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| 1 | Comparison of Outcomes of Different Varicocelectomy Techniques: Open Inguinal, Laparoscopic, and Subinguinal Microscopic Varicocelectomy: A Randomized Clinical Trial显示文摘 | Ahmed M. Al-Kandari Hani Shabaan Hamdi M. Ibrahim Yehya H. Elshebiny Ahmed A. Shokeir | 2007 | Urology2007，，3： | 2 |
| 2 | Improved oxygenation 24 hours after transition to airway pressure release ventilation or high-frequency oscillatory ventilation accurately discriminates survival in immunocompromised pediatric patients with acute respiratory distress syndrome显示文摘 | Yehya N Topjian AA Thomas NJ | 2014 | Pediatr Crit Care Med2014，15，4： | 1 |
| 3 | Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and threedimensional in vitro models显示文摘BACKGROUND Colorectal cancer(CRC) is the second leading cause of cancer-related mortality.Cancer stem cells(CSCs) in CRC, which are spared by many chemotherapeutics,have tumorigenic capacity and are believed to be the reason behind cancer relapse. So far, there have been no effective drugs to target colon CSCs. Diiminoquinone(DIQ) has shown promising effects on targeting colon cancer.However, there is limited research on the effects of DIQ on eradicating CSCs in CRC.AIM To investigate the anticancer potential of DIQ on colon CSCs in two-dimensional(2D) and three-dimensional(3D) models using colonospheres and patient-derived organoids.METHODS Various 2D methods have been used to assess the effect and the mechanism of DIQ on HCT116and HT29 cell lines including cell proliferation and viability assays, migration and invasion assays,immunofluorescence staining, and flow cytometry. The potency of DIQ was also assessed in 3D culture using the sphere formation assay and colon cancer patient-derived organoid model.RESULTS Our results showed that DIQ significantly inhibited cell proliferation, migration, and invasion in HCT116 and HT29 cell lines. DIQ treatment induced apoptosis along with an accumulation of HCT116 and HT29 cancer cells in the sub-G1 region and an increase in reactive oxygen species in both CRC cell lines. DIQ reduced sphere-forming and self-renewal ability of colon cancer HCT116and HT29 stem/progenitor cells at sub-toxic doses of 1 μmol/L. Mechanistically, DIQ targets CSCs by downregulating the main components of stem cell-related-catenin, AKT, and ERK oncogenic signaling pathways. Potently, DIQ displayed a highly significant decrease in both the count and the size of the organoids derived from colon cancer patients as compared to control and 5-fluorouracil conditions.CONCLUSION This study is the first documentation of the molecular mechanism of the novel anticancer therapeutic DIQ via targeting CSC, a promising compound that needs further investigation. | Alissar Monzer Kevork Wakimian Farah Ballout Samar Al Bitar Amani Yehya Mariam Kanso Nour Saheb Ayman Tawil Samer Doughan Maher Hussein Deborah Mukherji Walid Faraj Hala Gali-Muhtasib Wassim Abou-Kheir | 2022 | World Journal of Gastroenterology2022，28，33： | 1 |
| 4 | CelI-free placentaI mRNA in ma- temaI pIasma to predict placentaI invasion in patients with pIacenta accre- ta显示文摘 | ManaI M E Etewa R L Yehya E A | 2010 | International Journal of GynecoIogy and Obstetrics2010，，109： | 1 |
| 5 | High- Frequency percussive ventilation and bronchoscopy during extracorporeal life support in chil- dren显示文摘 | Yehya N Dominick CL Connelly JT | 2014 | ASAIO Journal2014，60，4： | 1 |
| 6 | Nover Enhanced Magnetron Sputtering System显示文摘 | Yehya M Kelly P J | 2004 | Surface Engineering2004，20，3： | 1 |
| 7 | Recurrence of benign men- ingiomas : predictive value of proliferative index, BCL2, p53, hormonal receptors and HER2 expression 显示文摘 | Abdelzaher E El-gendi M Yehya A | 2011 | Br J Neurosurg2011，25，6： | 1 |
| 8 | Mechanisms and chemistry of dye adsorption on manganese oxides-modified diatomite显示文摘 | Mohammad A. Al-Ghouti Yehya S. Al-Degs Majeda A.M. Khraisheh Mohammad N. Ahmad Stephen J. Allen | 2009 | Journal of Environmental Management2009，，11： | 1 |
| 9 | A Novel Current mode Instrumentation Amplifier Based on Operational Floating Current Conveyor, Digital Object Identifier显示文摘 | GHALLAB Yehya H | 2005 | TIM2005，10，： | 1 |
| 10 | Cell-free placental mRNA in maternal plasma to predict placental invasion in patients with placenta accreta显示文摘 | Manal ME Etewa RL Yehya EA | 2010 | Intemational Journal of Gynecology and Obstetrics2010，109，： | 1 |
| 11 | Cell-free placental mRNA in maternal plasma to predict placental invasion in patients with placenta accreta显示文摘 | Manal M. El Behery Etewa Rasha L. Yehya El Alfy | 2009 | International Journal of Gynecology and Obstetrics2009，，1： | 1 |
| 12 | Pilot study of the sensitivity and specificity of the DNA integrity assay for stool-based detection of colorectal cancer in Malaysian patients显示文摘 | Yehya A H Yusoff N M Khalid I A | 2012 | Asian Pac J Cancer Prey2012，13，5： | 1 |
| 13 | Cell-free placental mRNA in maternal plasma to predict placental invasion in patients with placenta accreta显示文摘 | Manal M. El Behery Etewa Rasha L. Yehya El Alfy | 2009 | International Journal of Gynecology and Obstetrics2009，，1： | 1 |
| 14 | Latrogentic pulpat reactions to orthodontic extrusion显示文摘 | Yehya A Mostafa BDS | 1991 | Am J Orthod Dentofac Orthop1991，99，3： | 1 |
| 15 | MieroRNA modulate alveolar epithelial response to cyclic stretch显示文摘 | YEHYA N YERRAPUREDDY A TOBIAS J | 2012 | BMC Genomics2012，13，： | 1 |
| 16 | A comparative analysis of epidemiological characteristics of MERS-CoV and SARS-CoV-2 in Saudi Arabia显示文摘In this study,we determine and compare the incubation duration,serial interval,pre-symptomatic transmission,and case fatality rate of MERS-CoV and COVID-19 in Saudi Arabia based on contact tracing data we acquired in Saudi Arabia.The date of infection and infector-infectee pairings are deduced from travel history to Saudi Arabia or exposure to confirmed cases.The incubation times and serial intervals are estimated using parametric models accounting for exposure interval censoring.Our estimations show that MERS-CoV has a mean incubation time of 7.21(95%CI:6.59–7.85)days,whereas COVID-19(for the circulating strain in the study period)has a mean incubation period of 5.43(95%CI:4.81–6.11)days.MERS-CoV has an estimated serial interval of 14.13(95%CI:13.9–14.7)days,while COVID-19 has an estimated serial interval of 5.1(95%CI:5.0–5.5)days.The COVID-19 serial interval is found to be shorter than the incubation time,indicating that pre-symptomatic transmission may occur in a significant fraction of transmission events.We conclude that during the COVID-19 wave studied,at least 75%of transmission happened prior to the onset of symptoms.The CFR for MERS-CoV is estimated to be 38.1%(95%CI:36.8–39.5),while the CFR for COVID-191.67%(95%CI:1.63–1.71).This work is expected to help design future surveillance and intervention program targeted at specific respiratory virus outbreaks,and have implications for contingency planning for future coronavirus outbreaks. | Yehya Althobaity Jianhong Wu Michael J.Tildesley | 2022 | Infectious Disease Modelling2022，7，3： | 1 |
| 17 | Cholesteryl ester transfer protein rs1532624 gene polymorphism is associated with reduced response to statin therapy显示文摘 | Yehya A Irshaid Y Saleh AA | 2013 | Curr Mol Pharmacol2013，6，3： | 1 |
| 18 | Cholcsteryl ester transfer protein rsl 532624 gene polymorphism is associated with reduced response to sta- tin therapy 显示文摘 | Yehya A Irshaid Y Saleh A | 2013 | Curr Mol Pharmaeo12013，6，3： | 1 |
| 19 | Recurrence of be-nign meningiomas:predictive value of proliferative index, BCL2, p53, hormonal receptors and HER2 expression显示文摘 | Abdelzaher E El-Gendi S M Yehya A | | 0，，06： | 1 |
| 20 | Simulating flows in multi-layered and spatially-variable permeability media via a new Gray Lattice Boltzmann model 显示文摘 | YEHYA A NAJI H SUKOP M | 2015 | Computers and Geotechnies2015，70，： | 1 |
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