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| 1 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 2 | TNF-α suppresses sweat gland differentiation of MSCs by reducing FTO-mediated m^6 A-demethylation of Nanog mRNA显示文摘An effect of inhibition of tumor necrosis factor-α(TNF-α)on differentiation of mesenchymal stromal cells(MSCs)has been demonstrated,but the exact mechanisms that govern MSCs differentiation remain to be further elucidated.Here,we show that TNF-αinhibits the differentiation of MSCs to sweat glands in a specific sweat gland-inducing environment,accompanied with reduced expression of Nanog,a core pluripotency factor.We elucidated that fat mass and obesity-associated protein(FTO)-mediated m^6 A demethylation is involved in the regulation of MSCs differentiation potential.Exposure of MSCs to TNF-αreduced expression of FTO,which demethylated Nanog m RNA.Reduced expression of FTO increased Nanog m RNA methylation,decreased Nanog m RNA and protein expression,and significantly inhibited MSCs capacity for differentiation to sweat gland cells.Our finding is the first to elucidate the functional importance of m^6 A modification in MSCs,providing new insights that the microenvironment can regulate the multipotency of MSCs at the post-transcriptional level.Moreover,to maintain differentiation capacity of MSCs by regulating m^6 A modification suggested a novel potential therapeutic target for stem cellmediated regenerative medicine. | Yihui Wang Rui Wang Bin Yao Tian Hu Zhao Li Yufan Liu Xiaoli Cui Liuhanghang Cheng Wei Song Sha Huang Xiaobing Fu | 2020 | Science China(Life Sciences)2020，63，1： | 9 |
| 3 | Electro-mechanically controlled assembly of reconfigurable 3D mesostructures and electronic devices based on dielectric elastomer platforms显示文摘The manufacture of 3D mesostructures is receiving rapidly increasing attention,because of the fundamental significance and practical applications across wide-ranging areas.The recently developed approach of buckling-guided assembly allows deterministic formation of complex 3D mesostructures in a broad set of functional materials;with feature sizes spanning nanoscale to centimeter-scale.Previous studies mostly exploited mechanically controlled assembly platforms using elastomer substrates;which limits the capabilities to achieve on-demand local assembly;and to reshape assembled mesostructures into distinct 3D configurations.This work introduces a set of design concepts and assembly strategies to utilize dielectric elastomer actuators as powerful platforms for the electro-mechanically controlled 3D assembly.Capabilities of sequential-local loading with desired strain distributions allow access to precisely tailored 3D mesostructures that can be reshaped into distinct geometries,as demonstrated by experimental and theoretical studies of?30 examples.A reconfigurable inductive-capacitive radio-frequency circuit consisting of morphable 3D capacitors serves as an application example. | Wenbo Pang Xu Cheng Haojie Zhao Xiaogang Guo Ziyao Ji Guorui Li Yiming Liang Zhaoguo Xue Honglie Song Fan Zhang Zheng Xu Lei Sang Wen Huang Tiefeng Li Yihui Zhang | 2020 | National Science Review2020，7，2： | 8 |
| 4 | Preparation of berberine hydrochloride long-circulating liposomes by ionophore A23187-mediated ZnSO_(4)gradient method显示文摘The aim of the study was to prepare berberine hydrochloride long-circulating liposomes and optimize the formulation and process parameters,and investigate the influence of different factors on the encapsulation efficiency.Berberine hydrochloride liposomes were prepared in response to a transmembrane ion gradient that was established by ionophore A23187.Free and liposomal drug were separated by cation exchange resin,and then the amount of intraliposomal berberine hydrochloride was determined by UV spectrophotometry.The optimized encapsulation efficiency of berberine hydrochloride liposomes was 94.3%2.1%when the drug-to-lipid ratio was 1:20,and the mean diameter was 146.9 nm3.2 nm.As a result,the ionophore A23187-mediated ZnSO_(4)gradient method was suitable for the preparation of berberine hydrochloride liposomes that we could get the desired encapsulation efficiency and drug loading. | Xiang Luo Jing Li Ligang Guo Xiaobo Cheng Ting Zhang Yihui Deng | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，4： | 5 |
| 5 | Redirecting differentiation of mammary progenitor cells by 3D bioprinted sweat gland microenvironment显示文摘Background:Mammary progenitor cells(MPCs)maintain their reproductive potency through life,and their specific microenvironments exert a deterministic control over these cells.MPCs provides one kind of ideal tools for studying engineered microenvironmental influence because of its accessibility and continually undergoes postnatal developmental changes.The aim of our study is to explore the critical role of the engineered sweat gland(SG)microenvironment in reprogramming MPCs into functional SG cells.Methods:We have utilized a three-dimensional(3D)SG microenvironment composed of gelatin-alginate hydrogels and components from mouse SG extracellular matrix(SG-ECM)proteins to reroute the differentiation of MPCs to study the functions of this microenvironment.MPCs were encapsulated into the artificial SG microenvironment and were printed into a 3D cell-laden construct.The expression of specific markers at the protein and gene levels was detected after cultured 14 days.Results:Compared with the control group,immunofluorescence and gene expression assay demonstrated that MPCs encapsulated in the bioprinted 3D-SG microenvironment could significantly express the functional marker of mouse SG,sodium/potassium channel protein ATP1a1,and tend to express the specific marker of luminal epithelial cells,keratin-8.When the Shh pathway is inhibited,the expression of SG-associated proteins in MPCs under the same induction environment is significantly reduced.Conclusions:Our evidence proved the ability of differentiated mouse MPCs to regenerate SG cells by engineered SG microenvironment in vitro and Shh pathway was found to be correlated with the changes in the differentiation.These results provide insights into regeneration of damaged SG by MPCs and the role of the engineered microenvironment in reprogramming cell fate. | Rui Wang Yihui Wang Bin Yao Tian Hu Zhao Li Yufan Liu Xiaoli Cui Liuhanghang Cheng Wei Song Sha Huang Xiaobing Fu | 2019 | Burns & Trauma2019，7，1： | 5 |
| 6 | The anticancer efficacy of pixantrone-loaded liposomes decorated with sialic acid-octadecylamine conjugate显示文摘 | Zhennan She Ting Zhang Xuling Wang Xuan Li Yanzhi Song Xiaobo Cheng Zhenjun Huang Yihui Deng | 2014 | Biomaterials2014，，： | 2 |
| 7 | Linkages of flow regime and micro-topography:prediction for non-native mangrove invasion under sea-level rise显示文摘Flow regime is a key driver of invasive aquatic organisms,and the invasiveness of mangrove species may be simultaneously attributed to plant traits and flowing hydrological conditions at the estuary scale.We focused on hydrological and topographic conditions for a non-native mangrove species,Sonneratia apetala,in Zhangjiang Estuary of Fujian,China.A hydrological model and a micro-topographic model were used to predict its dispersal and early establishment,and field surveys and simulated experiments were integrated to estimate its future dispersal patterns.The mesohaline mudflat with a salinity of 8~10 PSU at the mangrove seaward edge was the most likely colonization area for S.apetala under current conditions.The south-western region of the estuary with native mangroves was the most likely area for its colonization according to the unstructured-grid finite-volume community ocean model(FVCOM)in September,when the largest tidal currents within a year and the maximum fruit maturity period occur.Approximately 42%of the mudflats throughout the whole estuary may be available for seedling establishment under the future sea-level rise RCP 4.5 scenarios compared with 44%for current establishment;however,the RCP 8.5 scenarios would significantly decrease seedling establishment by 2100 due to serious tidal inundation according to the micro-topographical model. | Luzhen Chen Hongyu Feng Xiaoxuan Gu Ying Dong Peng Cheng Xudong Guo Qiulian Lin Ting Tang Yihui Zhang Xudong Zhu Shengchang Yang | 2020 | Ecosystem Health and Sustainability2020，6，1： | 1 |
| 8 | All‐Elastomeric, Strain‐Responsive Thermochromic Color Indicators显示文摘 | Cunjiang Yu Yihui Zhang Dongkai Cheng Xuetong Li Yonggang Huang John A. Rogers | 2014 | Small2014，，7： | 1 |
| 9 | Mechanics of ultra-stretchable self-similar serpentine interconnects显示文摘 | Yihui Zhang Haoran Fu Yewang Su Sheng Xu Huanyu Cheng Jonathan A. Fan Keh-Chih Hwang John A. Rogers Yonggang Huang | 2013 | Acta Materialia2013，，20： | 1 |
| 10 | Isometric exercise promotes arteriogenesis in rats after myocardial infarction显示文摘Isometric exercise(IE)is a promising intervention of noninvasive revascularization in patients with acute myocardial infarction(AMI).This study aimed to investigate the impact and mechanisms of IE training on arteriogenesis in AMI.Male Sprague-Dawley rats were randomly assigned into the sham-operation group(SO),myocardial infarction(MI)group,and 13 IE subgroups treated according to training intensity,frequency,duration,or monocyte chemoattractant protein-1(MCP-1),or/and fibroblast growth factor-2(FGF-2)inhibitors for eight weeks.Our results demonstrated that the IE group achieved superior improvement compared with the MI group in terms of left ventricular ejection fraction(LVEF),myocardial infarction size(MIS),arterial density(AD),monocytes(MNCs),smooth muscle cells(SMCs),endothelial cells(ECs),relative collateral blood flow(RCBF),MCP-1,and FGF-2 at the endpoint.Positive correlations between MCP-1 and MNCs,MNCs and FGF-2,FGF-2 and SMCs,SMCs and AD,as well as AD and RCBF were observed.This study demonstrated that with MI of 100%load 20 times daily for eight weeks,the arteriogenesis was improved,which may be attributed to the recruitment of MNCs and SMCs in remote ischemic myocardium caused by increases in MCP-1 and FGF-2 expression. | Xintong Zhang Yu Zheng Canru Geng Juntao Guan Lu Wang Xiu Zhang Yihui Cheng Jian'an Li Xiao Lu | 2021 | The Journal of Biomedical Research2021，35，6： | 0 |
| 11 | The Warm Arctic-Cold Eurasia Pattern and Its Key Region in Winter in CMIP6 Model Simulations显示文摘An enhanced Warm Arctic-Cold Eurasia(WACE)pattern has been a notable feature in recent winters of the Northern Hemisphere.However,divergent results between model and observational studies of the WACE still remain.This study evaluates the performance of 39 climate models participating in the Coupled Model Intercomparison Project Phase 6(CMIP6)in simulating the WACE pattern in winter of 1980-2014 and explores the key factors causing the differences in the simulation capability among the models.The results show that the multimodel ensemble(MME)can better simulate the spatial distribution of the WACE pattern than most single models.Models that can/cannot simulate both the climatology and the standard deviation of the Eurasian winter surface air temperature well,especially the latter,usually can/cannot simulate the WACE pattern well.This mainly results from the different abilities of the models to simulate the range and intensity of the warm anomaly in the Barents Sea-Kara seas(BKS)region.Further analysis shows that a good performance of the models in the BKS area is usually related to their ability to simulate location and persistence of Ural blocking(UB),which can transport heat to the BKS region,causing the warm Arctic,and strengthen the westerly trough downstream,cooling central Eurasia.Therefore,simulation of UB is key and significantly affects the model’s performance in simulating the WACE. | Liang ZHAO Yunwen LIU Yihui DING Qingquan LI Wei DONG Xinyong SHEN Wei CHENG Haoxin YAO Ziniu XIAO | 2023 | Advances in Atmospheric Sciences2023，40，12： | 0 |
| 12 | Development of Alternative to Animal Testing on Cosmetics by Middle-out Strategy显示文摘 | Shujun Cheng Yu Chen Yihui Ke Xiaoting Qu Yao Qin Jiating Xu | 2016 | China Detergent & Cosmetics2016，1，4： | 0 |
| 13 | Response of Freezing/Thawing Indexes to the Wetting Trend under Warming Climate Conditions over the Qinghai–Tibetan Plateau during 1961–2010:A Numerical Simulation显示文摘Since the 1990s,the Qinghai–Tibetan Plateau(QTP)has experienced a strikingly warming and wetter climate that alters the thermal and hydrological properties of frozen ground.A positive correlation between the warming and thermal degradation in permafrost or seasonally frozen ground(SFG)has long been recognized.Still,a predictive relationship between historical wetting under warming climate conditions and frozen ground has not yet been well demonstrated,despite the expectation that it will become even more important because precipitation over the QTP has been projected to increase continuously in the near future.This study investigates the response of the thermal regime to historical wetting in both permafrost and SFG areas and examines their relationships separately using the Community Land Surface Model version 4.5.Results show that wetting before the 1990s across the QTP mainly cooled the permafrost body in the arid and semiarid zones,with significant correlation coefficients of 0.60 and 0.48,respectively.Precipitation increased continually at the rate of 6.16 mm decade–1 in the arid zone after the 1990s but had a contrasting warming effect on permafrost through a significant shortening of the thawing duration within the active layer.However,diminished rainfall in the humid zone after the 1990s also significantly extended the thawing duration of SFG.The relationship between the ground thawing index and precipitation was significantly negatively correlated(−0.75).The dual effects of wetting on the thermal dynamics of the QTP are becoming critical because of the projected increases in future precipitation. | Xuewei FANG Zhi LI Chen CHENG Klaus FRAEDRICH Anqi WANG Yihui CHEN Yige XU Shihua LYU | 2023 | Advances in Atmospheric Sciences2023，40，2： | 0 |
| 14 | Bioinspired 3D flexible devices and functional systems显示文摘Flexible devices and functional systems with elaborated three-dimensional(3D)architectures can endow better mechanical/electrical performances,more design freedom,and unique functionalities,when compared to their two-dimensional(2D)counterparts.Such 3D flexible devices/systems are rapidly evolving in three primary directions,including the miniaturization,the increasingly merged physical/artificial intelligence and the enhanced adaptability and capabilities of heterogeneous integration.Intractable challenges exist in this emerging research area,such as relatively poor controllability in the locomotion of soft robotic systems,mismatch of bioelectronic interfaces,and signal coupling in multi-parameter sensing.By virtue of long-time-optimized materials,structures and processes,natural organisms provide rich sources of inspiration to address these challenges,enabling the design and manufacture of many bioinspired 3D flexible devices/systems.In this Review,we focus on bioinspired 3D flexible devices and functional systems,and summarize their representative design concepts,manufacturing methods,principles of structure-function relationship and broad-ranging applications.Discussions on existing challenges,potential solutions and future opportunities are also provided to usher in further research efforts toward realizing bioinspired 3D flexible devices/systems with precisely programmed shapes,enhanced mechanical/electrical performances,and high-level physical/artificial intelligence. | Xu Cheng Zhangming Shen Yihui Zhang | 2024 | National Science Review2024，11，3： | 0 |
| 15 | Textured Asymmetric Membrane Electrode Assemblies of Piezoelectric Phosphorene and Ti_(3)C_(2)T_(x)MXene Heterostructures for Enhanced Electrochemical Stability and Kinetics in LIBs显示文摘Black phosphorus with a superior theoretical capacity(2596 mAh g^(-1))and high conductivity is regarded as one of the powerful candidates for lithium-ion battery(LIB)anode materials,whereas the severe volume expansion and sluggish kinetics still impede its applications in LIBs.By contrast,the exfoliated two-dimensional phosphorene owns negligible volume variation,and its intrinsic piezoelectricity is considered to be beneficial to the Li-ion transfer kinetics,while its positive influence has not been discussed yet.Herein,a phosphorene/MXene heterostructure-textured nanopiezocomposite is proposed with even phosphorene distribution and enhanced piezo-electrochemical coupling as an applicable free-standing asymmetric membrane electrode beyond the skin effect for enhanced Li-ion storage.The experimental and simulation analysis reveals that the embedded phosphorene nanosheets not only provide abundant active sites for Li-ions,but also endow the nanocomposite with favorable piezoelectricity,thus promoting the Li-ion transfer kinetics by generating the piezoelectric field serving as an extra accelerator.By waltzing with the MXene framework,the optimized electrode exhibits enhanced kinetics and stability,achieving stable cycling performances for 1,000 cycles at 2 A g^(-1),and delivering a high reversible capacity of 524 m Ah g^(-1)at-20℃,indicating the positive influence of the structural merits of self-assembled nanopiezocomposites on promoting stability and kinetics. | Yihui Li Juan Xie Ruofei Wang Shugang Min Zewen Xu Yangjian Ding Pengcheng Su Xingmin Zhang Liyu Wei Jing‑Feng Li Zhaoqiang Chu Jingyu Sun Cheng Huang | 2024 | Nano-Micro Letters2024，16，4： | 0 |
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