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| 1 | Adaptor protein APPL1 links neuronal activity to chromatin remodeling in cultured hippocampal neurons显示文摘Local signaling events at synapses or axon terminals are communicated to the nucleus to elicit transcriptional responses,and thereby translate information about the external environment into internal neuronal representations.This retrograde signaling is critical to dendritic growth,synapse development,and neuronal plasticity.Here,we demonstrate that neuronal activity induces retrograde translocation and nuclear accumulation of endosomal adaptor APPL1.Disrupting the interaction of APPL1 with Importin ocl abolishes nuclear accumulation of APPL1,which in turn decreases the levels of histone acetylation.We further demonstrate that retrograde translocation of APPL1 is required for the regulation of gene transcription and then maintenance of hippocampal late-phase long-term potentiation.Thus,these results illustrate an APPLl-mediated pathway that contributes to the modulation of synaptic plasticity via coupling neuronal activity with chromatin remodeling. | Yu Wu Xinyou Lv Haiting Wang Kai Qian Jinjun Ding Jiejie Wang Shushan Hua Tiancheng Sun Yiting Zhou Lina Yu Shuang Qiu | 2021 | Journal of Molecular Cell Biology2021，13，5： | 1 |
| 2 | To tune europium valence by controlling the composition in diphase silicate phosphors显示文摘Commercial phosphors always require fewer impurities and higher crystallinity, but sometimes it is difficult or strict to synthesize a pure phase compound. Indeed, if the practical application is not influenced, it is acceptable to synthesize a kind of phosphors with diphase matrix that have similar structure and photoluminescence properties. In present work, we designed and synthesized a series of(1-x)BaMSiO_4·xBa_2 MSi_2 O_7:Eu(M = Zn^(2+), Mg^(2+)) diphase phosphors which contained two phases BaMSiO_4(hexagonal, P63) and Ba2 MSi_2 O_7(monoclinic, C2/c) by a high temperature solid-state reaction in air condition. The structures and luminescence properties related to the phase transform from BaMSiO_4 to Ba_2 MSi_2 O_7 were analyzed carefully. The results show that the self-reduction ability of Eu^(3+) is not the best in above four compounds, respectively. But it reaches the maximum and gets the green emission under the UV lamp when the matrix is in a proper ratio of two phases, which suggests that the heterostructure between the two crystals(BaMSiO_4 and Ba_2 MSi_2 O_7) improves the self-reduction process of the diphase.The possible mechanism of the tunable europium valence and the luminescent properties in(1-x)BaMSiO_4·xBa2 MSi_2 O_7:Eu phosphors were discussed in detail. | Yiting Lin Jukui Zhou Zhongxian Qiu Wenli Zhou Jilin Zhang Chengzhi Li Liping Yu Shixun Lian | 2018 | Journal of Rare Earths2018，36，10： | 0 |
| 3 | Research on the Spillover Effects of Digital Transformation on the Sustainable Growth of Green Schools显示文摘The development of society and the advancement of science and technology have led to the widespread integration of digital transformation in the field of education.However,the current establishment of green schools faces various challenges,including non-environmental building facilities,high renovation costs,low organizational management efficiency,high energy consumption,outdated office tools,and insufficient environmental awareness among teachers and students.Through thorough research and analysis,it becomes evident that digital technology can play a pivotal role in addressing these challenges and contribute to all aspects of green school establishment.The incorporation of digital thinking concepts is essential for the construction of ecologically civilized campuses and inclusive innovation.The process of digital design and transformation proves instrumental in optimizing both software and hardware facilities within the campus,thereby reducing energy consumption.Simultaneously,comprehensive digital teaching management enhances overall efficiency in management and service delivery.Innovative digital teaching and learning models emerge as transformative tools,providing new avenues to create low-carbon,green classrooms for both teachers and students.By exploring the application of digital transformation in establishing green schools and examining the resulting spillover effects,valuable insights can be gained.These insights,in turn,serve as reference points for building diversified digital technology paths on campus and fostering the creation of green schools. | Yiting Qiu Qiuhua Chen Poh Soon Joseph Ng | 2023 | Proceedings of Business and Economic Studies2023，6，6： | 0 |
| 4 | Extension of the Lifespan of a Mouse Model of Rett Syndrome by Intracerebroventricular Delivery of MECP2显示文摘DearEditors,Rett Syndrome(RTT)is a severe neurodevelopmental disorder characterized by neural dysfunctions and a reduced lifespan,mainly in female patients,involving loss-of-function mutations in the methyl-CpG binding protein 2(MECP2)gene[1-4]. | Kan Yang Cheng Cheng Yiting Yuan Yuefang Zhang Shifang Shan Zilong Qiu | 2023 | Neuroscience Bulletin2023，39，2： | 0 |
| 5 | Fine controllable blue emission and its mechanism in Ce^(3+)-doped orthosilicate solid solution phosphors for different plant growths显示文摘The designed Ce^(3+)-doped alkaline-earth silicate phosphors Ca_mSr_(2-m-n)Ba_nSiO_4:Ce^(3+),Li^+(CSBS:Ce^(3+))were synthesized by a high temperature solid-state reaction. The crystal field splitting and the centroid shift from the free ion energy of 5 d configuration were approximated from the spectrum for Ca_2SiO_4,Sr_2SiO_4 and Ba_2SiO_4 phosphors. The single-phase purity was checked by means of X-ray diffraction. Here,when the doped concentration of Ca^(2+) is less than 80%(m ≤1.6), we report the structural phase transformation from monoclinic system β-Ca_2SiO_4 to orthorhombic system α-Ca_2SiO_4. The phosphors excited by near-ultraviolet(NUV) light at wavelengths ranging from 200 to 400 nm demonstrate a broad asymmetric blue emission band. The emission peak wavelength redshifts firstly from 417 nm of Ca_2SiO_4 to 438 nm of Sr_(0.3)Ca_(1.6)SiO_4, and then blueshifts to 411 nm of Sr_2SiO_4, and the end of 401 nm of Ba_2SiO_4.These results indicate that the tunable blue-emission of the phosphors can be realized through changing the solid solution components, which has a potential use as a blue component for fabricated precision modulation LEDs light sources and auxiliaries of SSC plastics films for different plant growths.We discuss in detail the possible mechanism and energy diagram of the tunable blue luminescence in Ca_mSr_(2-m-n)Ba_nSiO_4:Ce^(3+),Li^+ phosphors. | Yaru Yang Yiting Lin Yue Han Zhongxian Qiu Wenli Zhou Jilin Zhang Chengzhi Li Liping Yu Shixun Lian | 2018 | Journal of Rare Earths2018，36，11： | 0 |
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