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| 1 | Numerical study of methane/air jet flame in vitiated co-flow using tabulated detailed chemistry显示文摘Two different combustion models,the autoignition(AI)model and flamelet/progress variable(FPV)model,have been applied to study the auto-ignition process of methane/air jet flame in vitiated co-flow.A priori study was conducted to test the validity of the two models.Results show that the different range of predicted reaction rates is mainly responsible for their different performances in large eddy simulation(LES)studies.In this paper,beta PDF was used to model the mixture fraction distribution,while two different shapes of PDF,delta function and beta function,were applied for the reaction progress.Compared to the FPV model,the AI model combined with beta function for reaction progress could capture the auto-ignition process and predict the exact lifted height.Also the results indicate that the variance of reaction progress plays an important role in predicting the flame lifted height. | HAN Chao ZHANG Pei YE TaoHong CHEN YiLiang | 2014 | Science China(Technological Sciences)2014，57，9： | 7 |
| 2 | Large eddy simulation of unconfined turbulent swirling flow显示文摘Large eddy simulations(LES) were performed to study the non-reacting flow fields of a Cambridge swirl burner. The dynamic Smagorinsky eddy viscosity model is used as the sub-grid scale turbulence model. Comparisons of experimental data show that the LES results are capable of predicting mean and root-mean-square velocity profiles. The LES results show that the annular swirling flow has a minor impact on the formation of the bluff-body recirculation zone. The vortex structures near the shear layers, visualized by the iso-surface of Q-criterion, display ring structures in non-swirling flow and helical structures in swirling flow near the burner exit. Spectral analysis was employed to predict the occurrence of flow oscillations induced by vortex shedding and precessing vortex core(PVC). In order to extract accurately the unsteady large-scale structures in swirling flow, a three-dimensional proper orthogonal decomposition(POD) method was developed to reconstruct turbulent fluctuating velocity fields. POD analysis reveals that flow fields contain co-existing helical and toroidal shaped coherent structures. The helical structure associated with the PVC is the most energetic dynamic flow structure. The latter toroidal structure associated with vortex shedding has lower energy content which indicates that it is a secondary structure. | ZHANG HongDa HAN Chao YE TaoHong ZHANG JiMin CHEN YiLiang | 2015 | Science China(Technological Sciences)2015，58，10： | 5 |
| 3 | Simulation of bluff body stabilized flows with hybrid RANS and PDF method显示文摘这研究的动机是由使用概率调查骚乱化学相互作用密度功能(PDF ) 方法。历久不渝的混合雷纳兹平均 Navier 司烧(RANS )/PDF 方法被用来模仿狂暴的非反应、反应的流动。联合波动速度频率作文 PDF 方程结合了雷纳兹平均密度,动量和精力方程被与有限体积(FV ) 相结合的拉格兰加恩·蒙蒂·卡洛(MC ) 方法在未组织的网孔上解决方法。稳定的非反应的流动回答的 axisymmetric 绝壁身体的模拟在这篇论文被介绍。再通行地区的计算长度在对试验性的数据的好同意。而且,有 jet-to-coflow 动量流动比率的增加的流动模式的重要变化很好被预言。另外,比较在联合 PDF 模型和二个不同雷纳兹压力模型之间被做。 | Minming Zhu Xingsi Han Haiwen Ge Yiliang Chen | 2007 | Acta Mechanica Sinica2007，23，3： | 4 |
| 4 | Study of the mechanisms of the flame propagation and stabilization in porous media显示文摘The CH4/air premixed gas combustion processes in porous media were numerically studied using the two-temperature reacting fluid model with dispersions and detailed chemical reaction mechanism GRI 3.0. The mechanisms of the propagation and stabilization of submerge flames and surface flames in porous media were illuminated distinctly by considering the magnitude of the terms in the two energy equations, analyzing the sensibility of flame propagation speed to flame location, heat exchange coefficient between gas and solid, thermal conductivity and radiative extinction coefficient of porous media. It was concluded that the propagation mechanism of a submerged flame is similar to that of a free flame with an additional preheat zone and that the surface-flame propagation mechanism in porous media is similar to that of a free flame with heat loss in reaction zone. | ZHAO PingHui YE TaoHong JIANG Hai CHEN YiLiang | 2008 | Science China(Technological Sciences)2008，51，7： | 3 |
| 5 | Numerical investigation on hydrogen production by CH_4-Rich combustion in an alumina foam显示文摘The two-phase volume-averaged model with the detailed chemistry reaction mechanism GRI 3.0 was adopted in the quasi-steady-state simulation of hydrogen production by CH4-rich filtration combustion in an alumina foam under fully developed conditions. The relations among the combustion wave velocity, the inlet gas velocity and the equivalence ratio were discussed, and their influences on the distributions of temperature and species in the alumina foam and on H2 yield, CH4 conversion, H2 selectivity and CO selectivity were analyzed in detail. The results show that the combustion wave velocity increases with the increase of equivalence ratio or inlet gas velocity. The H2 yield exceeded 50% with equivalence ratio between 2.0 and 3.0 and combustion wave velocity larger than 0.4 mm/s. The H2 selectivity exceeded 50% with equivalence ratio larger than 2.0 and CO selectivity exceeded 80% with equivalence ratio between 1.8 and 2.0 and combustion wave velocity larger than 0.4 mm/s. | ZHAO PingHui, YE TaoHong, ZHU MinMing, JIANG Hai & CHEN YiLiang Thermal Science & Energy Engineering Department, University of Science & Technology of China, Hefei 230027, China | 2009 | Science China(Technological Sciences)2009，52，10： | 3 |
| 6 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 7 | Continuum-based slip model and its validity for micro-channel flows显示文摘In this paper, the low Mach number he- lium and nitrogen flows in micro-channels are inves- tigated numerically with variations of inlet to outlet pressure ratios, aspect ratios, out pressures and fluid mediums by using different continuum-based slip models. Theoretical solutions based on perturbation expansions of the Navier-Stokes equations have been developed under different order slip conditions. The validity of slip models has been examined by the corresponding experiments and the DSMC method at different Knudsen numbers. Simulations have shown good predictions of the compressibility, rarefaction and thermal creep effects on micro-channel flows with the present slip models. The higher order slip models relatively decrease the rarefaction effects comparing with a first-order slip model. Both of the Knudsen number and the Reynolds number have been identified as key parameters, which govern the rarefaction effects and thermal creep effects, respec- tively. The present slip models have been also dem- onstrated to be appropriate for micro-channel nitro- gen flows with the Knudsen number less than 0.15, and the higher order slip conditions improve the Na- vier-Stokes predictions in the slip flow regime with Kn<0.08. However, the continuum-based slip models significantly under-predict the rarefaction effects in the transitional flow regime as the Knudsen number exceeds 0.2. | ZHANG Genxuan LIU Minghou ZHANG Xianfeng YE Taohong CHEN Yiliang WANG Lu | 2006 | Chinese Science Bulletin2006，51，9： | 3 |
| 8 | Effects of stable aqueous fullerene nanocrystal (nC_(60)) on Daphnia magna:Evaluation of hop frequency and accumulations under different conditions显示文摘We investigated the effects of environmental factors and properties of water-stable crystal fullerene (nC60) on the uptake of nC60 by Daphnia magna based on known accumulation in our laboratory.This study was performed for seven days using different environmental factors including temperature,pH,water hardness,concentration (density of particle),and particle size.Results demonstrated that body burden of C60 increased with time in all experiments.Body burden of C60 increased with increasing concentration and particle size,and uptake of particles >100 nm reached their maximums more quickly than those <100 nm.Under high hardness in aqueous systems with lower pH and high temperature,uptake was higher than those under opposite conditions.Uptake in all batch tests reached balance within five days.Both nC60 properties and environmental factors influenced uptake of nC60 by D.magna in an aqueous system.Additionally,environmental factors may have affected accumulation by changing nC60 properties,which are critical to understand the accumulation of fullerenes in aqueous systems. | Xianji Yao Yiliang He Bo Zhang Yongsheng Chen Joseph B. Hughes | 2011 | Journal of Environmental Sciences2011，23，2： | 2 |
| 9 | Calibration of a new very large eddy simulation(VLES)methodology for turbulent flow simulation显示文摘Following the idea of Speziale's Very Large Eddy Simulation(VLES) method,a new unified hybrid simulation approach was proposed which can change seamlessly from RANS(Reynolds-Averaged Navier-Stokes) to LES(Large Eddy Simulation) method depending on the numerical resolution.The model constants were calibrated in accordance with other hybrid methods.Besides being able to approach the two limits of RANS and LES,the new model also provides a proper VLES mode between the two limits,and thus can be used for a wide range of mesh resolutions.Also RANS simulation can be recovered near the wall which is similar to the Detached Eddy Simulation(DES) concept.This new methodology was implemented into Wilcox's k-ω model and applications were conducted for fully developed turbulent channel flow at Reτ = 395 and turbulent flow past a square cylinder at Re = 22000.Results were compared with LES predictions and other studies.The new method is found to be quite efficient in resolving large flow structures,and can predict satisfactory results on relative coarse mesh. | HAN XingSi YE TaoHong CHEN YiLiang | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，10： | 2 |
| 10 | Optimizing progress variable definition in flamelet-based dimension reduction in combustion显示文摘An automated method to optimize the definition of the progress variables in the flamelet-based dimension reduction is proposed.The performance of these optimized progress variables in coupling the flamelets and flow solver is presented.In the proposed method, the progress variables are defined according to the first two principal components(PCs) from the principal component analysis(PCA) or kernel-density-weighted PCA(KEDPCA) of a set of flamelets.These flamelets can then be mapped to these new progress variables instead of the mixture fraction/conventional progress variables.Thus,a new chemistry look-up table is constructed.A priori validation of these optimized progress variables and the new chemistry table is implemented in a CH4/N2/air lift-off flame.The reconstruction of the lift-off flame shows that the optimized progress variables perform better than the conventional ones, especially in the high temperature area.The coefficient determinations(R2 statistics) show that the KEDPCA performs slightly better than the PCA except for some minor species.The main advantage of the KEDPCA is that it is less sensitive to the database.Meanwhile, the criteria for the optimization are proposed and discussed.The constraint that the progress variables should monotonically evolve from fresh gas to burnt gas is analyzed in detail. | Jing CHEN Minghou LIU Yiliang CHEN | 2015 | Applied Mathematics and Mechanics(English Edition)2015，36，11： | 2 |
| 11 | A new compressibility modification k-ε turbulence model with shock unsteadiness effect显示文摘A new compressibility modification k-ε model,including shock unsteadiness effect and the previous compressibility modification of pressure dilatation and dilatational dissipation rate,was developed with a simple formulation for numerical simulation in supersonic complex turbulent flows.The shock unsteadiness effect was modeled by inhibiting turbulent kinetic energy production in the governing equations of turbulent kinetic energy and the turbulent kinetic energy dissipation rate.Sarkar's correction models were employed accounting for the dilatational compressibility effects in the new model.Two types of flows,the free supersonic mixing layers and complex supersonic flow with transverse injection were simulated with different flow conditions.Comparisons with experimental data of the free supersonic mixing layers showed that the new compressibility modification k-ε model significantly inhibited the excessive growth of turbulent kinetic energy and improved predictions.On the supersonic mixing layer flows,prediction results with the new model were in close agreement with experimental data,accurately predicting the decreasing trend of the mixing layer spreading rate with the increase of the convective Mach number.Due to the complicated flow field with flow separation,shock unsteadiness modification inhibited excessive growth of the turbulent kinetic energy in shock regions and wider shock regions are predicted,thereby significantly improving results of the flow with a strong separation forecast.The flow separation was stronger,which was the primary modification effect of the new model.Predictions accord with experimental results even in strong separation flows. | HAN XingSi YE TaoHong ZHU MinMing CHEN YiLiang | 2008 | Chinese Science Bulletin2008，53，24： | 2 |
| 12 | Nonvolatile rewritable memory effects in graphene oxide functionalized by con- jugated polymer containing fluorene and carbazole unit显示文摘 | Zhang Bin Liu Yiliang Chen Yu | 2011 | Chem Eur J2011，17，10： | 1 |
| 13 | Atmospheric gaseous organic acids in winter in a rural site of the North China Plain显示文摘Organic acids are important contributors to the acidity of atmospheric precipitation,but their existence in the Chinese atmosphere is largely unclear.In this study,twelve atmospheric gaseous organic acids,including C_(1)-C_(9) alkanoic acids,methacrylic acid,pyruvic acid,and benzoic acid,were observed in the suburb of Wangdu,Hebei Province,a typical rural site in the northern China plain from 16^(th) December,2018 to 22^(nd) January,2019,using a Vocus■ Proton-Transfer-Reaction time-of-flight mass spectrometer(Vocus PTR-ToF).The quantification of C_(2)-C_(4) alkanoic acids by the Vocus PTR-ToF was calibrated according to the titration of a NaOH solution by C_(2)-C_(4) alkanoic acids from home-made permeation sources,and the other organic acids except for formic acid were quantified based on the k_(cap)-sensitivity linearity in the Vocus PTR-ToF,whereas formic acid was not quantified because our instrument setting led to a significant underestimation in its concentration.The average total concentration of eleven gaseous organic acids was 6.96±5.20 ppbv(parts per billion by volume).The average concentration of acetic acid was the highest(3.86±3.00 ppbv),followed by propanoic acid,butyric acid,and methacrylic acid.Domestic straw burning was likely the dominant source of the observed gaseous organic acids according to the good correlations between acetonitrile and organic acids and between particulate K+and organic acids,and traffic emissions could also have contributed.During episodes with continuously high concentrations of organic acids,short-distance transport dominated in Wangdu according to the backward trajectory analysis.Baoding,Shijiazhuang,and Hengshui areas were the main source areas based on potential source contribution function and concentration weighing track analysis. | Xiaoyu Hu Gan Yang Yiliang Liu Yiqun Lu Yuwei Wang Hui Chen Jianmin Chen Lin Wang | 2022 | Journal of Environmental Sciences2022，34，3： | 1 |
| 14 | Nonvolatile rewritable memory effects in graphene oxide funetionalized by con- jugated polymer containing fluorene and carhazole units显示文摘 | Zhang Bin Liu Yiliang Chen Yu et z | 2011 | Chem Eur J2011，17，10： | 1 |
| 15 | Numerical simulation on micromixer based on synthetic jet显示文摘这篇论文学习了微混合器的一个概念,一口合成喷气在一条矩形的隧道的底部放了。由于周期的喷射从和进隧道的吸,液体有效地被混合。学习入口的效果速度,喷气紧张和频率,和混合效率上的喷气地点, 3-D 微混合器的数字模拟被执行了。当喷气紧张和频率被修理时,混合效率增加,这被发现了什么时候 Re <
50,并且当时,减少 50 在 Re = 与混合效率的最好完成了的 Re >
50。当到入口速度的喷气速度大小的比率作为 10 被拿,喷气频率是 100 Hz 时,混合索引到达最高的价值。变得更好混合效率也被发现了那,合成喷气的孔应该是一相称性地定位了离开隧道的中心线。 | Minghou Liu Chen Xie Xiangfeng Zhang Yiliang Chen | 2008 | Acta Mechanica Sinica2008，24，6： | 1 |
| 16 | Trajectory and velocity measurement of a particle in spray by digital holography 显示文摘 | Lu Qieni Chen Yiliang Yuan Rui | 2009 | ApplOpt2009，48，36： | 1 |
| 17 | Recent advances in RNA structurome显示文摘RNA structures are essential to support RNA functions and regulation in various biological processes. Recently, a range of novel technologies have been developed to decode genome-wide RNA structures and novel modes of functionality across a wide range of species. In this review, we summarize key strategies for probing the RNA structurome and discuss the pros and cons of representative technologies. In particular, these new technologies have been applied to dissect the structural landscape of the SARS-CoV-2 RNA genome. We also summarize the functionalities of RNA structures discovered in different regulatory layers-including RNA processing, transport, localization, and mRNA translation-across viruses, bacteria, animals, and plants. We review many versatile RNA structural elements in the context of different physiological and pathological processes(e.g., cell differentiation, stress response, and viral replication). Finally, we discuss future prospects for RNA structural studies to map the RNA structurome at higher resolution and at the single-molecule and single-cell level, and to decipher novel modes of RNA structures and functions for innovative applications. | Bingbing Xu Yanda Zhu Changchang Cao Hao Chen Qiongli Jin Guangnan Li Junfeng Ma Siwy Ling Yang Jieyu Zhao Jianghui Zhu Yiliang Ding Xianyang Fang Yongfeng Jin Chun Kit Kwok Aiming Ren Yue Wan Zhiye Wang Yuanchao Xue Huakun Zhang Qiangfeng Cliff Zhang Yu Zhou | 2022 | Science China(Life Sciences)2022，65，7： | 1 |
| 18 | MCF-7 breast cancer cells overexpressing transfectedc-erbB-2 have anin vitro growth advantage in estrogen-depleted conditions and reduced estrogen-dependence and tamoxifen-sensitivityin vivo显示文摘 | Yiliang Liu Dorraya El-Ashry Denise Chen Ivan Yi Fan Ding Francis G. Kern | 1995 | Breast Cancer Research and Treatment1995，，2： | 1 |
| 19 | Synthesis, Characterization, and Antifungal Evaluation of Thiolactomycin Derivatives显示文摘5-Substituted benzylidene 3-acylthiotetronic acids are antifungal.A series of 3-acylthiotetronic acid derivatives with varying substitutions at the 5-position were designed,synthesized,and characterized,based on the binding pose of 3-acyl thiolactone with the protein C171Q KasA.Fungicidal activities of these compounds were screened against Valsa Mali,Curvularia lunata,Fusarium graminearum,and Fusarium oxysporum f.sp.lycopersici.Most target compounds exhibited excellent fungicidal activities against target fungi at the concentration of 50μg·mL-1.Compounds 11c and 11i displayed the highest activity with a broad spectrum.The median effective concentration(EC50)values of 11c and 11i were 1.9–10.7 and 3.1–7.8μg·mL-1,respectively,against the tested fungi,while the EC50 values of the fungicides azoxystrobin,carbendazim,and fluopyram were respectively 0.30,4.22,and>50μg·mL-1 against V.Mali;6.7,41.7,and 0.18μg·mL-1 against C.lunata;22.4,0.42,and 0.43μg·mL-1 against F.graminearum;and 4.3,0.12,and>50μg·mL-1 against F.oxysporum f.sp.lycopersici.The structures and activities of the target compounds against C.lunata were analyzed to obtain a statistically significant comparative molecular field analysis(CoMFA)model with high prediction abilities(q2=0.9816,r2=0.8060),and its reliability was verified.The different substituents on the benzylidene at the 5-position had significant effects on the activity,while the introduction of a halogen atom at the benzene ring of benzylidene was able to improve the activity against the tested fungi. | Pei Lv Yiliang Chen Dawei Wang Xiangwei Wu Qing XLi Rimao Hua | 2020 | Engineering2020，6，5： | 0 |
| 20 | N-acyl homoserine lactonase attenuates the virulence of Salmonella typhimurium and its induction of intestinal damages in broilers显示文摘This study aimed to investigate the potential mitigating effects of N-acyl homoserine lactonase(AHLase)on the virulence of Salmonella typhimurium and its induction of intestinal damages in broilers.In vitro study was firstly conducted to examine if AHLase treatment could attenuate the virulence of S.typhimurium.Then,an in vivo experiment was performed by allocating 240 broiler chicks at 1 d old into 3 groups(8 replicates per group):negative control(NC),positive control(PC),and PC supplemented with 10,000 U/kg AHLase.All chicks except those in NC were orally challenged by S.typhimurium from 8to 10 d of age.Parameters were measured on d 11 and 21.The results showed that treatment with 1 U/mL AHLase suppressed the biofilm-forming ability(including biofilm biomass,extracellular DNA secretion and biofilm formation-related gene expression),together with swarming motility and adhesive capacity of S.typhimurium.Supplemental 10,000 U/kg AHLase counteracted S.typhimurium-induced impairments(P<0.05)in broiler growth performance(including final body weight,average daily gain and average daily feed intake)during either 1-11 d or 12-21 d,and increases(P<0.05)in the indexes of liver,spleen and bursa of Fabricius on d 11,together with reductions(P<0.05)in ileal villus height and its ratio to crypt depth on both d 11 and 21.AHLase addition also normalized the increased(P<0.05)m RNA expression of ileal occludin on both d 11 and 21 in S.typhimurium-challenged broilers.However,neither S.typhimurium challenge nor AHLase addition altered(P>0.05)serum diamine oxidase activity of broilers.Noticeably,S.typhimurium challenge caused little change in the mRNA expression of ileal inflammatory cytokines except for an increase(P<0.05)in interleukin-8 expression on d 11,whereas AHLase addition normalized(P<0.05)this change.In conclusion,AHLase treatment could attenuate the virulence and pathogenicity of S.typhimurium,thus contributing to alleviate S.typhimurium-induced growth retardation and intestinal damages in broilers. | Weiwei Wang Yiliang Chen Hui Ye Zemin Dong Changming Zhang Dingyuan Feng Qingyun Cao Shujie Liang Jianjun Zuo | 2023 | Animal Nutrition2023，，3： | 0 |
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