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| 1 | Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells显示文摘人的导致的 pluripotent 茎(iPS ) 房间类似于胚胎的茎(ES ) 房间,和罐头强烈地增殖并且区分进许多房间类型。然而,人的 iPS 房间的肝的区别还没被报导了。在这份报告,人的 iPS 房间被导致由一个逐步的协议区分进肝的房间。肝房间标记的表达式和人的 iPS 的肝相关的函数导出房间的房间被监视并且与区分的人的 ES 房间和主要人的 hepatocytes 的相比。在白天 7 点的约 60% 区分的人的 iPS 房间表示了肝的标记 alpha fetoprotein 和白长袍的。在白天 21 点的区分的房间包括白朊 Asecretion,肝糖合成,脲生产和可诱导的细胞色素 P450 活动展出了肝房间功能。肝的标记的表示和 iPS 的肝相关的功能导出房间的肝的房间比得上人的 ES 导出房间的肝的房间的。这些结果证明人的 iPS 房间,类似于人的 ES 房间,能高效地被导致区分房间进象 hepatocyte 一样。 | Zhihua Song Jun Cai Yanxia Liu Dongxin Zhao Jun Yong Shuguang Duo Xijun Song Yushan Guo Yang Zhao Han Qin Xiaolei Yin Chen Wu Jie Che Shichun Lu Mingxiao Ding Hongkui Deng | 2009 | Cell Research2009，19，11： | 63 |
| 2 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 3 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 4 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 5 | Catalytic fast pyrolysis of Kraft lignin with HZSM-5 zeolite for producing aromatic hydrocarbons显示文摘 | Xiangyu LI Lu SU Yujue WANG Yanqing YU Chengwen WANG Xiaoliang LI Zhihua WANG | 2012 | Frontiers of Environmental Science & Engineering2012，6，3： | 14 |
| 6 | A Modelling Study of Inter-Annual Variation of Kuroshio Intrusion on the Shelf of East China Sea显示文摘Inter-annual variability of the Kuroshio water intrusion on the shelf of East China Sea (ECS) was simulated with a nested global and Northwest Pacific ocean circulation model.The model analysis reveals the influence of the variability of Kuroshio transport east of Taiwan on the intrusion to the northeast of Taiwan:high correlation (r=0.92) with the on-shore volume flux in the lower layer (50 200 m) ;low correlation (r=0.50) with the on-shore flux in the upper layer (0 50 m) .Spatial distribution of correlations between volume fluxes and sea surface height suggests that inter-annual variability of the Kuroshio flux east of Taiwan and its subsurface water intruding to the shelf lag behind the sea surface height anomalies in the central Pacific at 162 E by about 14 months,and could be related to wind-forced variation in the interior North Pacific that propagates westward as Rossby waves.The intrusion of Kuroshio surface water is also influenced by local winds.The intruding Kuroshio subsurface water causes variations of temperature and salinity of bottom waters on the southern ECS shelf.The influence of the intruding Kuroshio subsurface water extends widely from the shelf slope northeast of Taiwan northward to the central ECS near the 60 m isobath,and northeastward to the region near the 90 m isobath. | LI Jiaxing WEI Hao ZHANG Zhihua LU Youyu | 2013 | Journal of Ocean University of China2013，12，4： | 6 |
| 7 | Tail loss affects fecundity but not offspring traits in the Chinese skink Eumeces chinensis显示文摘 | Hongliang LU Jianfang GAO Xiaohao MA Zhihua LIN Xiang JI | 2012 | Current Zoology2012，58，2： | 5 |
| 8 | The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortality of patients with hepatitis B-related liver failure based on real-world clinical data显示文摘On the basis of real-world clinical data,the study aimed to explore the effect and mechanisms of the treatment plan of“traditional Chinese medicine(TCM)regulating liver regeneration.”A total of 457 patients with HBV-related liver failure were retrospectively collected.The patients were divided into three groups:the modern medicine control group(MMC group),patients treated with routine medical treatment;the control group combining traditional Chinese and Western medicine(CTW),patients treated with routine medical treatment plus the common TCM formula;and the treatment group of“TCM regulating liver regeneration”(RLR),patients treated with both routine medical treatment and the special TCM formula of RLR.After 8 weeks of treatment,the mortality of patients in the RLR group(12.31%)was significantly lower than those in the MMC(50%)and CTW(29.11%)groups.Total bilirubin level significantly decreased and albumin increased in the RLR group when compared with the MMC and CTW groups(P<0.05).In addition,there were significant differences in the expression of several cytokines related to liver regeneration in the RLR group compared with the MMC group.RLR treatment can decrease jaundice,improve liver function,and significantly reduce the mortality in patients with HBV-related liver failure.The mechanism may be related to the role of RLR treatment in influencing cytokines related to liver regeneration. | Ling Dai Xiang Gao Zhihua Ye Hanmin Li Xin Yao Dingbo Lu Na Wu | 2021 | Frontiers of Medicine2021，15，3： | 4 |
| 9 | Aquaculture area extraction and vulnerability assessment in Sanduao based on richer convolutional features network model显示文摘Sanduao is an important sea-breeding bay in Fujian,South China and holds a high economic status in aquaculture.Quickly and accurately obtaining information including the distribution area,quantity,and aquaculture area is important for breeding area planning,production value estimation,ecological survey,and storm surge prevention.However,as the aquaculture area expands,the seawater background becomes increasingly complex and spectral characteristics differ dramatically,making it difficult to determine the aquaculture area.In this study,we used a high-resolution remote-sensing satellite GF-2 image to introduce a deep-learning Richer Convolutional Features(RCF)network model to extract the aquaculture area.Then we used the density of aquaculture as an assessment index to assess the vulnerability of aquaculture areas in Sanduao.The results demonstrate that this method does not require land and water separation of the area in advance,and good extraction can be achieved in the areas with more sediment and waves,with an extraction accuracy>93%,which is suitable for large-scale aquaculture area extraction.Vulnerability assessment results indicate that the density of aquaculture in the eastern part of Sanduao is considerably high,reaching a higher vulnerability level than other parts. | LIU Yueming YANG Xiaomei WANG Zhihua LU Chen LI Zhi YANG Fengshuo | 2019 | Journal of Oceanology and Limnology2019，37，6： | 4 |
| 10 | HTDet:A Clustering Method Using Information Entropy for Hardware Trojan Detection显示文摘Hardware Trojans(HTs)have drawn increasing attention in both academia and industry because of their significant potential threat.In this paper,we propose HTDet,a novel HT detection method using information entropybased clustering.To maintain high concealment,HTs are usually inserted in the regions with low controllability and low observability,which will result in that Trojan logics have extremely low transitions during the simulation.This implies that the regions with the low transitions will provide much more abundant and more important information for HT detection.The HTDet applies information theory technology and a density-based clustering algorithm called Density-Based Spatial Clustering of Applications with Noise(DBSCAN)to detect all suspicious Trojan logics in the circuit under detection.The DBSCAN is an unsupervised learning algorithm,that can improve the applicability of HTDet.In addition,we develop a heuristic test pattern generation method using mutual information to increase the transitions of suspicious Trojan logics.Experiments on circuit benchmarks demonstrate the effectiveness of HTDet. | Renjie Lu Haihua Shen Zhihua Feng Huawei Li Wei Zhao Xiaowei Li | 2021 | Tsinghua Science and Technology2021，26，1： | 4 |
| 11 | Adiabatic approximation in PT-symmetric quantum mechanics显示文摘In this paper, we present a quantitative sufficient condition for adiabatic approximation in PT-symmetric quantum mechanics,which yields that a state of the PT-symmetric quantum system at any time will remain approximately in the m-th eigenstate up to a multiplicative phase factor whenever it is initially in the m-th eigenstate of the Hamiltonian. In addition, we estimate the approximation errors by the distance and the fidelity between the exact solution and the adiabatic approximate solution to the time evolution equation, respectively. | GUO ZhiHua CAO HuaiXin LU Ling | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，10： | 3 |
| 12 | Impact of type 2 diabetes mellitus on short-term and long-term outcomes of patients with esophageal squamous cell cancer undergoing resection: a propensity score analysis显示文摘Background:The association between type 2 diabetes mellitus(T2DM)and the risk of esophageal cancer remains unclear.The present study aimed to evaluate the impact of T2DM on short-term outcomes and long-term survival in patients with esophageal squamous cell cancer(ESCC).Methods:The present retrospective study included 862 patients diagnosed with ESCC between January 2001 and December 2010.Among them,280 patients had T2DM.A 1:1 propensity score-matched cohort consisting of 280 patients with and 280 without T2DM was selected from the 862 patients.The associations between T2DM and clinico-pathologic characteristics were assessed using theχ2 or Fisher’s exact test.Survival of ESCC patients with and without T2DM was calculated by using the Kaplan-Meier method and compared by using the Cox regression model between the two groups.Results:The occurrence rate of anastomotic leakage was significantly higher in patients with T2DM than in those without T2DM(P<0.001).In the subgroup with weight loss rate≤5.05%,ESCC patients with T2DM had a signifi-cant longer overall survival than did those without T2DM(P=0.003),whereas in the subgroup with weight loss rate>5.05%,the patients without T2DM showed a longer survival(P=0.001).Univariate and multivariate analysis results showed that T2DM was not an independent prognostic factor for patient survival.Conclusions:Type 2 diabetes mellitus is not an independent prognostic factor in patients with ESCC.However,the combination of T2DM with severe weight loss would be a predictor of poor prognosis. | Wang Yao Yuqi Meng Mingjian Lu Wenzhe Fan Jinhua Huang Jiaping Li Zhihua Zhu | 2018 | Cancer Communications2018，38，1： | 2 |
| 13 | Boosting of reversible capacity delivered at a low voltage below 0.5 V in mildly expanded graphitized needle coke anode for a high-energy lithium ion battery显示文摘The rate performance and cycle stability of graphitized needle coke(GNC)as anode are still limited by the sluggish kinetics and volume expansion during the Li ions intercalation and de-intercalation process.Especially,the output of energy density for lithium ion batteries(LIBs)is directly affected by the delithiation capacity below 0.5 V.Here,the mildly expanded graphitized needle coke(MEGNC)with the enlarged interlayer spacing from 0.346 to 0.352 nm is obtained by the two-step mild oxidation intercalation modification.The voltage plateau of MEGNC anode below 0.5 V is obviously broadened as compared to the initial GNC anode,contributing to the enhancement of Li storage below the low voltage plateau.Moreover,the coin full cell and pouch full cell configured with MEGNC anode exhibit much enhanced Li storage ability,energy density and better cycling stability than those full cells configured with GNC and commercial graphite anodes,demonstrating the practical application value of MEGNC.The superior anode behaviors of MEGNC including the increased effective capacity at low voltage and superior cyclic stability are mainly benefited from the enlarged interlayer spacing,which not only accelerates the Li ions diffusion rate,but also effectively alleviates the volume expansion and fragmentation during the Li ions intercalation process.In addition,the above result is further confirmed by the density functional theory simulation.This work provides an effective modification strategy for the NC-based graphite to enhance the delithiation capacity at a low voltage plateau,dedicated to improving the energy density and durability of LIBs. | Dong Sun Lu Zhao Zhihua Xiao Kai Zhao Rundan Lin Hongmei Song Xilu Zhang Xinlong Ma Chong Peng Xiaoqiao Huang Xingxun Li Jinsen Gao Chunming Xu | 2022 | Journal of Energy Chemistry2022，31，11： | 2 |
| 14 | Object-based classification of cloudy coastal areas using medium-resolution optical and SAR images for vulnerability assessment of marine disaster显示文摘Efficient and accurate access to coastal land cover information is of great significance for marine disaster prevention and mitigation.Although the popular and common sensors of land resource satellites provide free and valuable images to map the land cover,coastal areas often encounter significant cloud cover,especially in tropical areas,which makes the classification in those areas non-ideal.To solve this problem,we proposed a framework of combining medium-resolution optical images and synthetic aperture radar(SAR)data with the recently popular object-based image analysis(OBIA)method and used the Landsat Operational Land Imager(OLI)and Phased Array type L-band Synthetic Aperture Radar(PALSAR)images acquired in Singapore in 2017 as a case study.We designed experiments to confirm two critical factors of this framework:one is the segmentation scale that determines the average object size,and the other is the classification feature.Accuracy assessments of the land cover indicated that the optimal segmentation scale was between 40 and 80,and the features of the combination of OLI and SAR resulted in higher accuracy than any individual features,especially in areas with cloud cover.Based on the land cover generated by this framework,we assessed the vulnerability of the marine disasters of Singapore in 2008 and 2017 and found that the high-vulnerability areas mainly located in the southeast and increased by 118.97 km2 over the past decade.To clarify the disaster response plan for different geographical environments,we classified risk based on altitude and distance from shore.The newly increased high-vulnerability regions within 4 km offshore and below 30 m above sea level are at high risk;these regions may need to focus on strengthening disaster prevention construction.This study serves as a typical example of using remote sensing techniques for the vulnerability assessment of marine disasters,especially those in cloudy coastal areas. | YANG Fengshuo YANG Xiaomei WANG Zhihua LU Chen LI Zhi LIU Yueming | 2019 | Journal of Oceanology and Limnology2019，37，6： | 2 |
| 15 | Maternal Thermal Effects on Female Reproduction and Hatchling Phenotype in the Chinese Skink(Plestiodon chinensis)显示文摘We maintained gravid Chinese skinks(Plestiodon chinensis) at three constant temperatures(25, 28 and 31 °C) during gestation, and randomly assigned eggs from each female to one of the same three temperatures for incubation to determine maternal thermal effects on female reproduction and hatchling phenotype. Maternal temperature affected egg-laying date, hatching success and hatchling linear size(snout-vent length, SVL) but not clutch size, egg size, egg component, and embryonic stage at laying. More specifically, females at higher temperatures laid eggs earlier than did those at low temperatures, eggs laid at 31 °C were less likely to hatch than those laid at 25 °C or 28 °C, and hatchlings from eggs laid at 31 °C were smaller in SVL. Our finding that maternal temperature(pre-ovipositional thermal condition) rather than incubation temperature(post-ovipositional thermal condition) affected hatching success indicated that embryos at early stages were more vulnerable to temperature than those at late stages. Our data provide an inference that moderate maternal temperatures enhance reproductive fitness in P. chinensis. | Li MA Zhihua LIN Jianfang GAO Hong LI Xiang JI Hongliang LU | 2018 | Asian Herpetological Research2018，9，4： | 2 |
| 16 | Analytical investigation and optimal design of sandwich panels subjected to shock loading显示文摘 | Zhu Feng Wang Zhihua Lu Guoxing | 2009 | Materials and Design2009，30，1： | 1 |
| 17 | The microbial community in the feces of the giant panda(Ailuropoda melanoleuca)as determined by PCR-TGGE profiling and clone library analysis显示文摘 | Guifang Wei Haifeng Lu Zhihua Zhou | 2007 | Microbial Ecol2007，54，： | 1 |
| 18 | Thermal Residual Stresses in W Fibers/Zr-based Metallic Glass Composites by High-energy Synchrotron X-ray Diffraction显示文摘Thermal residual stresses in W fibers/Zr-based metallic glass composites were measured by in situ high energy synchrotron X-ray diffraction(HEXRD). The W fibers for the composites were 300,500,and 700 m m in diameter,respectively. Coaxial cylinder model(CCM) and finite element model(FEM) were employed to simulate the distribution of thermal residual stress,respectively. HEXRD results showed that the selected diameters of W fiber had little influence on the value of thermal residual stresses in the present composites. Thermal residual stresses simulated by CCM and FEM were in good agreement with HEXRD measured results. In addition,FEM results exhibited that thermal residual stress concentrated on interface between the two phases and area where the two W fibers were the closest ones to each other. | Xinqiang Zhang Yunfei Xue Haifeng Zhang Huameng Fu Zhengbin Wang Zhihua Nie Lu Wang | 2015 | Journal of Materials Science & Technology2015，31，2： | 1 |
| 19 | Analysis and deign of a low- voltage RF CMOS mixer 显示文摘 | Liu Lu Wang Zhihua | 2006 | IEEE Trans Circuits Syst II2006，53，3： | 1 |
| 20 | Sublinear operators with rough kernel on generalized Morrey space 显示文摘 | Lu Shanzhen Yang Dachun Zhou Zhihua | 1998 | Hokkaido Mathematical Journal1998，27，1： | 1 |
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