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| 1 | Cryo-EM structure of human mTOR complex 2显示文摘 | Xizi Chen Mengjie Liu Yuan Tian Jiabei Li Yilun Qi Dan Zhao Zihan Wu Min Huang Catherine C. L. Wong Hong-Wei Wang Jiawei Wang Huirong Yang Yanhui Xu | 2018 | Cell Research2018，28，5： | 8 |
| 2 | Cryo-EM structure of human DNA-PK holoenzyme显示文摘 | Xiaotong Yin Mengjie Liu Yuan Tian Jiawei Wang Yanhui Xu | 2017 | Cell Research2017，27，11： | 8 |
| 3 | Ultraselective carbon molecular sieve membrane for hydrogen purification显示文摘Hydrogen is a green clean fuel and chemical feedstock. Its separation and purification from hydrogencontaining mixtures is the key step in the production of hydrogen with high purity(>99.99%). In this work, carbon molecular sieve(CMS) membranes with ultrahigh permselectivity for hydrogen purification were fabricated by high-temperature(700–900 ℃) pyrolysis of polymeric precursor of phenolphthaleinbased cardo poly(arylene ether ketone)(PEK-C). The evolution of the microstructural texture and ultramicroporous structure and gas separation performance of the CMS membrane were characterized via TG-MS, FT-IR, XRD, TEM, CO2 sorption analysis and gas permeation measurements. CMS membranes prepared at 700 ℃ exhibited amorphous turbostratic carbon structures and high H2 permeability of 5260 Barrer with H2/CH4, H2/N2 and H2/CO selectivities of 311, 142, 75, respectively. When carbonized at900 ℃, the CMS membrane with ultrahigh H2/CH4 selectivity of 1859 was derived owing to the formation of the dense and ordered carbon structure. CMS membranes with ultrahigh permselectivity exhibit an attractive application prospect in hydrogen purification. | Ruisong Xu Liu He Lin Li Mengjie Hou Yongzhao Wang Bingsen Zhang Changhai Liang Tonghua Wang | 2020 | Journal of Energy Chemistry2020，29，11： | 8 |
| 4 | A Case of Hepatitis B Reactivation due to the Hepatitis B Virus Escape Mutant in a Patient undergoing Chemotherapy显示文摘A 62-year-old man had chronic hepatitis B virus (HBV) infection and was diagnosed with liver cirrhosis.At the time of diagnosis the patient's virologic markers were positive for hepatitis B surface antigen (HBsAg),antibody to hepatitis B e antigen (anti-HBe) and antibody to hepatitis B core antigen (anti-HBc),while antibody to hepatitis B surface antigen (anti-HBs) and HBV DNA were negative.Later the patient received chemotherapy for malignancy.However,this was interrupted due to elevated liver enzymes.At the same time HBV DNA became positive.Lamivudine (LMV) therapy was administered immediately.However,the levels of serum aminotransferase and total bilirubin (TB) were still rising.Finally the patient died of fulminant hepatic failure.A sequence revealed HBV genotype C (HBsAg subtype adw) with immune escape mutations,F8L,S34L,F41S,G44V,F93C,V96G,L110I,C149Y and F161Y.The high morbidity and mortality of this complication is one of the major obstacles to completing the standard treatment for malignancy in HBV carriers.Therefore,the relative risk of antiviral prophylactic failure should be further assessed and the optimal strategy for antiviral prophylaxis in HBsAg-positive patients with oncologic and hematologic malignancies undergoing chemotherapy should be revised. | Chunchen Wu Hui Shi Yun Wang Mengji LU Yang Xu Xinwen Chen | 2012 | Virologica Sinica2012，27，6： | 7 |
| 5 | 4.4 A Resolution Cryo-EM structure of human mTOR Complex 1显示文摘 | Huirong Yang Jia Wang Mengjie Liu Xizi Chen Min Huang Dan Tan Meng-Qiu Dong Catherine C. L, Wong Jiawei Wang Yanhui Xu Hong-Wei Wang | 2016 | Protein & Cell2016，7，12： | 7 |
| 6 | Ketamine induces tau hyperphosphorylation at serine 404 in the hippocampus of neonatal rats显示文摘Male Wistar 7-day-old rats were injected with 40 mg/kg ketamine intraperitoneally, followed by three additional injections of 20 mg/kg ketamine each upon restoration of the righting reflex. Neonatal rats injected with equivalent volumes of saline served as controls. Hippocampal samples were collected at 1, 7 or 14 days following administration. Electron microscopy showed that neuronal structure changed noticeably following ketamine treatment. Specifically, microtubular structure became irregular and disorganized. Quantitative real time-PCR revealed that phosphorylated tau mRNA was upregulated after ketamine. Western blot analysis demonstrated that phosphorylated tau levels at serine 396 initially decreased at 1 day after ketamine injection, and then gradually returned to control values. At 14 days after injection, levels of phosphorylated tau were higher in the ketamine group than in the control group. Tau protein phosphorylated at serine 404 significantly increased after ketamine injection, and then gradually decreased with time. However, the levels of tau protein at serine 404 were significantly greater in the ketamine group than in the control group until 14 days. The present results indicate that ketamine induces an increase of phosphorylated tau mRNA and excessive phosphorylation of tau protein at serine 404, causing disruption of microtubules in the neonatal rat hippocampus and potentially resulting in damage to hippocampal neurons. | Haiyan Jin Zhiyong Hu Mengjie Dong Yidong Wu Zhirui Zhu Lili Xu | 2013 | Neural Regeneration Research2013，8，17： | 5 |
| 7 | Discrimination of False Negative Results in RT-PCR Detection of SARS-CoV-2 RNAs in Clinical Specimens by Using an Internal Reference显示文摘Reverse transcription-polymerase chain reaction(RT-PCR)is an essential method for specific diagnosis of SARS-CoV-2 infection.Unfortunately,false negative test results are often reported.In this study,we attempted to determine the principal causes leading to false negative results of RT-PCR detection of SARS-CoV-2 RNAs in respiratory tract specimens.Multiple sputum and throat swab specimens from 161 confirmed COVID-19 patients were tested with a commercialfluorescent RT-PCR kit targeting the ORF1 ab and N regions of SARS-CoV-2 genome.The RNA level of a cellular housekeeping gene ribonuclease P/MRP subunit p30(RPP30)in these specimens was also assessed by RT-PCR.Data for a total of 1052 samples were retrospectively re-analyzed and a strong association between positive results in SARS-CoV-2 RNA tests and high level of RPP30 RNA in respiratory tract specimens was revealed.By using the ROC-AUC analysis,we identified Ct cutoff values for RPP30 RT-PCR which predicted false negative results for SARS-CoV-2 RT-PCR with high sensitivity(95.03%–95.26%)and specificity(83.72%–98.55%)for respective combination of specimen type and ampli-fication reaction.Using these Ct cutoff values,false negative results could be reliably identified.Therefore,the presence of cellular materials,likely infected host cells,are essential for correct SARS-CoV-2 RNA detection by RT-PCR in patient specimens.RPP30 could serve as an indicator for cellular content,or a surrogate indicator for specimen quality.In addition,our results demonstrated that false negativity accounted for a vast majority of contradicting results in SARS-CoV-2 RNA test by RT-PCR. | Yafei Zhang Changtai Wang Mingfeng Han Jun Ye Yong Gao Zhongping Liu Tengfei He Tuantuan Li Mengyuan Xu Luping Zhou Guizhou Zou Mengji Lu Zhenhua Zhang | 2020 | Virologica Sinica2020，35，6： | 5 |
| 8 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 9 | Cryo-EM structure of human ATR-ATRIP complex显示文摘ATR (变异毛细管扩张、 Rad3 相关的混乱) 蛋白质 kinase 并且(交往 ATR 蛋白质) 起锚形成建筑群并且响应复制应力和 DNA 损坏起一个关键作用。这里,我们决定了在 4.7 点 ATR 起锚复杂的人的 cryo 电子显微镜学(他们) 结构吗?分辨率并且造了 ATR 的 C 终端催化核心的一个原子模型(残余 1 521-2 644 ) 在 3.9 点?分辨率。建筑群采用空心形状,由在不同符合构造的二 ATR 单体组成。他们地图为起锚表明 14 热在扩大 S 形状重复。ATR 的 conformational 灵活性起锚允许适当地锁二 ATR 单体的 N 终点赞成 ATR 起锚复杂的形成和功能的差异。孤立的头头和尾巴尾巴各个采用假 2 褶层对称。外面的催化衣袋脸和底层存取没被禁止的元素限制。我们的研究为理解集会提供一个结构的基础 ATR 起锚,为描绘调停 ATR 的 DNA 的建筑群和一个框架修理小径。 | Qinhui Rao Mengjie Liu Yuan Tian Yuhan Hao Lei Song Zhaoyu Qin Chen Ding Hong-Wei Wang Jiawei Wang Yanhui Xu | 2018 | Cell Research2018，28，2： | 4 |
| 10 | Complementation of Wild-Type and Drug-Resistant Hepatitis B Virus Genomes to Maintain Viral Replication and Rescue Virion Production under Nucleos(t)ide Analogs显示文摘As the open reading frames of hepatitis B virus(HBV)genomes are overlapping,resistance mutations(MTs)in HBV polymerase may result in stop codon MTs in hepatitis B surface proteins,which are usually detected as a mixed population with wild-type(WT)HBV.The question was raised how the coexistence of nucleos(t)ide analogs(NAs)resistance MTs and WT sequences affects HBV replication.In the present study,HBV genomes with frequently detected reverse transcriptase(RT)/surface truncation MTs,rtA181T/sW172^*,rtV191I/sW182^*and rtM204I/sW196^*,were phenotypically characterized alone or together with their WT counterparts in different ratios by transient transfection in the absence or presence of Nas.In the absence of Nas,RT/surface truncation MTs impaired the expression and secretion of HBV surface proteins,and had a dose-dependent negative effect on WT HBV virion secretion.However,in the presence of Nas,coexistence of MTs with WT maintained viral replication,and the presence of WT was able to rescue the production of MT HBV virions.Our findings reveal that complementation of WT and MT HBV genomes is highly effective under drug treatment. | Chunchen Wu Baolin Li Xiaoyong Zhang Kaitao Zhao Yingshan Chen Yifei Yuan Yan Liu Rongjuan Chen Dongping Xu Xinwen Chen Mengji Lu | 2019 | Virologica Sinica2019，34，4： | 4 |
| 11 | 雷公藤红素通过靶向核受体Nur77促进损伤线粒体自噬而抑制炎症反应显示文摘文章简介线粒体在细胞死亡、自噬、免疫和炎症中起着不可或缺的作用。前期研究发现,孤儿核受体Nur77通过靶向线粒体诱导细胞凋亡。本文报道了Nur77作为具有抗炎作用的雷公藤红素的直接靶点,介导雷公藤红素通过自噬清除损伤线粒体,抑制炎症反应而达到治疗炎症疾病包括肥胖症的功能。 | Mengjie Hu Qiang Luo Gulimiran Alitongbieke Shuyi Chong Chenting Xu Lei Xie Xiaohui Chen Duo Zhang Yuqi Zhou Zhaokai Wang Xiaohong Ye Lijun Cai Fang Zhang Huibin Chen Fuquan Jiang Hui Fang Shanjun Yang Jie Liu Maria T.Diaz-Meco Ying Su Hu Zhou Jorge Moscat Xiangzhi Lin 张晓坤 | 2018 | 科学新闻2018，0，4： | 3 |
| 12 | Spatial Analysis of HIV/AIDS Cases Among Out-of-School Youth Aged 15-24 Years-China,2010-2020显示文摘Summary What is already known about this topic?There are 4,000 new HIV infections every day worldwide,and 31%of which are in adolescents aged 15–24 years old.However,previous study is not aware of the distribution of out-of-school youth among this age group. | Shaorong Wang Junjie Wang Peng Xu Wanting Lyu Mengjie Han | 2021 | China CDC weekly2021，3，48： | 3 |
| 13 | High-entropy(Ca_(0.2)Sr_(0.2)Ba_(0.2)La_(0.2)Pb_(0.2))TiO_(3) perovskite ceramics with A-site short-range disorder for thermoelectric applications显示文摘Novel high-entropy perovskite-type(Ca_(0.2)Sr_(0.2)Ba_(0.2)La_(0.2)Pb_(0.2))TiO_(3)(CSBLP)ceramics with cubic structure of Pm-3 m space group were successful prepared by solid-state reaction method.Results of XRD,SEM-EDS,HRTEM confirmed a homogeneous distribution and equimolar arrangement of multicomponent cations on the A-site.The high-entropy CSBLP ceramics showed long-range structural order and short-range chemical disorder with widely dispersed nanoscale grains varying sizes of 4-6 nm in the microstructure.Because of increased configurational entropy,the CSBLP ceramic has an enhanced Seebeck coefficient(|S|=272μV/K at 1073 K)and low thermal conductivity(k=1.75 W/m·K at 1073 K)when annealed at1300℃.This work demonstrates the possibility of effectively reducing thermal conductivity and improving the performance of thermoelectric oxides through high-entropy composition design. | Ping Zhang Zhihao Lou Mengjie Qin Jie Xu Jiatong Zhu Zongmo Shi Qian Chen Michael J.Reece Haixue Yan Feng Gao | 2022 | Journal of Materials Science & Technology2022，，2： | 3 |
| 14 | NSC-640358 acts as RXRa ligand to promote TNFa-mediated apoptosis of cancer cell显示文摘 | Fan Chen Jiebo Chen Jiacheng Lin Anton V. Cheltsov Lin Xu Ya Chen Zhiping Zeng Liqun Chen Mingfeng Huang Mengjie Hu Xiaohong Ye YuqiZhou Guanghui Wang Ying su Long Zhang Fangfang Zhou Xiao-kun Zhang HU Zhou | 2015 | Protein & Cell2015，6，9： | 2 |
| 15 | A Case of Hepatitis B Reactivation in an Anti-HBs Positive,Anti-HBc Positive non-Hodgkin’s Lymphoma Patient显示文摘Dear Editor,We report a case of HBV reactivation in an anti-HBs positive, anti-HBc positive non-Hodgkin’s lymphoma patient. Hepatitis B virus (HBV) reactivation is a well-recognized complication of patients undergoing chemotherapy or immunosuppressive therapy for lymphomas. The presence of antibodies to the | Chunchen Wu Hui Shi Mengji Lu Yang Xu Xinwen Chen | 2013 | Virologica Sinica2013，28，1： | 2 |
| 16 | Regulation of Hepatitis C Virus Replication and Gene Expression by the MAPK-ERK Pathway显示文摘The mitogen activated protein kinases-extracellular signal regulated kinases (MAPK-ERK) pathway is involved in regulation of multiple cellular processes including the cell cycle. In the present study using a Huh7 cell line Con1 with an HCV replicon, we have shown that the MAPK-ERK pathway plays a significant role in the modulation of HCV replication and protein expression and might influence IFN-α signalling. Epithelial growth factor (EGF) was able to stimulate ERK activation and decreased HCV RNA load while a MAPK-ERK pathway inhibitor U0126 led to an elevated HCV RNA load and higher NS5A protein amounts in Con1 cells. It could be further demonstrated that the inhibition of the MAPK-ERK pathway facilitated the translation directed by the HCV internal ribosome entry site. Consistently, a U0126 treatment enhanced activity of the HCV reporter replicon in transient transfection assays. Thus, the MAPK-ERK pathway plays an important role in the regulation of HCV gene expression and replication. In addition, cyclin-dependent kinases (CDKs) downstream of ERK may also be involved in the modulation of HCV replication since roscovitine, an inhibitor of CDKs had a similar effect to that of U0126. Modulation of the cell cycle progression by cell cycle inhibitor or RNAi resulted consistently in changes of HCV RNA levels. Further, the replication of HCV replicon in Con1 cells was inhibited by IFN-α. The inhibitory effect of IFN-α could be partly reversed by pre-incubation of Con-1 cells with inhibitors of the MAPK-ERK pathway and CDKs. It could be shown that the MAPK-ERK inhibitors are able to partially modulate the expression of interferon-stimulated genes. | Rongjuan Pei Xiaoyong Zhang Song Xu Zhongji Meng Michael Roggendorf Mengji Lu Xinwen Chen | 2012 | Virologica Sinica2012，27，5： | 2 |
| 17 | Effects of Inclusion of Chrysin in Cucurbit[8]uril on Its Stability, Solubility and Antioxidant Potential显示文摘 | XU Zhiling LIAN Xiaowei LI Mengjie ZHANG Xiaodong WANG Yi TAO Zhu ZHANG Qianjun | 2017 | Chemical Research in Chinese Universities2017，33，5： | 2 |
| 18 | Optimization study on the rehydration process of lyophilized human platelets显示文摘Long-term preservation of human platelets will greatly reduce the risk of their shortage. Lyophilization has been proved feasible for this purpose. For the recovery of lyophilized platelets,rehydration is an important process. In this paper,the rehydration proc-esses for 1 mL and 2 mL samples were studied. The effects of prehydration duration(15,30,60,90,120 and 150 min) in 37°C water vapor and the concentration of rehydration solution(25%,50%,75%,100% platelet-poor plasma) on the recovery rate,MPV(mean platelet volume) and PDW(platelet distribution width) were investigated. The mass changes during the prehydration process were weighed. The optimized rehydration conditions are as follows:(1) for 1 mL sample,the prehydration duration was 15 min and for 2 mL sample the prehydration duration was 90 min;(2) the rehydration solution was 75% platelet-poor plasma. Under optimized conditions,the morphology of the rehydrated platelets kept normal and their ultrastructures kept intact,their aggregation capacity to thrombin(1 U/mL) was 82.8% of the fresh ones. These results will be helpful for designing the freeze-drying protocols for human platelets. | FAN JuLi XU XianGuo ZHANG ShaoZhi XU MengJie ZHU FaMing CHEN GuangMing | 2011 | Chinese Science Bulletin2011，56，4： | 2 |
| 19 | HIV-Related Knowledge, Attitude, and Practices Research Among College Students-Six Chinese Cities, 2021显示文摘Summary What is already known about this topic?The number of newly diagnosed human immunodeficiency virus(HIV)cases among Chinese youth 15–24 years of age shows an upward trend between 2010 and 2019.What is added by this report?This survey is on a larger scale as compared to previous studies.It shows inadequate HIV knowledge—especially on HIV treatment,self-testing,and postexposure prophylaxis—among college students.A significant gap exists between knowledge and behavior as indicated by the low condom use rate despite a high knowledge level. | Hui Liu Qiyu Zhu Lei Zhang Yujing Liu Peng Xu Maohe Yu Jixiang Fan Xiaohong Pan Xi Chen Huifang Xu Qinying He Mengjie Han | 2022 | China CDC weekly2022，4，47： | 2 |
| 20 | Low-Voltage Activating, Fast Responding Electro-thermal Actuator Based on Carbon Nanotube Film/PDMS Composites显示文摘The electro-thermal actuators(ETA)are smart devices that can convert electric energy into mechanical energy under electro-heating stimulation,showing great potential in the fields of soft robotics,artificial muscle and aerospace component.In this study,to build a low-voltage activating,fast responding ETA,a robust and flexible carbon nanotube film(CNTF)with excellent electrical and thermal conductivity was adopted as the conductive material.Then,an asymmetric bilayer structured ETA was manufactured by coating a thin layer of polydimethylsiloxane(PDMS)with high coefficient of thermal expansion(9.3×10^(-4)℃^(−1)),low young’s modulus(2.07 MPa)on a thin CNTF(~11μm).The as-produced CNTF/PDMS composite ETA exhibited a large deformation(bending angle~324°)and high electro heating performance(351℃)at a low driving voltage of 8 V within~12 s.The actuated movement and the generated heat could be controlled by adjusting the driving voltages and showed almost the same values in 20 cycles.Furthermore,the influences of the PDMS thickness and driving voltage on CNTF/PDMS composite ETA performance were systematically investigated.The CNTF/PDMS soft robotic hand which can lift 5.1 times and crab 1.3 times of its weight demonstrated its potential capability. | Mohamed Amine Aouraghe Zhou Mengjie Yiping Qiu Xu Fujun | 2021 | Advanced Fiber Materials2021，3，1： | 2 |
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