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| 1 | The first all-season sample set for mapping global land cover with Landsat-8 data显示文摘We report the world's first all-season training and validation sample sets for global land cover classification with Landsat-8 data.Prior to this,such samples were only available at a single date primarily from the growing season.It is unknown how much limitation such a single-date sample has to mapping global land cover in other seasons of the year.To answer this question,we selected available Landsat-8 images from four seasons and collected training and validation samples from them.We compared the performances of training samples in different seasons using Random Forest algorithm.We found that the use of training samples from any individual season would result in the best overall classification accuracy when validated by samples in the same season.The global overall accuracy from combined best seasonal results was 67.2% when classifying the 11 Level-1 classes in the Finer Resolution Observation and Monitoring of Global Land Cover(FROM-GLC) classification system.The use of training samples from all seasons(named all-season training sample set hereafter) produced an overall accuracy of 67.0%.We also tested classification within 10° latitude 60° longitude zones using all-season training subsample within each zone and obtained an overall accuracy of 70.2%.This indicates that properly grouped subsamples in space can help improve classification accuracies.All the results in this study seem to suggest that it is possible to use an all-season training sample set to reach global optimality with universal applicability in classifying images acquired at any time of a year for global land cover mapping. | Congcong Li Peng Gong Jie Wang Zhiliang Zhu Gregory S. Biging Cui Yuan Tengyun Hu Haiying Zhang Qi Wang Xuecao Li Xiaoxuan Liu Yidi Xu Jing Guo Caixia Liu Kwame O. Hackman Meinan Zhang Yuqi Cheng Le Yu Jun Yang Huabing Huang Nicholas Clinton | 2017 | Science Bulletin2017，62，7： | 21 |
| 2 | One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs显示文摘CRISPR/Cas9 系统是一个有效编辑基因的方法,但是编辑基因的动物的多数显示出 mosaicism,与编辑仅仅在房间的部分发生。这里,我们证明那单个基因或多重基因能被 Cas9 mRNA 和多重邻近的单个指南的 RNA 的 zygotic 注射完全在老鼠和猴子胚胎击倒(spaced 10-200 bp 分开) 指向仅仅一把单个钥匙每基因的 exon。个别地在 Y 染色体上跟随八基因的指向的删除的 F0 老鼠的 Phenotypic 分析在产生猛烈老鼠表明了这条途径的坚韧性。重要地,这条途径在高效率交付完全的基因大美人(Arntl 上的 100% 并且 91% 在 Prrt2 上) 在猴子胚胎。最后,我们能在一个单个步骤产生一只完全的 Prrt2 猛烈猴子,表明在很快建立编辑基因的猴子模型的这条途径的实用性。 | Erwei Zuo Yi-Jun Cai Kui Li Yu Wei Bang-An Wang Yidi Sun Zhen Liu Jiwei Liu Xinde Hu Wei Wei Xiaona Huo Linyu Shi Cheng Tang Dan Liang Yan Wang Yan-Hong Nie Chen-Chen Zhang Xuan Yao Xing Wang Changyang Zhou Wenqin Ying Qifang Wang Ren-Chao Chen Qi Shen Guo-Liang Xu Jinsong Li Qiang Sun Zhi-Qi Xiong Hui Yang | 2017 | Cell Research2017，27，7： | 21 |
| 3 | Annual 30-m land use/land cover maps of China for 1980–2015 from the integration of AVHRR, MODIS and Landsat data using the BFAST algorithm显示文摘Annual land use land cover(LULC)change information at medium spatial resolution(i.e.at 30 m)is required in numerous subjects,such as biophysical modelling,land management and global change studies.Annual LULC information,however,is usually not available at continental or national scale due to reasons such as insufficient remote sensing data coverage or lack of computational capabilities.Here we integrate high temporal resolution and coarse spatial resolution satellite images(i.e.,Moderate Resolution Imaging Spectroradiometer(MODIS)and Global Inventory Modelling and Mapping Studies(GIMMS)normalized difference vegetation index(NDVI))with high spatial resolution datasets(China’s Land-Use/cover Datasets(CLUDs)derived from 30-meter Landsat TM/ETM+/OLI)to generate reliable annual nominal 30 m LULC maps for the whole of China between 1980 and 2015.We also test the performance of a statistical based change detection algorithm(Breaks for Additive Seasonal and Trend),originally designed for tracking forest change,in classifying all-type LULC change.As a result,a nominal 30 m annual land use/land cover datasets(CLUD-A)from 1980 to 2015 was developed for the whole China.The mapping results were assessed with a change sample dataset,a regional annual validation sample set and a three-year China sample set.Of the detected change years,75.61%matched the exact time of conversion within±1 year.Annual mapping results provided a detail process of urbanization,deforestation,afforestation,water and cropland dynamics over the past 36 years.The consistent characterization of land change dynamics for China can be further used in scientific research and to support land management for policy-makers. | Yidi XU Le YU Dailiang PENG Jiyao ZHAO Yuqi CHENG Xiaoxuan LIU Wei LI Ran MENG Xinliang XU Peng GONG | 2020 | Science China Earth Sciences2020，63，9： | 12 |
| 4 | Inlet Recirculation Influence to the Flow Structure of Centrifugal Impeller显示文摘Inlet recirculation is proved as an effective way for centrifugal compressor surge margin extension,and is successively used in some engineering applications.Unfortunately its working mechanism is still not being well understood,which leads to redesigning of inlet recirculation mostly by experience.Also,most study about inlet recirculation is steady to date.It is necessary to study surge margin extension mechanism about inlet recirculation.To expose the mechanism in detail,steady and unsteady numerical simulations were performed on a centrifugal compressor with and without inlet recirculation.The results showed that,with inlet recirculation,the inlet axial velocity is augmented,relative Mach number around blade tip leading edge area is significantly reduced and so is the flow angle.As the flow angle decreased,the incidence angle reduced which greatly improves the flow field inside the impeller.Moreover,inlet recirculation changes the blade loading around blade tip and restrains the flow separation on the blade suction side at the leading edge area.The unsteady results of static pressure around blade surface,entropy at inlet crossflow section and vorticity distributions at near tip span surface indicated that,at near stall condition,strong fluctuation exists in the vicinity of tip area due to the interaction between tip leakage flow and core flow.By inlet recirculation these strong flow fluctuations are eliminated so the flow stability is greatly enhanced.All these improvements mentioned above are the reason for inlet recirculation delays compressor stall.This research reveals the surge margin extension reason of inlet recirculation from an unsteady flow viewpoint and provides important reference for inlet recirculation structure design. | YANG Ce CHEN Shan LI Du YANG Changmao WANG Yidi | 2010 | Chinese Journal of Mechanical Engineering2010，23，5： | 10 |
| 5 | Analyzing Influencing Factors of Rural Poverty in Typical Poverty Areas of Hainan Province: A Case Study of Lingao County显示文摘Rural poverty and poverty reduction are not only the focal issues that have attracted worldwide attention, but also the vital issues on people's livelihood that has attached great importance and aimed to be solved by the central and local governments of China. Based on the survey data of 354 farming households, this paper, taking the national poverty county of Lingao County, Hainan Province for an example, examined the characteristics of rural poverty of the county. Moreover, this paper established the spatial lag model(SLM) from five dimensions, namely, status of the household head, household structure, health status, income composition and traffic accessibility, to analyze the main influencing factors of rural poverty according to the values of Moran's I and the diagnosis of spatial dependence of the OLS model. It is found that the poor farming households gathered mainly in five towns in the north and southwest of the county, and the rural poverty have the characteristics of low educational level of the heads, more minor children, high population of farming peasants, high incidence of disease and low proportion of household wage-equivalent income. The results also showed that the variables such as the number of minor children, the number of migrant worker, the number of farming peasants and the proportion of wage-equivalent income have significant effectiveness on rural poverty, while the status of the household head, health status and traffic accessibility have little influence. It is an important way to realize the goal of poverty alleviation by controlling the number of farmers' fertility, strengthening the vocational skills training of farmers, vigorously developing specialization and large-scale agriculture and increasing the employment opportunities of farmers. | ZHANG Jinping ZUO Feng ZHOU Yanmei ZHAI Mengxiao MEI Lin FU Yidi CHENG Yeqing | 2018 | Chinese Geographical Science2018，28，6： | 7 |
| 6 | High-energy cathode materials for Li-ion batteries: A review of recent developments显示文摘Lithium ion batteries(LIBs) represent one of the most promising solutions for environmentally friendly transportation such as electric vehicles. The demand for high energy density, low cost and environmentally friendly batteries makes high-capacity cathode materials very attractive for future LIBs. Layered Li NixCoyMnzO2(x+y+z=1), Li-rich oxides and Li-V-O compounds have attracted much attention due to their high capacities in recent years. In this review, we focus on the state-of-the-art research activities related to Li NixCoyMnzO2, Li-rich oxides and Li-V-O compounds, including their structures, reaction mechanisms during cycling, challenges and strategies that have been studied to improve their electrochemical performances. | ZHANG YiDi LI Yi XIA XinHui WANG XiuLi GU ChangDong TU JiangPing | 2015 | Science China(Technological Sciences)2015，58，11： | 7 |
| 7 | Quality control of Semen Ziziphi Spinosae standard decoction based on determination of multi-components using TOF-MS/MS and UPLC-PDA technology显示文摘A sensitive,fast and comprehensive method for the quality assessment of Semen Ziziphi Spinosae(SZS)standard decoction with characterization of its chemical components was developed and validated.UPLC-Q/TOF-MS/MS system was used to identify thirty-six chemical components of SZS standard decoction which included nucleosides,phenolic acids,alkaloids,and flavonoids.Furthermore,a UPLC-PDA method was validated to simultaneously determine adenosine,protocatechuic acid,magnoflorine,catechin,protocatechin,vicenin II,spinosin,kaempferol-3-rutinoside,and 6'''-feruloylspinosin which represent four species of characteristic compounds.The qualitative method had been validated according to Chinese Pharmacopoeia(2015 edition)in terms of lineary,repeatability,recovery and stability for all analytes,with the results showing good precision,accuracy and stability.In conclusion,the method using UPLC combined with MS and PDA provided a novel way for the standardization and identification of SZS standard decoction,and also offered a basis for qualitative analysis and quality assessment of the preparations for SZS standard decoction. | Di Wang Qing Li Ran Liu Huarong Xu Yidi Yin Yifan Wang Huijia Wang Kaishun Bi | 2019 | Journal of Pharmaceutical Analysis2019，9，6： | 6 |
| 8 | Immunotherapy of Epstein-Barr Virus Associated Malignancies Using Mycobacterial HSP70 and LMP2A356-364 Epitope Fusion Protein显示文摘Epstein-Barr virus infection is strongly associated with a number of malignancies.The EBV latent membrane protein 2A has been implicated as one of the most attractive candidates for immunotherapy of related malignancies.In previous studies,the T cell epitopes of LMP2A have been identified systematically.However,the epitope-based vaccine generally meets inefficient immunogenicity when used in vivo directly,which could be overcome by combination with appropriate adjuvants.Heat shock protein is a natural chaperon,which is able to activate the classical major histocompatibility complex class I antigen-processing pathway(cross-presentation).In this study,a minigene encoding LMP2A356-364(FLYALALLL)was genetically fused to the carboxy-terminal of mycobacterial heat shock protein 70.The epitope fusion protein was expressed and purified,and the cross-presentation of LMP2A_(356-364) by monocyte-derived dendritic cells pulsed with the epitope fusion protein was evaluated.Results showed that the epitope fusion protein-pulsed mDCs were much more efficient than the single peptide-pulsed mDCs on CTL activation.Immunization of HLA-A2.1 transgenic mice with MtHsp70-LMP2A_(356-364) generated peptide specific CTL more effectively than a single peptide plus incomplete Freund's adjuvant(IFA).Growth of LMP2A expressing B16 melanoma tumor cells was suppressed in the vaccinated groups.Our results suggested that MtHsp70-LMP2A_(356-364) fusion protein was more effective than the CD8^(+)T cell epitope alone on anti-tumor immunity.As a result,the MtHsp70-LMP2A_(356-364) fusion protein is considered to be a promising candidate vaccine for EBV related malignancies. | Genyan Liu Kun Yao Bing Wang Yun Chen Feng Zhou Yidi Guo Jian Xu Hongzhen Shi | 2009 | Cellular & Molecular Immunology2009，6，6： | 6 |
| 9 | Highly efficient base editing in human tripronuclear zygotes显示文摘 | Changyang Zhou Meiling Zhang Yu Wei Yidi Sun Yun Sun Hong Pan Ning Yao Wanxia Zhong Yixue Li Weiping Li3 Hui Yang Zi-jiang Chen | 2017 | Protein & Cell2017，8，10： | 6 |
| 10 | Simultaneously Regulating Uniform Zn^(2+) Flux and Electron Conduction by MOF/rGO Interlayers for High‑Performance Zn Anodes显示文摘Owing to the merits of low cost,high safety and environmental benignity,rechargeable aqueous Zn-based batteries(ZBs)have gained tremendous attention in recent years.Nevertheless,the poor reversibility of Zn anodes that originates from dendrite growth,surface passivation and corrosion,severely hinders the further development of ZBs.To tackle these issues,here we report a Janus separator based on a Zn-ion conductive metal-organic framework(MOF)and reduced graphene oxide(rGO),which is able to regulate uniform Zn2+flux and electron conduction simultaneously during battery operation.Facilitated by the MOF/rGO bifunctional interlayers,the Zn anodes demonstrate stable plating/stripping behavior(over 500 h at 1 mA cm^(−2)),high Coulombic efficiency(99.2%at 2 mA cm^(−2) after 100 cycles)and reduced redox barrier.Moreover,it is also found that the Zn corrosion can be effectively retarded through diminishing the potential discrepancy on Zn surface.Such a separator engineering also saliently promotes the overall performance of Zn|MnO2 full cells,which deliver nearly 100%capacity retention after 2000 cycles at 4 A g^(−1) and high power density over 10 kW kg^(−1).This work provides a feasible route to the high-performance Zn anodes for ZBs. | Ziqi Wang Liubing Dong Weiyuan Huang Hao Jia Qinghe Zhao Yidi Wang Bin Fei Feng Pan | 2021 | Nano-Micro Letters2021，13，5： | 3 |
| 11 | Robust minimum-variance time-reversal beamforming for target detection and localization in uncertain environment显示文摘在有颠倒( TR )技术是 investigated.TR 的柔韧的时间的不明确的环境的目标察觉和本地化是物理进程以及信号 processing.Therefore 的一个方法,经由 TR 执行 beamforming 是自然的,即, TR beamforming ( TRBF ) .To 还原剂 TR 上的环境无常的效果时间空间的集中,播送 TRBF 与当模特儿而不是物理探查来源被学习,有斜装载的柔韧的最小变化的收到 TRBF 被放 forward. | RUAN Yidi PAN Xiang LI Jianlong GONG Xianyi | 2010 | Chinese Journal of Acoustics2010，29，1： | 3 |
| 12 | Rabies virus co-localizes with early(Rab5) and late(Rab7) endosomal proteins in neuronal and SH-SY5Y cells显示文摘Rabies virus(RABV) is a highly neurotropic virus that follows clathrin-mediated endocytosis and p H-dependent pathway for trafficking and invasion into endothelial cells. Early(Rab5, EEA1) and late(Rab7, LAMP1) endosomal proteins play critical roles in endosomal sorting, maturity and targeting various molecular cargoes, but their precise functions in the early stage of RABV neuronal infection remain elusive. In this study, the relationship between enigmatic entry of RABV with these endosomal proteins into neuronal and SH-SY5 Y cells was investigated.Immunofluorescence, TCID_(50) titers, electron microscopy and western blotting were carried out to determine the molecular interaction of the nucleoprotein(N) of RABV with early or late endosomal proteins in these cell lines. The expression of N was also determined by down-regulating Rab5 and Rab7 in both cell lines through RNA interference. The results were indicative that N proficiently colocalized with Rab5/EEA1 and Rab7/LAMP1 in both cell lines at 24 and 48 h post-infection, while N titers significantly decreased in early infection of RABV. Down-regulation of Rab5 and Rab7 did not inhibit N expression, but it prevented productive infection via blocking the normal trafficking of RABV in a low pH environment. Ultrathin sections of cells studied by electron microscope also verified the close association of RABV with Rab5 and Rab7 in neurons. From the data it was concluded that primary entry of RABV strongly correlates with the kinetics of Rab-proteins present on early and late vesicles, which provides helpful clues to explain the early events of RABV in nerve cells. | Waqas Ahmad Yingying Li Yidi Guo Xinyu Wang Ming Duan Zhenhong Guan Zengshan Liu Maolin Zhang | 2017 | Virologica Sinica2017，32，3： | 3 |
| 13 | RBCC引射模态发动机设计技术研究进展显示文摘RBCC发动机未来可实现地面自主水平起降、可重复使用等功能,具有潜在的低成本和高可靠性优势,因而成为天地往返推进系统备选方案之一。但引射模态发动机性能偏低,限制了RBCC发动机的应用,引射模态发动机性能亟需提升。针对多模态RBCC引射模态发动机性能偏低的问题,阐述了RBCC引射模态发动机基本气动热力过程。综述了引射模态推力增益、主次流相互作用以及二次燃烧组织等引射模态发动机关键技术的研究进展,并分析了RBCC引射模态发动机设计进一步的研究方向。 | 林彬彬 Yidi Tang 尚永锋 张恒铭 | 2020 | 飞航导弹2020，，2： | 2 |
| 14 | Ten years after Hurricane Katrina: monitoring recovery in New Orleans and the surrounding areas using remote sensing显示文摘Remote sensing data have been widely used in pre-hazard prevention/preparation, emergency response and post-hazard recovery monitoring. Hurricane Katrina caused serious damage to the environment, society and economy in the southern United States in 2005. On the 10 th anniversary of Hurricane Katrina, we monitored the recovery process in New Orleans and the surrounding area based on remote sensing. Results from multi-source remote sensing data indicated that the average vegetation conditions of the affected areas have not fully recovered compared with the pre-disaster conditions, especially in the hurricane's landfall area. Analysis from moderate resolution Landsat data showed that many civil engineering works have been undertaken in the city of New Orleans to prevent future disasters. Frequent observation using highresolution images recorded the progress of some of these civil construction projects(e.g. the 17 th Street Canal pumping station) in New Orleans. In this case study, we illustrated the capabilities of remote sensing techniques in recovery monitoring following a natural disaster. International/institutional cooperation is suggested to improve Earth observation capability in hazard monitoring. More Chinese Earth observation data are expected to be used in international monitoring. | Xuecao Li Le Yu Yidi Xu Jun Yang Peng Gong | 2016 | Science Bulletin2016，61，18： | 2 |
| 15 | Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos显示文摘Dear Editor,Newly discovered characteristics like'collateral effect'or trans-cleavage in CRISPR-Cas13 and CRISPR-Cas12 systems have enabled their usage in nucleic acid detection(Gootenberg et al.2017,2018;Chen et al.2018).The collateral RNA cleavage of Cas13a has been reported to be harmful for cell development(Wang et al.2019;Buchman et al.2020).As a representative gene editor of CRISPR-Cas12 system,CRISPR-Cas12a(Cpf1)holds great potential for therapeutic applications in the future(Zetsche et al.2015;Koo et al.2018;Campa et al.2019). | Yu Wei Yingsi Zhou Yajing Liu Wenqin Ying Ruiming Lv Qimeng Zhao Haibo Zhou Erwei Zuo Yidi Sun Hui Yang Changyang Zhou | 2021 | Protein & Cell2021，12，9： | 2 |
| 16 | Research on High Temperature and High Density White Oil Based Drilling Fluid and Its Application in Well 201H7-6显示文摘As the depth and horizontal length of shale gas development wells increase,the requirement for the temperature resistance and the ability of the drilling fluids to stabilize the shale formation becomes higher.A new type of high temperature and high density white oil based drilling fluid system has been developed in laboratory.Research shows that the drilling fluid system has good rheological property,low filtration loss,strong anti-debris pollution capability and good plugging performance at high temperature and high density.The system has been successfully applied in the 201H7-6 well.Application results show that the drilling fluid rheology,high temperature and high pressure fluid loss and demulsification voltage meet the field requirements.The drilling fluid performance is stable in drilling an 1800 m horizontal section,and no stuck or shale swelling and wellbore collapsing are induced.It is the first well drilled successfully with domestic white oil-based drilling fluid in Zigong Region.It also sets several new records including the deepest well,the shortest drilling cycle,and the fastest drilling speed in that region,which provides valuable experience for the future drilling activities. | Bobo Qin Yidi Wang Chunzhi Luo Gang Liu | 2019 | Open Journal of Yangtze Oil and Gas2019，4，3： | 2 |
| 17 | Generation of a Golden Leaf Triploid Poplar by Repressing the Expression of GLK Genes显示文摘Poplar trees are excellent varieties widely used for gardening and greening.However,their single color and floating fluffy seeds are major disadvantages.Plant species or varieties with variegated leaves are desperately needed to meet various demands for gardens,urban greening and landscape decoration,as they produce rich foliage colors that are aesthetically pleasing and functional.In this study,we generated a golden leaf triploid poplar(P.alba×P.berlinensis)by repressing the expression of GLK(Golden2-like)genes in leaves.The triploid golden leaf poplar had reduced chlorophyll content but almost no change in the growth rate.It has great potential in landscaping once it passes safety assessments. | Yidi Li Chenrui Gu Huixin Gang Yu Zheng Guifeng Liu Jing Jiang | 2021 | Forestry Research2021，1，1： | 1 |
| 18 | Effects of shape and particle size on the photocatalytic kinetics and mechanism of nano-CeO_(2)显示文摘Nanomaterials have been widely applied to many fields because of their excellent photocatalytic performance.The performance is closely related to the catalytic kinetics,but it is not completely clear about the influencing regularities of shape and particle size on the photocatalytic kinetics of nanomaterials and the photocatalytic kinetic mechanism.In this paper,nano-CeO_(2)with different shapes and particle sizes were prepared,the kinetic parameters of adsorption and photocatalytic degradation were determined,and the effects of shape and particle size on the kinetics of adsorption and photocatalysis and photocatalytic mechanism were discussed.The results show that the shape and particle size have significant influences.With the decreases of diameter,the performances of adsorption and photocatalysis of nano-CeO_(2)are improved;and these performances of spherical nano-CeO_(2)are greater than those of linear nano-CeO_(2).The shape and particle size have no effects on the kinetic order and mechanism of the whole photocatalytic process.Then a generalized mechanism of photocatalytic kinetics of nanomaterials was proposed and the mechanism rate equation was derived.Finally,the conclusion can be drawn:the desorption of photodegradation products is the control step of photocatalytic kinetics,and the kinetic order of photocatalytic degradation reaction is 1.The mechanism is universal and all nanomaterials have the same photocatalytic kinetic mechanism and order. | Zixiang Cui Lu Zhang Yongqiang Xue Ya’nan Feng Mengying Wang Jiaojiao Chen Boteng Ji Chenyu Wang Yidi Xue | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，12： | 1 |
| 19 | Disruption of splicing-regulatory elements using CRISPR/Cas9 to rescue spinal muscular atrophy in human iPSCs and mice显示文摘We here report a genome-editing strategy to correct spinal muscular atrophy(SMA).Rather than directly targeting the pathogenic exonic mutations,our strategy employed Cas9 and guide-sg RNA for the targeted disruption of intronic splicing-regulatory elements.We disrupted intronic splicing silencers(ISSs,including ISS-N1 and ISS+100)of survival motor neuron(SMN)2,a key modifier gene of SMA,to enhance exon 7 inclusion and full-length SMN expression in SMA iPSCs.Survival of splicing-corrected iPSC-derived motor neurons was rescued with SMN restoration.Furthermore,co-injection of Cas9 mRNA from Streptococcus pyogenes(SpCas9)or Cas9 from Staphylococcus aureus(SaCas9)alongside their corresponding sgRNAs targeting ISS-N1 into zygotes rescued 56%and 100%of severe SMA transgenic mice(Smn-/-,SMN2tg/-).The median survival of the resulting mice was extended to>400 days.Collectively,our study provides proof-of-principle for a new strategy to therapeutically intervene in SMA and other RNA-splicing-related diseases. | Jin-Jing Li Xiang Lin Cheng Tang Ying-Qian Lu Xinde Hu Erwei Zuo He Li Wenqin Ying Yidi Sun Lu-Lu Lai Hai-Zhu Chen Xin-Xin Guo Qi-Jie Zhang Shuang Wu Changyang Zhou Xiaowen Shen Qifang Wang Min-Ting Lin Li-Xiang Ma Ning Wang Adrian R.Krainer Linyu Shi Hui Yang Wan-Jin Chen | 2020 | National Science Review2020，7，1： | 1 |
| 20 | Kinase-substrate Edge Biomarkers Provide a More Accurate Prognostic Prediction in ER-negative Breast Cancer显示文摘The estrogen receptor(ER)-negative breast cancer subtype is aggressive with few treatment options available.To identify specific prognostic factors for ER-negative breast cancer,this study included 705,729 and 1034 breast invasive cancer patients from the Surveillance,Epidemiology,and End Results(SEER)and The Cancer Genome Atlas(TCGA)databases,respectively.To identify key differential kinase-substrate node and edge biomarkers between ER-negative and ERpositive breast cancer patients,we adopted a network-based method using correlation coefficients between molecular pairs in the kinase regulatory network.Integrated analysis of the clinical and molecular data revealed the significant prognostic power of kinase-substrate node and edge features for both subtypes of breast cancer.Two promising kinase-substrate edge features,CSNK1A1-NFATC3 and SRC-OCLN,were identified for more accurate prognostic prediction in ERnegative breast cancer patients. | Yidi Sun Chen Li Shichao Pang Qianlan Yao Luonan Chen Yixue Li Rong Zeng | 2020 | Genomics, Proteomics & Bioinformatics2020，18，5： | 1 |
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