| 1 | Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway显示文摘短链的丰满的酸和他们的相应 acyl-CoAs 在新陈代谢的小径的十字路口坐并且在多样的细胞的过程起重要作用。他们也是为蛋白质 translational 以后离氨酸 acylation 修正的先锋。一个引人注目的例子是最新识别的离氨酸 2-hydroxyisobutyrylation (K 从 2-hydroxyisobutyrate 和 2-hydroxyisobutyryl-CoA 被导出的 hib ) 。Histone K hib 被显示了在 spermatogenic 房间与活跃基因表示被联系。然而,调整这条 translational 以后离氨酸 acylation 小径的关键元素仍然保持未知。这妨碍了这修正由施加它的生物功能的机制的描述。这里,我们在开始发育的酵母显示出那 Esa1p,它在人的相当或相同事物 Tip60 能增加 K hib 到在 vitro 并且在 vivo 的底层蛋白质。另外,我们作为主要的酶识别了 HDAC2 和 HDAC3 移开 K hib 。而且,我们报导第一 K 在哺乳动物的房间的 hib proteome,识别 6 548 K 1 725 底层蛋白质上的 hib 地点。我们的学习因此为 histone K hib 标记,和主要 K hib 蛋白质底层。这些结果不仅说明这条新离氨酸 acylation 小径的风景,而且为学习与这条小径联系的细胞的代谢物的多样的功能打开新大街。 | He Huang Zhouqing Luo Shankang Qi Jing Huang Peng Xu Xiuxuan Wang Li Gao Fangyi Li Jian Wang Wenhui Zhao Wei Gu Zhucheng Chen Lunzhi Dai Junbiao Dai Yingming Zhao | 2018 | Cell Research2018，28，1： | 2 |
| 5 | Analysis of Performance Stability and Clinical Efficacy of OBERS - 3000 Hemodialysis Machine显示文摘Objective To explore the method of safety and efficacy validation of hemodialysis machine,and observe the clinical efficacy of OBERS-3000 multifunctional hemodialysis machine.Methods Randomized,open,two-phase crossover and positive control design,a total of 72 patients from two hospitals were included.OBERS-3000 multifunctional hemodialysis machine was the test machine,and the Fresenius 4008 series hemodialysis machine was as the control machine,indicators of blood routine test,serum electrolytes,liver and kidney function test,blood gas analysis,CRP were compared,body weight before and after hemodialysis,ultrafiltration volume were recorded,urea clearance index,urea reduction ratio were calculated.The XL90 conductivity meter was connected in series in the test machine,to monitor the temperature,conductance,venous pressure and arterial pressure during the dialysis in real time,and the measured value were compared with the machine monitoring value.Results Both of the test machine and the control machine could effectively eliminate creatinine,urea nitrogen and other uremic toxins,could continuously supply qualified dialysate,and precisely control the ultrafiltration volume.There were no significant differences in temperature,conductance,venous pressure and arterial pressure monitoring with the real time measured value by XL90 conductivity meter.Conclusions OBERS-3000 multifunctional hemodialysis machine can effectively eliminate uremic toxins,maintain electrolyte and acid-base balance,and can accurately display the monitoring parameters. | Lianghong Yin Bo Hu Lihua Luo Lifeng Yang Guanmin Wu Liangyong Hu Fanna Liu Yu Chen Peitian Yang Long Xiao Huiyuan Zheng Tong Liu Hongwei Hu Chen Yun Ying Huang Xia Yu Folan Li Aiyun Cha Xiangnan Dong Huanhuan Liu Mingming Ma Yongpin Lu Taksui Wong Baozhang Guan Yingming Gu Zuhui Chen | 2017 | 临床医学工程2017，24，S1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员