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| 1 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 2 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 3 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 4 | Glycyrrhizic acid promotes sciatic nerves recovery in type 1 diabetic rats and protects Schwann cells from high glucose-induced cytotoxicity显示文摘The present study aims to investigate the therapeutic effect and mechanism of glycyrrhizic acid(GA)in diabetic peripheral neuropathy(DPN).GA significantly mitigated nerve conduction velocity(NCV)deficit and morphological abnormality and reduced high-mobility group box-1(HMGB1)expression in the sciatic nerves of diabetic rats independent of blood glucose and body weight.Notably,GA alleviated the increase of HMGB1 and the decrease of cell viability in high glucose-stimulated RSC96 cells.Furthermore,GA obviously reduced the concentration of inflammatory cytokines in the sciatic nerves of diabetic rats and supernatants of high glucose-exposed RSC96 cells,then restored the decreased expression levels of nerve growth factor(NGF)and neuritin-1,and the increased expression levels of cleaved caspase-3 and neuron-specific enolase.Additionally,GA markedly inhibited receptor for advanced glycation end products(RAGE)expression,p38MAPK phosphorylation,and the nuclear translocation of NF-κBp65 in diabetic rats and high glucose-exposed RSC96 cells.The promotional effect of high glucose in RSC96 cells was diminished following Hmgb1 siRNA treatment.Our findings indicate that GA may exert neuroprotection on DPN by suppressing HMGB1,which lead to extenuation of inflammation response,balance of NGF,neuritin-1 and caspase-3,as well as inactivation of RAGE/p38MAPK/NF-κBp65 signaling pathway. | Min Shi Xiangcheng Zhang Ridong Zhang Hong Zhang Dalong Zhu Xiao Han | 2022 | The Journal of Biomedical Research2022，36，3： | 5 |
| 5 | Role of Fas-Associated Death Domain-containing Protein (FADD) Phosphorylation in Regulating Glucose Homeostasis: from Proteomic Discovery to Physiological Validation显示文摘 | Chun Yao Hongqin Zhuang Pan Du Wei Cheng Bingya Yang Shengwen Guan Yun Hu Dalong Zhu Miller Christine Lv Shi Zi-Chun Hua | 2013 | Molecular & Cellular Proteomics2013，，10： | 1 |
| 6 | Biphasic Insulin as2part 30 three times daily Is more effective than a twice2daily regi2men, without Increasing hypoglycemia, in chinese subjects withtype 2 diabetes Inadequately controlled on oral antidiabetes drugs显示文摘 | Wenying Yang Qiuhe J i Dalong Zhu | 2008 | Diabetes Care2008，31，1： | 1 |
| 7 | Biphasic Insulin aspart 30 three times daily Is more effective than a twice-daily regimen, without Increasing hypoglycemia, in chinese subjects with type 2 diabetes Inadequately controlled on oral antidiabetes drugs 显示文摘 | Wenying Yang Qiuhe Ji Dalong Zhu | 2008 | Diabetes Care2008，31，： | 1 |
| 8 | Prevalence of diabetes among menand women in China显示文摘 | Yang Wenying Lu Juming Weng Jianping Jia Weiping Ji Linong Xiao Jianzhong Shan Zhongyan Liu Jie Tian Ha- oming Ji Qiuhe Zhu Dalong Ge Jiapu Lin Lixiang Chen Li Guo Xiaohui Zhao Zhigang Li Qiang Zhou Zhiguang Shan Guangliang He Jiang | 2010 | N Engl J Med2010，362，： | 1 |
| 9 | Serum Lipids and Lipoproteins in Chinese Men and Women显示文摘 | Wenying Yang Jianzhong Xiao Zhaojun Yang Linong Ji Weiping Jia Jianping Weng Juming Lu Zhongyan Shan Jie Liu Haoming Tian Qiuhe Ji Dalong Zhu Jiapu Ge Lixiang Lin Li Chen Xiaohui Guo Zhigang Zhao Qiang Li Zhiguang Zhou Guangliang Shan Jiang He | 2012 | Circulation2012，，18： | 1 |
| 10 | Supplementation with yak (Bos grunniens) bone collagen hydrolysate altered the structure of gut microbiota and elevated short-chain fatty acid production in mice显示文摘In this study, yak bone collagen hydrolysate(YBCH)was produced by mixed proteases and provided to standard-diet mice at a different dose(low dose(LD), medium dose(MD), and high dose(HD))to investigate its effects on the composition of gut microbiota and short-chain fatty acids(SCFA)production. It was found that YBCH was mainly composed of small molecular peptides whose molecular weight below 2 000 Da. Notably, supplementation with different doses of YBCH could significantly downregulate the ratio of Firmicutes to Bacteroidetes in the fecal microbiota. At the family level, the Lachnospiraceae abundance was significantly reduced in the YBCH gavage groups(mean reduction ratio 41.7 %, 35.2%, and 36.4% for LD, MD, and HD group, respectively). The predicted functions of gut microbes in the MD group were significantly increased at “lipid metabolism” and “glycan biosynthesis and metabolism”. Moreover, the SCFA production in the YBCH groups was elevated. Especially, the concentration of acetic acid, propionic acid, and butyric acid in the MD group was separately increased 79.7%, 89.2%, and 78.8% than that in the NC group. These results indicated that YBCH might be applied in the development of functional food for intestinal microecological regulation. | Zitao Guo Dalong Yi Bo Hu Lingyu Zhu Ji Zhang Yuliang Yang Chunyu Liu Yi Shi Zhenghua Gu Yu Xin Huaigao Liu Liang Zhang | 2023 | Food Science and Human Wellness2023，12，5： | 1 |
| 11 | Biphasic Insulin aspart30 three times daily Ismore effective than a twice-daily reg-i men, without Increasing hypoglycemia, in chinese subjects with type 2 diabetes Inadequately conlrolled on oral antidiabetes drugs 显示文摘 | Wenying Yang Qiuhe Ji Dalong Zhu | 2008 | Diabetes Care2008，31，： | 1 |
| 12 | Biphasic insulin aspert 30 three times daily Is more effective than a twice-daily regimen,without Increasing hypoglycemia,in chinese subjects with type 2 diabetesInadequately controlled on oral antidiabetes drugs显示文摘 | Wenying Yang Qiuhe Ji Dalong Zhu | | 0，，05： | 1 |
| 13 | Biphasie insulin aspart 30 three times daily is more effective than a twicedaily regimen, without increasing hypoglycemia, in Chinese subjects with type 2 diabetes inadequately controlled on oral antidiabetes drugs显示文摘 | Wenying Yang Qiuhe Ji Dalong Zhu | 2008 | Diabetes Care2008，31，5： | 1 |
| 14 | Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury显示文摘Acute kidney injury(AKI)leads to unacceptably high mortality due to difficulties in timely intervention and less efficient renal delivery of therapeutic drugs.Here,a series of polyvinylpyrrolidone(PVP)-curcumin nanoparticles(PCurNP)are designed to meet the renal excretion threshold(~45 kDa),presenting a controllable delivery nanosystem for kidney targeting.Renal accumulation of the relatively small nanoparticles,^(89)Zr-PCurNP M10 with the diameter between 5 and 8 nm,is found to be 1.7 times and 1.8 times higher than the accumulation of^(89)Zr-PCurNP M29(20-50 nm)and M40(20-50 nm)as revealed by PET imaging.Furthermore,serum creatinine analysis,kidney tissues histology,and tubular injury scores revealed that PCurNP M10 efficiently treated cisplatin-induced AKI.Herein,PCurNP offers a novel and simple strategy for precise PET image-guided drug delivery of renal protective materials. | Hao Wei Dawei Jiang Bo Yu Dalong Ni Mengting Li Yin Long Paul A.Ellison Cerise M.Siamof Liang Cheng Todd E.Barnhart Hyung-Jun Im Faquan Yu Xiaoli Lan Xiaohua Zhu Qianjun He Weibo Cai | 2023 | Bioactive Materials2023，，1： | 0 |
| 15 | Atomic Physics—State-selective Single Electron Capture by O3d- Ions on He and H2显示文摘 | Zhu Xiaolong Ma Xinwen Zhang Shaofeng Feng Wentian Liu Huiping Qian Dongbin Zhang Daeheng Li Bin Wen Weiqiang Zhang Pengju Yan Shuncheng Wang Qian Guo Dalong | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 16 | Image of Electron Emission in p-He Collisions at Intermediate Energies显示文摘 | Feng Wentian Ma Xinwen Zhu Xiaolong Zhang Shaofeng Liu Huiping Li Bin Yan Shuncheng Zhang Ruitian Wang Qian Guo Dalong | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 17 | Electron Capture to Continuum of Transfer Ionization in 30 keV/u He2+ on Argon Collision显示文摘 | Zhang Ruitian Ma Xinwen Zhang Shaofen Zhu Xiaolong Feng Wentian Guo Dalong Li Bin Liu Huiping Wang Jianguo Yan Shuncheng Zhang Pengju Wang Qian | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 18 | 4-6 Measurement of the Ratio of C3+ and O4+ Ions Produced by ECR Source to Prepare a Laser Cooling Experiment at Storage Rings显示文摘The cooling of heavy ions can provide high-quality beams that are especially important for high-precisionexperimental nuclear and atomic physics. The laser cooling of relativistic C3+ ion beams at the experimental coolerstorage ring (CSRe) is being currently prepared at Institute of Modern Physics (IMP) in Lanzhou. An electroncyclotron resonance ion source (ECRIS) will be used to produce C3+ ion beams. Meanwhile, O4+ ions could alsobe produced due to residual gas because of the same mass-to-charge ratio. Therefore, both C3+ and O4+ ion beamswill be injected and circulate in a storage ring during the laser cooling experiment at the same time. A higher ratioof C3+ ions will lead to a better result for the laser cooling experiment. | Zhu Xiaolong Wen Weiqiang Ma Xinwen Li Jinyu Feng Wentian Zhang Ruitian Yan Shuncheng Guo Dalong Hai Bang Qian Dongbin Zhang Pengju Xu Shenyue Zhao Dongmei Yang Jie Zhang Dacheng Li Bin Gao Yong Huang Zhongkui Wang Hanbing | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 19 | 4-10 Classical-trajectory Monte Carlo method for the Investigation of the Dynamics of Ion-atom Collisions显示文摘The reaction microscope (COLTRIMS as well) is a novel technique for the investigation of the dynamics ofion-atoms collisions. Exploiting this technique, a large variety of kinematically complete experiments on electrontransfer and ionization have been performed. However, the understanding of these experimental results is farfrom satisfactory, especially for collision energy in the intermediate-energy range. The classical-trajectory MonteCarlo method (CTMC) proposed by Abrines and Percival[1] shed some light on the problem. This method has ademonstrated region of applicability in the intermediate-energy range. | Guo Dalong Ma Xinwen Zhang Shaofeng Zhu Xiaolong Feng Wentian Zhang Ruitian Gao Yong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 20 | 4-11 Nucleus-nucleus Interactions in Transfer Ionization of He2+ -He Collisions显示文摘The transfer ionization of atom by ion impact offers a very suitable test ground of quantum many-body problem[1],because the final state involves three particles (the projectile, the emitted electron and the recoil ion). The experimentaltechniques are available to perform kinematically complete measurements on these processes now.The experiment was performed using a reaction microscope at the Institute of Modern Physics, CAS[2]. Thedata was analyzed in terms of Dalitz spectrum which is presented in Fig. 1. In this figure, the Dalitz plot is | Feng Wentian Ma Xinwen Zhu Xiaolong Yan Shuncheng Zhang Ruitian Guo Dalong Gao Yong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
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