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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Factors Affecting Cr(Ⅲ) Oxidation by Manganese Oxides显示文摘The high oxidation ability of manganese oxides or soils was used to study effects of pH and coatingon Cr(Ⅲ) oxidation. The results indicated that Cr(Ⅲ) oxidation peaked in pH 4.0-6.5. The amount andrate of Cr(Ⅲ) being oxidized by uncoated δ-MnO2 were larger than those by Fe oxide- or CaCO3-coatedone. Inorganic Cr(Ⅲ) was more easi1y oxidized by MnO2 than organic complex Cr(Ⅲ) due to differentsurface affinities. Precipitated Cr(Ⅲ) and adsorbed Cr(Ⅲ) might be transferred onto MnO2 surface andthen oxidized to Cr(VI). | CHEN YINGXU CHEN YIYI LIN QI HU ZIQIANG HU HONG and WU JIANYANG(Dept. of Environ. Sci., Zhejiang Agricultural Univereity, Hangzhou, 310029 (China)) | 1997 | Pedosphere1997，7，2： | 5 |
| 3 | Preparation and application of a phosphorous free and non- nitrogen scale inhibitor in industrial cooling water systems显示文摘钙碳酸盐,锌(II ) 和铁(III ) 的一种新奇环境地友好的类型规模禁止者丙烯酸的 acidallylpolyethoxy 羧化物共聚物(AAAPEL ) 被综合。向 CaCO 的 AA-APEL 的反规模性质 < 潜水艇 class= “ a-plus-plus ” > 3 , 锌(II ) 和人工的冷却水里的铁(III ) 通过静态的规模抑制测试被学习。观察证明两钙碳酸盐,锌(II ) 和铁(III ) 抑制与增加 AA-APEL 的剂量增加。CaCO 的形成上的效果 < 潜水艇 class= “ a-plus-plus ” > 3 与扫描电子显微镜学(SEM ) 的联合被调查,传播电子显微镜学(TEM ) , X 光检查粉末衍射(XRD ) 分析和 fourier 分别地转变红外线的分光计。结果证明 AA-APEL 共聚物不仅影响的钙碳酸盐水晶形态学和水晶尺寸而且 crystallinity。CaCO 的结晶化 < 潜水艇 class= “ a-plus-plus ” > 当禁止者不在时的 3 是菱形的方解石水晶,而有 vaterite 晶体的方解石的混合物面对 AAAPEL 共聚物被发现。抑制机制被建议在钙或铁离子和聚乙烯乙二醇(木钉) 之间的相互作用是基本动力在使水系统凉下来制止规模的形成。 | Guangqing LIU Mengwei XUE Jingyi HUANG Huchuan WANG Yuming ZHOU Qingzhao YAO Lei LING Ke CAO Yahui LIU Yunyun BU Yiyi CHEN Wendao WU Wei SUN | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 3 |
| 4 | Applications and challenges for single-bacteria analysis by flow cytometry显示文摘Flow cytometry(FCM)is a powerful technique for single-bacteria analysis via simultaneous light-scattering and fluorescence measurements.By offering high-throughput,quantitative,and multiparameter analysis at the single-cell level,FCM has gained an increased popularity in microbiological research,food safety monitoring,water quality control,and clinical diagnosis.Here we will review the recent applications of flow cytometry in areas such as(1)total bacterial cell count,(2)bacterial viability analysis,(3)specific bacterial detection and identification,(4)characterization of physiological changes under environmental perturbations,and(5)biological function studies.Nevertheless,despite these widespread applications,challenges still remain for the detection of small sizes of bacteria and biochemical features that cannot be brightly stained via fluorescence.Recent improvement in FCM instrumentation will be discussed,and particularly the development of high sensitivity flow cytometry for advanced analysis of single bacterial cells will be highlighted. | lina wu shuo wang yiyi song xu wang xiaomei yan | 2016 | Science China Chemistry2016，59，1： | 3 |
| 5 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 6 | Preliminary study on the fabrication of 14Cr-ODS FeCrAl alloy by powder forging显示文摘A simple powder forging process was presented herein to fabricate an Fe-14 Cr-4.5 Al-2 W-0.4 Ti-0.5 Y_(2)O_(3)ODS Fe Cr Al alloy.The forged alloy exhibits a high density that exceeds 97%of the theoretical density.The ODS alloy was investigated in terms of the residual porosity,morphology and phase structure of oxide nanoparticles,impact toughness and tensile properties.It was found that refined grains were obtained during powder forging.A residual porosity less than 1.1%has no impact on the precipitation of oxide nanoparticles.The average diameter of the oxide particles is 7.99 nm,with a number density of 2.75×10^(22)m^(-3).Almost all of the oxides are identified as orthorhombic YAl O3 particles.The refined grains and uniformly distributed oxide nanoparticles enable the alloy to show excellent mechanical strength and ductility below 700℃,and enable the ductile-to-brittle transition temperature to be close to room temperature.However,a slight decrease in strength at 1000℃and the Charpy upper shelf energy has been suggested to be due to the residual porosity.These results indicate that powder forging can be used as a promising technique for the fabrication of ODS alloys. | Sajian Wu Jing Li Changji Li Yiyi Li Liangyin Xiong Shi Liu | 2021 | Journal of Materials Science & Technology2021，，24： | 2 |
| 7 | The relationship between ulcer recurrence and helicobacter pylori:a prospective one-year follow-up study in China显示文摘 | Si Jianmin Jin yiyi Wu jiaguo | | Journal of Zhejiang University(Science Edition)0，，： | 1 |
| 8 | A dynamic assessment method for urban eco-environmental quality evaluation 显示文摘 | Kou Gang Wu Wenshuai Zhao Yiyi | 2011 | Journal of Multi-Criteria Decision Analy sis2011，18，1： | 1 |
| 9 | The relationship between ulcer recurrence and heicobacter pyior: a prospective one year follow - up study in China显示文摘 | Si Jianmin Jin Yiyi Wu Fiaguo | 2000 | Journal of Zhjiang University ( SCIENCE )2000，1，： | 1 |
| 10 | The Relationship between Ulcer Recurrence and Helicobacter Pylori:Prospective One-year follow up Study in China显示文摘 | SIJIAMIN JIN YIYI WU JIAGUO | 2000 | Journal of Zhejiang University Science (S1009-3095)2000，1，： | 1 |
| 11 | Reasonable location of stopping line in close‑distance underlying coal seam and partition support of large cross‑section roadway显示文摘Close-distance coal seams are widely distributed over China,and the coal pillars left by the overlying coal seams afect the retracement channel of the underlying coal seam in the stopping stage.Based on the engineering background of close-distance seam mining in a coal mine,the reasonable position of the underlying coal seam's stopping line and the support method of the large section roadway during stopping are investigated using feld measurements,similar simulation experiments,and numerical simulations.There are three types of location relationships between the stopping line of the underlying coal seam and the stopping line of the overlying coal seam:'externally staggered with the upper stopping line'(ESUL,stops mining under the overlying goaf),'overlapped with upper stopping line'(OUL),and'internally staggered with the upper stopping line'(ISUL,ISUL-SD for shorter internal staggered distances,ISUL-LD for longer ones).There are diferent stress arch structures in the overlying strata of the above three positions,and the stress arch evolution process exists in the process of ESUL→OUL→ISUL-SD→ISUL-LD:a front and rear double stress arch structure→the front arch gradually decreases→the front arch dies out,and the double arch synthesizes the single arch→the single-arch range expands→the nested double arch.The relationship between the stress arch structure and the position of the stopping line is evaluated as follows:(1)ESUL:the stress concentration in the roof plate of the retracement channel of the underlying coal seam is the highest,because the overburden block of the extensive collapse zone acts directly on the roof plate of the retracement channel,resulting in relative difculties in roof support.(2)OUL:although the retracement channel roof pressure is minimal,the overlying rock structure has the potential for rotation or slippage instability.(3)ISUL-SD:the pressure on the roof of the retracement channel is small and the overburden structure is stable,which is conducive to the safe retraction of the support and not limited by the width of the end-mining coal pillar.(4)ISUL-LD:it is basically the same as the condition of stopping under the non-goaf;however,it has a limitation on the width of the end-mining coal pillar.The location of the stopping line is selected as ISUL-SD,and the retraction process of the self-excavating retraction channel was adopted.A partition asymmetric support scheme which is proven by feld practice is proposed,through a comprehensive analysis of the pre-stress feld simulation of the support scheme,based on the diferent control requirements of the roof above the support and the roof of the retracement channel in the stopping area.This method realizes safe and smooth withdrawal of the support. | Dongdong Chen Yiyi Wu Shengrong Xie Fangfang Guo Fulian He Ruipeng Liu | 2022 | International Journal of Coal Science & Technology2022，9，4： | 1 |
| 12 | Concentrations, transport, fate, and releases of polybrominated diphenyl ethers in sewage treatment plants in the Pearl River Delta, South China显示文摘 | Xianzhi Peng Caiming Tang Yiyi Yu Jianhua Tan Qiuxin Huang Jiangping Wu Shejun Chen Bixian Mai | 2008 | Environment International2008，，2： | 1 |
| 13 | Improving the accuracy of genomic prediction for meat quality traits using whole genome sequence data in pigs显示文摘Background Pork quality can directly affect customer purchase tendency and meat quality traits have become valu-able in modern pork production.However,genetic improvement has been slow due to high phenotyping costs.In this study,whole genome sequence(WGS)data was used to evaluate the prediction accuracy of genomic best linear unbiased prediction(GBLUP)for meat quality in large-scale crossbred commercial pigs.Results We produced WGS data(18,695,907 SNPs and 2,106,902 INDELs exceed quality control)from 1,469 sequenced Duroc×(Landrace×Yorkshire)pigs and developed a reference panel for meat quality including meat color score,marbling score,L*(lightness),a*(redness),and b*(yellowness)of genomic prediction.The prediction accuracy was defined as the Pearson correlation coefficient between adjusted phenotypes and genomic estimated breeding values in the validation population.Using different marker density panels derived from WGS data,accuracy differed substantially among meat quality traits,varied from 0.08 to 0.47.Results showed that MultiBLUP outperform GBLUP and yielded accuracy increases ranging from 17.39%to 75%.We optimized the marker density and found medium-and high-density marker panels are beneficial for the estimation of heritability for meat quality.Moreover,we conducted genotype imputation from 50K chip to WGS level in the same population and found average concord-ance rate to exceed 95%and r^(2)=0.81.Conclusions Overall,estimation of heritability for meat quality traits can benefit from the use of WGS data.This study showed the superiority of using WGS data to genetically improve pork quality in genomic prediction. | Zhanwei Zhuang Jie Wu Yibin Qiu Donglin Ruan Rongrong Ding Cineng Xu Shenping Zhou Yuling Zhang Yiyi Liu Fucai Ma Jifei Yang Ying Sun Enqin Zheng Ming Yang Gengyuan Cai Jie Yang Zhenfang Wu | 2023 | Journal of Animal Science and Biotechnology2023，14，5： | 1 |
| 14 | Low-cost and low-density carbonized facial tissue supported uniform NiCo_(2)S_(4)nanotubes for high capacity flexible solid-state supercapacitors显示文摘Recently,rapid development of intelligent wearable electronic equipment has triggered great needs for flexible and lightweight portable energy storage systems.Here,we demonstrate a low-cost($0.5 m^(-2))and low density carbonized facial tissue paper(FCP)for high-conductive NiCo_(2)S_(4)nanotubes assisted novel ultra-flexible solid-state supercapacitors(SSCs).The hydrothermal synthesized FCP-900@NiCo_(2)S_(4)electrodes in this paper only have a density of 5 mg cm^(-2)and show large specific capacitance of 3115 mF cm^(-2)at 2 mA cm^(-2).Based on the high performance of FCP-900@NiCo_(2)S_(4)electrodes,the as assembled SSCs can deliver an energy density of 1.2 mWh cm^(-3),high power density of 58.16 mW cm-3.It also shows great bending-state capacitive performance with high capacitance retention after 5000 cycles,providing a new opportunity for developing high-performance flexible wearable energy storage devices. | Haiwei Wu Jingxuan Bi Yiyi Li Li Wang Xiaofei Pang Chuanyin Xiong Zhijian Li | 2021 | Journal of Materiomics2021，7，1： | 1 |
| 15 | A dynamic assessment method for Urban Eco--environmental quali- ty evaluation显示文摘 | Kou Gang Wu Wenshuai Zhao Yiyi | 2011 | Journal of Multi--Criteria Decision A- nalysis2011，18，1： | 1 |
| 16 | Failure analysis and control technology of intersections of large‑scale variable cross‑section roadways in deep soft rock显示文摘In deep underground mining,achieving stable support for roadways along with long service life is critical and the complex geological environment at such depths frequently presents a major challenge.Owing to the coupling action of multiple factors such as deep high stress,adjacent faults,cross-layer design,weak lithology,broken surrounding rock,variable cross-sections,wide sections up to 9.9 m,and clusters of nearby chambers,there was severe deformation and breakdown in the No.10 intersection of the roadway of large-scale variable cross-section at the−760 m level in a coal mine.As there are insufcient examples in engineering methods pertaining to the geological environment described above,the numerical calculation model was oversimplifed and support theory underdeveloped;therefore,it is imperative to develop an efective support system for the stability and sustenance of deep roadways.In this study,a quantitative analysis of the geological environment of the roadway through feld observations,borehole-scoping,and ground stress testing is carried out to establish the FLAC 3D variable cross-section crossing roadway model.This model is combined with the strain softening constitutive(surrounding rock)and Mohr–Coulomb constitutive(other deep rock formations)models to construct a compression arch mechanical model for deep soft rock,based on the quadratic parabolic Mohr criterion.An integrated control technology of bolting and grouting that is mainly composed of a high-strength hollow grouting cable bolt equipped with modifed cement grouting materials and a high-elongation cable bolt is developed by analyzing the strengthening properties of the surrounding rock before and after bolting,based on the Heok-Brown criterion.As a result of on-site practice,the following conclusions are drawn:(1)The plastic zone of the roof of the cross roadway is approximately 6 m deep in this environment,the tectonic stress is nearly 30 MPa,and the surrounding rock is severely fractured.(2)The deformation of the roadway progressively increases from small to large cross-sections,almost doubling at the largest cross-section.The plastic zone is concentrated at the top plate and shoulder and decreases progressively from the two sides to the bottom corner.The range of stress concentration at the sides of the intersection roadway close to the passageway is wider and higher.(3)The 7 m-thick reinforced compression arch constructed under the strengthening support scheme has a bearing capacity enhanced by 1.8 to 2.3 times and increase in thickness of the bearing structure by 1.76 times as compared to the original scheme.(4)The increase in the mechanical parameters c andφof the surrounding rock after anchoring causes a signifcant increase inσt;the pulling force of the cable bolt beneath the new grouting material is more than twice that of ordinary cement grout,and according to the test,the supporting stress feld shows that the 7.24 m surrounding rock is compacted and strengthened in addition to providing a strong foundation for the bolt(cable).On-site monitoring shows that the 60-days convergence is less than 30 mm,indicating that the stability control of the roadway is successful. | Shengrong Xie Yiyi Wu Dongdong Chen Ruipeng Liu Xintao Han Qiucheng Ye | 2022 | International Journal of Coal Science & Technology2022，9，2： | 1 |
| 17 | VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance显示文摘Radiotherapy remains the mainstay for treatment of various types of human cancer;however,the clinical efficacy is often limited by radioresistance,in which the underlying mechanism is largely unknown.Here,using esophageal squamous cell carcinoma(ESCC)as a model,we demonstrate that guanine nucleotide exchange factor 2(VAV2),which is overexpressed in most human cancers,plays an important role in primary and secondary radioresistance.We have discovered for the first time that VAV2 is required for the Ku70/Ku80 complex formation and participates in non-homologous end joining repair of DNA damages caused by ionizing radiation. | Weiling Liu Chuanwang Miao Shaosen Zhang Yachen Liu Xiangjie Niu Yiyi Xi Wenjia Guo Jiahui Chu Ai Lin Hongjin Liu Xinyu Yang Xinjie Chen Ce Zhong Yuling Ma Yuqian Wang Shihao Zhu Shuning Liu Wen Tan Dongxin Lin Chen Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 18 | The relationship between ulcer recurrence and helicobacter pylori: a prospective one-year follow up study in china显示文摘 | Si Jianmin Jin Yiyi Wu Jiaguo | 2000 | Journal of Zhejiang University Science2000，1，： | 1 |
| 19 | A dynamic assessment method for urban eco-environmental quality evaluation显示文摘 | Kou Gang Wu Wenshuai Zhao Yiyi | 2011 | Journal of Multi-Criteria Decision Analy- sis2011，18，1： | 1 |
| 20 | The relationship between ulcer recurrence and helicobacter pylori a prospective one-year follow up study in china显示文摘 | Jin yiyi Wu jiaguo | 2000 | Journal of Zhejiang University science2000，，1： | 1 |
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