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| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 2 | The three human monocyte subsets: implications for health and disease 显示文摘 | Wong K L Yeap W H Tai J J | 2012 | Immunol Res2012，53，123： | 1 |
| 3 | The promising future of chia,Salvia hispanica L显示文摘 | MOHD Al N YEAP S K HO W Y | 2012 | Journal of Biomedicine and Biotechnology2012，2012，17： | 1 |
| 4 | Erlotinib at a dose of 25 mg daily for non small cell lung cancers with EGFR mutations显示文摘 | Yeo W L Riely G J Yeap B Y | 2010 | J ThoracOncol2010，5，7： | 1 |
| 5 | Quantitative real-time BT-PCR analysis of PML-RAR а mBNA in acute promyelocytie leukemia:as-sesament of prog nostie significance in adult patients from intergroup protocol 0129显示文摘 | Galla Gher RE Yeap BY Bi W | 2003 | Blood2003，101，7： | 1 |
| 6 | Paradoxical effects of IFN- gamma in graft- versus-host disease reflect promotion of lymphohematopoietic graftversus- host reactions and inhibition of epithelial tissue injury 显示文摘 | Wang H Asavaroengchai W Yeap BY | 2009 | Blood2009，113，15： | 1 |
| 7 | Comparison of safety and immunogenicity of a Vi polysaccharide typhoid vaccine with a wholecell killed vaccine in Malaysian Air Force recruits显示文摘 | Panchanathan V Kumar S Yeap W | 2001 | Bull World Health Organ2001，79，9： | 1 |
| 8 | A lipid- lowering therapy and pe- ripheral sensory neuropathy in type 2 diabetes: The Fremantle Dia- betes Study显示文摘 | Davis TM Yeap BB Davis W | 2008 | Diabetologia2008，51，4： | 1 |
| 9 | Comparison of safety and immunogenicity of a Vi polysaccharide typhoid vaccine with a whole-cell killed vaccine in Malaysian Air Force recruits显示文摘 | Panchanathan V Kumar S Yeap W | 2001 | Bull WH02001，79，9： | 1 |
| 10 | An unusual hydrolysable tannin from Phyllanthus amarus显示文摘 | Yeap Foo L Herbert W Phyllanthusiin D | 1992 | Phytochemistry1992，31，2： | 1 |
| 11 | Quantitative real-time RTPCR analysis of PML-RAR alpha mRNA in acute promyelocytic leukemia:assessment of prognostic significance in adult patients from intergroup protocol 0129显示文摘 | Gallagher RE Yeap BY Bi W | 2003 | Blood2003，101，7： | 1 |
| 12 | Paradoxical effects of IFN-gamma in graft-versus-host disease reflect promotion of lym?phohematopoietic graft-versus-host reactions and inhibition of ep?ithelial tissue injury显示文摘 | Wang H Asavaroengchai W Yeap BY | 2009 | Blood2009，113，15： | 1 |
| 13 | Comparison of safety and immunogenicity of a Vi polysaccharide typhoid vaccine with a whole-cell killed vaccine in Malaysian Air Force recruits 显示文摘 | Panchanathan V Kumar S Yeap W | 2001 | Bull World Health Organ2001，79，9： | 1 |
| 14 | Evaluation of suitable reference genes for qRT-PCR gene expression normalization in reproductive, vegetative tissues and during fruit development in oil palm 显示文摘 | Yeap W C Loo J M Wong Y C Kulaveerasingam H | 2014 | Plant Cell Tissue Organ Culture2014，116，1： | 1 |
| 15 | Phylogenetic relationships of nearctic Reticuliternes species (Isoptera: Rhinotermitidae) with particular reference to Reticulitermes arenincola Goellner显示文摘 | Yeap W Lee C Y Scheffrahn R H | 2004 | Molecular Phylogenetics and Evolution2004，30，： | 1 |
| 16 | Quantitative real-time RT-PCR analysis of PML-RAR alpha mRNA in acute promyelocytic leukemia:assessment of prognostic significance in adult patients from intergroup protocol 0129显示文摘 | Gallagher RE Yeap BY Bi W | 2003 | Blood2003，101，： | 1 |
| 17 | Alteration in lymphocyte responses,cytokine and chemokineprofiles in chickens infected with genotype VII and VIII velogenic Newcastle disease virus显示文摘 | Rasoli M Yeap S K Tan S W | 2014 | Comp Immunol Microb2014，37，1： | 1 |
| 18 | XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk 显示文摘 | Liu G Zhou W Yeap BY | 2007 | Carcinogenesis2007，28，6： | 1 |
| 19 | Quantitative real-time RT PCR analysis of PML-RAR alpha mRNA in Acute promyelocytic leukemia: assessment of prognostic significance in adult patients from intergroup protocol 0129显示文摘 | GALLAGHER R E YEAP B Y BI W | 2003 | Blood2003，101，： | 1 |
| 20 | Lipid-lowering therapy and peripheral sensory neuropathy in type 2 diabe- tes: the Fremantle Diabetes Study显示文摘 | Davis T M Yeap B B Davis W A | 2008 | Diabetologia2008，51，4： | 1 |
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