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| 1 | Circadian clock gene expression regulates cancer cell growth through glutaminase显示文摘夫酸安是为恶意的肿瘤房间的必要氨基酸。使夫酸安产生代射变化的 Glutaminase 到达肿瘤立即在最大的增长前评估的最大的 expressionin。肿瘤房间在日子期间以不同的率成长。我们 postulatedthat 在肿瘤房间的 glutaminase 的活动服从于生理节奏的钟基因的规定。我们测量了由在在六 equispaced 时间的肝和 tumorcells 的即时聚合酶链反应的西方的污点分析和生理节奏的钟基因表示削尖的 glutaminaseby 在一张 12/12 h 光 / 黑暗时间表的单个鼠标今日。结果显示出 thatthe 忍受肿瘤的鼠标,在正常下面日报条件,生理节奏地被乘火车,由正常主机 locomotoractivity 节奏和有韵律的肝钟基因表示思考了。在这些老鼠以内的肿瘤生理节奏地也被组织,由生理节奏的钟基因(Bmal1 ) 的 asreflected 表示。是很显著的的,是肾类型 glutaminase 也在一样的模式 withtumor 显示出生理节奏的节奏在肝癌症异种皮移植模型的生理节奏的钟基因表示,有条件地显示那禁止 glutaminaseactivity 可以为癌症提供一个新目标治疗。 | Aixia Huang Bingbo Bao H Rex Gaskins Haijun Liu Xueli Zhang Liwen Lu Shan Gao Yihai Shi Ming Zhang Yuanzhou Shan Jing Feng Guoxiang Yao | 2014 | Acta Biochimica et Biophysica Sinica2014，46，5： | 3 |
| 2 | Nuclear transfer using nonquiescent adult fibroblasts from a bovine ear显示文摘The natural reproduction of mammal is sexual reproduction, which needs fertilization involving sperm and oocyte. Nuclear transfer provided an asexual reproduction method for mammal. Donor cells used in previous experiments of nuclear transfer were mostly from undif-ferentiated or non-terminally differentiated cells, such as embryonic or fetal cells. However, since Wilmut et al. obtained a viable lamb by transfer of an adult sheep somatic cell into | Jilong Liu Minkang Wang Li Lian Jinsong Li Shaorong Gao Zhiming Han Qingyuan Sun Xiangfen Song Dongmei Zhang Yihai Li et al. | 1999 | Chinese Science Bulletin1999，44，21： | 2 |
| 3 | A facile and general method for synthesis of antibiotic-free protein-based hydrogel:Wound dressing for the eradication of drug-resistant bacteria and biofilms显示文摘Antibacterial protein hydrogels are receiving increasing attention in the aspect of bacteria-infected-wound healing. However, bacterial drug resistance and biofilm infections lead to hard healing of wounds, thus the construction of biological agents that can overcome these issues is essential. Here, a simple and universal method to construct antibiotic-free protein hydrogel with excellent biocompatibility and superior antibacterial activity against drug-resistant bacteria and biofilms was developed. The green industrial microbicide tetrakis (hydroxymethyl) phosphonium sulfate (THPS) as cross-linking agent can be quickly cross-linked with model protein bovine serum albumin (BSA) to form antibacterial hydrogel through simple mixing without any other initiators, subsequently promoting drug-resistance bacteria-infected wound healing. This simple gelatinization strategy allows at least ten different proteins to form hydrogels (e.g. BSA, human serum albumin (HSA), egg albumin, chymotrypsin, trypsin, lysozyme, transferrin, myohemoglobin, hemoglobin, and phycocyanin) under the same conditions, showing prominent universality. Furthermore, drug-resistance bacteria and biofilm could be efficiently destroyed by the representative BSA hydrogel (B-Hydrogel) with antibacterial activity, overcoming biofilm-induced bacterial resistance. The in vivo study demonstrated that the B-Hydrogel as wound dressing can promote reepithelization to accelerate the healing of methicillin-resistant staphylococcus aureus (MRSA)-infected skin wounds without inducing significant side-effect. This readily accessible antibiotic-free protein-based hydrogel not only opens an avenue to provide a facile, feasible and general gelation strategy, but also exhibits promising application in hospital and community MRSA disinfection and treatment. | Jiang Ouyang Qingyue Bu Na Tao Mingkai Chen Haijun Liu Jun Zhou Jinggong Liu Bo Deng Na Kong Xingcai Zhang Tianfeng Chen Yihai Cao Wei Tao | 2022 | Bioactive Materials2022，7，12： | 2 |
| 4 | Novel associations between rhizobial populations and legume species within the genera Lathyrus and Oxytropis grown in the temperate region of China显示文摘Fifty rhizobial isolates of Lathyrus and Oxytropis collected from northern regions of China were studied in their genotypic characterization based upon analyses of ARDRA, 16S-23S IGS PCR-RFLP, TP-RAPD, MLEE, sequences of 16S rDNA gene and housekeeping genes of atpD, recA and glnII. The results demonstrated that most of the Lathyrus rhizobia belonged to Rhizobium and most of the Oxytropis rhizobia belonged to Sinorhizobium. A novel group of Rhizobium sp. I and S. meliloti were identified as the main microsymbionts respectively associated with Lathyrus and Oxytropis species in the collection area, which were new associations between rhizobia and the mentioned hosts. This study also provides new evidence for biogeography of rhizobia. | SUI XinHua, HAN LiLi, WANG EnTao, JIANG Feng, LIU YiHai & CHEN WenXin State Key Laboratory for AgroBiotechnology, Key Laboratory of Agro-Microbial Resource and Application, Ministry of Agricul- ture/College of Biological Sciences, China Agricultural University, Beijing 100193, China | 2009 | Science China(Life Sciences)2009，52，2： | 2 |
| 5 | Synthesis,Conductivity and Photosensitivity of 2-D Conjugated Polymers of Metal-porphyrazine with Sulfur Bridges显示文摘Theporphyrazines(Pzs),i.e.tetraazaporphyrins(TAPs),andphthalocyanines(Pcs)andtheirpoly-mershavebeenreportedinmanypapers[1~13]... | Peng Zhenghe,\ Chen Xiaogui,\ Wang Zhengping,\ Wei Yihai,\ Qin Zibin College of Chemistry,Wuhan University, Wuhan 430072,China | 1998 | Wuhan University Journal of Natural Sciences1998，3，3： | 2 |
| 6 | Coupled fixed points for mixed monotone condensing operators and an existencetheorem of the solution for a class of functional equations arising in dynamic programming显示文摘 | MA Yihai | 1991 | J Math Anal Appl1991，160，： | 1 |
| 7 | Angiogenesis inhibited by drinking tea显示文摘 | Cao Renhai | 1999 | Nature1999，381，： | 1 |
| 8 | Bioactive phenolics from the fruits of Livistona chinensis显示文摘 | Xiaobin Zeng Yihai Wang Qian Qiu Chenguang Jiang Yuntiao Jing Guofu Qiu Xiangjiu He | 2011 | Fitoterapia2011，，1： | 1 |
| 9 | Quality of Service for Ad Hoc On -Demand Distance Vector Routing 显示文摘 | Zhang Yihai Gulhver T A | 2005 | IEEE Int''l Wireless and Mobile Computing Networking and Communications2005，3，2224： | 1 |
| 10 | Characterization of Newly Emerging Newcastle Disease Virus Isolates from the People's Republic of China and Taiwan 显示文摘 | Li Yu Zhiliang Wang Yihai Jiang | 2001 | J Clin Microbiol2001，39，10： | 1 |
| 11 | Synthesis of well-defined copper nanocubes by a one-pot solution process显示文摘 | Wang Yihai Chen Penglei Liu Minghua | 2006 | Nanotechnology2006，17，24： | 1 |
| 12 | Angiogenesis inhibited by drinking tea显示文摘 | Yihai Cao Renhai Cao | 1999 | Nature1999，398，： | 1 |
| 13 | Spinal cord repair in adult paraplegic rat:partial restoration of hind limb function显示文摘 | Cheng H Yihai D | 1996 | Science1996，273，5274： | 1 |
| 14 | Forty - year journey of an-giogenesis translational research 显示文摘 | Cao Yihai Arhiser J D Amato RJ | 2011 | Scie Translational Med2011，3，114： | 1 |
| 15 | Angiogenesis inhibited by drinking tea显示文摘 | YIHAI C RENHAI C | 1999 | Nature1999，398，： | 1 |
| 16 | Therapeutic potentials of angiostatin in the treatment of cancer显示文摘 | Cao Yihai | | 0，，07： | 1 |
| 17 | In vitro and in vivo antimammary tumor activities and mechanisms of the apple total triterpenoids显示文摘 | HE Xiangjiu WANG Yihai HU Hui | 2012 | Journal of Agricultural and Food Chemistry2012，60，37： | 1 |
| 18 | Characterization of Newly Emerging Newcastle Disease Virus Isolates from the People's Republic of China and Taiwan显示文摘 | Li Yu Zhiliang Wang Yihai Jiang | 2001 | Clin Microbiol2001，39，10： | 1 |
| 19 | Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis 显示文摘 | Cao Yihai | 2005 | Nat Rev Cancer2005，5，9： | 1 |
| 20 | Spinal cord repair in adult paraplegic rats:partial restoration of hind limb function显示文摘 | Cheng H Cao Yihai Olson L | 1996 | Science1996，273，7： | 1 |
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