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| 1 | Photoperiod- and thermo-sensitive genic male sterility in rice are caused by a point mutation in a novel noncoding RNA that produces a small RNA显示文摘光周期敏感、 thermo 敏感的遗传因子的男绝育(PGMS 和 TGMS ) 是为在庄稼的混合繁殖的核心部件。基于使用的较普通活字大一倍的系统, PGMS 和 TGMS 衬里的混合大米是成功地在农业广泛地发展了并且适用。然而,位于 PGMS 和 TGMS 的控制下面的分子的机制仍然保持阴暗。在这研究,我们印射并且克隆一个主要地点, p/tms12-1 (染色体 12 上的感光性或 thermo 敏感的遗传因子的男绝育地点) 它在装饰用的梨树米饭线 Nongken 58S (NK58S ) 授与 PGMS 和在 indica 米饭的 TGMS 衬里 Peiai 64S (PA64S,源于 NK58S ) 。包含野类型的等位基因 P/TMS12-1 的 A 2.4-kb DNA 碎片能在基因互补恢复 NK58S 和 PA64S 植物的花粉富饶。P/TMS12-1 编码唯一的 noncoding RNA,它生产 21 核苷酸我们说出 osa-smR5864w 的小 RNA。在 p/tms12-1 的 C-to-G 的替换,相对 P/TMS12-1 的唯一的多型性,在变异的小 RNA 是在场的,也就是 osa-smR5864m。而且,在转基因的 NK58S 和 PA64S 植物的 P/TMS12-1 的一个 375-bp 序列的 overexpression 也生产了 osa-smR5864w 并且恢复了花粉富饶。小 RNA 在年轻圆锥花序优先地被表示,但是它的表示没被不同的天长度或温度显著地影响。我们的结果表明在 p/tms12-1 的点变化,可能为 osa-smR5864m 导致 loss-of-function,分别地在装饰用的梨树和 indica 线为 PGMS 和 TGMS 组成一个普通原因。我们的调查结果因此建议那小 RNA 基因是的这 noncoding 男开发的一个重要管理者由在基因网络和环境条件之间的串音控制了。 | Hai Zhou Qinjian Liu Jing Li Dagang Jiang Lingyan Zhou Ping Wu Sen Lu Feng Li Liya Zhu Zhenlan Liu Letian Chen Yao-Guang Liu Chuxiong Zhuang | 2012 | Cell Research2012，22，4： | 99 |
| 2 | Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis显示文摘AIM:To perform a meta-analysis of observational studies and randomized controlled trials(RCTs)on the association between Helicobacter pylori(H.pylori)and iron deficiency anemia(IDA).METHODS:A defined search strategy was used to search Medline,Embase,the Cochrane Library,Clinical Trials,Cochrane Central Register of Controlled Trials,Premedline and Healthstar.Odds ratio(OR)was used to evaluate observational epidemiology studies,and weighted mean difference(WMD)was used to demonstrate the difference between control and intervention groups.RESULTS:Fifteen observational studies and 5 RCTs were identified and used for calculation.The pooled OR for observational studies was 2.22(95%CI:1.52-3.24,P<0.0001).The WMD for hemoglobin(HB) was 4.06 g/L(95%CI:-2.57-10.69,P=0.01),and the WMD for serum ferritin(SF)was 9.47μg/L(95%CI:-0.50-19.43,P<0.0001).Results were heterogeneous for all comparisons.CONCLUSION:This meta-analysis on observational studies suggests an association between H.pylori and IDA.In RCTs,eradication of H.pylori can improve HB and SF levels but not significantly. | Qu, Xin-Hua Huang, Xiao-Lu Xiong, Ping Zhu, Cui-Ying Huang, You-Liang Lu, Lun-Gen Sun, Xu Rong, Lan Zhong, Liang Sun, Da-Yu Lin, Hai Cai, Ming-Ci Chen, Zhi-Wei Hu, Bing Wu, Lian-Ming Jiang, Yi-Bin Yan, Wei-Li | 2010 | World Journal of Gastroenterology2010，16，7： | 34 |
| 3 | Temperature variations in the past 6000 years inferred from δ^(18)O of peat cellulose from Hongyuan,China显示文摘Trends of the temperature variations recorded in δ18O in Hongyuan peat cellulose are similar to those recorded in δ18O of Jinchuan peat cellulose and in δ18O of Dunde ice core. Climate events have been identified to be globally homogeneous. Two notable climate transition periods have been detected in the past 6000 years, namely 4000 aBP with climate shifting from cold to warm and 1500 aBP with climate shifting from warm to relatively cold. Power spectrum analysis was performed to investigate the periodical signals in the δ18O time series. Typical periodicities of 1200-1087 a, 752 a, 444 a, 325 a, 213 a, 127-123 a, 88 a, 79 a were discovered, indicating an integrated influence on Hongyuan climate from solar, monsoon and ocean activities. Solar forcing has been addressed to be the main driving forcing of Hongyuan climate. | XU Hai, HONG Yetang, LIN Qinghua, HONG Bing, JIANG Hongbo & ZHU YongxuanInstitute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China Graduate School of Chinese Academy of Sciences, Beijing 100039, China | 2002 | Chinese Science Bulletin2002，47，18： | 31 |
| 4 | Brucellosis in China:history,progress and challenge显示文摘Brucellosis is a neglected zoonosis.It causes acute febrile illness and a potentially debilitating chronic infection in humans,and livestock infection has substantial socioeconomic impact.Over the past two decades,improvements have been made to better understand the various aspects of human and animal brucellosis.Meanwhile,especially in the developing world,immense challenges that remain in controlling and eradicating brucellosis are novel diagnostics tools and efficacious vaccines.Here,we will focus on the remarkable issues on epidemiological survey,as well as the priority and challenge of brucellosis in China.Brucellosis will be controlled with meaningful collaboration between local and public partnerships effectively applying a One Health framework. | Hai Jiang David O’Callaghan Jia-Bo Ding | 2020 | Infectious Diseases of Poverty2020，9，3： | 25 |
| 5 | Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior显示文摘为过去的几十年,在中国的传染疾病侧面在社会、经济的方面,环境,食物的质量,水,住房,和公共健康基础结构与快速的开发一直在变。尤其是, 5 应具报的传染疾病几乎被根除了,并且 18 另外的应具报的传染疾病的发生显著地被减少了。出人意料地,包括 HIV,普鲁斯病,梅毒,和登革热发烧,超过 10 应具报的传染疾病的发生一直在增加。不过,经常的传染疾病爆发 / 事件每年几乎被报导了,并且进口了传染疾病自从 2015,增加了。已知的病原体的新病原体和超过 100 新遗传型或 serotypes 被识别了。一些传染疾病似乎被各种各样的因素加重,包括快速的都市化,大量候鸟工人,在气候的变化,生态学,和政策,例如把农田还给森林。这评论在设法出现和 re-emerging 从中国总结当前的经验和课传染疾病,特别生态学的效果,气候,和行为,它应该在帮助另外的国家控制并且阻止传染疾病有优点。 | Qiyong Liu Wenbo Xu Shan Lu Jiafu Jiang Jieping Zhou Zhujun Shao Xiaobo Liu Lei Xu Yanwen Xiong Han Zheng Sun Jin Hai Jiang Wuchun Cao Jianguo Xu | 2018 | Frontiers of Medicine2018，12，1： | 23 |
| 6 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 7 | A Single Nucleotide Deletion in J Encoding GmELF3 Confers Long Juvenility and Is Associated with Adaption of Tropic Soybean显示文摘 | Yanlei Yue Nianxi Liu Bingjun Jiang Mu Li Haijie Wang Ze Jiang Huanting Pan Qiuju Xia Qibin Ma Tianfu Han Hai Nian | 2017 | Molecular Plant2017，10，4： | 20 |
| 8 | Laparoscopic radical cystectomy with orthotopic ileal neobladder in the female: report of 14 cases显示文摘背景膀胱癌是在中国的最普通的恶意的 urological 肿瘤。我们在场我们有在有到 2008 年 2月的从2003年2月的膀胱 carcinoma.Methods 的女病人的 orthotopic ileal neobladder 的 laparoscopic 激进分子囊切除术(纵向冗余码校验)的初步的经验和结果,有膀胱癌的 14 个女病人与 orthotopic ileal neobladder 经历了纵向冗余码校验。九个这些病人经历了子宫切除和卵巢切除术,和子宫和卵巢的附器的另外的 5 有的保藏。当需要时,标准双边的骨盆的 lymphadenectomy 被与子宫切除和卵巢切除术 laparoscopically 被完成的激进的囊切除术跟随。肿瘤被一 4-5 厘米移开更低的中线腹的切口,由 ileal neobladder 和 ureter-neobladder 的身体外的吻合的构造列在后面。neobladder 在在 14 个病人的吝啬的起作用的时间和血损失是的 laparoscope.Results 下面被吻合到尿道的树桩 350.2 分钟和 349.8 ml, respectively.Postoperative 复杂并发症在 1 个病人在 1 耐心、小袋阴道的管包括了 uretero 小袋 anastomotic 苛评。所有病人的后续时间从 3 ~ 60 个月,并且 12 个病人被跟随在上面为半年里的超过 6 个月和完成的频尿。一耐心的有的偶尔的白天尿不能自制和 2 有的夜间不能自制。经历了 hystectomy 和卵巢切除术的二个病人在一年以后有 voiding 困难,它被断断续续的 self-catheterization 对待。neobladder 和剩余尿的吝啬的体积分别地是 333.6 ml 和 31.2 ml。外科的边缘是为所有病人免费的肿瘤。一个病人有骨头转移并且死在有在女病人的 orthotopic ileal neobladder 的 operation.Conclusions 纵向冗余码校验以后的 11 个月是有低病态和可接受的 neobladder 功能的一个技术上可行、安全、微型侵略的过程。长期的后续被要求证实 neobladder 功能和 oncological 结果。 | LIN Tian-xin ZHANG Cai-xia XU Ke-wei HUANG Hai JIANG Chun HAN Jin-li YAO You-sheng GUO Zheng-hui XIE Wen-lian YIN Xin-bao HUANG Jian | 2008 | Chinese Medical Journal2008，，10： | 18 |
| 9 | Clinical application and mechanism of traditional Chinese medicine in treatment of lung cancer显示文摘Lung cancer is a malignant tumor characterized by a rapid proliferation rate,less survivability,high mortality,and metastatic potential.This review focuses on updated research about the clinical application of traditional Chinese medicine(TCM)as an adjuvant therapy to lung cancer treatment and the mechanisms of TCM effect on lung cancer in vitro and in vivo.We summarized the recent 5 years of different research progress on clinical applications and antitumor mechanisms of TCM in the treatment of lung cancer.As a potent adjuvant therapy,TCM could enhance conventional treatments(chemotherapy,radiation therapy,and epidermal growth factor receptors[EGFRs]tyrosine kinase inhibitors[TKIs])effects as well as provide synergistic effects,enhance chemotherapy drugs chemosensitivity,reverse drug resistance,reduce adverse reactions and toxicity,relieve patients’pain and improve quality of life(QOL).After treating with TCM,lung cancer cells will induce apoptosis and/or autophagy,suppress metastasis,impact immune reaction,and therapeutic effect of EGFR-TKIs.Therefore,TCM is a promisingly potent adjuvant therapy in the treatment of lung cancer and its multiple mechanisms are worthy of an in-depth study. | Xiao-Lin Su Jiang-Wei Wang Hui Che Chang-Fu Wang Hai Jiang Xia Lei Wan Zhao Hai-Xue Kuang Qiu-Hong Wang | 2020 | Chinese Medical Journal2020，，24： | 16 |
| 10 | An Anthropomorphic Robot Hand Developed Based on Underactuated Mechanism and Controlled by EMG Signals显示文摘When developing a humanoid myo-control hand,not only the mechanical structure should be considered to afford a highdexterity,but also the myoelectric (electromyography,EMG) control capability should be taken into account to fully accomplishthe actuation tasks.This paper presents a novel humanoid robotic myocontrol hand (AR hand Ⅲ) which adopted an underac-tuated mechanism and a forearm myocontrol EMG method.The AR hand Ⅲ has five fingers and 15 joints,and actuated by threeembedded motors.Underactuation can be found within each finger and between the rest three fingers (the middle finger,the ringfinger and the little finger) when the hand is grasping objects.For the EMG control,two specific methods are proposed:thethree-fingered hand gesture configuration of the AR hand Ⅲ and a pattern classification method of EMG signals based on astatistical learning algorithm-Support Vector Machine (SVM).Eighteen active hand gestures of a testee are recognized ef-fectively,which can be directly mapped into the motions of AR hand Ⅲ.An on-line EMG control scheme is established basedon two different decision functions:one is for the discrimination between the idle and active modes,the other is for the recog-nition of the active modes.As a result,the AR hand Ⅲ can swiftly follow the gesture instructions of the testee with a time delayless than 100 ms. | Da-peng Yang~1 Jing-dong Zhao~1 Yi-kun Gu~1 Xin-qing Wang~1 Nan Li~1 Li Jiang~1Hong Liu~(1,2) Hai Huang~3 Da-wei Zhao~41.State Key Laboratory of Robotics and System,Harbin Institute of Technology,Harbin 150001,P.R.China2.Institute of Robotics and Mechatronics,German Aerospace Center,Munich 82230,Germany3.College of Shipbuilding Engineering,Harbin Engineering University,Harbin 150001,P.R.China4.College of Automation,Harbin Engineering University,Harbin 150001,P.R.China | 2009 | Journal of Bionic Engineering2009，6，3： | 16 |
| 11 | Expression of lung resistance protein in patients with gastric carcinoma and its clinical significance显示文摘INTRODUCTION The efficacy of chemotherapy in the treatment of cance patients is often hampered by the presence or appearance of multidrug resistance(MDR) of tumor cells. | Zhong Min Liu Nan Hai Shou Xi Hong Jiang | 2000 | World Journal of Gastroenterology2000，6，3： | 15 |
| 12 | Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011显示文摘Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011.Methods Seventy-four Streptococcal pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011.Emm genotyping,pulsed-field gel electrophoresis (PFGE),superantigen (SAg) genes and antimicrobial susceptibility profiling were analyzed for these isolates.Results A total of 4 different emm types were identified.Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles.Emm12 (79.7%) and emml (14.9%) accounted for approximately 94%of all the isolates.The speA gene was all negative in emm12 isolates and positive in emml isolates.All strains were resistant to erythromycin,and 89.4%of them were resistant to erythromycin,tracycline,and clindamycin simultaneously.Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains,though no new emm type was found in this outbreak.The data provide a baseline for further surveillance of scarlet fever,which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. | YOU Yuan Hai SONG Yan Yan YAN Xiao Mei WANG Hai Bin ZHANG Meng Han TAO Xiao Xia Li Lei Lei ZHANG Yu Xin JIANG Xi Hong ZHANG Bing Hua ZHOU Hao XIAO Di JIN Lian Mei FENG Zi Jian LUO Feng Ji ZHANG Jian Zhong | 2013 | Biomedical and Environmental Sciences2013，26，11： | 15 |
| 13 | Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat显示文摘AIM To evaluate the hepatoprotective effect of lycopene(Ly) on non-alcoholic fatty liver disease(NAFLD) in rat. METHODS A rat model of NAFLD was first established by feeding a high-fat diet for 14 wk. Sixty-five rats were randomly divided into normal group, model group and Ly treatment groups. Alanine aminotransferase(ALT), aspartate aminotransferase(AST), triglycerides(TG), total cholesterol(TC) in serum and low density lipoproteincholesterol(LDL-C), high density lipoprotein-cholesterol(HDL-C), free fatty acid(FFA), malondialdehyde(MDA), superoxide dismutase(SOD), glutathione(GSH) in liver tissue were evaluated, respectively. While the hepatoprotective effect was also confirmed by histopathological analysis, the expression levels of TNF-α and cytochrome P450(CYP) 2E1 in rat liver were determined by immunohistochemistry analysis.RESULTS A significant decrease was observed in the levels of serum AST(2.07-fold), ALT(2.95-fold), and the blood lipid TG(2.34-fold) and TC(1.66-fold) in the dose of 20 mg/kg Ly-treated rats(P < 0.01), compared to the model group. Pretreatment with 5, 10 and 20 mg/kg of Ly significantly raised the levels of antioxidant enzyme SOD in a dose-dependent manner,to 90.95 ± 9.56, 109.52 ± 11.34 and 121.25 ± 10.68(P < 0.05, P < 0.01), as compared with the model group. Similarly, the levels of GSH were significantly increased(P < 0.05, P < 0.01) after the Ly treatment. Meanwhile, pretreatment with 5, 10 and 20 mg/kg of Ly significantly reduced MDA amount by 30.87, 45.51 and 54.49% in the liver homogenates, respectively(P < 0.01). The Ly treatment group showed significantly decreased levels of lipid products LDL-C(P < 0.05, P < 0.01), improved HDL-C level and significantly decreased content of FFA, compared to the model group(P < 0.05, P < 0.01). Furthermore, the Ly-treated group also exhibited a down-regulated TNF-α and CYP2E1 expression, decreased infiltration of liver fats and reversed histopathological changes, all in a dosedependent manner(P < 0.05, P < 0.01). CONCLUSION This study suggests that Ly has a protective effect on NAFLD, down-regulates expression of TNF-α, and that CYP2E1 may be one of the action mechanisms for Ly. | Wei Jiang Mei-Hua Guo Xin Hai | 2016 | World Journal of Gastroenterology2016，22，46： | 15 |
| 14 | Preparation of calcium carbonate particles coated with titanium dioxide显示文摘The preparation of a new mineral composite material,calcium carbonate particles coated with titanium dioxide,was studied.The mechanism of the preparation process was proposed.The new mineral composite material was made by the mechanochemical method under the optimum condition that the mass ratio of calcium carbonate particles to titanium dioxide was 6.5:3.5.The mass ratios of two different types of titanium dioxide(anatase to rutile) and grinding media to grinded materials were 8:2 and 4:1 respectively,and the modified density was 60%.Under this condition,the new material was capable of forming after 120-min modification.The hiding power and oil absorption of this new material were 29.12 g/m2 and 23.30%,respectively.The results show that the modification is based on surface hydroxylation.After coating with titanium dioxide,the hiding power of calcium carbonate can be improved greatly.The new mineral composite materials can be used as the substitute for titanium dioxide. | Hai Lin Ying-bo Dong Le-yong Jiang | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，5： | 13 |
| 15 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 16 | Molecular Typing of Brucella Suis Collected from 1960s to 2010s in China by MLVA and PFGE显示文摘Brucellosis is a bacterial anthropozoonosis usually caused by Brucella abortus, Brucella melitensis, Brucella suis and Brucella canis. Brucella suis, the causative agent of swine brucellosis, is classified into five biovars and preferentially infects different animal hosts [1] . | LI Zhen Jun CUI Bu Yun CHEN Hai CHEN Jing Diao ZHAO Hong Yan PIAO Dong Ri JIANG Hai ZHANG Li TANG Xu KE Chang Wen YAO zhen TIAN Guo Zhong | 2013 | Biomedical and Environmental Sciences2013，26，6： | 13 |
| 17 | Superparamagnetic iron oxide nanoparticle targeting of adipose tissue-derived stem cells in diabetes-associated erectile dysfunction显示文摘可勃起的机能障碍(编辑) 是糖尿病的主要复杂并发症,并且有编辑的许多糖尿病的人对普通编辑治疗倔强。脂肪质的导出织物的干细胞(ADSC ) 被显示了在糖尿病的动物模型改进可勃起的功能。然而,到损坏地点的不适当的房间 homing 限制了他们的功效。因此,我们探索了在与一个外部磁场改进导致 streptozotocin 的糖尿病的老鼠的可勃起的功能上用 superparamagnetic 氧化铁 nanoparticles (SPION ) 标记的 ADSC 的效果。我们发现那 SPION 有效地合并了到 ADSC 并且没在干细胞性质上施加任何否定效果。ADSC 的磁性的指向在阴茎海绵体贡献了长期的细胞保留并且独自与 ADSC 注射相比改进了糖尿病的老鼠的可勃起的功能。另外, ADSC 的 paracrine 效果看起来在功能、结构的恢复起主要作用。因此,磁性的指导地的 ADSC 治疗是为联系糖尿病的编辑治疗的一条有效途径。 | Lei-Lei Zhu Zheng Zhang He-Song Jiang Hai Chen Yun Chen Yu-Tian Dai | 2017 | Asian Journal of Andrology2017，19，4： | 11 |
| 18 | MAPPING OF THE RICE (ORYZA SATIVA L.) THERMO-SENSITIVE GENIC MALE STERILE GENE TMS5 WITH EST AND SSR MARKERS显示文摘With the cDNA suppression subtraction hybridization method, a spikelet-specific cDNA library was constructed that expressed at meiosis stage in rice. A total of 121 cDNA fragments were selected from the library and used as EST (expressed se-quence tags) markers to detect the polymorphism between Annong N, a normal fertile Indica rice line and Annong S-1, its spontaneous mutant with thermo-sensitive genic male sterility, using the RFLP (restriction fragment length polymorphism) technique. HN57, one of the EST probes, could detect poly-morphism between them. The results of segregation analysis with the F2 population developed from An-nong S-1 and Annong N indicate that HN57 co-seg- regates with the thermo-sensitive genic male-sterility controlled by tms5, the recessive gene in Annong S-1. This marker is located on the 31.2-cM region of the chromosome 2 of RGP (rice genome research pro-gram) genetic map. To further determine the location of tms5, 80 SSR (simple sequence repeat) markers around this region were developed, and 12 of them were polymorphic. And finally, the tms5 was mapped within region of 181 kb by using these new markers. | JIANG Dagang LU Sen ZHOU Hai WU Xiaojin ZHUANG Chuxiong LIU Yaoguang | 2006 | Chinese Science Bulletin2006，51，4： | 10 |
| 19 | Fluoxetine ameliorates symptoms of refractory chronic prostatitis/chronic pelvic pain syndrome显示文摘背景范畴长期的 prostatitis/chronic 骨盆的疼痛症候群(CP/CPPS ) 是有生活的质量上的重要影响的不清楚的病原学的普通症候群。因为为 CP/CPPS 的多重治疗的结果远离同意,可能的心理因素被认为在这上在 CP/CPPS.Based 起一个重要作用,我们在这研究与倔强的 CP/CPPS.Methods 在人调查了抗抑郁剂药( fluoxetine )的角色,没有对标准治疗的反应,与倔强的 CP/CPPS 诊断的 42 个人(包括多重抗菌素功课和 a-blockers )为 fluoxetine 被提交治疗。所有病人收到了 fluoxetine (20 mg/d ) 三个月并且以前临床上被评估(基线) ,并且在治疗的 4, 8 和 12 个星期以后。评估包括了健康长期的前列腺炎症状索引(NIH-CPSI ) 和贝克萧条的研究所盘点的一个公民(BDI ) 问询表。而且,主观全球评价( SGA )在 therapy.Results 的 第4 , 第8 和 第12 星期被估计重要减少为全部的 NIH-CPSI ( 28.55~9.29 )被观察, NIH-CPSI 疼痛( 14.69~5.19 ), NIH-CPSI 尿( 4.95~1.88 ),生活( 8.83~2.20 )的 NIH-CPSI 质量,和 BDI ( 34.67~13.95 )与基线相比得分,所有 P 珍视 0.05 。(69.05%) 29 在主观全球评价以后报导了显著改进,(78.57%) 33 有一比在在治疗(第 12 星期) 的结束的 NIH-CPSI 的 50% 减少大。同时,皮尔森关联系数分析表明了在 BDI 分数和每个 CPSI 分数之间的积极关联。没有不利事件在这 study.Conclusions Fluoxetine 被报导看起来是在改善的安全、有效的治疗症状在,和生活的质量,有困难的 CP/CPPS 的人。而且,困难的 CP/CPPS-related 症状的改善能与在压抑的症状的减少有关。 | XIA Dan WANG Ping CHEN Jun WANG Shuo JIANG Hai | 2011 | Chinese Medical Journal2011，，14： | 10 |
| 20 | Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation显示文摘Cyclin 依赖的 kinase 1 (Cdk1 )/cyclin B1 建筑群是为有丝分裂的入口的驱动力,并且它的激活被 G2/M 检查点紧调整。我们原来报导了那新奇蛋白质 C53 (也作为 Cdk5rap3 和 LZAP 知道) 加强由 modulating 的 DNA 导致损坏的房间死亡 G2/M 检查点。更最近,王等。(2007 ) 发现 C53/LZAP 可以通过禁止 NF-魏 B 发信号作为肿瘤 suppressor 工作。我们这里作为 Cdk1 激活的一个新奇管理者报导 C53 蛋白质的鉴定。我们 C53 蛋白质原因发现那击倒推迟的 Cdk1 激活和有丝分裂的入口。在 DNA 损坏反应期间,检查点 kinase 的激活(Chk1 和 Chk2 ) 1 和 2 被 C53 overexpression 部分禁止。有趣地,我们发现 C53 与 Chk1 交往并且反对它的功能。而且, C53 蛋白质的部分 potently 在中心体,和指向中心体的 C53 是局部性的支持本地 Cdk1 激活。一起拿,我们的结果强烈建议 C53 是检查点反应的一个新奇否定管理者。由抵抗 Chk1, C53 在两不受搅乱的房间周期前进和 DNA 损坏反应支持 Cdk1 激活和有丝分裂的入口。 | Hai Jiang Jianchun Wu Chen He Wending Yang Honglin Li | 2009 | Cell Research2009，19，4： | 9 |
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