damage. Midkine has anti-apoptotic and cytoprotective role during Cd toxicity. Further studies are needed to explain the mechanism of midkine secretion and cytoprotective role of midkine during Cd exposure. Midkine may be a promising theurapatic agent in different toxic hepatic diseases. | Nuray Yazihan Haluk Ataoglu Ethem Akcil Burcu Yener Bulent Salman Cengiz Aydin | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 2 | Erythropoietin attenuates hydrogen peroxide - induced damage of hepatocytes 显示文摘 | Yazihan N Ataoglu H Yener B | 2007 | Turk J Gastroenterol2007，8，4： | 1 |
| 3 | Erythropoietin improves oxidative stress following spinal cord trauma in rats 显示文摘 | Yazihan N Uzuner K Salman B | 2008 | Injury2008，39，12： | 1 |
| 4 | Eryxhropoie- tin reduces llpopolysaccharide-induced cell Damage and mid- kine secretion in U937 human histiocytic lyrnphoma cells显示文摘 | YAZIHAN N KARAKURT O ATAOGLU H | 2008 | Advances in Therapy2008，25，5： | 1 |
| 5 | Relationship of brain natriuretic peptide with metabolic syndrome parameters:an obser- vational study显示文摘 | Oztekin S Karakurt O Yazihan N | 2011 | Anadolu Kardiyol Derg2011，1，8： | 1 |
| 6 | Imatinib mesylate decreases the cytotoxic effect of roscovitine on human glioblastoma cells in vitro and the role of midkine 显示文摘 | Erguven M Bilir A Yazihan N | 2012 | Oncol Lett2012，3，1： | 1 |
| 7 | The effect of KATP channel blockage during erythropoietin treatment in renal ischemia reperfusion injury显示文摘 | Yazihan N Ataoglu H Kavas GO | 2008 | J Invest Surg2008，2，6： | 1 |
| 8 | Carvedilol in glioma treatment alone and with imatinib in vitro显示文摘 | Erguven M Yazihan N Aktas E | 2010 | lnt J Oncol2010，36，4： | 1 |
| 9 | Protective role of erythropoietin during testicular torsion of the rats显示文摘 | Yazihan N Ataoglu H Koku N | 2007 | World J Urol2007，25，5： | 1 |
| 10 | Erythropoietin improves oxidative stress following spinal cord trauma in rats 显示文摘 | Yazihan N Uzuner K Salman B | 2008 | Injury2008，39，12： | 1 |
| 11 | Erythropoietin attenuates hydrogen peroxide-induced damage of hepatocytes显示文摘 | Yazihan N Ataoglu H Yener B | 2007 | Turk J Gastroenterol2007，18，4： | 1 |
| 12 | Protective role of erythropoietin during testicular torsion of the rats显示文摘 | Yazihan N Ataoglu H Koku N | 2007 | World J Urol2007，25，5： | 1 |
| 13 | Enhancement of vinorelbine-induced cytotoxicity and apoptosis by elomipramine and lithium chloride in human neuroblastoma cancer cell line SH-SY5Y 显示文摘 | Bilir A Erguven M Yazihan N | 2010 | Neurooncol2010，100，3： | 1 |
| 14 | Erythropoietin attenuates hydrogen peroxide-induced damange of hepatocytes显示文摘 | Yazihan N Ataoglu H Yener B | | 0，，04： | 1 |
| 15 | Midkine in inflammatory and toxic conditions显示文摘 | Yazihan N | 2013 | Curr Drug Deliv2013，10，： | 1 |
| 16 | Impaired fight ventricular functions in metabolic syndrome patients with preserved left ven-trieular ejection fraction显示文摘 | Karakurt O Oztekin S Yazihan N | 2011 | Turk Kardiyol Dern Ars2011，39，7： | 1 |
| 17 | Carvedilol in glioma treatment alone and with imatinib in vitro显示文摘 | Mine Erguven Nuray Yazihan Esin Aktas Akin Sabanci Chiang Li Gulperi Oktem Ayhan Bilir | 2010 | International Journal of Oncology2010，，4： | 1 |
| 18 | Cord blood zinc status effects on pregnancy outcomes and its relation with maternal serum zinc levels:a systematic review and meta-analysis显示文摘Background The association between maternal and cord blood zinc level and pregnancy outcomes remains uncertain.The present study aims to assess whether maternal blood zinc level represents cord blood zinc level correctly.Methods In this meta-analysis,systematic search was performed in PubMed,Web of Science,and Scopus databases for relevant available English articles which included mean and standard deviation values of cord blood zinc level up to April 2019.For the assessment of the relation between cord blood zinc level and pregnancy outcomes,the pooled standard mean difference with 95%confidence interval(CI)was used and 23 studies were analyzed.Results Cumulative analysis showed that cord blood zinc level was found significantly decreased in pregnancies with complications compared with healthy pregnancy controls[REM:P=0.0007,mean difference−7.9(−12.48,−3.31)].For further analysis,maternal serum zinc level status was determined from same studies to compare with cord blood levels and subgroups were detected as“Preterm”,“Preeclampsia”,“Small for gestational age/Intrauterine growth restriction and Low birth weight”.It was observed that cord blood zinc levels in subgroup analysis were also decreased and/or tend to be decreased compared to healthy pregnancies,except for preeclampsia subgroup.Also,a correlation was seen between cord blood and maternal blood zinc level status(R=0.4365,95%CI−0.530,0.756;P=0.0351).Conclusion It was thought that cord blood zinc level might tend to decrease more than maternal serum zinc level in the pathological conditions during pregnancies. | Sevginur Akdas Nuray Yazihan | 2020 | World Journal of Pediatrics2020，16，4： | 0 |
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