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| 1 | Multifunctional modification of Fe_(3)O_(4) nanoparticles for diagnosis and treatment of diseases:A review显示文摘With the rapid improvements in nanomaterials and imaging technology,great progresses have been made in diagnosis and treatment of diseases during the pastdecades.Fe_(3)O_(4) magnetic nanoparticles(MNPs)with good biocompatibility and super-paramagnetic property are usually used as contrast agent for diagnosis of diseases inmagnetic resonance imaging(MRI).Currently,the combination of multiple imagingtechnologies has been considered as new tendency in diagnosis and treatment ofdiseases,which could enhance the accuracy and reliability of disease diagnosis andprovide new strategies for disease treatment.Therefore,novel contrast agents used formultifunctional imaging are urgently needed.Fe_(3)O_(4) MNPs are believed to be a potentialcandidate for construction of multifunctional platform in diagnosis and treatment ofdiseases.In recent years,there are a plethora of studies concerning the construction ofmultifunctional platform presented based on Fe_(3)O_(4) MNPs.In this review,we introducefabrication methods and modification strategies of Fe_(3)O_(4) MNPs,expecting greatimprovements for diagnosis and treatment of diseases in the future. | Miao QIN Mengjie XU Lulu NIU Yizhu CHENG Xiaolian NIU Jinlong KONG Xiumei ZHANG Yan WEI Di HUANG | 2021 | Frontiers of Materials Science2021，15，1： | 1 |
| 2 | Citric Acid-Based Intrinsic Band-Shifting Photoluminescent Materials显示文摘Citric acid,an important metabolite with abundant reactive groups,has been demonstrated as a promising starting material to synthesize diverse photoluminescent materials including small molecules,polymers,and carbon dots.The unique citrate chemistry enables the development of a series of citric acid-based molecules and nanomaterials with intriguing intrinsic band-shifting behavior,where the emission wavelength shifts as the excitation wavelength increases,ideal for chromatic imaging and many other applications.In this review,we discuss the concept of“intrinsic band-shifting photoluminescent materials”,introduce the recent advances in citric acid-based intrinsic band-shifting materials,and discuss their potential applications such as chromatic imaging and multimodal sensing.It is our hope that the insightful and forward-thinking discussion in this review will spur the innovation and applications of the unique band-shifting photoluminescent materials. | Dingbowen Wang Yizhu Chen Tunan Xia Mariana Claudino Allison Melendez Xingjie Ni Cheng Dong Zhiwen Liu Jian Yang | 2023 | Research2023，，4： | 0 |
| 3 | Simultaneous and Spatial Quantification of Telomerase Activity and DNA Methylation in Living Cells by a Deformable Satellite Nanocapsule显示文摘Telomerase plays an essential role in many biological processes.DNA methylation regulates the expression of many genes,including telomerase.Here,we propose a deformable satellite nanocapsule fluorescein isothiocyanate(FITC)-hollowbowl mesoporous organicsilica@gold nanoparticles-methyl-CpG-binding protein 2(MECP 2)-silver nanoclusters(FHBMO@AMA),for simultaneous quantitative detection of both cytoplasmic telomerase activity and the degree of DNA methylation.This strategy enabled spatial-based detection in cells.The total cytoplasmic telomerase activity was detected by fluorescence energy resonance transfer(FRET)between FHBMO and gold nanoparticles(Au NPs),while the DNA methylation in the nucleus was detected by enhanced fluorescence of silver nanoclusters(Ag NCs).Furthermore,FHBMO@AMA could intuitively distinguish between the differences in telomerase expression in cells during the DNA synthesis period at the mitotic phase(S/M)of the cell cycle.Interestingly,the ratio of the two detections(telomerase activity/DNA methylation)significantly correlated with the efficacy of anticancer drugs.At the same time,there was no apparent linear relationship between any single detection target and the efficacy of the anticancer drugs.Therefore,based on the relationship between telomerase activity and DNA methylation,our newly developed approach serves as new and feasible method for evaluating the efficacy of anticancer drugs,thereby,extending the technology toolbox for precision in medical and pharmaceutical analysis of drug potency. | Shan Huang Cheng Ma Jiahao Lin Wenjing Wang Yizhu Xu Xingxin Wu Jian-Rong Zhang Jun-Jie Zhu | 2021 | CCS Chemistry2021，3，4： | 0 |
| 4 | Self-healing poly(acrylic acid) hydrogels fabricated by hydrogen bonding and Fe^(3+) ion cross-linking for cartilage tissue engineering显示文摘Autonomous self-healing hydrogels were achieved through a dynamic combination of hydrogen bonding and ferric ion(Fe^(3+))migration.N,N′-methylenebis(acrylamide)(MBA),a cross-linking agent,was added in this study.Poly(acrylic acid)(PAA)/Fe^(3+)and PAA–MBA/Fe^(3+)hydrogels were prepared by introducing Fe^(3+)into the PAA hydrogel network.The ionic bonds were formed between Fe^(3+)ions and carboxyl groups.The microstructure,mechanical properties,and composition of hydrogels were characterized by field emission scanning electron microscopy and Fourier transform infrared spectroscopy.The experimental results showed that PAA/Fe^(3+)and PAA–MBA/Fe^(3+)hydrogels healed themselves without external stimuli.The PAA/Fe^(3+)hydrogel exhibited good mechanical properties,i.e.,the tensile strength of 50 kPa,the breaking elongation of 750%,and the self-healing efficiency of 82%.Meanwhile,the PAA–MBA/Fe^(3+)hydrogel had a tensile strength of 120 kPa.These fabricated hydrogels are biocompatible,which may have promising applications in cartilage tissue engineering. | Min Kang Yizhu Cheng Yinchun Hu Huixiu Ding Hui Yang Yan Wei Di Huang | 2023 | Frontiers of Materials Science2023，17，3： | 0 |
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