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| 1 | Quantitative analysis of site-specific N-glycans on sera haptoglobin βchain in liver diseases显示文摘在有临床的申请的潜力的 glycoproteins 的 N-glycans 的地点特定的描述是重要的。在我们的以前的报告,链被发现在肝疾病不同的 sera haptoglobin (Hp ) 的全面 N-glycans。Hp 链包含 N-glycosylation 的四个潜在的地点。在这研究,我们以一种地点特定的方式在 Hp 链上调查了 N-glycans 的潜在的变化。在象有肝炎 B 病毒( HBV )的病人一样的健康个人的 Sera Hp 链,肝肝硬化( LC )和 hepatocellular 癌( HCC )被净化,消化并且使遭到了到液体 chromatography-electrospray 电离高度精力碰撞分离团 spectrometry ,它允许鉴定和 glycopeptide 的结构决心,象在每 glycopeptide 上在场的 glycans 的相对 quantification 一样。量的结果表明 NLFLN207HSEN211ATAK 和 fucosylated 的 sialylation 根本组织在 HBV 病人和健康个人与那些相比在 LC 和 HCC 病人显著地增加的 glycopeptides。在各种各样的肝疾病的 Hp 链的一套不同 N-glycan 模式被决定了。因此, sialylated 和 Hp 链力量的 fucosylated glycoforms 与早 hepatocarcinogenesis 有关并且可能也作为为 LC 和 HCC 病人的新奇微分标记有用。 | Shu Zhang Kai Jiang Chun Sun Haojie Lu Yinkun Liu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 3 |
| 2 | Active canopy sensor-based precision N management strategy for rice显示文摘 | Yinkun Yao Yuxin Miao Shanyu Huang Lei Gao Xiaobo Ma Guangming Zhao Rongfeng Jiang Xinping Chen Fusuo Zhang Kang Yu Martin Gnyp Georg Bareth Cheng Liu Liqin Zhao Wen Yang Huamin Zhu | 2012 | Agronomy for Sustainable Development2012，，4： | 1 |
| 3 | Tumor-derived secretory clusterin induces epithelial–mesenchymal transition and facilitates hepatocellular carcinoma metastasis显示文摘 | Cun Wang Kai Jiang Xiaonan Kang Dongmei Gao Chun Sun Yan Li Lu Sun Shu Zhang Xiaohui Liu Weizhong Wu Pengyuan Yang Kun Guo Yinkun Liu | 2012 | International Journal of Biochemistry and Cell Biology2012，，12： | 1 |
| 4 | Engineering Saccharomyces cerevisiae for enhanced(–)-α-bisabolol production显示文摘(–)-α-Bisabolol is naturally occurring in many plants and has great potential in health products and pharma-ceuticals.However,the current extraction method from natural plants is unsustainable and cannot fulfil the increasing requirement.This study aimed to develop a sustainable strategy to enhance the biosynthesis of(–)-α-bisabolol by metabolic engineering.By introducing the heterologous gene MrBBS and weakening the competitive pathway gene ERG9,a de novo(–)-α-bisabolol biosynthesis strain was constructed that could produce 221.96 mg/L(–)-α-bisabolol.Two key genes for(–)-α-bisabolol biosynthesis,ERG20 and MrBBS,were fused by a flexible linker(GGGS)3 under the GAL7 promoter control,and the titer was increased by 2.9-fold.Optimization of the mevalonic acid pathway and multi-copy integration further increased(–)-α-bisabolol production.To promote product efflux,overexpression of PDR15 led to an increase in extracellular production.Combined with the optimal strategy,(–)-α-bisabolol production in a 5 L bioreactor reached 7.02 g/L,which is the highest titer reported in yeast to date.This work provides a reference for the efficient production of(–)-α-bisabolol in yeast. | Yinkun Jiang Lu Xia Song Gao Ning Li Shiqin Yu Jingwen Zhou | 2023 | Synthetic and Systems Biotechnology2023，8，2： | 0 |
| 5 | The impact of body weight trajectory from childhood on chronic inflammation in adulthood: The Bogalusa Heart Study显示文摘Importance:The impact of long-term burden of excessive body weight,beginning in childhood,on inflammatory status in adulthood has been poorly described.Objective:To characterize the longitudinal body mass index(BMI)trajectory from childhood and examine its relationship with inflammatory status in adulthood.Methods:We included 1285 adults who had 4-15 repeat measurements of BMI from childhood to adulthood.The area under the curve(AUC)of growth curves was calculated to characterize long-term burden(total AUC)and trends(incremental AUC)of BMI.Results:After adjusting for covariates,higher values of BMI in terms of childhood and adulthood,as well as total and incremental AUC,were strongly associated with elevated levels of adult C-reactive protein(CRP)in the four race-sex groups.There were significant differences in linear and nonlinear curve parameters between the normal and high CRP groups for all race-sex groups(P<0.01).Compared with participants who had consistently low BMI in both childhood and adulthood,participants with high BMI in adulthood had higher CRP levels(P<0.001),irrespective of their childhood BMI status;participants with high BMI in childhood but low BMI in adulthood had similar adult CRP levels.Interpretation:The impact of excessive body weight on inflammation is cumulative and exacerbated over time.The influence of childhood overweight/obesity on inflammatory status in adulthood can be alleviated by reducing adiposity in adulthood. | Yinkun Yan Shengxu Li Yang Liu Lydia Bazzano Jiang He Jie Mi Wei Chen | 2021 | Pediatric Investigation2021，5，1： | 0 |
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