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| 1 | Mechanochemical decomposition of pentachlorophenol by ball milling显示文摘The mechanochemical dechlorination of pentachlorophenol (PCP) was studied using CaO and SiO2 powder as additives. The effects of the milling time and additives on the dechlorination rate were investigated. The resulting product was characterized by X-ray diffraction (XRD), Fourier transform infrared spectra (FT-IR), thermogravimetric analysis (TG) and ion chromatography (IC). It is found that grinding operation could dechlorinate PCP, with the formation of inorganic chloride and amorphous carbon. The addition of quartz to the grinding mixture facilitated dechlorination. On the basis of the experimental results, the decomposition mechanism was proposed. Decomposition predominantly proceeds through rupture of C-Cl bond in PCP molecule, followed by the formation of inorganic chlorides. | WEI Yinglei, YAN Jianhua, LU Shengyong, LI XiaodongState Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou 310027, China. | 2009 | Journal of Environmental Sciences2009，21，12： | 11 |
| 2 | The endocytosis and intracellular fate of nanomedicines: Implication for rational design显示文摘Nanomedicines employ multiple endocytic pathways to enter cells.Their following fate is interesting,but it is not sufficient understood currently.This review introduces the endocytic pathways,presents new technologies to confirm the specific endocytic pathways and discusses factors for pathway selection.In addition,some intriguing implication about nanomedicine design based on endocytosis will also be discussed at the end.This review may provide new thoughts for the design of novel multifunctional nanomedicines. | Longfa Kou Jin Sun Yinglei Zhai Zhonggui He | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，1： | 10 |
| 3 | Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer显示文摘Diabetes is one of the most prevalent diseases in the world with high-mortality and complex complications including diabetic foot ulcer(DFU). It has been reported that the difficulties in repairing the wound related to DFU has much relationship with the wound infection,change of inflammatory responses, lack of extracellular matrix(ECM), and the failure of angiogenesis. Following the development of medical materials and pharmaceutical technology, nanofibers has been developed by electrospinning with huge porosity, excellent humidity absorption, a better oxygen exchange rate, and some antibacterial activities. That is to say, as a potential material, nanofibers must be a wonderful candidate for the DFU treatment with so many benefits. Careful selection of polymers from natural resource and synthetic resource can widen the nanofibrous application. Popular methods applied for the nanofibrous fabrication consist of uniaxial electrospinning and coaxial electrospinning. Furthermore, nanofibers loading chemical, biochemical active pharmaceutical ingredient(API)or even stem cells can be wonderful dosage forms for the treatment of DFU. This review summarizes the present techniques applied in the fabrication of nanofibrous dressing(ND)that utilizes a variety of materials and active agents to offer a better health care for the patients suffering from DFU. | Yan Liu Shiya Zhou Yanlin Gao Yinglei Zhai | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 10 |
| 4 | Energy Saving Cooperative Communication over Fading Channels with Relay Selection and Power Control显示文摘In order to save energy and make more efficient use of wireless channel, this article puts forward an energy saving cooperative relaying scheme which actuates the cooperative transmission only when the feedback from the destination indicates failure of the direct transmission. The proposed scheme selects the optimal relay and its corresponding transmission power in each time slot based on channel condition and residual energy with the objective of minimizing energy consumption and extending network lifetime. In the study, the finite-state Markov channel model is used to characterize the correlation structure of channel fading in wireless networks, and the procedure of relay selection and transmission power decision is formulated as a Markov decision process. Numerical and simulation results show that the proposed scheme consumes less energy and prolongs the network lifetime. | Wei Yifei Teng Yinglei Wang Li Song Mei Man Yi | 2012 | China Communications2012，9，6： | 7 |
| 5 | Early Permian Sunidyouqi suprasubduction-zone ophiolites in the central Solonker suture zone(Inner Mongolia, China)显示文摘Different final closing ages have been proposed for the evolution of the Paleo-Asian Ocean(PAO),including Late Silurian, pre-Late Devonian, Early Permian, Late-Permian and Late Permian-Early Triassic.Ophiolites represent fragments of ancient oceanic crust and play an important role in identifying the suture zone and unveiling the evolutionary history of fossil oceans. Our detailed geological, geochemical and geochronological investigations argue for the existence of Early Permian(297 Ma) SSZ type ophiolites in the Sunidyouqi area of central Inner Mongolia, China. The gabbros and basalts show LREE depleted REE patterns and left-leaning primitive mantle-normalized spider diagrams with variable negative Nb-Ta anomalies(Nb~*= 0.24-1.28 and 0.29-0.55, respectively). The Sunidyouqi ophiolites were generated in a mature back-arc basin. The Sunidyouqi ophiolites share the same petrological,geochemical and geochronological characteristics with the other ophiolites along the Solonker suture zone, delineating a Late Paleozoic ocean and arc-trench system. This Late Paleozoic ocean and arc-trench system coincides with a Permian paleobiogeographical boundary, i.e. the boundary between the northern cold climate(Boreal faunal-Angaraland floral realm), and a southern warm climate(Tethys faunal-Cathaysian floral realm). A tectonic scenario was proposed at last for the closure of the SE PAO involving(1) Late Ordovician to Middle Permian continuous southward subduction beneath the northern margin of North China;(2) Carboniferous to Middle Permian continuous northward subduction the forming the Northern Accretionary Orogen;(3) Late Permian final closure of the SE PAO. | Guo Xu Huichuan Liu Yinglei Li Zhan Xu Yan Xie | 2019 | Geoscience Frontiers2019，10，3： | 5 |
| 6 | Pure drug nano-assemblies: A facile carrier-free nanoplatform for efficient cancer therapy显示文摘Nanoparticulate drug delivery systems(Nano-DDSs) have emerged as possible solution to the obstacles of anticancer drug delivery. However, the clinical outcomes and translation are restricted by several drawbacks, such as low drug loading, premature drug leakage and carrier-related toxicity.Recently, pure drug nano-assemblies(PDNAs), fabricated by the self-assembly or co-assembly of pure drug molecules, have attracted considerable attention. Their facile and reproducible preparation technique helps to remove the bottleneck of nanomedicines including quality control, scale-up production and clinical translation. Acting as both carriers and cargos, the carrier-free PDNAs have an ultra-high or even100% drug loading. In addition, combination therapies based on PDNAs could possibly address the most intractable problems in cancer treatment, such as tumor metastasis and drug resistance. In the present review, the latest development of PDNAs for cancer treatment is overviewed. First, PDNAs are classified according to the composition of drug molecules, and the assembly mechanisms are discussed. Furthermore, the co-delivery of PDNAs for combination therapies is summarized, with special focus on the improvement of therapeutic outcomes. Finally, future prospects and challenges of PDNAs for efficient cancer therapy are spotlighted. | Shuwen Fu Guanting Li Wenli Zang Xinyu Zhou Kexin Shi Yinglei Zhai | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 4 |
| 7 | Antimicrobial peptide LL-37 forms complex with bacterial DNA to facilitate blood translocation of bacterial DNA and aggravate ulcerative colitis显示文摘Bacterial DNA(bacDNA) is frequently found in serum of patient with ulcerative colitis(UC) and Crohn's disease, even blood bacterial culture is negative. How bacDNA evades immune elimination and is translocated into blood remain unclear. Here, we showed that bacDNA avoids elimination and disables bacteriakilling function of antimicrobial peptide LL-37(Cramp in mice) by forming complex with LL-37, which is inducible after culture with bacteria or bacterial products. Elevated LL-37-bacDNA complex was found in plasma and lesions of patients with UC. LL-37-bacDNA promoted inflammation by inducing Th1, Th2 and Th17 differentiation and activating toll-like receptor-9(TLR9). The complex also increased paracellular permeability, which possibly combines its inflammatory effects to promote local damage and bacDNA translocation into blood. Cramp-bacDNA aggravated mouse colitis severity while interference with the complex ameliorated the disease. The study identifies that inflammatogenic bacDNA utilizes LL-37 as a vehicle for blood translocation and to evade immune elimination. Additionally, bacteria may make a milieu by releasing bacDNA to utilize and resist host antimicrobial peptides as a ‘trojan horse'. | Zilei Duan Yaqun Fang Yang Sun Ning Luan Xue Chen Mengrou Chen Yajun Han Yizhu Yin James Mwangi Junkun Niu Kunhua Wang Yinglei Miao Zhiye Zhang Ren Lai | 2018 | Science Bulletin2018，63，20： | 4 |
| 8 | Porous bulk metallic glass fabricated by powder hot pressing显示文摘A synthesis method for the production of porous bulk metallic glass (BMG) was introduced. This method utilizes the su- perplastic forming ability of amorphous powder in the supercooled liquid (SCL) state and intenerating salt mixture as a placeholder to produce BMG foam by using a hot die pressing method. Scanning electron microscope (SEM), X-ray diffraction (XRD) and dif- ferential scanning calorimetry (DSC) were employed to characterize the morphologies of foaming structure, the crystallization and the percentage of crystallization of the as-produced porous BMG. The results suggested that the formation of porous structure by su- perplastic forming process is feasible. Good bonding effect was observed between amorphous powder particles. Less than 6.5% of crystalline phases were formed during hot pressing, and less than 5.5% of residual salt was enclosed in the foam. To remove any re- sidual salt particles, salt preforms with three-dimensional network and good connectivity is necessary. | Keqiang Qiu1), Bo Yu2), and Yinglei Ren1) 1) School of Materials Science and Engineering, Shenyang University of Technology, Shenyang 110023, China 2) Shenyang Research Institute of Foundry, Shenyang 110022, China | 2007 | International Journal of Minerals,Metallurgy and Materials2007，15，S1： | 4 |
| 9 | The development of polycarbophil as a bioadhesive material in pharmacy显示文摘Polycarbophil(PCP),a kind of pharmaceutical polymers with superior bioadhesive properties has been widely used in the field of controlled drug delivery systems.It could be used as a highly efficient thickener,bioadhesive agent,suspending aid and emulsion stabilizer when dispersed in water or other polar solvents.These exceptional utilities of the polymers result from their hydrophilic nature.Hydrogen bonding plays an important role in most adhesion behaviours and becomes the main adhesion force.This paper reviews the applications of PCP in pharmacy over the past decades,and clarifies its unique advantages in the bioadhesive formulations.After an introduction discussing its structural characteristics and action mechanism,the focus turned to the description of its available applications in detail with particular emphasis on the ocular,nasal,vagina and oral drug delivery systems.The other less developed formulations are also described,including the buccal and the transdermal delivery systems. | Zhaolu Zhu Yinglei Zhai Ning Zhang Donglei Leng Pingtian Ding | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，4： | 3 |
| 10 | Broadband & Digital Content-Couple Subscriber Cooperative Relaying Networks for Uplink Transmission using Hierarchical Game Approach显示文摘 | Song Meil Teng Yinglei Niu Fang Zhang Yong Wang Li | 2010 | China Communications2010，7，2： | 3 |
| 11 | A NOVEL ALGORITHM OF MULTI-SENSOR IMAGE FUSION BASED ON WAVELET PACKET TRANSFORM显示文摘In order to enhance the image information from multi-sensor and to improve the abilities of the information analysis and the feature extraction, this letter proposed a new fusion approach in pixel level by means of the Wavelet Packet Transform (WPT). The WPT is able to decompose an image into low frequency band and high frequency band in higher scale. It offers a more precise method for image analysis than Wavelet Transform (WT). Firstly, the proposed approach employs HIS (Hue, Intensity, Saturation) transform to obtain the intensity component of CBERS (China-Brazil Earth Resource Satellite) multi-spectral image. Then WPT transform is employed to decompose the intensity component and SPOT (Systeme Pour I'Observation de la Therre ) image into low frequency band and high frequency band in three levels. Next, two high frequency coefficients and low frequency coefficients of the images are combined by linear weighting strategies. Finally, the fused image is obtained with inverse WPT and inverse HIS. The results show the new approach can fuse details of input image successfully, and thereby can obtain a more satisfactory result than that of HM (Histogram Matched)-based fusion algorithm and WT-based fusion approach. | Cheng Yinglei Zhao Rongchun Hu Fuyuan Li Ying | 2006 | Journal of Electronics(China)2006，23，2： | 3 |
| 12 | Tribological study of N-containing borate derivatives and their synergistic antioxidation effects with T531显示文摘Two N-containing borates, BTES and BMES, were synthesized with dodecyl phenol, 2-(N-containing heterocyclic) ethan-1-ol, boric acid, and dibutylamine, and their tribological properties in rapeseed oil(RSO) were investigated using a four-ball tester. The results showed that the load-carrying ability(P_B value) of RSO can be improved by 40.9% and 67.9%, respectively, when using 0.5 wt% BTES and BMES. Moreover, the antiwear and friction-reducing performances of the additive-containing oils increased with the additive concentration. The X-ray photoelectron spectroscopy results of the worn steel ball surfaces showed that BTES and BMES formed protective films, which contained boron oxide, iron oxide, ferrous sulfate, ferrous sulfide(for BMES), and other organic nitrogen compounds, on the metal surfaces. The better load-carrying and antiwear performances of BMES than those of BTES might be due to their different sulfur contents, which result in different tribochemical reaction films on the contact surfaces. The oxidation stability tests showed that BTES and BMES possessed synergistic antioxidation activity with N-phenyl-α-naphthylamine(T531), and consequently, the oxidation activation energy of the oil sample increased by 77.85% and 82.19%, respectively, compared with that of RSO when the oil sample contained 0.05 wt% BTES/BMES and 0.25% T531. | Liping XIONG Zhongyi HE Jian LIU Jianqiang HU Xu XIN Sheng HAN Yinglei WU Shaoming YANG | 2019 | Friction2019，7，5： | 3 |
| 13 | The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer显示文摘Objective:The novel compound GCJ-490A has been discovered as a pan-histone deacetylase(HDAC)inhibitor that exerts potent inhibitory activity against HDAC1,HDAC3,and HDAC6.Because of the important roles of HDACs in lung cancer development and the high distribution of GCJ-490A in lung tissue,we explored the anti-tumor potency of GCJ-490A against non-small cell lung cancer(NSCLC)in vitro and in vivo in this study.Methods:The in vitro effects of GCJ-490A alone or combined with the EGFR inhibitor gefitinib against NSCLC were measured with proliferation,apoptosis,and colony formation assays.NSCLC xenograft models were used to investigate the efficacy of GCJ-490A combined with gefitinib for the treatment of NSCLC in vivo.Western blot assays,luciferase reporter assays,chromatin immunoprecipitation assays,quantitative real time-PCR,immunohistochemistry,and transcription factor activity assays were used to elucidate possible mechanisms.Results:GCJ-490A effectively inhibited NSCLC cell proliferation and induced apoptosis in vitro and in vivo.Interestingly,inhibition of HDAC1 and HDAC6 by GCJ-490A increased histone acetylation at the IKKαpromoter and enhanced IKKαtranscription,thus decreasing c-Met.Moreover,this c-Met downregulation was found to be essential for the synergistic anti-tumor activity of GCJ-490A and gefitinib.Conclusions:These findings highlight the promising potential of HDAC inhibitors in NSCLC treatment and provide a rational basis for the application of HDAC inhibitors in combination with EGFR inhibitors in clinical trials. | Ting He Yinglei Gao Yanfen Fang Yangming Zhang Shuwei Zhang Fajun Nan Jian Ding Yi Chen | 2022 | Cancer Biology & Medicine2022，19，8： | 3 |
| 14 | Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study显示文摘Genomic alterations are commonly found in the signaling pathways of fibroblast growth factor receptors(FGFRs). Although there is no selective FGFR inhibitors in market, several promising inhibitors have been investigated in clinical trials, and showed encouraging efficacies in patients. By designing a hybrid between the FGFR-selectivity-enhancing motif dimethoxybenzene group and our previously identified novel scaffold, we discovered a new series of potent FGFR inhibitors, with the best one showing sub-nanomolar enzymatic activity. After several round of optimization and with the solved crystal structure, detailed structure–activity relationship was elaborated. Together with in vitro metabolic stability tests and in vivo pharmacokinetic profiling, a representative compound(35) was selected and tested in xenograft mouse model, and the result demonstrated that inhibitor 35 was effective against tumors with FGFR genetic alterations, exhibiting potential for further development. | Peng Wei Bo Liu Ruifeng Wang Yinglei Gao Lanlan Li Yuchi Ma Zhiwei Qian Yuelei Chen Maosheng Cheng Meiyu Geng Jingkang Shen Dongmei Zhao Jing Ai Bing Xiong | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 15 | Synthesis and Thermal Behavior of 1,8-Dihydroxy- 4,5-dinitroanthraquinone Manganese Salt显示文摘 | WANG Yinglei ZHAO Fengqi JI Yueping YI Jianhua WANG Wei XU Siyu AN Ting PEI Qing | 2014 | Chemical Research in Chinese Universities2014，30，3： | 2 |
| 16 | Investigation of PM_(2.5) pollution during COVID-19 pandemic in Guangzhou,China显示文摘The COVID-19 pandemic has raised awareness about various environmental issues,includ-ing PM_(2.5) pollution.Here,PM_(2.5) pollution during the COVID-19 lockdown was traced and an-alyzed to clarify the sources and factors influencing PM_(2.5) in Guangzhou,with an emphasis on heavy pollution.The lockdown led to large reductions in industrial and traffic emissions,which significantly reduced PM_(2.5) concentrations in Guangzhou.Interestingly,the trend of PM_(2.5) concentrations was not consistent with traffic and industrial emissions,as minimum concentrations were observed in the fourth period(3/01-3/31,22.45 μg/m^(3))of the lockdown.However,the concentrations of other gaseous pollutants,e.g.,SO_(2),NO_(2) and CO,were corre-lated with industrial and traffic emissions,and the lowest values were noticed in the sec-ond period(1/24-2/0_(3))of the lockdown.Meteorological correlation analysis revealed that the decreased PM_(2.5) concentrations during COVID-19 can be mainly attributed to decreased in-dustrial and traffic emissions rather than meteorological conditions.When meteorological factors were included in the PM_(2.5) composition and backward trajectory analyses,we found that long-distance transportation and secondary pollution offset the reduction of primary emissions in the second and third stages of the pandemic.Notably,industrial PM_(2.5) emis-sions from western,southern and southeastern Guangzhou play an important role in the formation of heavy pollution events.Our results not only verify the importance of control-ling traffic and industrial emissions,but also provide targets for further improvements in PM_(2.5) pollution. | Luyao Wen Chun Yang Xiaoliang Liao Yanhao Zhang Xuyang Chai Wenjun Gao Shulin Guo Yinglei Bi Suk-Ying Tsang Zhi-Feng Chen Zenghua Qi Zongwei Cai | 2022 | Journal of Environmental Sciences2022，34，5： | 2 |
| 17 | Geochemical and Nd-Hf Isotopic Constraints on the Petrogenesis of an Archean Granitoid in the Erguna Massif, NE China显示文摘Crystalline basement and Precambrian crustal growth of the continental massifs within the Central Asian Orogenic Belt(CAOB) are still pending problems. Our geological and geochemical investigations identified an Archean(2606 Ma) granitic pluton in the Biliya area of the Erguna Massif. The Neoarchean granitoids show high and positive in-situ zircon ε_(Ht)(t)(+0.3 to +10.0), whole-rock ε_(Nd)(t)(+4.8) and whole-rock ε_(Ht)(t) values(+2.1). They are characterized by high Y + Ce + Zr + Nb(> 220 ppm) and Zr contents and could be classified as A-type granites. These granitoids are characterized by high Zr saturation temperatures(T;)(796–836°C). They were derived from partial re-melting of juvenile mafic lower crust in an intracontinental back-arc extensional environment. This newly identified Neoarchean granitic pluton may represent the crystalline basement of the several continent massifs within the CAOB, and their high ε_(Ht)(t)–ε_(Nd)(t) values may also indicate the occurrence of lateral crustal growth events in these massifs during the Neoarchean. | SHAO Jun LI Yinglei WANG Deli SONG Wanbing WU Xinwei LIU Hongzhang | 2021 | Acta Geologica Sinica(English Edition)2021，95，6： | 2 |
| 18 | QoE-Oriented Resource Allocation for Multiuser-Multiservice Femtocell Networks显示文摘The pursuit of high data rate and assurance of quality of experience(QoE) for end users represent the main goals of future wireless communication systems.By introducing MOS(Mean Opinion Score) based assessment models for different types of applications,this paper proposed novel QoE-oriented radio resource allocation(RRA) algorithms for multiuser-multiservice femtocell networks.An optimal QoE-oriented RRA strategy is first analyzed using time-sharing method which is applicable to best effort applications.RRA algorithms based on the cross-layer architecture are then proposed for all types of applications by considering parameters extracted from different layers of networking protocols.In the proposed algorithms,a priority mechanism is employed to ensure fairness.Simulation results show that the proposed algorithms can significantly improve the overall perceived quality from the users' perspective in comparison with traditional Quality of Service(QoS)oriented algorithms. | YUAN Deyu SONG Mei TENG Yinglei MA Ding WANG Xiaojun LU Guofeng | 2015 | China Communications2015，12，10： | 2 |
| 19 | The implied cost of capital: A new approach显示文摘 | Kewei Hou Mathijs A. van Dijk Yinglei Zhang | 2011 | Journal of Accounting and Economics2011，，3： | 2 |
| 20 | Erratum to Simultaneous inhibition of PI3Kα and CDK4/6synergistically suppresses KRAS-mutated non-small cell lung cancer显示文摘In the published Figure 11,errors appeared in Figure 1B on page 69.In Figure 1B,bands for p-Akt S473,Akt,and Actin in H1355 cells were mistakenly placed.Here,we have updated Figure 1B to correct the mistake above.The errors do not impact the conclusions of this article.We apologize for the errors and for any confusion it may have caused. | Yuxiang Wang Xian Li Xueling Liu Yi Chen Chunhao Yang Cun Tan Bobo Wang Yiming Sun Xi Zhang Yinglei Gao Jian Ding Linghua Meng | 2019 | Cancer Biology & Medicine2019，16，4： | 1 |
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