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| 1 | A Brief Review on the Mechanisms of miRNA Regulation显示文摘MicroRNAs (miRNAs) are a class of short,endogenously-initiated non-coding RNAs that post-transcriptionally control gene expression via either translational repression or mRNA degradation.It is becoming evident that miRNAs are playing significant roles in regulatory mechanisms operating in various organisms,including developmental timing and host-pathogen interactions as well as cell differentiation,proliferation,apoptosis and tumorigenesis.Likewise,as a regulatory element,miRNA itself is coordinatively modulated by multifarious effectors when carrying out basic functions,such as SNP,miRNA editing,methylation and circadian clock.This mini-review summarized the current understanding of interactions between miRNAs and their targets,including recent advancements in deciphering the regulatory mechanisms that control the biogenesis and functionality of miRNAs in various cellular processes. | Yimei Cai Xiaomin Yu Songnian Hu Jun Yu | 2009 | Genomics, Proteomics & Bioinformatics2009，7，4： | 55 |
| 2 | Simultaneous quantification of several classes of antibiotics in water, sediments, and fish muscles by liquid chromatography-tandem mass spectrometry显示文摘为表面水,沉积,和鱼肌肉里的抗菌素,包括的磺胺, fluoroquinolones, macrolides,四圜素,和 trimethoprim 的不同的班的同时的决心的精确、敏感的方法被开发。在水样品,药被递给 1000 水的 mL 通过与稳固阶段的抽取(SPE ) 提取吸水脂性平衡(HLB ) SPE 子弹。沉积样品是提取溶剂的,由双人脚踏车 SPE (强壮的阴离子交换(萨克斯风管)+ HLB ) 列在后面大扫除。鱼肌肉被 acetonitrile 和柠檬性的缓冲区的混合物提取(80:20, v/v ) 答案,并且由 SPE 清洗了。有监视的多重反应(MRM ) 的液体层析双人脚踏车团 spectrometry (LC-MS/MS ) 察觉被采用确定所有混合物。为刺的水,沉积,和鱼样品里的抗菌素的恢复分别地是 60.2%95.8% , 48.1%105.3% ,和 59.8%103.4% 。方法被用于从达恩奇·莱克,拿的样品中国。它证明检测抗菌素的集中从 quantification (LOQ ) 的限制到 713.6 ng 獵瀭畬 ????? 猯'T ￣慮潮吗?? | Yimei WEI Yuan ZHANG Jian XU Changsheng GUO Lei LI Wenhong FAN | 2014 | Frontiers of Environmental Science & Engineering2014，8，3： | 10 |
| 3 | Rehabilitation and Sustainable Use Pattern of Rocky-desertified Land in Southwest China’s Poverty-stricken Karst Mountainous Areas——A Case Study in Benggu Township, Xichou County, Yunnan, China显示文摘The rocky desert in a karst area directly causes the lack of soil, water and forest, hence leading to the poverty there. In 1990, the villagers from the Muzhe Village in Benggu Township, Xichou County, Yunnan declared a war against rocky desert in an attempt to ask the fields for more yields. They invented a distinctive land rehabilitation and sustainable use pattern called “transforming heavenand earth” that had been practiced in Southwest China’s karst areas. The key mechanism of the pattern was to develop terraced fields with well conserved soil, water and fertility by exploding rocks in the fields, building stone walls, gathering more soil, and improving soil quality and productivity for the fields in combination with building of irrigation facilities and roads, as well as with forestation and agriculture structure adjustment. The purpose of the pattern was to alleviate poverty in the karst areas by improving soil productivity and promoting agriculturaldevelopment. A typical area was studied with the help of Participatory Rural Appraisal (PRA) and the pattern was carried out there for fifteen years, have produced excellent ecological benefits and good economic benefits. Its application in the area approved that it was a sustainable land use pattern for rocky desert areas. | YANG Zisheng LIU Yansui BAO Guangjing LI Zhiguo HE Yimei | 2006 | Journal of Mountain Science2006，3，3： | 10 |
| 4 | Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition显示文摘The response of endothelial cells to signaling stimulation is critical for vascular morphogenesis,homeostasis and function.Vascular endothelial growth factor-a(VEGFA)has been commonly recognized as a pro-angiogenic factor in vertebrate developmental,physiological and pathological conditions for decades.Here we report a novel finding that genetic ablation of CDP-diacylglycerol synthetase-2(CDS2),a metabolic enzyme that controls phosphoinositide recycling,switches the output of VEGFA signaling from promoting angiogenesis to unexpectedly inducing vessel regression.Live imaging analysis uncovered the presence of reverse migration of the angiogenic endothelium in cds2 mutant zebrafish upon VEGFA stimulation,and endothelium regression also occurred in postnatal retina and implanted tumor models in mice.In tumor models,CDS2 deficiency enhanced the level of tumorsecreted VEGFA,which in-turn trapped tumors into a VEGFA-induced vessel regression situation,leading to suppression of tumor growth.Mechanistically,VEGFA stimulation reduced phosphatidylinositol(4,5)-bisphosphate(PIP2)availability in the absence of CDS2-controlled-phosphoinositide metabolism,subsequently causing phosphatidylinositol(3,4,5)-triphosphate(PIP3)deficiency and F0X01 activation to trigger regression of CDS2-null endothelium.Thus,our data indicate that the effect of VEGFA on vasculature is context-dependent and can be converted from angiogenesis to vascular regression. | Wencao Zhao Le Cao Hanru Ying Wenjuan Zhang Dantong Li Xiaolong Ziiu Wenzhi Xue Shuang Wu Mengye Cao Cong Fu Haonan Qi Yimei Hao Yun-Chi Tang Jun Qin Tao PZhong Xiaoxi Lin Luyang Yu Xuri Li Lin Li Dianqing Wu Weijun Pan | 2019 | Cell Research2019，29，11： | 9 |
| 5 | Evolution and molecular epidemiology of foot-and-mouth disease virus in China显示文摘Foot-and-mouth disease (FMD),caused by foot-and-mouth disease virus (FMDV),is considered one of the most important viral diseases of cloven-hoofed animals,causing severe economic losses in affected regions of the world.Three serotypes (A,O,and Asia 1) of FMDV have been identified in China since 1958.In addition,the occurrence of novel subtypes within these serotypes has made the epidemiology of FMDV more complicated over the last few years.In this review,we summarize the history and the current epidemiological situation in China,genetic diversity (e.g.,quasispecies dynamics,antigenic heterogeneity,and functional constraints),intertypic recombination,and the evidence for positive selection of different FMDV serotypes.We also assess these genetic data to understand the origin,evolution,and transmission of FMDV,the findings of which may be useful in developing control measures for future epidemics. | BAI XingWen LI PingHua BAO HuiFang LIU ZaiXin LI Dong LU ZengJun CAO YiMei SHANG YouJun SHAO JunJun CHANG HuiYun LUO JianXun LIU XiangTao | 2011 | Chinese Science Bulletin2011，56，21： | 7 |
| 6 | Construction of PR domain eukaryotic expression vector and its inhibitory effect on esophageal cancer cells显示文摘Objective:PR domain is responsible for the tumor suppressing activity of RIZ1.The study aimed to construct human PR domain eukaryotic expression vectors,transfect human esophageal cancer cells(TE13),and evaluate the anticancer activity of PR domain on human esophageal cancer TE13 cells.Methods:First,mRNA was extracted from human esophageal cancer tissue by RT-PCR,then reversetranscribed to cDNA.After amplifying from the DNA template,PR domain was linked to T vector.Second,after extraction,PR domain was cut using enzyme and linked to pcDNA3.1(+).Then,the plasmid was transfered to Trans1-T1 phage resistant competent cells,following by extracting the ultrapure plasmid,and transfecting into TE13 cells.In the end,the protein expression of pcDNA3.1(+)/PR domain in TE13 was detected by Western blot,and the apoptosis of TE13 by technique of flow cytometry.Results:More than 5,000 bp purposed band of pcDNA3.1(+)/PR domain plasmid was found by agarose gel electrophoresis.After transfection,the PR domain(molecular weight of about 28 Da)was found only in 3,4 and 5 groups by Western blot.Flow cytometry assay showed apoptosis in experimental group was significantly more than that in the control group(P<0.05).Conclusions:The PR domain eukaryotic expression vector was constructed successfully.The protein of the PR domain could be expressed in esophageal cancer TE13 cells firmly after transfection,and a single PR domain could promote apoptosis of TE13 cells. | Yuan Chen Peng Zhang Yuanguo Wang Shangwen Dong Yimei Liu | 2013 | Chinese Journal of Cancer Research2013，25，5： | 6 |
| 7 | Geochemical significance of the relative enrichment of pristane and the negative excursion of δ^(13)C_(Pr) across the Permian-Triassic Boundary atMeishan, China显示文摘Changes in the distribution of isoprenoid hy-drocarbons and in δ 13Ckero or δ 13CPr across the section from the Changxing Formation to the lower Yinkeng Formation at Meishan (the GSSP of PTB) are studied, in which a relative enrichment of pristane and a sharp shift in both δ 13Ckero and δ 13Cmole near the boundary are revealed. A possible mecha-nism for the abnormal accumulation of pristane near PTB is suggested: Lipids in some marine animals and their metabo-lites, rich in pristane, can be preserved and accumulate in some suitable depositing facies under certain special condi-tions, such as the catastrophic death of animals and/or de-veloping of an anoxic water column, and thus the pristane enrichment occurs in the sediment. The occurrences of iso-prenoid enrichment and high Pr/Ph ratios have been found in other typical marine anoxic sediments accompanied by mass extinction in various extent during the most important geological periods, such as Late Ordovician, end of Devonian,Early Jurassic and Late Cretaceous. These occurrences sup-port to a certain extent the above mechanism that interprets the genesis of a high Pr/Ph ratio in some typical marine an-oxic sediments. The synchronous sharp negative shifts in δ 13Cmole, δ 13Ckero and δ 13Ccarb from Beds 24 to 26 of the Me-ishan profile indicate that a sudden and strong variation of carbon source in the atmosphere-ocean system occurred during the quick but equable evolution from the end-Permian to Early Triassic, and the coupling between the pristane enrichment and negative shift in δ 13Ckero and δ 13CPr may well indicate the importance of the release of methane hydrates and marine anoxia in the end-Permian mass extinc-tion. | WANG Chunjiang LIU Yimei LIU Hongxiu ZHU Lei SHI Quan | 2005 | Chinese Science Bulletin2005，50，19： | 5 |
| 8 | T-2 toxin induces developmental toxicity and apoptosis in zebrafish embryos显示文摘T-2 toxin is one of the most important trichothecene mycotoxins occurring in various agriculture products. The developmental toxicity of T-2 toxin and the exact mechanism of action at early life stages are not understood precisely. Zebrafish embryos were exposed to different concentrations of the toxin at 4–6 hours post fertilization(hpf) stage of development, and were observed for different developmental toxic effects at 24, 48, 72, and 144 hpf. Exposure to 0.20 μmol/L or higher concentrations of T-2 toxin significantly increased the mortality and malformation rate such as tail deformities, cardiovascular defects and behavioral changes in early developmental stages of zebrafish. T-2 toxin exposure resulted in significant increases in reactive oxygen species(ROS) production and cell apoptosis, mainly in the tail areas, as revealed by Acridine Orange staining at 24 hpf. In addition, T-2 toxin-induced severe tail deformities could be attenuated by co-exposure to reduced glutathione(GSH). T-2 toxin and GSH co-exposure induced a significant decrease of ROS production in the embryos. The overall results demonstrate that T-2 toxin is able to produce oxidative stress and induce apoptosis, which are involved in the developmental toxicity of T-2 toxin in zebrafish embryos. | Guogang Yuan Yimei Wang Xiaoyan Yuan Tingfen Zhang Jun Zhao Liuyu Huang Shuangqing Peng | 2014 | Journal of Environmental Sciences2014，26，4： | 5 |
| 9 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 10 | Gut microbiota contributes to the development of endometrial glands in gilts during the ovary-dependent period显示文摘Background:The hyper-prolificacy Meishan gilts achieved a superior endometrial gland development(EGD)than white crossbred gilts during the ovary-independent period(before 60 d of age).Then,the EGD continues under the management of ovary-derived steroid hormones that regulated by gut microbiota(after 60 d of age).However,whether Meishan gilts’superiority in EGD lasting to the ovary-dependent period(after 60 d of age)and the role of gut microbiota in this period both remain unclear.Methods:Meishan gilts and Landrace x Yorkshire(LxY)gilts were raised under the same housing and feeding conditions until sexual maturity and then we compared their EGD and gut microbiota.Meanwhile,we transplanted fecal microbiota from Meishan gilts to L×Y gilts to explore the role of gut microbiota in EGD.We sampled plasma every 3 weeks and collected the uterus,ovary,liver,and rectal feces after the sacrifice.We then determined the hormone concentrations and expressions of the EGD-related genes.We also profiled the gut microbiota using 16S rDNA sequencing and metabolites of plasma and liver tissue using untargeted metabolomics.Finally,the correlation analysis and significant test was conducted between FMT-shifted gut microbes and EGD-related indices.Results:Meishan gilts have larger endometrial gland area(P<0.001),longer uterine horn length(P<0.01)but lighter uterine horn weight(P<0.05),a distinctive gut microbiota compared with L×Y gilts.Fecal microbiota transplantation(FMT)increased endometrial gland area(P<0.01).FMT markedly shifted the metabolite profiles of both liver and plasma,and these differential metabolites enriched in steroid hormone biosynthesis pathway.FMT increased estradiol and insulin-like growth factor 1 but decreased progesterone dynamically.FMT also increased the expression of the EGD-related genes estrogen receptor 1 gene,epithelial cadherin,and forkhead box protein A2.There is a significant correlation between FMT-shifted gut microbes and EGD-related indices.Conclusion:Sexually matured Meishan gilts achieved a superior EGD than LxY gilts.Meanwhile,gut microbiota contribute to the EGD potentially via regulating of steroid hormones during the ovary-dependent period. | Baoyang Xu Wenxia Qin Yiqin Yan Yimei Tang Shuyi Zhou Juncheng Huang Chunlin Xie Libao Ma Xianghua Yan | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 4 |
| 11 | Derivation of Putative Porcine Embryonic Germ Cells and Analysis of Their Multi-Lineage Differentiation Potential显示文摘Embryonic germ(EG)cells are cultured pluripotent stem cells derived from the primordial germ cells(PGCs)that migrate from the dorsal mesentery of the hindgut to the developing genital ridge.In this study,the morphology of the porcine genital ridge was assessed in embryos harvested on days 22-30 of pregnancy.PGCs from embryos at these stages were cultured to obtain porcine EG cell lines,and EG-like cells were derived from PGCs from embryos harvested on days 24-28 of pregnancy.The EG-like cells expressed Oct4,Sox2,Nanog,SSEA-3,SSEA-4 and alkaline phosphatase(AP).These cells were able to form embryoid bodies(EBs)in suspension culture and differentiate into cells representative of the three germ layers as verified by a-fetoprotein(AFP),a-smooth muscle actin(a-SMA),and Nestin expression.Spontaneous differentiation from the porcine EG-like cells of delayed passage in vitro showed that they could differentiate into epithelial-like cells,mesenchymal-like cells and neuron-like cells.In vitro directed differentiation generated osteocytes,adipocytes and a variety of neural lineage cells,as demonstrated by alizarin red staining,oil red O staining,and immunofluorescence for neuronal classⅢb-tubulin(Tuj1),glial fibrillary protein(GFAP)and galactosylceramidase(GALC),respectively.These results indicate that porcine EG-like cells have the potential for multi-lineage differentiation and are useful for basic porcine stem cell research. | Yimei Cong Jing Ma Ruizhen Sun Jianyu Wang Binghua Xue Jiaqiang Wang Bingteng Xie Juan Wang Kui Hu Zhonghua Liu | 2013 | Journal of Genetics and Genomics2013，40，9： | 4 |
| 12 | Advancement of maxillary anterior segment by distraction osteogenesis for severe maxillary retrusion in cleft lip and palate显示文摘 | Gao Feng Yang Minlie Zhao Zhenmin Sun Xiaomei Yin Ningbei Wang Yongqian Song Tao Li Haidong Wu Di Yin Jiapeng Cao Yimei Tong Haizhou | 2014 | Chinese Medical Journal2014，，3： | 4 |
| 13 | Single-/fused-band dual-mode mid-infrared imaging with colloidal quantum-dot triple-junctions显示文摘Image data acquired with fused multispectral information can be used for effective identification and navigation owing to additional information beyond human vision,including thermal distribution,night vision,and molecular composition.However,the construction of photodetectors with such capabilities is hindered by the structural complexity arising from the integration of multiple semiconductor junctions with distinct energy gaps and lattice constants.In this work,we develop a colloidal quantum-dot dual-mode detector capable of detecting,separating,and fusing photons from various wavelength ranges.Using three vertically stacked colloidal quantum-dot homojunctions with alternating polarity,single-band short-wave infrared imaging and fused-band imaging(short-wave and mid-wave infrared)can be achieved with the same detector by controlling bias polarity and magnitude.The dual-mode detectors show detectivity up to 8×10^(10)Jones at the fused-band mode and 3.1×10^(11)Jones at the single-band mode,respectively.Without image post-processing algorithms,the dual-mode detectors could provide both night vision and thermal information-enhanced night vision imaging capability.To the best of our knowledge,this is the first colloidal quantum-dot detector that can achieve such functionality.The operation mode can be changed at a high frequency up to 1.7 MHz,making it possible to achieve simultaneously dual-mode imaging and remote temperature sensing. | SHUO ZHANG GE MU JIE CAO YUNING LUO QUN HAO MENGLU CHEN YIMEI TAN PENGFEI ZHAO XIN TANG | 2022 | Photonics Research2022，10，8： | 3 |
| 14 | Learning Bayesian networks using genetic algorithm显示文摘A new method to evaluate the fitness of the Bayesian networks according to the observed data is provided. The main advantage of this criterion is that it is suitable for both the complete and incomplete cases while the others not. Moreover it facilitates the computation greatly. In order to reduce the search space, the notation of equivalent class proposed by David Chickering is adopted. Instead of using the method directly, the novel criterion, variable ordering, and equivalent class are combined,moreover the proposed mthod avoids some problems caused by the previous one. Later, the genetic algorithm which allows global convergence, lack in the most of the methods searching for Bayesian network is applied to search for a good model in this space. To speed up the convergence, the genetic algorithm is combined with the greedy algorithm. Finally, the simulation shows the validity of the proposed approach. | Chen Fei Wang Xiufeng Rao Yimei | 2007 | Journal of Systems Engineering and Electronics2007，18，1： | 3 |
| 15 | An enhanced least squares residual RAIM algorithm based on optimal decentralized factor显示文摘The Least Squares Residual(LSR)algorithm is commonly used in the Receiver Autonomous Integrity Monitoring(RAIM).However,LSR algorithm presents high Missed Detection Risk(MDR)caused by a large-slope faulty satellite and high False Alert Risk(FAR)caused by a small-slope faulty satellite.In this paper,the LSR algorithm is improved to reduce the MDR for a large-slope faulty satellite and the FAR for a small-slope faulty satellite.Based on the analysis of the vertical critical slope,the optimal decentralized factor is defined and the optimal test statistic is conceived,which can minimize the FAR with the premise that the MDR does not exceed its allowable value of all three directions.To construct a new test statistic approximating to the optimal test statistic,the Optimal Decentralized Factor weighted LSR(ODF-LSR)algorithm is proposed.The new test statistic maintains the sum of pseudo-range residual squares,but the specific pseudo-range residual is weighted with a parameter related to the optimal decentralized factor.The new test statistic has the same decentralized parameter with the optimal test statistic when single faulty satellite exists,and the difference between the expectation of the new test statistic and the optimal test statistic is the minimum when no faulty satellite exists.The performance of the ODFLSR algorithm is demonstrated by simulation experiments. | Guanghui SUN Chengdong XU Dan SONG Yimei JIAN | 2020 | Chinese Journal of Aeronautics2020，33，12： | 3 |
| 16 | Ginsenoside Rb1 Reduces D-GalN/LPS-induced Acute Liver Injury by Regulating TLR4/NF-κB Signaling and NLRP3 Inflammasome显示文摘Background and Aims:The effect of ginsenoside Rb1 on D-galactosamine(D-GalN)/lipopolysaccharide(LPS)-induced acute liver injury(ALI)is unknown.The aim of this study was to evaluate the effect of ginsenoside Rb1 on ALI and its underlying mechanisms.Methods:Mice were pretreated with ginsenoside Rb1 by intraperitoneal injection for 3 days before D-GalN/LPS treatment,to induce ALI.The survival rate was monitored every hour for 24 h,and serum biochemical parameters,hepatic index and histopathological analysis were evaluated to measure the degree of liver injury.ELISA was used to detect oxidative stress and inflammatory cytokines in hepatic tissue and serum.Immunohistochemistry staining,RT-PCR and western blotting were performed to evaluate the expression of toll-like receptor 4(TLR4),nuclear factorkappa B(NF-κB),and NLR family,pyrin domain-containing 3 protein(NLRP3)in liver tissue and Kupffer cells(KCs).Results:Ginsenoside Rb1 improved survival with D-GalN/LPS-induced ALI by up to 80%,significantly ameliorated the increased alanine and aspartate transaminase,restored the hepatic pathological changes and reduced the levels of oxidative stress and inflammatory cytokines altered by D-GalN/LPS.Compared to the control group,the KCs were increased in the D-GalN/LPS groups but did not increase significantly with Rb1 pretreatment.D-GalN/LPS could upregulate while Rb1 pretreatment could downregulate the expression of interleukin(IL)-1β,IL-18,NLRP3,apoptosis associated specklike protein containing CARD(ASC)and caspase-1 in isolated KCs.Furthermore,ginsenoside Rb1 inhibited activation of the TLR4/NF-κB signaling pathway and NLRP3 inflammasome induced by D-GalN/LPS administration.Conclusions:Ginsenoside Rb1 protects mice against D-GalN/LPS-induced ALI by attenuating oxidative stress and the inflammatory response through the TLR4/NF-κB signaling pathway and NLRP3 inflammasome activation. | Yimei Liu Ninghua Liu Yujing Liu Hongyu He Zhe Luo Wenjun Liu Nan Song Minjie Ju | 2022 | Journal of Clinical and Translational Hepatology2022，10，3： | 2 |
| 17 | 临床健康素养的特征及其影响因素——一个全国住院病人样本的分析显示文摘目的从临床视角了解住院病人的健康素养状况及其影响因素,为改善病人健康素养提供依据和建议。方法采用分层整群抽样方法,调查全国7个省市、77家综合医院的8238例住院病人。临床健康素养包括病情表述的难度和正确服药的难度;影响因素包括结构因素(性别、年龄、文化程度、婚姻状况、经济状况以及地域分布)和调节因素(家庭成员支持、亲属中从事医护人员的数量和最近三年的住院次数)。结果调查对象病情表述难度“较多/很多”的比例,男性占17.7%,女性占20.6%;正确服药难度“较多/很多”的比例,男性占12.4%,女性占11.6%。Logistic回归分析结果显示,相对大学及以上文化程度的患者而言,小学及以下文化程度的患者在病情表述和正确服药方面的难度均多(OR=1.44,95%CI:1.16~1.80;OR正确服药=2.07,95%CI:1.57~2.73);相对经济状况好的患者而言,经济状况差的患者在病情表述和正确服药方面的难度均多(OR=2.14,95%CI:1.76~2.61;OR正确服药=2.05,95%CI:1.62~2.59);相对住院次数3次及以上的患者,没有住过院的患者对病情表述的难度小(OR=0.66,95%CI:0.56~0.78)。结论病人病情表述上的困难多于正确服药上的困难,影响因素中结构因素(特别是文化程度和经济状况)的作用可能比调节因素(特别是最近三年住院次数)的作用更为重要。 | 洪雅君 叶贝珠 张萍 程瑶 蒋红卫 孙奕 王乔凤 谢小华 Zhu Yimei 张乃兴 梁渊 | 2020 | 中国社会医学杂志2020，37，1： | 2 |
| 18 | Effects of Space Radiation Mutation on Germination and Growth of Sugarcane Hybrid Seeds显示文摘[Objectives] This study was conducted to investigate the mutagenic effects of space radiation mutagenesis on sugarcane hybrid seeds. [Methods] Sugarcane hybrid spikes were subjected to space radiation mutagenesis treatment to identify the effects on the germination, seedling growth and plant growth and development of sugarcane hybrid seeds. [Results] The space radiation treatment had a great impact on the germination and growth of sugarcane hybrid seeds, especially on the germination of sugarcane seeds. The germination number per gram of seeds increased significantly, and the survival rate of seedlings increased significantly. The effect on the growth status was relatively small. The average number of tillers decreased slightly, the percentage of available stems increased, and the plants became higher, which resulted in a greater effect on sugarcane yield. Sugarcane sucrose was increased. The seed germination and late growth status indicated that space radiation promoted the germination and growth of sugarcane hybrid seeds. [Conclusions] This study provides a basis for the space radiation mutagenesis breeding of sugarcane hybrid seeds and the promotion of sugarcane breeding process. | Yimei GAN Yuanli WU Jun ZENG Wenwei CAI Zhengying CAO Lishun PENG Benpeng YANG | 2019 | Agricultural Biotechnology2019，8，6： | 2 |
| 19 | Ecosystem service valuation of bays in East China Sea and its response to sea reclamation activities显示文摘Ecosystem service values(ESVs)of bays and their response to sea reclamation are of great practical importance for forming bay eco-compensation policy and extension of blue economic space.Based on land use information of bays collected during the period of 1990–2015,the spatiotemporal evolution of ESVs of 12 main bays in East China Sea and their response to sea reclamation activities over the past 25 years were quantitatively analyzed.The analysis results indicate that ESVs of bays in East China Sea showed a continuous downward trend and the whole ecosystem was continuously degraded,in which the degradation degree of ESV in the southern bays was higher than that in the northern bays.Spatial zoning of ESVs of bays in East China Sea was remarkable,showing a continuous downward trend from low-value to high-value zone.Spatial variation of ESVs of each bay was also significant,expanding from a city and from inland to the coast,which suggests that human activities,mainly reclamation,have become main agents for ESV evolution of bays in East China Sea.ESVs of bays have a significant response to sea reclamation,manifested as a significant negative correlation between ESV and reclamation intensity.The correlation in the southern bays was stronger than that in the northern bays,which was caused by different effects of sea reclamation modes on ESV evolution of muddy and bedrock bays.A negative effect of sea reclamation activities on bay ecosystem was hysteretic.Therefore,an attention should be paid to dynamic monitoring and early warning of development status in offshore areas,ecosystem-level reclamation control policy,and coastal wetland reserves planning.Moreover,the spatial coupling mechanism study between bay ecosystem service demand and its service supply capacity should be strengthened to realize systematic regulation of bay ecological security pattern. | LIU Ruiqing XU Hao LI Jialin PU Ruiliang SUN Chao CAO Luodan JIANG Yimei TIAN Peng WANG Lijia GONG Hongbo | 2020 | Journal of Geographical Sciences2020，30，7： | 2 |
| 20 | Ofloxacin induces apoptosis in microencapsulated juvenile rabbit chondrocytes by caspase-8-dependent mitochondrial pathway显示文摘 | Zhiguo Sheng Xiaojuan Cao Shuangqing Peng Changyong Wang Qianqian Li Yimei Wang Mifeng Liu | 2007 | Toxicology and Applied Pharmacology2007，，2： | 2 |
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