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| 1 | Genome resequencing and transcriptome profiling reveal structural diversity and expression patterns of constitutive disease resistance genes in Huanglongbing-tolerant Poncirus trifoliata and its hybrids显示文摘Huanglongbing(HLB)is the most destructive bacterial disease of citrus worldwide.While most citrus varieties are susceptible to HLB,Poncirus trifoliata,a close relative of Citrus,and some of its hybrids with Citrus are tolerant to HLB.No specific HLB tolerance genes have been identified in P.trifoliata but recent studies have shown that constitutive disease resistance(CDR)genes were expressed at much higher levels in HLB-tolerant Poncirus hybrids and the expression of CDR genes was modulated by Candidatus Liberibacter asiaticus(CLas),the pathogen of HLB.The current study was undertaken to mine and characterize the CDR gene family in Citrus and Poncirus and to understand its association with HLB tolerance in Poncirus.We identified 17 CDR genes in two citrus genomes,deduced their structures,and investigated their phylogenetic relationships.We revealed that the expansion of the CDR family in Citrus seems to be due to segmental and tandem duplication events.Through genome resequencing and transcriptome sequencing,we identified eight CDR genes in the Poncirus genome(PtCDR1-PtCDR8).The number of SNPs was the highest in PtCDR2 and the lowest in PtCDR7.Most of the deletion and insertion events were observed in the UTR regions of Citrus and Poncirus CDR genes.PtCDR2 and PtCDR8 were in abundance in the leaf transcriptomes of two HLB-tolerant Poncirus genotypes and were also upregulated in HLB-tolerant,Poncirus hybrids as revealed by real-time PCR analysis.These two CDR genes seem to be good candidate genes for future studies of their role in citrus-CLas interactions. | Nidhi Rawat Brajendra Kumar Ute Albrecht Dongliang Du Ming Huang Qibin Yu Yi Zhang Yong-Ping Duan Kim D Bowman Fred G Gmitter Jr Zhanao Deng | 2017 | Horticulture Research2017，4，1： | 5 |
| 2 | Hypertrophic adenoids in patients with nasopharyngeal carcinoma:appearance at magnetic resonance imaging before and after treatment显示文摘Introduction:Patients with nasopharyngeal carcinoma(NPC) sporadically develop abnormal adenoids.Nasopharyngeal adenoids are usually included in the gross tumor volume(GTV) but may have different therapeutic responses than tumor tissue.Therefore,distinguishing adenoids from tumor tissue may be required for precise and efficient chemoradiotherapy and radiotherapy.We characterized nasopharyngeal adenoids and investigated the therapeutic responses of NPC and nasopharyngeal adenoids using magnetic resonance imaging(MRI).Methods:MRI data from 40 NPC patients with a coexisting adenoid mass before and after treatment were analyzed.The features of the adenoid masses,including location,striped appearance,size,interface,symmetry/asymmetry,and cysts,were evaluated.Treatment response were scored according to the World Health Organization guidelines.Results:A striped appearance was observed in 36 cases before treatment and in all cases after treatment.In these 36 cases,the average GTVs including and excluding the uninvolved adenoids were 19.8 cm^3 and 14.8 cm^3,respectively.The average percentage change after excluding the uninvolved adenoids from the GTV was 31.0%.Stable disease in the adenoids was identified in 27(96.4%) of 28 patients after neoadjuvant chemotherapy,while NPC clearly regressed.Partial adenoid responses were identified in 33(82.5%) of 40 patients at 3 months after chemoradiotherapy or radiotherapy,whereas complete tumor responses were achieved in all patients.Six months after treatment,the adenoids continued to atrophy but did not disappear,and tumor recurrence was not found.Conclusions:Nasopharyngeal adenoids and carcinoma tissue in NPC patients can be distinguished by using MRI and have different responses to chemoradiotherapy and radiotherapy.These findings contribute to better delineating the GTV of NPC,based on which spatially optimized strategies can be developed to render precise and efficient chemoradiotherapy and radiotherapy.Additionally,we observed a clear difference in the responses of these two tissue types to current therapies.This finding may reduce or avoid unnecessary biopsies or overtreatment. | Yao-Pan Wu Pei-Qiang Cai Li Tian Jie-Hua Xu Richard Alan Mitteer Jr Yi Fan Zhenfeng Zhang | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 3 | Paracrine effects of hepatocyte growth factor/scatter factor on non-small-cell lung carcinoma cell lines显示文摘 | Yi S Chen JR Viallet J | 1998 | Br J Cancer1998，77，12： | 1 |
| 4 | Controlling potassium channel activities: Interplay between the membrane and intracellular factors 显示文摘 | Yi BA Minor DL Jr Lin YF | 2001 | Proc Natl Acad Sci USA2001，98，11： | 1 |
| 5 | Classifying Software Changes: Clean or Buggy?显示文摘 | Kim Sunghun Whitehead Jr E James Zhang Yi | 2008 | IEEE Transactions on Software Engineering2008，，2： | 1 |
| 6 | Detection in human sera of IgG,IgM and IgA to excreted/secreted antigens from Toxoplasma gondii by use of dot-ELISA and immunoblot assay显示文摘 | Yamamoto YI Mineo JR Meneghisse CS | 1998 | Ann Trop Med Parasitol1998，92，： | 1 |
| 7 | Total ginsenosides of Radix Ginseng modulates tricarboxylic acid cycle protein expression to enhance cardiac energy metabolism in ischemic rat heart tissues显示文摘 | Wang JR Zhou H Yi XQ | 2012 | Molecules2012，17，12： | 1 |
| 8 | Chemokine CXCL16 expression suppresses migration and invasiveness and induces apoptosis in breast cancer cells显示文摘 | Fang Y Henderson FC Jr Yi Q Lei Q U Y Chen N | 2014 | Mediators InjZamm2014，2014，47： | 1 |
| 9 | Developing Data Management Services at the Johns Hopkins University显示文摘 | Yi Shen Virgil E Varvel Jr | 2013 | Journal of aca- demic librarianship2013，，6： | 1 |
| 10 | Antioxidant activities of a new lignan and a neolignan from Saururus chinensis显示文摘 | Baek YI Kim JR | 2004 | Bioorg & Med Chem Lett2004，14，： | 1 |
| 11 | A hash trie filter method for approximate string matching in genomic databases 显示文摘 | Chang YI Chen JR Hsu MT | 2010 | Applied Intelligence2010，33，1： | 1 |
| 12 | Failure responses of a dental porcelain having three surface treatments under three stressing conditions显示文摘 | YI Y J Kelly JR | 2011 | DentMater2011，27，12： | 1 |
| 13 | Detection in human sera of IgG, IgM and IgA to excreted/secreted antigens from Toxoplasma gondii by use of dot-ELISA and immunoblot assay 显示文摘 | Yamamoto YI Mineo JR Meneghisse CS | 1998 | AnnTrop Med Parasitol1998，92，1： | 1 |
| 14 | Interleukin and the mesangial cell显示文摘 | Sedor JR Nakzato YI Kowski Mk | 1992 | Kidney Int1992，41，： | 1 |
| 15 | Effect of tea polyphenols on microbiological and biochemical quality of Collichthys fish ball显示文摘 | Yi SM Li JR Zhu JL | | Journal of the Science of Food and Agriculture0，，9： | 1 |
| 16 | Plasma membrane and mitochondrial transport of hepatic reduced glutathione显示文摘 | Fernandez-Checa JC Yi JR Garcia Ruiz C | | 0，，02： | 1 |
| 17 | Interleukin and the mesangial cell 显示文摘 | Sedor JR Nakzato YI Kowski Mk | 1992 | Kidney Int1992，41，： | 1 |
| 18 | Plasma membrane and mitoehondrial transport of hepatic reduced glutathione 显示文摘 | Fernandez - Checa JC Yi JR Garcia Ruiz C | 1996 | Semin Liv Dis1996，16，： | 1 |
| 19 | Effect of occlusal contact size on inter- facial stresses and failure of a bonded ceramic: FEAand monotonic loading analyses显示文摘 | Yi YJ Kelly JR | 2008 | Dent Mater2008，24，3： | 1 |
| 20 | Transforming Growth Factor- 1 Expression and Myofibroblast Formation During Arterial Repair显示文摘 | O′Brien JE Jr Fard A | 1996 | Arteriosclero Thromb Vasc Biol1996，16，10： | 1 |
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