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| 1 | Chinese Society of Clinical Oncology(CSCO) diagnosis and treatment guidelines for malignant lymphoma 2021(English version)显示文摘1. General guidelines2. Diagnosis3. Staging4. Treatment4.1 Diffuse large B-cell lymphoma(DLBCL)4.2 Follicular lymphoma(FL)4.3 Mantle cell lymphoma(MCL)4.4 Marginal zone lymphoma(MZL)4.5 Burkitt lymphoma(BL)4.6 CLL/Small lymphocytic lymphoma(SLL)4.7 Extra-nodal natural killer/T-cell lymphoma(ENKTCL), nasal type4.8 Peripheral T-cell lymphoma(PTCL)4.9 HL4.10 Primary central nervous system lymphoma5. Prognosis Lymphomas are a group of heterogeneous diseases. | Jun Zhu Jun Ma Union for China Lymphoma Investigators of Chinese Society of Clinical Oncology Zhixiang Shen Zifen Gao Huiqiang Huang Xiaoqiu Li Yexiong Li Lugui Qiu Weili Zhao Qingyuan Zhang | 2021 | Chinese Journal of Cancer Research2021，33，3： | 18 |
| 2 | Down-staging depth score to predict outcomes in locally advanced rectal cancer achieving ypl stage after neoadjuvant chemo-radiotherapy versus de novo stage pl cohort:A propensity score-matched analysis显示文摘Objective:Prognosis of patients with locally advanced rectal cancer(LARC)but achieving yp T1–2N0 stage after neoadjuvant concurrent chemo-radiotherapy(CRT)has been shown to be favorable.This study aims to determine whether the long-term outcome of yp T1–2N0 cases can be comparable to that of p T1–2N0 cohort that received definitive surgery for early disease.Method:From January 2008 to December 2013,449 consecutive patients with rectal cancer were treated and their outcome maintained in a database.Patients with LARC underwent total mesorectal excision(TME)surgery at4–8 weeks after completion of CRT,and those achieving stage yp I were identified as a group.As a comparison,stage p I group pertains to patients whose initially limited disease was not upstaged after TME surgery alone.After propensity score matching(PSM),comparisons of local regional control(LC),distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were performed using Kaplan-Meier analysis and log-rank test between yp I and p I groups.Down-staging depth score(DDS),a novel method of evaluating CRT response,was used for subset analysis.Results:Of the 449 patients,168 matched cases were generated for analysis.Five-year LC,DMFS,DFS and OS for stage p I vs.yp I groups were 96.7%vs.96.4%(P=0.796),92.7%vs.73.6%(P=0.025),91.2%vs.73.6%(P=0.080)and 93.1%vs.72.3%(P=0.040),respectively.In the DDS-favorable subset of the yp I group,LC,DMFS,DFS and OS resulted in no significant differences in comparison with the p I group(P=0.384,0.368,0.277 and0.458,respectively).Conclusions:LC was comparable in both groups;however,distant metastasis developed more frequently in down-staged LARC than de novo early stage cases,reflecting the need to improve the efficacy of systemic treatment despite excellent pathologic response.DDS can be an indicator to identify a subset of the yp I group whose longterm oncologic outcomes are as good as those of stage p I cohort. | Ning Li Jing Jin Jing Yu Shuai Li Yuan Tang Hua Ren Wenyang Liu Shulian Wang Yueping Liu Yongwen Song Hui Fang Zihao Yu Yexiong Li | 2018 | Chinese Journal of Cancer Research2018，30，3： | 4 |
| 3 | Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study显示文摘 | Qiujin Shen Jia Fan Xin-Rong Yang Yexiong Tan Weifeng Zhao Yang Xu Ning Wang Yongdong Niu Zheng Wu Jian Zhou Shuang-Jian Qiu Ying-Hong Shi Bin Yu Ning Tang Wei Chu Min Wang Jinhua Wu Zhigang Zhang Shengli Yang Jianren Gu Hongyang Wang Wenxin Qin | 2012 | Lancet Oncology2012，，8： | 4 |
| 4 | Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics显示文摘 | Qiang Huang Yexiong Tan Peiyuan Yin Guozhu Ye Peng Gao Xin Lu Hongyang Wang Guowang Xu | 2013 | Cancer Research2013，，16： | 2 |
| 5 | Addition of rituximab is not associated with survival benefit compared with CHOP alone for patients with stage I diffuse large B-cell lymphoma显示文摘Background:The role of rituximab in combination with CHOP regimen in patients with stage I diffuse large B-cell lymphoma(DLBCL) remains to be defined.We aimed to compare CHOP plus rituximab(R-CHOP) with CHOP alone and determine the value of radiotherapy in these patients.Methods:Between 2003 and 2009,140 untreated patients with stage I DLBCL were retrospectively analyzed in this study.Results:Seventy-eight patients were treated in R-CHOP group and 62 in CHOP group.Ninety-one patients received additional radiotherapy at the end of chemotherapy.The different treatment groups were well-balanced with respect to baseline characteristics.Complete response(CR) rate was 77% both in R-CHOP and CHOP groups(P=0.945).After a median follow-up period of 56 months,patients received R-CHOP regimen had similar 5-year progression-free survival(PFS)(76%vs.85%;log-rank P=0.215)and 5-year overall survival(OS)(90%vs.96%;log-rank P=0.175) compared with those with CHOP alone.Patients with radiotherapy had significantly increased 5-year PFS compared with those who had chemotherapy alone(86%vs.71%;log-rank P=0.005).At multivariate analysis,patients who had CR(P=0.008) and received radiotherapy(P=0.003) were significantly associated with superior PFS.Conclusions:CHOP alone could be as effective as R-CHOP regimen and additional radiotherapy would be necessary for stage I or stage I non-bulky DLBCL patients. | Bo Jia Yuankai Shi Suyi Kang Sheng Yang Shaoxuan Hu Yexiong Li Mei Dong Weihu Wang Jianliang Yang Liqiang Zhou Peng Liu Shengyu Zhou Yan Qin Lin Gui Changgong Zhang Hua Lin Shanshan Chen Lin Wang Xiaohui He | 2015 | Chinese Journal of Cancer Research2015，27，5： | 2 |
| 6 | MXR7 facilitates liver cancer metastasis via epithelial-mesenchymal transition显示文摘MXR7 is a cell-surface protein and highly expressed in hepatocellular carcinoma(HCC). The aim of this study is to determine the expression profile of MXR7 in HCC and investigate the influence of MXR7 on invasion and metastasis of HCC cells. For this purpose, immunohistochemical assay was used to identify the differential expression of MXR7 in 94 HCC specimens. Expression of MXR7 in 4 pairs of HCC and portal vein tumor thrombus(PVTT) was also tested. The motility of HCC cells were characterized by transwell migration and matrigel invasion assays. In vivo metastasis potential was determined via tail vein injection assay.Moreover, compared with noninvasive HCC tumors or human HCC cell lines with low metastatic potential, invasive HCC samples and HCC cell lines with high metastatic potential exhibited higher MXR7 expression. Furthermore, forced expression of MXR7 in SMMC-7721 promoted cell proliferation, migration and invasion in vitro and accelerated tumor growth and metastasis in vivo. Conversely, knockdown of MXR7 expression in HuH7 cells inhibited proliferation and motility of cells. Mechanically,overexpression of MXR7 promoted epithelial-mesenchymal transition(EMT) progress, and MXR7 depletion repressed the EMT phenotype. In conclusion, MXR7 is a mediator of EMT and metastasis in HCC and may serve as a novel therapeutic target. | guishuai lv yexiong tan hongwei lv tian fang changzheng wang ting li yanting yu congli hu wen wen hongyang wang wen yang | 2017 | Science China(Life Sciences)2017，60，11： | 2 |
| 7 | Management of extramedullary plasmacytoma: Role of radiotherapy and prognostic factor analysis in 55 patients显示文摘Objective: To investigate potential prognostic factors affecting patient outcomes and to evaluate the optimal methods and effects of radiotherapy(RT) in the management of extramedullary plasmacytoma(EMP).Methods: Data from 55 patients with EMP between November 1999 and August 2015 were collected. The median age was 51(range, 22–77) years. The median tumor size was 3.5(range, 1.0–15.0) cm. The median applied dose was 50.0(range, 30.0–70.0) Gy. Thirty-nine patients(70.9%) presented with disease in the head or neck region. Twelve patients received RT alone, 9 received surgery(S) alone, 3 received chemotherapy(CT) alone, and 3 patients did not receive any treatment. Combination therapies were applied in 28 patients.Results:The median follow-up duration was 56 months.The 5-year local recurrence-free survival(LRFS),multiple myeloma-free survival(MMFS),progression-free survival(PFS)and overall survival(OS)rates were 79.8%,78.6%,65.2% and 76.0%,respectively.Univariate analysis revealed that RT was a favourable factor for all examined endpoints.Furthermore,head and neck EMPs were associated with superior LRFS,MMFS and PFS.Tumor size<4 cm was associated with superior MMFS,PFS and OS;serum M protein negativity was associated with superior MMFS and PFS;age≥50 years and local recurrence were associated with poor MMFS.The dose≥45 Gy group exhibited superior 5-year LRFS,MMFS and PFS rates(94.7%,94.4%,90.0%,respectively),while the corresponding values for the dose<45 Gy group were 62.5%(P=0.008),53.3%(P=0.036)and 41.7%(P<0.001).Conclusions:Involved-site RT of at least 45 Gy should be considered for EMP.Furthermore,patients with head and neck EMP,tumor size<4 cm,age<50 years and serum M protein negativity had better outcomes. | Ge Wen Weihu Wang Yujing Zhang Shaoqing Niu Qiwen Li Yexiong Li | 2017 | Chinese Journal of Cancer Research2017，29，5： | 2 |
| 8 | Suppressing laser phase noise in an optomechanical system显示文摘We propose a scheme to suppress the laser phase noise without increasing the optomechanical single-photon coupling strength.In the scheme,the parametric amplification terms,created by Kerr and Duffing nonlinearities,can restrain laser phase noise and strengthen the effective optomechanical coupling,respectively.Interestingly,decreasing laser phase noise leads to increasing thermal noise,which is inhibited by bringing in a broadband-squeezed vacuum environment.To reflect the superiority of the scheme,we simulate quantum memory and stationary optomechanical entanglement as examples,and the corresponding numerical results demonstrate that the laser phase noise is extremely suppressed.Our method can pave the way for studying other quantum phenomena. | Yexiong Zeng Biao Xiong Chong Li | 2022 | Frontiers of physics2022，17，1： | 2 |
| 9 | Wave control of a flexible space tether based on elastic metamaterials显示文摘This study proposes a spider‐web elastic metamaterial to suppress vibrations in space slender structures,such as flexible space tethers.The metamaterial consists of unit cells that are periodically distributed on the space tether to obtain band gaps.The finite element model of the unit cell is established by employing the absolute nodal coordinate formulation(ANCF)due to the large deformation of the structure.The eigenfrequencies and corresponding vibration modes of the unit cell are obtained by ANCF.Moreover,the band gap of the unit cell is calculated based on the phonon crystal theory.The relationship between the vibration modes and the band gaps is analyzed.Finally,an experiment is conducted to verify the vibration transmission characteristics of finite period cells.The results show the effectiveness of the spider‐web elastic metamaterial for vibration suppression of a flexible tether.This study provides insights into the use of elastic metamaterials for vibration isolation in space tether systems. | Yexiong Huang Enmin Chen Jialiang Sun Dongping Jin | 2023 | International Journal of Mechanical System Dynamics2023，3，1： | 1 |
| 10 | Comparative proteomic analysis of liver regeneration-preliminary results显示文摘 | ZHOU Dongxun TAN Yexiong HU Heping | 2006 | Journal of Gastroenterology and Hepatology2006，21，： | 1 |
| 11 | Down-staging depth score could be a survival predictor for locally advanced gastric cancer patients after preoperative chemoradiotherapy显示文摘Objective:The predictive effect of preoperative chemoradiotherapy(CRT)is low and difficult in guiding individualized treatment.We examined a surrogate endpoint for long-term outcomes in locally advanced gastric cancer patients after preoperative CRT.Methods:From April 2012 to April 2019,95 patients with locally advanced gastric cancer who received preoperative concurrent CRT and who were enrolled in three prospective studies were included.All patients were stage T_(3/4) N_(+).Local control,distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were evaluated.Clinicopathological factors related to long-term prognosis were analyzed using univariate and multivariate analyses.The down-staging depth score(DDS),which is a novel method of evaluating CRT response,was used to predict long-term outcomes.Results:The median follow-up period for survivors was 30 months.The area under the curve(AUC)of the receiver operating characteristic(ROC)curve predicted by the DDS was 0.728,which was better than the pathological complete response(pCR),histological response and ypN0.Decision curve analysis further affirmed that DDS had the largest net benefit.The DDS cut-off value was 4.pCR and ypN0 were associated with OS(P=0.026 and 0.049).Surgery and DDS are correlated with DMFS,DFS and OS(surgery:P=0.001,<0.001 and<0.001,respectively;and DDS:P=0.009,0.013 and 0.032,respectively).Multivariate analysis showed that DDS was an independent prognostic factor of DFS(P=0.021).Conclusions:DDS is a simple,short-term indicator that was a better surrogate endpoint than pCR,histological response and ypN0 for DFS. | Ning Li Xin Wang Yuan Tang Dongbin Zhao Yihebali Chi Lin Yang Liming Jiang Jun Jiang Jinming Shi Wenyang Liu Hua Ren Hui Fang Yu Tang Bo Chen Ningning Lu Hao Jing Shunan Qi Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin | 2021 | Chinese Journal of Cancer Research2021，33，4： | 1 |
| 12 | Reactivation of a silenced minimal mutator transposable element system following low-energy nigrogenion implantation in maize显示文摘 | Qian Yexiong Cheng Xiao Liu Yan | 2010 | Plant Cell Rep2010，29，12： | 1 |
| 13 | From proteomic analysis to clinical significance: overexpression of cytokeratin 19 correlates with hepatocellular carcinoma metastasis 显示文摘 | Ding Shijian Li Yah Tan YeXiong | 2004 | Mol CellProteomics2004，3，1： | 1 |
| 14 | One-step plasmonic welding and photolithographic patterning of silver nanowire network by UV-programable surface atom diffusion显示文摘Silver nanowire(AgNW)based transparent electrode(TE)plays a pivotal role in optoelectronics where TE is generally required to have fine pattern and high performance.Despite the rapid technological advances in either welding or patterning of AgNWs,there are few studies that combine the two processes in a simple and practical manner.Here,aiming to fabricate high-performance patterned AgNW TE,we develop a simplified photolithography that enables both plasmonic nanowelding with low-level UV exposure(20 mW/cm^(2))and high-resolution micropatterning without photoresist and etching process by conjugating AgNW with diphenyliodonium nitrate(DPIN)and UV-curable cellulose.The cellulose as a binder can effectively enhance plasmonic heating,adhesion,and stability,while the photosensitive DPIN,capable of modulating surface atom diffusion,can boost the plasmonic welding at AgNW junction and induce patterning in AgNW network with Plateau-Rayleigh instability.The fabricated AgNW TE has high figure of merit of up to 1,000(3.7Ω/sq at 90%transmittance)and minimal pattern size down to 3µm,along with superior robustness.Finally,a flexible smart window with high performance is demonstrated using the patterned and welded AgNW TEs,verifying the applicability of the simplified photolithography technique to optoelectronic devices. | Gui-Shi Liu Ting Wang Yexiong Wang Huajian Zheng Yunsen Chen Zijie Zeng Lei Chen Yaofei Chen Bo-Ru Yang Yunhan Luo Zhe Chen | 2022 | Nano Research2022，15，3： | 0 |
| 15 | An RNA-RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity显示文摘Hepatocellular carcinoma(HCC)is the global leading cause of cancer-related deaths due to the deficiency of targets for precision therapy.A new modality of epigenetic regulation has emerged involving RNA-RNA crosstalk networks where two or more competing endogenous RNAs(ceRNAs)bind to the same microRNAs.However,the contribution of such mechanisms in HCC has not been well studied.Herein,potential HMGB1-driven RNA-RNA crosstalk networks were evaluated at different HCC stages,identifying the mT0RC2 component RICTOR as a potential HMGB1 ceRNA in HBV^(+)early stage HCC.Indeed,elevated HMGB1 mRNA was found to promote the expressio n of RICTOR mRNA through competitively bin ding with the miR-200 family,especially miR-429.Functio nal assays emplo ying overexpressi on or in terference strategies dem on strated that the HMGB1 and RICTOR 3zuntra nslated regions(UTR)epigenetically promoted the malignant proliferation,self-renewal,and tumorigenesis in HCC cells.Intriguingly,in terference agai nst HMGB1 and RICTOR in HCC cells promoted a stron ger an ti-PD-L1 immuno therapy resp on se,which appeared to associate with the production of PD-L1^(+)exosomes.Mechanistically,the HMGB1-driven RNA-RNA crosstalk network facilitated HCC cell glutamine metabolism via dual mechanisms,activating a positive feedback loop involving mT0RC2-AKT-C-MYC to upregulate glutamine synthetase(GS)expression,and inducing mTORCI signaling to derepress SIRT4 on glutamate dehydrogenase(GDH).Meanwhile,this crosstalk network could impede the efficacy of immunotherapy through mTORCI-P70S6K dependent PD-L1 production and PD-L1^(+)exosomes activity.In conclusion,our study highlights the non-coding regulatory role of HMGB1 with implicatio ns for RNA-based therapeutic targeting together with a predictio n of an ti-PD-L1 immuno therapy in HCC. | Yanping Wei Xuewu Tang Yibin Ren Yun Yang Fengliang Song Jingbo Fu Shuowu Liu Miao Yu Jing Chen Suyang Wang Kecheng Zhang Yexiong Tan Zhipeng Han Lixjn Wei Baohua Zhang Zhangjun Cheng Liang Li Hongyang Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 16 | Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapy显示文摘Objective:The identification of biomarkers for predicting chemoradiotherapy efficacy is essential to optimize personalized treatment.This study determined the effects of genetic variations in genes involved in apoptosis,pyroptosis,and ferroptosis on the prognosis of patients with locally advanced rectal cancer receiving postoperative chemoradiotherapy(CRT).Methods:The Sequenom MassARRAY was used to detect 217 genetic variations in 40 genes from 300 patients with rectal cancer who received postoperative CRT.The associations between genetic variations and overall survival(OS)were evaluated using hazard ratios(HRs)and 95%confidence intervals(CIs)computed using a Cox proportional regression model.Functional experiments were performed to determine the functions of the arachidonate 5-lipoxygenase(ALOX5)gene and the ALOX5 rs702365 variant.Results:We detected 16 genetic polymorphisms in CASP3,CASP7,TRAILR2,GSDME,CASP4,HO-1,ALOX5,GPX4,and NRF2 that were significantly associated with OS in the additive model(P<0.05).There was a substantial cumulative effect of three genetic polymorphisms(CASP4 rs571407,ALOX5 rs2242332,and HO-1 rs17883419)on OS.Genetic variations in the CASP4 and ALOX5 gene haplotypes were associated with a higher OS.We demonstrated,for the first time,that rs702365[G]>[C]represses ALOX5 transcription and corollary experiments suggested that ALOX5 may promote colon cancer cell growth by mediating an inflammatory response.Conclusions:Polymorphisms in genes regulating cell death may play essential roles in the prognosis of patients with rectal cancer who are treated with postoperative CRT and may serve as potential genetic biomarkers for individualized treatment. | Hongxia Chen Luxi Yin Jie Yang Ningxin Ren Jinna Chen Qixuan Lu Ying Huang Yanru Feng Weihu Wang Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin Wen Tan Dongxin Lin | 2023 | Cancer Biology & Medicine2023，20，4： | 0 |
| 17 | Self-assembled monolayer modulated Plateau-Rayleigh instability and enhanced chemical stability of silver nanowire for invisibly patterned,stable transparent electrodes显示文摘Patterned silver nanowire(AgNW)networks have been widely used as transparent electrodes in many optoelectrical devices.However,obvious patterning visibility and poor thermostability of AgNW are still limiting its practical application.Herein,we report self-assembled monolayer(SAM)modulated Plateau-Rayleigh instability(PRI)of AgNW,which allows invisible patterning and superior stability of the AgNW network.Two opposite effects of different SAMs on the PRI are identified:the alkanethiol SAMs activate surface atom diffusion while the mercaptobenzoheterocyclic(MBH)SAMs suppress the diffusion.The degradation temperature of the AgNWs can be therefore,for the first time,tuned in the range of 193-381℃,so that the AgNW network can be patterned via PRI with a tiny optical difference between the insulative and conductive regions,i.e.,patterning invisible.Besides,the MBH SAMs provide AgNW with excellent durability under thermal annealing and oxidation,which enhances the maximum heating temperature of the AgNW transparent heater by over 120℃.Beyond the micro-patterning,we consider that the developed SAM strategy can be extended to other metal nanowires for stability improvement and has huge potential in nanoengineering of one-dimensional metal materials. | Gui-Shi Liu Huajian Zheng Zijie Zeng Yexiong Wang Weidong Guo Ting Wang Heng Chen Yunsen Chen Shiqi Hu Lei Chen Yaofei Chen Weiguang Xie Bo-Ru Yang Yunhan Luo | 2022 | Nano Research2022，15，5： | 0 |
| 18 | Adaptive ultra-hypofractionated whole-pelvic radiotherapy in high-risk and very high-risk prostate cancer on 1.5-Tesla MR-Linac:Estimated delivered dose and early toxicity results显示文摘Background: Magnetic resonance(MR)-guided ultra-hypofractionated radiotherapy with whole-pelvic irradiation(UHF-WPRT)is a novel approach to radiotherapy for patients with high-risk(HR)and very high-risk(VHR)prostate cancer(PCa).However,the inherent complexity of adaptive UHF-WPRT might inevitably result in longer on-couch time.We aimed to estimate the delivered dose,study the feasibility and safety of adaptive UHF-WPRT on a 1.5-Tesla MR-Linac.Methods: Ten patients with clinical stage T3a-4N0-1M0-1c PCa,who consecutively received UHF-WPRT,were enrolled prospectively.The contours of the target and organ-at-risks on the position verification-MR(PV-MR),beam-on 3D-MR(Bn-MR),and post-MR(after radiotherapy delivery)were derived from the pre-MR data by deformable image registration.The physician then manually adjusted them,and dose recalculation was performed accordingly.GraphPad Prism 9(GraphPad Prism Software Inc.)was utilized for conducting statistical analyses.Results: In total,we collected 188 MR scans(50 pre-MR,50 PV-MR,44 Bn-MR,and 44 post-MR scans).With median 59 min,the mean prostate clinical target volume(CTV)-V_(100%)was 98.59%±2.74%,and the mean pelvic CTVp-V_(100%)relative percentages of all scans was 99.60%±1.18%.The median V29 Gy change in the rectal wall was−2%(−18%to 20%).With a median follow-up of 9 months,no patient had acute Common Terminology Criteria for Adverse Events(CTCAE)grade 2 or more severe genitourinary(GU)or gastrointestinal(GI)toxicities(0%).Conclusion: UHF-RT to the prostate and the whole pelvis with concomitant boost to positive nodes using an Adapt-To-Shape(ATS)workflow was technically feasible for patients with HR and VHR PCa,presenting only mild GU and GI toxicities.The estimated target dose during the beam-on phase was clinically acceptable based on the 3D-MR-based dosimetry analysis.Clinical trial registration Chinese Clinical Trial Registry ChiCTR2000033382. | Linrui Gao Ran Wei Shirui Qin Yuan Tian Wenlong Xia Yongwen Song Shulian Wang Hui Fang Yu Tang Hao Jing Yueping Liu Yuan Tang Shunan Qi Bo Chen Yexiong Li Nianzeng Xing Ningning Lu | 2024 | Chronic Diseases and Translational Medicine2024，10，1： | 0 |
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