|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms显示文摘 | Liu Ming Wang Jianye Yang Yong An Ruihua Wen Jianguo Guan Zhichen Zheng Shaobin Wang Dongwen Song Bo Liao Limin Guo Hongqian Xiao Jiaquan Sun Yinghao Shen Zhoujun Kong Chuize He Dalin Huang Yiran Wang Xiaofeng Zhang Xu Li Hanzhong Huang Jian Zhao Xiaokun Zeng Puqing Song Xishuang Ye Zhangqun | 2014 | Chinese Medical Journal2014，，2： | 7 |
| 2 | Electrochemiluminescence Imaging Techniques for Analysis and Visualizing显示文摘Electrochemiluminescence(ECL)-based imaging analysis is a dominant method to inspect the electrode composition,to study electrochemical reaction kinetics at a microscopic level,and also a rapid emerging technology in bioanalysis with high spatiotemporal resolutions,high-throughput and visualization characteristics.In comparison with other imaging microscopes,an optical excitation is not involved in imaging,thus the approach is free from background noise resulting in a low detec-tion limit.In this review work,the principle of ECL,its unique natures compared to other luminescence techniques were briefed at first.Then after,the progress and basic principles of ECL imaging were summarized.Furthermore,recent and representative advances of ECL imaging for visualizing and sensing applications were reviewed.Finally,the perspectives in ECL imaging for further perspective were discussed. | Tadesse Haile Fereja Fangxin Du Chao Wang Dmytro Snizhko Yiran Guan Guobao Xu | 2020 | Journal of Analysis and Testing2020，4，2： | 2 |
| 3 | Tumor neoantigens: Novel strategies for application of cancer immunotherapy显示文摘Neoantigen-targeted immunotherapy is a rapidly advancing field that holds great promise for treating cancer.The recognition of antigens by immune cells is a crucial step in tumor-specific killing,and neoantigens generated by mutations in cancer cells possess high immunogenicity and are selectively expressed in tumor cells,making them an attractive therapeutic target.Currently,neoantigens find utility in various domains,primarily in the realm of neoantigen vaccines such as DC vaccines,nucleic acid vaccines,and synthetic long peptide vaccines.Additionally,they hold promise in adoptive cell therapy,encompassing tumor-infiltrating cells,T cell receptors,and chimeric antigen receptors which are expressed by genetically modified T cells.In this review,we summarized recent progress in the clinical use of tumor vaccines and adoptive cell therapy targeting neoantigens,discussed the potential of neoantigen burden as an immune checkpoint in clinical settings.With the aid of state-of-the-art sequencing and bioinformatics technologies,together with significant advancements in artificial intelligence,we anticipated that neoantigens will be fully exploited for personalized tumor immunotherapy,from screening to clinical application. | HANYANG GUAN YUE WU LU LI YABING YANG SHENGHUI QIU ZHAN ZHAO XIAODONG CHU JIASHUAI HE ZUYANG CHEN YIRAN ZHANG HUI DING JINGHUA PAN YUNLONG PAN | 2023 | Oncology Research2023，31，4： | 1 |
| 4 | Dopamine-mimetic-coated polyamidoamine-functionalized Fe_(3)O_(4) nanoparticles for safe and efficient gene delivery显示文摘Fe_(3)O_(4) nanoparticles(NPs)are widely used in the construction of drug and gene delivery vectors because of their particular physicochemical properties.Surface modification can not only reduce the cytotoxicity of Fe_(3)O_(4),but also further improve the biocompatibility and delivery efficiency.In this work,firstly,polydopamine(PDA)-coated Fe_(3)O_(4) NPs(named Fe_(3)O_(4)@PDA)were prepared by using the self-polymerization characteristics of dopamine in alkaline environment.Then,polyamidoamine(PAMAM)was modified by the Michael addition reaction to prepare water-soluble core shell magnetic NPs of Fe_(3)O_(4)@PDA@PAMAM,and its potential as gene vector was further evaluated.The results revealed that Fe_(3)O_(4)@PDA@PAMAM had the ability to condense and protect DNA,and showed lower cytotoxicity,higher cell uptake and transfection efficiency than those of PAMAM.It has the potential to become a magnetic targeted gene vector for further study. | Liang Liu Chaobing Liu Zhaojun Yang Yiran Chen Xin Chen Jintao Guan | 2023 | Frontiers of Materials Science2023，17，1： | 0 |
| 5 | Recent advances in electrochemiluminescence imaging analysis显示文摘Electrochemiluminescence(ECL)has been widely applied in imaging owing to features that distinguish it from other microscopic techniques and electrochemical methods,including its high signal-to-noise ratio,remarkable sensitivity,wide linear range,high spatiotemporal resolution,and near-zero background light.Imaging technology based on ECL has been used in the fields of immunosensing,pathological cell detection,and drug analysis.Additionally,its simple operation and ability to detect dynamic processes and catalytic sites strengthen its potential for research on material surfaces and interfaces,in vivo biological analysis,and cell visualization.At the same time,the emergence of a variety of nanomaterials and new microscopic analysis equipment has further promoted the development of high-resolution ECL imaging technology.This paper introduces the development of ECL technology and the mechanisms of the main ECL systems.It then describes various forms of ECL imaging methods,and reviews research progress on ECL imaging technology in the fields of single-particle imaging,fingerprint structure analysis,and single-cell microscopic imaging.Finally,the authors offer their views about the prospects for ECL imaging technology. | Chengda Meng Sara Knežević Fangxin Du Yiran Guan Frédéric Kanoufi Neso Sojic Guobao Xu | 2022 | eScience2022，2，6： | 0 |
| 6 | Strong metal-support interaction between AuPd nanoparticles and oxygen-rich defect ZrO_(2) for enhanced catalytic 5-hydroxymethylfurfural oxidation显示文摘The unique properties of metal oxide surfaces,crystal surfaces and defects play vital roles in biomass upgrading reactions.In this work,hierarchical porous bowl-shaped ZrO_(2)(HB-ZrO_(2))with mixed crystal phase was designed and employed as the support for loading AuPd bimetal with different proportions to synthesize AuPd/HB-ZrO_(2) catalysts.The effects of surface chemistry,oxygen defects,bimetal interaction and metal-support interaction of AuPd/HB-ZrO_(2) on catalytic performance for the selective oxidation of 5-hydroxymethylfurfural(HMF)to 2,5-furandicarboxylic acid(FDCA)were systematically investigated.The Au 2 Pd1/HB-ZrO_(2) catalyst afforded a satisfactory FDCA yield of 99.9%from HMF oxidation using O_(2) as the oxidant in water,accompanied with an excellent FDCA productivity at 97.6 mmol g^(−1) h^(−1).This work offers fresh insights into rationally designing efficient catalysts with oxygen-rich defects for the catalytic upgrading of biomass platform chemicals. | Yunlei Zhang Yiran Liu Wen Guan Mengxue Cao Yao Chen Pengwei Huo | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员