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| 1 | Protective effect of steroidal saponins from rhizome of Anemarrhena asphodeloides on ovariectomy-induced bone loss in rats显示文摘瞄准:为了从知母属调查 steroidal saponins 的保护的效果,卵巢切除术(OVX ) 上的 asphodeloides (ATS ) 导致了骨头损失。方法:Sprague-Dawley 老鼠被划分成假冒并且 OVX 组。OVX 老鼠与车辆, nylestriol 或 steroidal saponins 摘录被对待 12 个星期。浆液钙,磷,雌二醇(E (2 )) , osteocalcin 集中和浆液硷性磷酸酯酶活动被测量。骨头密度是由双精力的 X 光检查 absorptiometry 的 assayed。波形钙化纵近似胫骨先验(PTM ) 节为 histomorphometric 被切并且染色骨头的分析。结果:在 OVX 老鼠,在浆液的硷性磷酸酯酶活动显著地被增加, osteocalcin 的集中被 ATS 处理减少,它没在体重上有影响。同时,子宫的萎缩和骨头矿物质密度(BMD ) 的降下被处理与 ATS 一起压制。另外, ATS 们完全改正了减少在浆液的钙和 E (2 ) 的集中在 OVX 观察了老鼠。组织学的结果证明 ATS 们在在近似胫骨干骺端(PTM ) 的小梁的分离的小梁的厚度和 OVX 老鼠的增加阻止了减少。然而,它没在 OVX 老鼠改变骨破折数字。而且, ATS (300 mg/kg ) 在在 OVX 老鼠支持骨头形成行动上有显著效果。Nylestriol 处理减少了骨头形成率和矿物质并置率。结论:知母属 asphodeloides 的 steroidal saponins 的足够的供应通过骨头形成的提升然而并非骨吸收的抑制在老鼠阻止了导致 OVX 的骨头损失。 | Hua NIAN Lu-ping QIN Wan-sheng CHEN Qiao-yan ZHANG Han-chen ZHENG Yin WANG | 2006 | Acta Pharmacologica Sinica2006，27，6： | 20 |
| 2 | Associations of blood pressure and arterial compliance with occupational noise exposure in female workers of textile mill显示文摘在那里的背景是噪音暴露的动脉的依从上的很少研究。学习是理解在听见损失,血压和在噪音在工作地点铺平的纺织品 mill.Methods 暴露了到职业噪音的女工人的动脉的依从之间的关系的这的目的与一 HS6288 健全水平米被测量。堆积噪音暴露(CNE ) 根据噪音紧张和暴露时期被计算。听说能力和动脉的依从在 618 噪音被测量暴露了工人。数据库与 EpiData 被建立,统计分析与噪音铺平的 SAS 软件 9.1.3 .Results 被执行是到 113.5dB (A) ,在监视地点的 92.5% 噪音的层次在国家标准上是的 80.1dB (A) 。高频率听觉损失(HFHL ) 的发生是 24.43% ,语言频率听觉缺陷(LFHI ) 是 0.81% 。高血压的发生是 7.93% 。收缩血压(SBP ) 和在高频率听觉损失组的心脏舒张的血压(DBP ) 比在正常听觉组(P0.05 ) 的那些显著地高,当 C1 (大动脉依从) 和 C2 (小动脉依从) 显著地更低时(P0.05 ) 。高血压组的高频率听觉阀值(HFHT ) 比在正常血压组(P0.05 ) 显著地高,当 C1 和 C2 显著地更低时(P0.05 ) 。 C1 和 C2 与 HFHT 有否定关联, SBP , DBP ,动脉的压力(地图)的平均数,脉搏压力( PP )和多重回归分析的 .The 显示出的脉搏率( PR )( P0.05 )血压和 PR 是 C1 和 C2.LFHT 上的主要影响因素,这是对 C2 的影响, C1.Conclusions 纺织品工厂噪音污染上的 HFHT 是很严肃的并且在工人的家上有明显的影响听觉的功能。有 Iow 动脉依从或与高血压的女工人可能正在受不了听觉损失;那些与噪音导致了听说如果她常常暴露于大声工业的噪音,损失可能正在患高血压。 | NI Chun-hui CHEN Zhi-yong ZHOU Yin ZHOU Jian-wei Pan Jing-jing LIU Nian WANG Jun LIANG Chen-ke ZHANG Zhi-zhong ZHANG Yu-jun | 2007 | Chinese Medical Journal2007，，15： | 12 |
| 3 | Cucurbitane triterpenoids from Hemsleya penxianensis显示文摘Two new cucurbitacins,jinfushanencins A(1)and B(2),seven new cucurbitane glycosides,jinfushanosides E-K(3-9),along with nine known analogues,were obtained from the tubers of Hemsleya penxianensis.Their structures were elucidated on the basis of extensive spectroscopic and chemical methods.Selected isolates were tested their anti-HIV-1 activities,and compound 5 showed weak anti-HIV-1 in C8166 cell(EC50=5.9μg/mL)with a selectivity index of 13.5. | Jian-Chao CHEN Lin ZHOU Yun-Hua WANG Ren-Rong TIAN Yun-Xin YAN Yin NIAN Yun SUN Yong-Tang ZHENG Ming-Hua QIU | 2012 | Natural Products and Bioprospecting2012，2，4： | 8 |
| 4 | Potential rat model of anxiety-like gastric hypersensitivity induced by sequential stress显示文摘AIM To establish a rat model of anxiety-like gastric hyper-sensitivity(GHS) of functional dyspepsia(FD) induced by novel sequential stress.METHODS Animal pups were divided into two groups from postnatal day 2: controls and the sequential-stress-treated. The sequential-stress-treated group received maternal separation and acute gastric irritation early in life and restraint stress in adulthood; controls were reared undisturbed with their mothers. Rats in both groups were followed to adulthood(8 wk) at which point the anxietylike behaviors and visceromotor responses to gastric distention(20-100 mm Hg) and gastric emptying were tested. Meanwhile, alterations in several anxiety-related brain-stomach modulators including 5-hydroxytryptamine(5-HT), γ-aminobutyric acid(GABA), brain-derived neurotrophic factor(BDNF) and nesfatin-1 in the rat hippocampus, plasma and gastric fundus and the 5-HT1 A receptor(5-HT1 AR) in the hippocampal CA1 subfield and the mucosa of the gastric fundus were examined.RESULTS Sequential-stress-treated rats simultaneously demonstrated anxiety-like behaviors and GHS in dose-dependent manner compared with the control group. Although rats in both groups consumed similar amount of solid food, the rate of gastric emptying was lower in the sequentialstress-treated rats than in the control group. Sequential stress significantly decreased the levels of 5-HT(51.91 ± 1.88 vs 104.21 ± 2.88, P < 0.01), GABA(2.38 ± 0.16 vs 5.01 ± 0.13, P < 0.01) and BDNF(304.40 ± 10.16 vs 698.17 ± 27.91, P < 0.01) in the hippocampus but increased the content of nesfatin-1(1961.38 ± 56.89 vs 1007.50 ± 33.05, P < 0.01) in the same site; significantly decreased the levels of 5-HT(47.82 ± 2.29 vs 89.45 ± 2.61, P < 0.01) and BDNF(257.05 ± 12.89 vs 536.71 ± 20.73, P < 0.01) in the plasma but increased the content of nesfatin-1 in it(1391.75 ± 42.77 vs 737.88 ± 33.15, P < 0.01); significantly decreased the levels of 5-HT(41.15 ± 1.81 vs 89.17 ± 2.31, P < 0.01) and BDNF(226.49 ± 12.10 vs 551.36 ± 16.47, P < 0.01) in the gastric fundus but increased the content of nesfatin-1 in the same site(1534.75 ± 38.52 vs 819.63 ± 38.04, P < 0.01). The expressions of 5-HT1 AR in the hippocampal CA1 subfield and the mucosa of the gastric fundus were down-regulated measured by IHC(Optical Density value: Hippocampus 15253.50 ± 760.35 vs 21149.75 ± 834.13; gastric fundus 15865.25 ± 521.24 vs 23865.75 ± 1868.60; P < 0.05, respectively) and WB(0.38 ± 0.01 vs 0.57 ± 0.03, P < 0.01)(n = 8 in each group). CONCLUSION Sequential stress could induce a potential rat model of anxiety-like GHS of FD, which could be used to research the mechanisms of this intractable disease. | Fu-Chun Jing Jun Zhang Chen Feng Yuan-Yuan Nian Jin-Hai Wang Hao Hu Bao-De Yang Xiao-Ming Sun Jian-Yun Zheng Xiao-Ran Yin | 2017 | World Journal of Gastroenterology2017，23，42： | 8 |
| 5 | Tribo-informatics:Concept,architecture,and case study显示文摘Friction plays a vital role in energy dissipation,device failure,and even energy supply in modern society.After years of research,data and information on tribology research are becoming increasingly available.Because of the strong systematic and multi-disciplinary coupling characteristics of tribology,tribology information is scattered in various disciplines with different patterns,e.g.,technical documents,databases,and papers,thereby increasing the information entropy of the system,which is inconducive to the preservation and circulation of research information.With the development of computer and information science and technology,many subjects have begun to be combined with information technology,and multi-disciplinary informatics has been born.This paper describes the combination of information technology with tribology research,presenting the connotation and architecture of tribo-informatics,and providing a case study on implementing the proposed concept and architecture.The proposal and development of tribo-informatics described herein will improve the research efficiency and optimize the research process of tribology,which is of considerable significance to the development of this field. | Zhinan ZHANG Nian YIN Shi CHEN Chengliang LIU | 2021 | Friction2021，9，3： | 5 |
| 6 | New 9,19-cycloartane triterpenoid from the root of Cimicifuga foetida显示文摘AIM: To study the 9, 19-cycloartane triterpenes from the roots of Cimicifuga foetida. METHOD: Chromatographic separations by silica gel, C18 reversed phase silica gel, and high-performance liquid chromatography(HPLC) were used. All of the structures were elucidated on the basis of spectroscopic analysis and chemical methods. RESULTS: Five 9, 19-cycloartane triterpenes,(3β, 12β, 15α, 24R)-12, 2'-diacetoxy-24, 25-epoxy-15-hydroxy-16, 23-dione-3-O-α-L-arabinopyranoside(1), actein(2), 23-epi-26-deoxyactein(3), asiaticoside B(4), and 12β-hydroxycimigenol(5) were isolated from the roots of Cimicifuga foetida. CONCLUSION: Compound 1 is a new triterpene with two acetoxy groups at C-2' and C-12. | ZHU Di-Fan NIAN Yin WANG Hai-Yan ZHANG Zhi-Run SONG Yan-Bo LI Rong-Tao QIU Ming-Hua | 2014 | Chinese Journal of Natural Medicines2014，12，4： | 4 |
| 7 | Delayed improvements in visual memory task performance among chronic schizophrenia patients after high-frequency repetitive transcranial magnetic stimulation显示文摘BACKGROUND Cognitive impairments are core characteristics of schizophrenia,but are largely resistant to current treatments.Several recent studies have shown that highfrequency repetitive transcranial magnetic stimulation(rTMS)of the left dorsolateral prefrontal cortex(DLPFC)can reduce negative symptoms and improve certain cognitive deficits in schizophrenia patients.However,results are inconsistent across studies.AIM To examine if high-frequency rTMS of the DLPFC can improve visual memory deficits in patients with schizophrenia.METHODS Forty-seven chronic schizophrenia patients with severe negative symptoms on stable treatment regimens were randomly assigned to receive active rTMS to the DLPFC(n=25)or sham stimulation(n=22)on weekdays for four consecutive weeks.Patients performed the pattern recognition memory(PRM)task from the Cambridge Neuropsychological Test Automated Battery at baseline,at the end of rTMS treatment(week 4),and 4 wk after rTMS treatment(week 8).Clinical symptoms were also measured at these same time points using the Scale for the Assessment of Negative Symptoms(SANS)and the Positive and Negative Syndrome Scale(PANSS).RESULTS There were no significant differences in PRM performance metrics,SANS total score,SANS subscores,PANSS total score,and PANSS subscores between active and sham rTMS groups at the end of the 4-wk treatment period,but PRM performance metrics(percent correct and number correct)and changes in these metrics from baseline were significantly greater in the active rTMS group at week 8 compared to the sham group(all P<0.05).Active rTMS treatment also significantly reduced SANS score at week 8 compared to sham treatment.Moreover,the improvement in visual memory was correlated with the reduction in negative symptoms at week 8.In contrast,there were no between-group differences in PANSS total score and subscale scores at either week 4 or week 8(all P>0.05).CONCLUSION High-frequency transcranial magnetic stimulation improves visual memory and reduces negative symptoms in schizophrenia,but these effects are delayed,potentially due to the requirement for extensive neuroplastic changes within DLPFC networks. | Xiang-Dong Du Zhe Li Nian Yuan Ming Yin Xue-Li Zhao Xiao-Li Lv Si-Yun Zou Jun Zhang Guang-Ya Zhang Chuan-Wei Li Hui Pan Li Yang Si-Qi Wu Yan Yue Yu-Xuan Wu Xiang-Yang Zhang | 2022 | World Journal of Psychiatry2022，12，9： | 3 |
| 8 | Convergence of some finite element iterative methods related to different Reynolds numbers for the 2D/3D stationary incompressible magnetohydrodynamics显示文摘Based on the finite element method(FEM), some iterative methods related to different Reynolds numbers are designed and analyzed for solving the 2D/3D stationary incompressible magnetohydrodynamics(MHD) numerically. Two-level finite element iterative methods, consisting of the classical m-iteration methods on a coarse grid and corrections on a fine grid, are designed to solve the system at low Reynolds numbers under the strong uniqueness condition. One-level Oseen-type iterative method is investigated on a fine mesh at high Reynolds numbers under the weak uniqueness condition. Furthermore, the uniform stability and convergence of these methods with respect to equation parameters R_e, R_m, S_c, mesh sizes h, H and iterative step m are provided. Finally, the efficiency of the proposed methods is confirmed by numerical investigations. | DONG Xiao Jing HE Yin Nian | 2016 | Science China Mathematics2016，59，3： | 3 |
| 9 | Synthesis and Antitumor Activity of4β-(1,2,3-Triazol-1-yl) podophyllotoxins显示文摘Three 4β-(1,2,3-triazol-1-yl) podophyllotoxins 2~4 have been synthesized and testedtar their antitumor activity in vitro. The compound 3 was found to be much more cytotoxic than theclinically used etoposide (VP-16) against L 1210 cells. | Chang Nian CAO~2 Yu Yin CHEN1 Yan Guang WANG1 Yao Zu CHEN(1Department of Chemistry, Zhejiang University, Hangzhou 310027)(2Department of Applied Chemistry, Qinghai University, Xining 810000) | 1999 | Chinese Chemical Letters1999，10，12： | 3 |
| 10 | Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity显示文摘Four new 9,19-cycloartane triterpenoids,cimilactone E(1),cimilactone F(2),20-O-(E)-butenoyl-23-epi-26-deoxyactein(3),and 20,12b-O-diacetylcimiracemonol-3-O-b-D-xylopyranoside(4),together with four known constituents(5–8)were isolated from the roots of Cimicifuga foetida.The new structures were elucidated by extensive spectroscopic analysis.In addition,compounds 7 and 8 showed significant Wnt signaling pathway inhibitory activity,with IC50 values of 3.33 and 13.34 lM,respectively,using the luciferase reporter gene assay. | Di-Fan Zhu Guo-Lei Zhu Ling-Mei Kong Ni-Man Bao Lin Zhou Yin Nian Ming-Hua Qiu | 2015 | Natural Products and Bioprospecting2015，5，2： | 2 |
| 11 | Identification of Fucans from Four Species of Sea Cucumber by High Temperature ~1H NMR显示文摘Acidic polysaccharide, which has various biological activities, is one of the most important components of sea cucumber. In the present study, crude polysaccharide was extracted from four species of sea cucumber from three different geographical zones, Pearsonothuria graeffei(Pg) from Indo-Pacific, Holothuria vagabunda(Hv) from Norwegian Coast, Stichopus tremulu(St) from Western Indian Ocean, and Isostichopus badionotu(Ib) from Western Atlantic. The polysaccharide extract was separated and purified with a cellulose DEAE anion-exchange column to obtain corresponding sea cucumber fucans(SC-Fucs). The chemical property of these SC-Fucs, including molecular weight, monosaccharide composition and sulfate content, was determined. Their structure was compared simply with fourier infrared spectrum analyzer and identified with high temperature 1H nuclear magnetic resonance spectrum analyzer(NMR) and room temperature 13 C NMR. The results indicated that Fuc-Pg obtained from the torrid zone mainly contained 2,4-O-disulfated and non-sulfated fucose residue, whereas Fuc-Ib from the temperate zone contained non-, 2-O- and 2,4-O-disulfated fucose residue; Fuc-St from the frigid zone and Fuc-Hv from the torrid zone contained mainly non-sulfated fucose residue. The proton of SC-Fucs was better resolved via high temperature 1H NMR than via room temperature 1H NMR. The fingerprint of sea cucumber in different sea regions was established based on the index of anomer hydrogen signal in SC-Fucs. Further work will help to understand whether there exists a close relationship between the geographical area of sea cucumber and the sulfation pattern of SC-Fucs. | WU Nian CHEN Shiguo YE Xingqian LI Guoyun YIN Li'ang XUE Changhu | 2014 | Journal of Ocean University of China2014，13，5： | 2 |
| 12 | Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV:a phase 2 trial显示文摘The increased coronavirus disease 2019(COVID-19)breakthrough cases pose the need of booster vaccination.We conducted a randomised,double-blinded,controlled,phase 2 trial to assess the immunogenicity and safety of the heterologous prime-boost vaccination with an inactivated COVID-19 vaccine(BBIBP-CorV)followed by a recombinant protein-based vaccine(NVSI-06-07),using homologous boost with BBIBP-CorV as control.Three groups of healthy adults(600 individuals per group)who had completed two-dose BBIBP-CorV vaccinations 1–3 months,4–6 months and≥6 months earlier,respectively,were randomly assigned in a 1:1 ratio to receive either NVSI-06-07 or BBIBP-CorV boost.Immunogenicity assays showed that in NVSI-06-07 groups,neutralizing antibody geometric mean titers(GMTs)against the prototype SARS-CoV-2 increased by 21.01–63.85 folds on day 28 after vaccination,whereas only 4.20–16.78 folds of increases were observed in control groups.For Omicron variant,the neutralizing antibody GMT elicited by homologous boost was 37.91 on day 14,however,a significantly higher neutralizing GMT of 292.53 was induced by heterologous booster.Similar results were obtained for other SARS-CoV-2 variants of concerns(VOCs),including Alpha,Beta and Delta.Both heterologous and homologous boosters have a good safety profile.Local and systemic adverse reactions were absent,mild or moderate in most participants,and the overall safety was quite similar between two booster schemes.Our findings indicated that NVSI-06-07 is safe and immunogenic as a heterologous booster in BBIBP-CorV recipients and was immunogenically superior to the homologous booster against not only SARS-CoV-2 prototype strain but also VOCs,including Omicron. | Nawal Al Kaabi Yun Kai Yang Jing Zhang Ke Xu Yu Liang Yun Kang Ji Guo Su Tian Yang Salah Hussein Mohamed Saif ElDein Shuai Shao Sen Sen Yang Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Ning Liu Fu Jie Shen Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 2 |
| 13 | Multiscale analysis of friction behavior at fretting interfaces显示文摘Friction behavior at fretting interfaces is of fundamental interest in tribology and is important in material applications.However,friction has contact intervals,which can accurately determine the friction characteristics of a material;however,this has not been thoroughly investigated.Moreover,the fretting process with regard to different interfacial configurations have also not been systematically evaluated.To bridge these research gaps,molecular dynamics(MD)simulations on Al–Al,diamond–diamond,and diamond–silicon fretting interfaces were performed while considering bidirectional forces.This paper also proposes new energy theories,bonding principles,nanoscale friction laws,and wear rate analyses.With these models,semi-quantitative analyses of coefficient of friction(CoF)were made and simulation outcomes were examined.The results show that the differences in the hardness,stiffness modulus,and the material configuration have a considerable influence on the fretting process.This can potentially lead to the force generated during friction contact intervals along with changes in the CoF.The effect of surface separation can be of great significance in predicting the fretting process,selecting the material,and for optimization. | Zhinan ZHANG Shuaihang PAN Nian YIN Bin SHEN Jie SONG | 2021 | Friction2021，9，1： | 1 |
| 14 | Nano-TiO_2 Decorated Radial-Like Mesoporous Silica: Preparation,Characterization, and Adsorption-Photodegradation Behavior显示文摘Supported nanocrystalline Ti_O2 with a diameter of 15–30 nm was prepared from previously synthesized radial mesoporous silica(RMS) by a post-synthesis method. In addition, their adsorption-photocatalytic activity toward the degradation of methylene blue(MB) was determined. RMS was tailor-made with the main template of CTAB and the Si_O2 precursor of TEOS through a facile self-assembly process. The structural, morphological and textural properties of the well-designed Ti_O2/RMS samples were characterized.The RMS structure was retained after loading Ti_O2, but its surface area and pore diameter decreased as a result of partial pore blocking. The removal activity of MB for Ti_O2/RMS was significantly higher than that of commercial Ti_O2 nanoparticles. The optimal Ti_O2 loading(20 wt%) on the support could achieve the complete removal of MB within 70 min. The prepared Ti_O2/RMS particles can be easily separated and display good durability after six reaction cycles. | Tingting Qian Xiaoping Yin Jinhong Li Hong'en Nian Hui Xu Yong Deng Xiang Wang | 2017 | Journal of Materials Science & Technology2017，33，11： | 1 |
| 15 | Iteration framework for solving mixed lubrication computation problems显示文摘The general discrete scheme of time-varying Reynolds equation loses the information of the previous step,which makes it unreasonable.A discretization formula of the Reynolds equation,which is based on the Crank-Nicolson method,is proposed considering the physical message of the previous step.Gauss-Seidel relaxation and distribution relaxation are adopted for the linear operators of pressure during the numerical solution procedure.In addition to the convergent criteria of pressure distribution and load,an estimation framework is developed to investigate the relative error of the most important term in the Reynolds equation.Smooth surface with frill contacts and mixed elastohydrodynamic lubrication is tested for validation.The asperity contact and sinusoidal wavy surface are examined by the proposed discrete scheme.Results show the precipitous decline in the boundary of the contact area.The relative error suggests that the pressure distribution is reliable and reflects the accuracy and effectiveness of the developed method. | Shi CHEN Nian YIN Zhinan ZHANG Xiaojiang CAI | 2021 | Frontiers of Mechanical Engineering2021，16，3： | 1 |
| 16 | Abietane derived diterpenoids as Ca_(v)3.1 antagonists from Salvia digitaloides显示文摘Nineteen diterpenoids, including saldigitin A(1) bearing an unprecedented 10-methylated 6/7/6 carbon ring system, two new icetexanes(2, 3), and two new nor-abietanes(5, 6) were characterized from the roots of Salvia digitaloides. Their structures were elucidated by the analysis of the spectroscopic data,X-ray crystallography, and TDDFT calculations of ECD spectra. The novel architecture of 1 should be biogenetically derived through the cleavage and re-cyclization of the B/C rings from the normal abietane skeleton. Biologically, 1–5 exhibited noticeable inhibitions on Ca_(v)3.1 low voltage-gated Ca2+channel(LVGCC), with IC50values in the range of 3.43–11.70 μmol/L. They are the first example of diterpenoids with 6/7/6 carbon rings system as Ca_(v)3.1 antagonists. | Jianjun Zhao Shuzong Du Kun Hu Yali Hu Fan Xia Yansong Ye Jian Yang Yin Nian Gang Xu | 2023 | Chinese Chemical Letters2023，34，4： | 1 |
| 17 | A cohort study of cancer among benzene exposed workers in China overall results显示文摘 | Song Nian Yin Richard B H Martha S L | 1996 | Amer J Ind Med1996，29，： | 1 |
| 18 | SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1显示文摘Background:Notch is one of the most important signaling pathways involved in cell fate determination.Activation of the Notch pathway requires the binding of a membrane-bound ligand to the Notch receptor in the adjacent cell which induces proteolytic cleavages and the activation of the receptor.A unique feature of the Notch signaling is that processes such as modification,endocytosis or recycling of the ligand have been reported to play critical roles during Notch signaling,however,the underlying molecular mechanism appears context-dependent and often controversial.Results:Here we identified SNX17 as a novel regulator of the Notch pathway.SNX17 is a sorting nexin family protein implicated in vesicular trafficking and we find it is specifically required in the ligand-expressing cells for Notch signaling.Mechanistically,SNX17 regulates the protein level of Jag1a on plasma membrane by binding to Jag1a and facilitating the retromer-dependent recycling of the ligand.In zebrafish,inhibition of this SNX17-mediated Notch signaling pathway results in defects in neurogenesis as well as pancreas development.Conclusions:Our results reveal that SNX17,by acting as a cargo-specific adaptor,promotes the retromer dependent recycling of Jag1a and Notch signaling and this pathway is involved in cell fate determination during zebrafish neurogenesis and pancreas development. | Wenguang Yin Dapeng Liu Nian Liu Liangliang Xu Song Li Shuo Lin Xiaodong Shu Duanqing Pei | 2012 | Cell Regeneration2012，1，1： | 1 |
| 19 | Taylor expansion algorithm for the branching solution of the Navier- Stokes equations 显示文摘 | LI Kai- tai HE Yin - nian | 2005 | Int J Numer Anal and Modeling2005，2，4： | 1 |
| 20 | Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand.-Mazz显示文摘Sixteen diterpenoid alkaloids(DAs),including six aconitine-type alkaloids(5 and 9−13),seven 7,17-seco-aconitine-type alkaloids(1−4,6−8),two napelline-type alkaloids(14 and 15)as well as one veatchine-type alkaloid(16),were isolated from the aerial parts of Aconitum flavum Hand.-Mazz.In which,flavumolines A−D(1−4)were four new ones,and flavu-moline E(5)was reported as natural compound for the first time.Their chemical structures were elucidated by the analysis of extensive spectroscopic data.The inhibitory activities of these isolates on Cav3.1 low voltage-gated Ca^(2+)channel,NO production in LPS-activated RAW264.7cells,five human tumor cell lines,as well as acetylcholinesterase(AChE)were tested. | Na Zhang Fan Xia Song-Yu Li Yin Nian Li-Xin Wei Gang Xu | 2021 | Natural Products and Bioprospecting2021，11，4： | 1 |
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