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| 1 | Colon perforation due to antigenemia-negative cytomegalovirus gastroenteritis after liver transplantation: A case report and review of literature显示文摘BACKGROUND Cytomegalovirus(CMV) remains a critical complication after solid-organ transplantation. The CMV antigenemia(AG) test is useful for monitoring CMV infection. Although the AG-positivity rate in CMV gastroenteritis is known to be low at onset, almost all cases become positive during the disease course. We treated a patient with transverse colon perforation due to AG-negative CMV gastroenteritis, following a living donor liver transplantation(LDLT).CASE SUMMARY The patient was a 52-year-old woman with decompensated liver cirrhosis as a result of autoimmune hepatitis who underwent a blood-type compatible LDLT with her second son as the donor. On day 20 after surgery, upper and lower gastrointestinal endoscopy(GE) revealed multiple gastric ulcers and transverse colon ulcers. The biopsy tissue immunostaining confirmed a diagnosis of CMV gastroenteritis. On day 28 after surgery, an abdominal computed tomography revealed transverse colon perforation, and simple lavage and drainage were performed along with an urgent ileostomy. Although the repeated remission and aggravation of CMV gastroenteritis and acute cellular rejection made the control of immunosuppression difficult, the upper GE eventually revealed an improvement in the gastric ulcers, and the biopsy samples were negative for CMV. The CMV-AG test remained negative, therefore, we had to evaluate the status of the CMV infection on the basis of the clinical symptoms and GE.CONCLUSION This case report suggests a monitoring method that could be useful for AGnegative CMV gastroenteritis after a solid-organ transplantation. | Takahiro Yokose Hideaki Obara Masahiro Shinoda Yutaka Nakano Minoru Kitago Hiroshi Yagi Yuta Abe Yohei Yamada Kentaro Matsubara Go Oshima Shutaro Hori Sho Ibuki Hisanobu Higashi Yuki Masuda Masanori Hayashi Miho Kawaida Takehiko Mori Takumi Fujimura Ken Hoshino Kaori Kameyama Tatsuo Kuroda Yuko Kitagawa | 2019 | World Journal of Gastroenterology2019，25，15： | 5 |
| 2 | Calcification in large cell neuroendocrine carcinoma of the lung显示文摘 | Takamochi K Yokose T Yoshida J | 2003 | Jpn J Clin Oncol2003，33，1： | 2 |
| 3 | Localized Pure GroundGlass Opacity on High-Resolution CT: Histologic Characteristics显示文摘 | Nakajima R Yokose T Kakinuma R | 2002 | J Comput Assist Tomogr2002，26，3： | 1 |
| 4 | Increased cyclooxygenase 2 (COX-2) expression occurs frequently in precursor lesions of human adenocarcinoma of the lung 显示文摘 | Hosomi Y Yokose T Hirose Y | 2000 | Lung Cancer2000，30，： | 1 |
| 5 | A Theory of the Derailment of a Wheelset显示文摘 | YOKOSE K | 1966 | Japanese National Railway Quarterly Report1966，7，3： | 1 |
| 6 | Clinicopathologic characteristics of peripheral squamous cell carcinoma of the lung显示文摘 | Funai K Yokose T Ishii G | 2003 | Am J Surg Pathol2003，27，7： | 1 |
| 7 | Endobronchial lipoma: a report of three cases显示文摘 | YOKOZAKI M KODAMA T YOKOSE T | 1996 | Jpn J Clin Oncol1996，26，1： | 1 |
| 8 | Localized pure ground glas s opacity on high resolution CT:histologic characterist ics显示文摘 | Nakajima R Yokose T Kakinvma R | 2002 | J Comput Assist Tomogr2002，26，： | 1 |
| 9 | Effects of interleukin-12 on natural killer cell cytotoxicity and the production of interferon-gamma and tumour necrosis factor-alpha in patierts with myelodysplastic syndromes显示文摘 | Ogata K Tamura H Yokose N | 1995 | Br J Haematol1995，90，1： | 1 |
| 10 | Well-differentiated papillary mesothelioma, possibly giving rise to diffuse malignant mesothelioma: a case report显示文摘 | Washlml K Yokose T Amitani Y | 2013 | Pathol Int2013，63，4： | 1 |
| 11 | Young lung cancer patients in Japan: different characteristics between the sexes 显示文摘 | Sekine I Nishiwaki Y Yokose T | 1999 | Ann Thorac Surg1999，67，5： | 1 |
| 12 | Establishment of a novel species- and tissue-specific metastasis model of human prostate cancer in humanized non-obese diabetic/severe combined immunodeficient mice engrafted with human adult lung and bone显示文摘 | Yonou H Yokose T Karnijo T | 2001 | Cancer Res2001，61，5： | 1 |
| 13 | Chronic fatigue syndrome-51 cases in the Jikei University School of Medicine 显示文摘 | Hashimoto N Kuraishi Y Yokose T | 1992 | Nippon Rinsho1992，50，11： | 1 |
| 14 | Atypical sdenoma- tous hyperplasia of the lung: a clinicopathological study of 118 cases in cluding cases with multiple atypical adenomatous hy- perplasia显示文摘 | Nakahara R Yokose T Nagai K | 2001 | Thorax2001，5，： | 1 |
| 15 | Parathyroid hormone exerts dis- parate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells 显示文摘 | Ishizuya T Yokose S Hori M | 1997 | J Clin Invest1997，99，12： | 1 |
| 16 | Platelet-derived growth factor exerts disparate effects on odontoblast differentiation depending on the dimers in rat dental pulp cells显示文摘 | Satoshi Yokose Hiroshi Kadokura Naoto Tajima Akihiko Hasegawa Hiroshi Sakagami Kazuo Fujieda Tadashi Katayama | 2004 | Cell and Tissue Research2004，，3： | 1 |
| 17 | Parathyroid hormone exerts disparate effects on osteoblast di fferentiation depending on exposure time in rat osteoblastic cells显示文摘 | Ishizuya T Yokose S Hori M | 1997 | Journal of Clinical Investigation1997，99，12： | 1 |
| 18 | Monoclonality of both pale cells and cuboidal cells of sclerosing hemangioma of the lung显示文摘 | Suzuki K Yokose T | 1998 | Am J Pathol1998，152，4： | 1 |
| 19 | Genetic algorithms with assistant chromosomes for inverse shape optimization of electromagnetic devices显示文摘 | Yokose Y Cingoski V Yamashita H | | 0，，04： | 1 |
| 20 | Elevated plasma soluble interleukin 2 receptor level correlates with defective natural kiler and CD8+ T-cells in myelodysplastic syndromes显示文摘 | Yokose N Ogata K Ito T | 1994 | Leuk Res1994，18，10： | 1 |
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