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| 1 | PDCD5 regulates iNKT cell terminal maturation and iNKT1 fate decision显示文摘Invariant natural killer T1(iNKT1)cells are characterized by the preferential expression of T-box transcription factor T-bet(encoded by Tbx21)and the production of cytokine IFN-γ,but the relationship between the developmental process and iNKT1 lineage diversification in the thymus remains elusive.We report in the present study a crucial role of programmed cell death 5(PDCD5)in iNKT cell terminal maturation and iNKT1 fate determination.Mice with T cell-specific deletion of PDCD5 had decreased numbers of thymic and peripheral iNKT cells with a predominantly immature phenotype and defects in response toα-galactosylceramide.Loss of PDCD5 also selectively abolished the iNKT1 lineage by reducing T-bet expression in iNKT cells at an early thymic developmental stage(before CD44 upregulation).We further demonstrated that TOX2,one of the high mobility group proteins that was highly expressed in iNKT cells at stage 1 and could be stabilized by PDCD5,promoted the permissive histone H3K4me3 modification in the promoter region of Tbx21.These data indicate a pivotal and unique role of PDCD5/TOX2 in iNKT1 lineage determination.They also suggest that the fate of iNKT1 may be programmed at the developmental stage of iNKT cells in the thymus. | Ke Wang Xinwei Zhang Yifan Wang Gaowen Jin Mingyang Li Shusong Zhang Jie Hao Rong Jin Xiaojun Huang Hounan Wu Jun Zhang Yingyu Chen Qing Ge | 2019 | Cellular & Molecular Immunology2019，16，9： | 4 |
| 2 | Really interesting new gene finger protein 121 is a novel Golgi-localized membrane protein that regulates apoptosis显示文摘确实有趣的新基因(戒指) 手指蛋白质在人的染色体代表一个大蛋白质家庭,并且在生理的活动和癌症开发玩 crucialroles。一些戒指手指蛋白质的生物功能仍然是 unknown.Here,我们描述了新奇、人的 Golgi 局部性的戒指手指蛋白质的生物活动 121 (RNF121 ) ,是的 functionof,这样远,未知。不同于 endoplasmic 在 Caenorhabditis elegans 的蜂窝胃局部性的 RNF121,人的 RNF121 对 Golgi 仪器主要局部性。RNF121 击倒的禁止的房间生长和导致的 apoptosis,它被 caspase-3 激活和劈开伴随 poly (腺苷 diphosphate 核糖) 聚合酶。Z-VAD-FMK,一个 pan-caspase 禁止者,禁止了 RNF121 击倒导致 apoptosis。野类型的 RNF121 的在表示上,然而并非 RNF121 的 theRING 领域异种,减少的 RNF121 击倒导致 apoptosis,显示戒指领域被要求调整 forRNF121 的 apoptosis。而且, RNF121 击倒的提高的导致 etoposide 的 apoptosis。这是到 demonstratethat RNF121 的第一研究是 apoptosis 的一个新奇管理者并且为癌症提供一个新潜在的目标治疗。 | Yuanbo Zhao | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 3 |
| 3 | Clinical Features of Perforating Eye Injuries Complicated with Intraocular Foreign Bodies Located at the Posterior Global Wall显示文摘Purpose:To investigate the clinical characteristics and therapeutic effects of vitrectomy in patients with perforating eye injuries with foreign bodies at the exit wound in the posterior global wall.Methods:.Fifty-two cases,diagnosed with perforating eye injury with foreign bodies at the exit of the posterior global wall and admitted to our hospital between June 2010 and June2013,were enrolled in this study.All patients underwent vitrectomy and removal of intraocular foreign bodies and were followed up for 6 to 24 months.The causes of injuries were analyzed and postoperative visual acuity and overall treatment efficacy were evaluated.Results:Intraocular foreign bodies were successfully removed in all cases.The incidence of postoperative complication was low.Among 52 subjects,46 showed alleviated symptoms after treatment with an overall efficacy of 88.46%.Conclusion:.Perforating eye injuries combined with residual foreign bodies in the posterior global wall are commonly observed in young people who perform physical labor.Vitrectomy has a high efficacy for the treatment of perforating eye injuries complicated with foreign bodies located at the posterior global wall,with a low incidence of postoperative complications. | Zufeng Huang Linxing Chen Yingyu Zeng Caimei Lin | 2013 | Eye Science2013，28，4： | 3 |
| 4 | Lower Bounds and a Nearly Fastest General Parallel Branch-and-Bound Algorithm显示文摘In this paper, it is supposed that the B&B algorithm finds the first optimal solution after h nodes have been expanded and m active nodes have been created in the state-space tree. Then the lower bound Ω(m + hlog h) of the running time for the general sequential B&B algorithm and the lower bound Ω(m/p+ hlogp) for the general parallel best-first B&B algorithm in PRAMCREW are proposed, where p is the number of processors available. Moreover, the lower bound Ω(M/p+H+ (H/P) log (H/P)) is presented for the parallel algorithms on distributed memory system, where M and H represent total number of the active nodes and that of the expanded nodes processed by p processors, respectively. In addition, a nearly fastest general parallel best-first B&B algorithm is put forward. The parallel algorithm is the fastest one as p = max{hε,γ}, where ε= 1/──logh, and r is the largest branch number of the nodes in the state-space tree. | Wu, Jigang Xie, Xing Wan, Yingyu Chen, Guoliang | 2000 | Journal of Systems Engineering and Electronics2000，11，3： | 2 |
| 5 | Design of a sensorless commutation IC for BLDC motors显示文摘 | Chen Kuangyao Tzou Yingyu | 2003 | IEEE Transactions on Power Electronics2003，18，6： | 1 |
| 6 | Health promotion behaviors in Chinese Family caregivers of patients with stroke 显示文摘 | TANG Yingyu CHEN Shu | 2009 | Health Promotion In- ternational2009，17，4： | 1 |
| 7 | Risk Factors and Pregnancy Outcome in Women with a History of Cesarean Section Complicated by Placenta Accreta显示文摘Objective:To explore the risk factors and pregnancy outcomes in women with a history of cesarean section complicated by placenta accreta(PA).Methods:This case-control study included clinical data from singleton mothers with a history of cesarean section in 11 public tertiary hospitals in seven provinces of China between January 2017 and December 2017.According to the intraoperative findings after delivery,the study population was divided into PA and non-PA groups.We compared the pregnancy outcomes between the two groups,used multivariate logistic regression to analyze the risk factors for placental accreta.Results:For this study we included 11,074 pregnant women with a history of cesarean section;and of these,869 cases were in the PA group and 10,205 cases were in the non-PA group.Compared with the non-PA group,the probability of postpartum hemorrhage(236/10,205,2.31%vs.283/869,32.57%),severe postpartum hemorrhage(89/10,205,0.87%vs.186/869,21.75%),diffuse intravascular coagulation(3/10,205,0.03%vs.4/869,0.46%),puerperal infection(33/10,205,0.32%vs.12/869,1.38%),intraoperative bladder injury(1/10,205,0.01%vs.16/869,1.84%),hysterectomy(130/10,205,1.27%vs.59/869,6.79%),and blood transfusion(328/10,205,3.21%vs.231/869,26.58%)was significantly increased in the PA group(P<0.05).At the same time,the neonatal birth weight 3250.00(2950.00–3520.00)g vs.2920.00(2530.00–3250.00)g),the probability of neonatal comorbidities(245/10,205,2.40%vs.61/869,7.02%),and the rate of neonatal intensive care unit admission(817/10,205,8.01%vs.210/869,24.17%)also increased significantly(P<0.05).Weight(odds ratio)(OR)=1.03,95%confidence interval(CI):1.01–1.05)),parity(OR=1.18,95%CI:1.03–1.34),number of miscarriages(OR=1.31,95%CI:1.17–1.47),number of previous cesarean sections(OR=2.57,95%CI:2.02–3.26),history of premature rupture of membrane(OR=1.61,95%CI:1.32–1.96),previous cesarean-section transverse incisions(OR=1.38,95%CI:1.12–1.69),history of placenta previa(OR=2.44,95%CI:1.50–3.96),and the combination of prenatal hemorrhage(OR=9.95,95%CI:8.42–11.75)and placenta previa(OR=91.74,95%CI:74.11–113.56)were all independent risk factors for PA.Conclusion:There was an increased risk of adverse outcomes in pregnancies complicated by PA in women with a history of cesarean section,and this required close clinical attention.Weight before pregnancy,parity,number of miscarriages,number of previous cesarean sections,history of premature rupture of membranes,past transverse incisions in cesarean sections,a history of placenta previa,prenatal hemorrhage,and placenta previa were independent risk factors for pregnancies complicated with PA in women with a history of cesarean section.These independent risk factors showed a high value in predicting the risk for placentab accreta in pregnancies of women with a history of cesarean section. | Yingyu Liang Lizi Zhang Shilei Bi Jingsi Chen Shanshan Zeng Lijun Huang Yulian Li Minshan Huang Hu Tan Jinping Jia Suiwen Wen Zhijian Wang Yinli Cao Shaoshuai Wang Xiaoyan Xu Ling Feng Xianlan Zhao Yangyu Zhao Qiying Zhu Hongbo Qi Lanzhen Zhang Hongtian Li Lili Du Dunjin Chen | 2022 | Maternal-Fetal Medicine2022，4，3： | 1 |
| 8 | Uclear translocation of PDCD5 (TFAR19):an early signal for apoptosis?显示文摘 | Yingyu Chen Ronghua Sun Wenling Han | 2001 | FEBS Letter2001，509，27： | 1 |
| 9 | Design of a sensorless commutation IC for BLDC motors显示文摘 | Chen Kuangyao Tzou Yingyu | 2003 | IEEE Transactions on Power Electronics2003，18，6： | 1 |
| 10 | Design of a sensorless commutation IC for BLDC motors显示文摘 | Chen Kuangyao Tzou Yingyu | 2003 | IEEE Transactions on Power Electronics2003，18，6： | 1 |
| 11 | Efficacy of Progressive Addition Lenses in the Treatment of Ametropia after the Single Eye's IOL Implantation显示文摘Purpose: To investigate the efficacy of progressive addition lenses on the treatment of ametropia and loss of accomodation after the single eye's IOL implantation. Methods:.Eighty four patients undergoing IOL implantation in single eyes were prescribed with progressive addition lenses for ametropia correction and regularly followed up to observe subsequent correction effect. Results:.Among these 84 patients,.72 could comfortably adapt to the use of progressive addition lenses to improve visual acuity and accomondation,while the remaining 12 patients failed to accomodate the usage of progressive addition lenses. Conclusion:.Wearing progressive addition lenses acts as a relatively feasible approach to improve visual acuity and alleviate disorders of accomodation for patients who underwent IOL implantation in single eyes..The patients should be prescribed with progressive lenses under professional instructions and guidance. | Linxing Chen Yingyu Zeng Junwen Zeng Mingguang He | 2012 | Eye Science2012，27，3： | 1 |
| 12 | Closing wedge osteotomy versus opening wedge osteotomy in ankylosing spondylitis with thoracolumbar kyphotic deformity显示文摘 | Chang Kaowha Chen Yingyu | 2005 | Spine2005，30，： | 1 |
| 13 | Optimized priority based energy efficient routing algorithm for mobile ad hoc networks显示文摘 | Xiaohai Wei Guoliang Chen Yingyu Wan Fred Mtenzi | 2004 | Ad Hoc Networks2004，，3： | 1 |
| 14 | In situ measurement of atmospheric carbon dioxide at Yanbian,China:Estimating its northeast Asian emission regions显示文摘High-precision(±0.1 ppm) and high-frequency(hourly averaged) in situ measurements of atmospheric carbon dioxide(CO2) were made for the first time from August 2005 to July 2007 at Yanbian,China using a non-dispersive Infrared(NDIR) analyzer with National Oceanic and Atmospheric Administration/Earth System Research Laboratory(NOAA/ESRL) standards.The results of these measurements are presented in this paper and are used to investigate the regional representativeness of regional background data at Yanbian and determine the CO2 emission source regions in Northeast Asia.The phase of the monthly variations at Yanbian reflects the special regional characteristics,which were overall in excellent agreement with other observatories in the middle-to-high latitudes in the Northern Hemisphere.Applying a hybrid receptor model to the regional emission source events in cold period(November-April),we estimated the distribution of the major CO2 emissions in the northeast Asia.The results indicated that the strongest potential emission areas contributing to Yanbian are the Beijing & Tianjin metropolitan areas,southwestern part of Shandong Province including Jinan,and Vladivostok.The results of this study reveal the usefulness of in situ CO2 measurements at Yanbian in establishing the scientific foundation for monitoring the large CO2 emission areas in northern China and Russia.Continued monitoring of CO2 at Yanbian within a regional network should provide significant contributions to both understanding the global/regional carbon cycle and constraining 'top-down' emissions in Northeast Asia. | JIN FenJi FANG YingYu CHEN Tie LI DongHao KIM Jooil PARK Mi-Kyung PARK Sunyoung KIM Kyung-Ryul | 2012 | Science China Earth Sciences2012，55，10： | 1 |
| 15 | Arabidopsis cryptochrome 1 promotes stomatal development through repression of AGB1 inhibition of SPEECHLESS DNA-binding activity显示文摘Cryptochromes are blue light photoreceptors that mediate various light responses in plants and mammals. The heterotrimeric G-protein is known to regulate various physiological processes in plants and mammals. In Arabidopsis, cryptochrome 1(CRY1) and the G-protein β subunit AGB1 act antagonistically to regulate stomatal development.The molecular mechanism by which CRY1 and AGB1 regulate this process remains unknown.Here, we show that Arabidopsis CRY1 acts partially through AGB1, and AGB1 acts through SPEECHLESS(SPCH), a master transcription factor that drives stomatal initiation and proliferation, to regulate stomatal development. We demonstrate that AGB1 physically interacts with SPCH to block the b HLH DNA-binding domain of SPCH and inhibit its DNA-binding activity. Moreover, we demonstrate that photoexcited CRY1 represses the interaction of AGB1 with SPCH to release AGB1 inhibition of SPCH DNA-binding activity, leading to the expression of SPCH-target genes promoting stomatal development. Taken together, our results suggest that the mechanism by which CRY1 promotes stomatal development involves positive regulation of the DNA-binding activity of SPCH mediated by CRY1 inhibition of the AGB1-SPCH interaction. We propose that the antagonistic regulation of SPCH DNA-binding activity by CRY1 and AGB1 may allow plants to balance light and G-protein signaling and optimize stomatal density and pattern. | Xiaoli Cao Pengbo Xu Yao Liu Guangqiong Yang Minqing Liu Li Chen Yingyu Cheng Peng Xu Langxi Miao Zhilei Mao Wenxiu Wang Shuang Kou Tongtong Guo Hong‐Quan Yang | 2021 | Journal of Integrative Plant Biology2021，63，11： | 1 |
| 16 | Nuclear translocation of PDCD5 (TFAR19): an early signal for apoptosis? 显示文摘 | Yingyu Chen | 2001 | FEBS Letter2001，509，27： | 1 |
| 17 | 恶性胃肠道间质瘤CT特点与临床病理分析比较:影像学表现与恶性潜能相关性分析(英文)显示文摘Objective: In this pictorial essay, we described the clinical, pathologic, and computed tomographic (CT) findings of malignant gastrointestinal stromal tumors (MGISTs) and attempt to establish the correlation between radiologic appearance and malignant potential. Methods: This retrospective analysis included 20 patients receiving treatment for MGIST between 2008 and 2010. The diagnosis was established by pathology and immunohistochemistry. All these patients underwent preoperative CT. Clinical presentation, pathology and CT images were analyzed. Helical CT images were reviewed for morphologic features such as tumor size, number and location, tumor margins, necrosis, degree of enhancement and metastasis. Results: Gastrointestinal bleeding, abdominal pain and discomfort, and without clinical symptom were common findings and were observed in 9 (45%), 6 (30%), and 5 (25%) of the 20 patients. 8 (40%) tumors were located in stomach, and 10 (50%), 1 (5%) and 1 (5%) were located in small intestine, mesentery and peritoneum, respectively. Male to female ratio was about 1:2. The size of MGIST ranged from 2.6 cm to 17.5 cm with a mean of 8.7 cm. All tumors density was inhomogeneous and heterogeneous enhancement. MGISTs with highly malignant located in small intestine were about 30% higher than stomach. The 'satellite' tumours were found in 6 cases with high malignant risk. 7 cases were suffered from liver metastasis, and 4 cases went with seeding into the abdominal cavity, 1 cases went with lymph node metastasis. Histologically, 19 cases (95%) were of spindle cell type. Immunohistochemical stains demonstrated a strong positivity for both c-kit (CD117) and CD34s enhancement in 19 (95%). Conclusion: Clinical expression is varied in MGIST patients. Female might be predominance in MGIST. The GISTs located in small intestine would tend to be more aggressive. The satellite tumours, necrosis and cystic degeneration were strongly benefit for MGIST diagnosis. Furthermore, intestinal obstruction doesn't support the diagnosis. Lymph node metastasis and calcification is rare. | Zhifeng Xu Aizhen Pan Fang Yong Yingyu Chen Bin Li Qiang Gao Renhua Wu | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，11： | 0 |
| 18 | Deep Segmentation Feature-Based Radiomics Improves Recurrence Prediction of Hepatocellular Carcinoma显示文摘Objective and Impact Statement.This study developed and validated a deep semantic segmentation feature-based radiomics(DSFR)model based on preoperative contrast-enhanced computed tomography(CECT)combined with clinical information to predict early recurrence(ER)of single hepatocellular carcinoma(HCC)after curative resection.ER prediction is of great significance to the therapeutic decision-making and surveillance strategy of HCC.Introduction.ER prediction is important for HCC.However,it cannot currently be adequately determined.Methods.Totally,208 patients with single HCC after curative resection were retrospectively recruited into a model-development cohort(n=180)and an independent validation cohort(n=28).DSFR models based on different CT phases were developed.The optimal DSFR model was incorporated with clinical information to establish a DSFR-C model.An integrated nomogram based on the Cox regression was established.The DSFR signature was used to stratify high-and low-risk ER groups.Results.A portal phase-based DSFR model was selected as the optimal model(area under receiver operating characteristic curve(AUC):development cohort,0.740;validation cohort,0.717).The DSFR-C model achieved AUCs of 0.782 and 0.744 in the development and validation cohorts,respectively.In the development and validation cohorts,the integrated nomogram achieved C-index of 0.748 and 0.741 and time-dependent AUCs of 0.823 and 0.822,respectively,for recurrence-free survival(RFS)prediction.The RFS difference between the risk groups was statistically significant(P<0.0001 and P=0.045 in the development and validation cohorts,respectively).Conclusion.CECT-based DSFR can predict ER in single HCC after curative resection,and its combination with clinical information further improved the performance for ER prediction. | Jifei Wang Dasheng Wu Meili Sun Zhenpeng Peng Yingyu Lin Hongxin Lin Jiazhao Chen Tingyu Long Zi-Ping Li Chuanmiao Xie Bingsheng Huang Shi-Ting Feng | 2022 | Biomedical Engineering Frontiers2022，3，1： | 0 |
| 19 | Evaluation and application of a milk antibody ELISA for assessing the prevalence and incidence of bovine tuberculosis in dairy herds in Hubei Province,China显示文摘Bovine tuberculosis(bTB)is a chronic zoonotic disease that is endemic in China.Current in-vitro tests for bTB are mainly based on blood assays.Collection of samples results in some stress to the sampled cattle and associated economic losses for the herd owner.This study was designed to investigate the relationship between milk and serum antibody tests for bTB in dairy cows using 85 cows with milk and corresponding blood samples.Totally 4,395 milk samples were used to assesse the apparent(test)prevalence and incidence of bTB using the milk antibody ELISA.The association between levels of bTB milk antibody and milk quality was also evaluated.Milk and serum antibody tests showed a good correlation with a 87.5%(95%CI:61.7%,98.4)positive agreement and 98.7%(95%CI:95.4,99.8)negative agreement.The animal level lactoprevalence ranged from 0.3%(95%CI:0,1.2)to 33.3%(95%CI:26.6,40.6)in different farms and the incidence rate ranged from 0 head/cow-month(95%CI:0,0.02)to 0.04 head/cow-month(95%CI:0.02,0.07).Twenty percent of sampled farms met the criteria for bTB control in China.The prevalence on large-scale farms was lower(p<0.001)than on small farms.The bTB milk antibody levels had a negative correlation with milk yield and a positive correlation with somatic cell count(SCC),milk protein percentage(MPP)and percentage of total solids(TS).According to this research,milk ELISA could be used as a supplement of blood samples to assist in the surveillance for bTB and for alerting control and eradication of bTB. | Yingyu Chen Shuang Cheng Yu Wang Guiqiang Wang Xijuan Wu Ian D.Robertson Aizhen Guo | 2023 | Animal Diseases2023，3，2： | 0 |
| 20 | Cellular and Molecular Atlas of Peripheral Blood Mononuclear Cells from a Pregnant Woman After Recovery from COVID-19显示文摘Objective:This study aimed to investigate the immune response of a pregnant woman who recovered from the coronavirus disease 2019(COVID_(R)S)by using single-cell transcriptomic profiling of peripheral blood mononuclear cells(PBMCs)and to analyze the properties of different immune cell subsets.Methods:PBMCs were collected from the COVID_(R)S patient at 28 weeks of gestation,before a cesarean section.The PBMCs were then analyzed using single-cell RNA sequencing.The transcriptional profiles of myeloid,T,and natural killer(NK)cell subsets were systematically analyzed and compared with those of healthy pregnant controls from a published single-cell RNA sequencing data set.Results:We identified major cell types such as T cells,B cells,NK cells,and myeloid cells in the PBMCs of our COVID_(R)S patient.The increase of myeloid and B cells and decrease of T cells and NK cells in the PBMCs in this patient were quite distinct compared with that in the control subjects.After reclustering and Augur analysis,we found that CD16 monocytes and mucosal-associated invariant T(MAIT)cells were mostly affected within different myeloid,T,and NK cell subtypes in our COVID_(R)S patient.The proportion of CD16 monocytes in the total myeloid population was increased,and the frequency of MAIT cells in the total T and NK cells was significantly decreased in the COVID-RS patient.We also observed significant enrichment of gene sets related to antigen processing and presentation,T-cell activation,T-cell differentiation,and tumor necrosis factor superfamily cytokine production in CD16 monocytes,and enrichment of gene sets related to antigen processing and presentation,response to type II interferon,and response to virus in MAIT cells.Conclusion:Our study provides a single-cell resolution atlas of the immune gene expression patterns in PBMCs from a COVID_(R)S patient.Our findings suggest that CD16-positive monocytes and MAIT cells likely play crucial roles in the maternal immune response against severe acute respiratory syndrome coronavirus 2 infection.These results contribute to a better understanding of the maternal immune response to severe acute respiratory syndrome coronavirus 2 infection and may have implications for the development of effective treatments and preventive strategies for the coronavirus disease 2019 in pregnant women. | Lili Du Yingyu Liang Xiaoyi Wang Lijun Huang Xingfei Pan Jingsi Chen Dunjin Chen | 2023 | Maternal-Fetal Medicine2023，5，2： | 0 |
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