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| 1 | miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor显示文摘Embryo implantation is a crucial step in mammalian reproduction.However,little is known regarding the physiological roles of microRNAs in the regulation of embryo implantation.Here we show that a minimum uterine expression of miR-181 is essential for the onset of embryo implantation.Both transient and prolonged transgenic expression of miR-181 led to impaired implantation,which can be rescued by exogenous administration of leukemia inhibitory factor(LIF).Mechanistically,miR-181 is able to directly target LIF and downregulate LIF expression,thereby inhibiting embryo implantation.We also show that miR-181 expression is regu-lated by the transcriptional factor Emx2,and the Emx2–miR-181 axis plays an importantrole in regulating embryo implantation.Taken together,these results reveal a novel function of miR-181 in embryo implantation through the regulation of LIF,and also indicate a potential link between miR-181 dysregulation and human embryo implantation defects. | Bo Chu Liangwen Zhong Shuang Dou Jun Wang Jianmin Li Mingwei Wang Qinghua Shi Yide Mei Mian Wu | 2015 | Journal of Molecular Cell Biology2015，7，1： | 5 |
| 2 | Catalytic oxidation in supercritical water 显示文摘 | Zhong Yiding Frisch Michael A Li Lixiong | 1996 | Ind Eng Chem Res1996，35，10： | 1 |
| 3 | LOW VELOCITY RESPONSE CHARACTERISTICS OF COMPOSITE PLATE WITH EMBEDDED SHAPE MEMORY ALLOY显示文摘This paper analyzes the characteristics of utilizing shape memory e?ect (SME) of shape memory alloy (SMA) in improving the low velocity impact resistance performance of com- posite plate by using ?nite element method. The constitutive relation for SMA hybrid composite plates is presented. The analytic model of ?nite element for SMA composite plate subjected to low velocity impact is established. The modi?ed Hertz’s contact law is used to determine the impact contact force. The computing procedures for solving the ?nite element equation using Newmark direct integration method are given. The numerical modelling results show that the SMA can e?ectively improve the low velocity impact resistance performance of composite plate. | Wu Yongdong Zhong Weifang Liang Yide | 2004 | Acta Mechanica Solida Sinica2004，17，3： | 1 |
| 4 | Nanomeshed Si nanomembranes显示文摘One of the main challenges in stretchable electronics is to achieve high-performance stretchable semiconductors. Here, weintroduce an innovative concept of nanomeshed semiconductor nanomembrane which can be regarded almost as intrinsicallystretchable to conventional microelectronic layouts. By making a silicon film into homogeneous nanomeshes with spring-like nanotraces, we demonstrated a high electron mobility of 50 cm^(2)/V·s, and moderate stretchability with a one-time strain of 25% andcyclic strain of 14% after stretching for 1000 cycles, further improvable with optimized nanomesh designs. A simple analytic modelcovering both fractional material and trace sidewall surfaces well predicted the transport properties of the normally on siliconnanomesh transistors, enabling future design and optimizations. Besides potential applications in stretchable electronics, thissemiconductor nanomesh concept provides a new platform for materials engineering and is expected to yield a new family ofstretchable inorganic materials having tunable electronic and optoelectronic properties with customized nanostructures. | Xun Han Kyung Jin Seo Yi Qiang Zeping Li Sandra Vinnikova Yiding Zhong Xuanyi Zhao Peijie Hao Shuodao Wang Hui Fang | 2019 | npj Flexible Electronics2019，3，1： | 0 |
| 5 | Phase-transforming mechanical metamaterials with dynamically controllable shape-locking performance显示文摘Active mechanical metamaterials with customizable structures and deformations,active reversible deformation,dynamically controllable shape-locking performance and stretchability are highly suitable for applications in soft robotics and flexible electronics,yet it is challenging to integrate them due to their mutual conflicts.Here,we introduce a class of phase-transforming mechanical metamaterials(PMMs)that integrate the above properties.Periodically arranging basic actuating units according to the designed pattern configuration a nd positional relationship,PMMs can customize complex and diverse structures and deformations.Liquid-vapor phase transformation provides active reversible large deformation while a silicone matrix offers stretchability.The contained carbonyl iron powder endows PMMs with dynamically controllable shape-locking performance,thereby achieving magnetically assisted shape locking and energy storing in different working modes.We build a theoretical model and finite element simulation to guide the design process of PMMs,so as to develop a variety of PMMs with different functions suitable for different applications,such as a programmed PMM,reconfigurable antenna,soft lens,soft mechanical memory,biomimetic hand,biomimetic flytrap and self-contained soft gripper.PMMs are applicable to achieve various 2D deformations and 2D-to-3D deformations,and integrate multiple properties,including customizable structures and deformations,active reversible deformation,rapid reversible shape locking,adjustable energy storing and stretchability,which could open a new application avenue in soft robotics and flexible electronics. | Yiding Zhong Wei Tang Huxiu Xu Kecheng Qin Dong Yan Xujun Fan Yang Qu Zhaoyang Li Zhongdong Jiao Huayong Yang Jun Zou | 2023 | National Science Review2023，10，9： | 0 |
| 6 | 去甲苔藓蒽噻吩抑制血管生成作用的体外实验研究(英文)显示文摘Objective:The aim of the study was to investigate the effect of Demethyl bryoanthrathiophene(DBT) on proliferations of human umbilical vein endothelial cells(HUVECs) and human lung adenocarcinoma cell line A549,and antiangiogenic effect of DBT on HUVECs in vitro.Methods:MTT assay was used to observe the effect of DBT on proliferations of HUVECs and A549 cells,flat plate scarification assay and tube formation in vitro test were used to observe the impact of DBT on migration and vaso-formed ability of HUVECs.The effects of DBT on apoptosis and cell cycle of HUVECs were calculated by flow cytometry.Results:MTT assay showed that treatment with DBT resulted in strong inhibition to the growth of HUVECs and A549 cells.The inhibition effects of DBT on HUVECs and A549 cells were related to dosage and times of dependency.In different doses of DBT(0.16,0.32 and 0.48 μmol/L) of flat plate scarification for 24 h,inhibition rates of DBT to migration of HUVECs were 14.70%,38.23% and 58.82%,respectively.In dose of DBT from 0.04,0.20 to 0.40 μmol/L for 24 h in tube formation,there were significance differences(P < 0.01) in the decreasing number of angiogenesis and incomplete blood vessel compared with control groups.All results showed that DBT promoted the apoptosis rate of HUVECs,and the increase of concentration of DBT accompanied the acceleration of apoptosis rate.Conclusion:DBT could inhibit the proliferations of HUVECs and A549 cells,and effectively suppress angiogenesis in vitro. | Chen Zhong Xiangdong Zhou Minghui Zhang Yide Hu | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，2： | 0 |
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