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| 1 | An Analysis of Historical and Future Temperature Fluctuations over China Based on CMIP5 Simulations显示文摘The trends and fluctuations of observed and CMIP5-simulated yearly mean surface air temperature over China were analyzed. In general, the historical simulations replicate the observed increase of temperature, but the multi-model ensemble(MME) mean does not accurately reproduce the drastic interannual fluctuations. The correlation coefficient of the MME mean with the observations over all runs and all models was 0.77, which was larger than the largest value(0.65) from any single model ensemble. The results showed that winter temperatures are increasing at a higher rate than summer temperatures, and that winter temperatures exhibit stronger interannual variations. It was also found that the models underestimate the differences between winter and summer rates. The ensemble empirical mode decomposition technique was used to obtain six intrinsic mode functions(IMFs) for the modeled temperature and observations. The periods of the first two IMFs of the MME mean were 3.2 and 7.2, which represented the cycle of 2–7-yr oscillations. The periods of the third and fourth IMFs were 14.7 and 35.2, which reflected a multi-decadal oscillation of climate change. The corresponding periods of the first four IMFs were 2.69, 7.24, 16.15 and 52.5 in the observed data. The models overestimate the period of low frequency oscillation of temperature, but underestimate the period of high frequency variation. The warming rates from different representative concentration pathways(RCPs) were calculated, and the results showed that the temperature will increase by approximately 0.9℃, 2.4℃, 3.2℃ and 6.1℃ in the next century under the RCP2.6, RCP4.5, RCP6.0 and RCP8.5 scenarios, respectively. | LIU Yonghe FENG Jinming MA Zhuguo | 2014 | Advances in Atmospheric Sciences2014，31，2： | 15 |
| 2 | Analysis of main controlling factors for hydrocarbon accumulation in central rift zones of the Hailar-Tamtsag Basin using a fault-caprock dual control mode显示文摘The Hailar-Tamtsag Basin is a typical rift basin where two sets of regional caprocks are developed,i.e.,mudstone caprocks(containing a small amount of tuff)developed in strong rifting stage and fault-depression stage,respectively.The caprocks have a cumulative thickness of 50-120 m in general,and a single-layer thickness of 20-50 m,interbedded with sandstone about 1-2 m thick.The large set of mudstone is distributed continuously,as pure mudstone caprock.Forty-three mudstone and tuff samples were taken to perform displacement pressure test with our independently developed displacement pressure tester.Test result shows that the displacement pressure is 0.04-10.00 MPa,which is equivalent to 0.09-20.01 MPa after being corrected to the actual burial depth.As the burial depth increases,the displacement pressure rises gradually,and is 1-10 times greater than that of oil-bearing sandstone or conglomerate reservoir at the same burial depth.The difference between displacement pressure of mudstone caprock and sandstone or conglomerate reservoir increases greatly if the burial depth exceeds 1000 m.Because of the displacement pressure difference between caprock and reservoir,the maximum height of hydrocarbon column sealed by the caprock ranges from 300 m to 2000 m,much higher than the height of the trap closure at the same burial depth.No hydrocarbons will leak through such caprocks.Analysis of the reservoir GOI,homogeneous temperature,and crude maturity of both deep and shallow reservoirs in Well Wu-20 in the Wuerxun Depression shows that Damoguaihe II Member reservoir is a secondary reservoir developed during adjustment of early reservoir.It is mainly distributed in inverted structures.Faulting is one of the main factors breaking the integrity of caprocks.Three kinds of faults are often related to the migration of hydrocarbons across regional caprocks:the first type refers to the positive inverted faults breaking the early sealing conditions and making the hydrocarbons accumulated in the early period re-migration;the second type refers to the faults with shear mudstone smear structures which lose their continuity and open vertically when the fault throws exceed 5 times of the mudstone thickness;the third type refers to the normal faults developed in the structural inversion stage,which have a typical cataclastic structure and are easy to cause vertical migration of hydrocarbons.Hydrocarbon enriched horizons of the rift basins are co-controlled by 'fault-caprock'.Specifically,95% of the geological reserve is controlled by regional caprocks,and only 5% is controlled by open faults,secondary oil/gas reservoirs are developed over regional caprocks. | FU XiaoFei CHEN Zhe YAN BaiQuan YANG Mian SUN YongHe | 2013 | Science China Earth Sciences2013，56，8： | 15 |
| 3 | Effect of Sanhuangwuji powder,anti-rheumatic drugs,and ginger-partitioned acupoint stimulation on the treatment of rheumatoid arthritis with peptic ulcer:a randomized controlled study显示文摘OBjECTIVE:To observe the efficacy and safety of oral Sanhuangwuji powder,anti-rheumatic drugs(ARDs),and ginger-partitioned acupoint stimulation at Zusanli(ST 36) on the treatment of rheumatoid arthritis(RA) complicated by peptic ulcer.METHODS:This prospective randomized controlled study included 180 eligible inpatients and outpatients randomly assigned to an ARD treatment(n = 60),ginger-partitioned stimulation(n =60),or combination treatment(n = 60).Patients assigned to the ARD group were given oral celecoxib,methotrexate,and esomeprazole.Patients assigned to theginger-partitioned stimulation group were given ginger-partitioned acupoint stimulation at Zusanli(ST 36) in addition to the ARDs.Patients in the combination treatment group were given oral Sanhuangwuji powder,ginger-partitioned acupoint stimulation at Zusanli(ST 36),and ARDs.All patients were followed up for 2 months to evaluate clinical effects and safety.The study was registered in the World Health Organization database at the General Hospital of Chengdu Military Area Command Chinese People's Liberation Army(ChiCTR-TCC12002824).RESULTS:The combination treatment group had significantly greater improvements in RA symptoms,laboratory outcomes,and gastrointestinal symptom scores,compared with the other groups(P < 0.05).The peptic ulcer healing rate in the combination treatment group was significantly greater than that in the ARD treatment group(x^2 = 16.875,P < 0.05) and the ginger-partitioned stimulation group(x^2 = 6.171,P<0.05).CONCLUSION:Combination treatment with ginger-partitioned acupoint stimulation at Zusanli(ST36),oral Sanhuangwuji powder,and ARDs had a better clinical effect for RA with complicated peptic ulcer,compared with ARD treatmentalone or in combination with ginger-partitioned acupoint stimulation. | Liu Defang Guo Mingyang Hu Yonghe Liu Taihua Yan Jiao Luo Yong Yun Mingdong Yang Min Zhang Jun Guo Linglin | 2015 | Journal of Traditional Chinese Medicine2015，35，3： | 9 |
| 4 | One-step generation of myostatin gene knockout sheep via the CRISPR/Cas9 system显示文摘The CRISPR/Cas(clustered regularly interspaced short palindromic repeats/CRISPR-associated)adaptive immune system,which was discovered in bacteria and archaea,can specifically degrade invasive viral and plasmid DNA by base pairing between crRNAs(CRISPR RNAs)and the target DNA[1,2].Recently,the Streptococcus pyogenes type II CRISPR system was shown to be able to perform efficient targeted gene disruption by employing three fundamental components:(1)Cas9 endonuclease. | Hongbing HAN Yonghe MA Tao WANG Ling LIAN Xiuzhi TIAN Rui HU Shoulong DENG Kongpan LI Feng WANG Ning LI Guoshi LIU Yaofeng ZHAO Zhengxing LIAN | 2014 | Frontiers of Agricultural Science and Engineering2014，1，1： | 8 |
| 5 | Precession–nutation correction for star tracker attitude measurement of STECE satellite显示文摘Space Technology Experiment and Climate Exploration(STECE) is a small satellite mission of China for space technology experiment and climate exploration. A new test star tracker and one ASTRO 10 star tracker have been loaded on the STECE satellite to test the new star tracker's measurement performance. However,there is no autonomous precession–nutation correction function for the test star tracker,which causes an apparent periodic deflection in the inter-boresight angle between the two star trackers with respect to each other of up to ±500 arcsec,so the precession and nutation effect needs to be considered while assessing the test star tracker. This paper researches on the precession–nutation correction for the test star tracker's attitude measurement and presents a precession–nutation correction method based on attitude quaternion data. The periodic deflection of the inter-boresight angle between the two star trackers has been greatly eliminated after the precession and nutation of the test star tracker's attitude data have been corrected by the proposed method and the validity of the proposed algorithm has been demonstrated. The in-flight accuracy of the test star tracker has been assessed like attitude noise and low-frequency errors after the precession–nutation correction. | Lai Yuwang Liu Junhong Ding Yonghe Gu Defeng Yi Dongyun | 2014 | Chinese Journal of Aeronautics2014，27，1： | 7 |
| 6 | Effects of Xinfeng capsule on the Fas/FasL-mediated apoptotic pathway in patients with rheumatoid arthritis显示文摘OBJECTIVE:To observe the effects of Xinfeng capsule on the apoptosis of peripheral blood CD4+ T lymphocytes and changes in the Fas/Fas L-mediated apoptotic pathway in patients with rheumatoid arthritis(RA).METHODS:A total of 28 RA patients were included in the study;they were randomly divided into the Xinfeng capsule(XFC) group(3 capsules,3 per day)and the leflunomide(LEF) group(1 pellet,once per night).The treatment course in each groups was 12 weeks.The normal control(NC) group consisted of10 healthy people.The apoptotic rate was examined using flow cytometry.Fas,Fas L,caspase 8,caspase 3,bcl-2,and bax m RNA were examined using q RT-PCR.Apoptotic proteins Fas,Fas L,caspase8,and caspase 3 were examined using western blotting.RESULTS:After treatment,patients in the two groups all showed some trend of improvement.Disease activity indexes,joint morning stiffness time,joint swelling/tenderness number,health assessment questionnaire(HAQ) score,RA quality of life(RAQOL) questionnaire,and self-rating anxiety scale(SAS),as well as all apoptotic related indicators were reduced in both groups after treatment with no significant difference between groups.But the improvement in terms of the self-rating depression scale(SDS) in the XFC group was better than in the LEF group.RA patients showed lower apoptotic rates in CD4+ T cells,lower bax,Fas,caspase 8,and caspase 3 m RNA,and less protein expression of Fas,caspase 8,and caspase3 than in the NC group.These indicators increased after treatment.However,the level of Bcl-2 m RNA was higher in the XFC group than in the NC group before treatment,and it subsequently decreased.The XFC group expressed lower Bcl-2 m RNA than the LEF group.Negative correlations were found between ESR and the apoptotic rate in CD4 + T cells,Fas,and caspase 3;CRP and Fas;and,swollen joint count and Bax,while positive correlations were found between ESR and Bcl-2.CONCLUSION:XFC can regulate the Fas/Fas L system and promote CD4+ T cell apoptosis and thus reduce the abnormal immune response,which can improve symptoms in RA patients. | Sun Yue Liu Jian Cao Yonghe | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 7 |
| 7 | A MULTISCALE MECHANICAL MODEL FOR MATERIALS BASED ON VIRTUAL INTERNAL BOND THEORY显示文摘仅仅二个宏观的参数被需要描述线性有弹性的固体的机械性质,即泊松的比率和幼仔是模量。相应地,应该有二个显微镜的参数如果线性有弹性的固体的宏观的机械性质从显微镜的水平被导出,决定材料的机械性质。由这个想法照亮了,为材料的一个多尺度的机械模型,虚拟 multi-dimensionalinternal 契约(VMIB ) 模型,被把一张 shear 契约合并到虚拟内部契约(VIB ) 建议模型。由这修正, VMIB 模型联系宏有分离结构和相应关系在之间的显微镜的机械性质的材料的机械性质微并且宏参数被导出。精力密度功能的张肌质量,包含并列向量,算术地被证明。从观点 ofVMIB,材料的宏观的非线性的行为能被归因于强加的变丑导致的虚拟契约分发密度的进化。与这个理论假设,作为一个申请例子,易碎的材料的单轴的压缩失败被模仿。在试验性的结果和模仿的之间的好同意被发现。 | Zhang Zhennan Ge Xiurun Li Yonghe | 2006 | Acta Mechanica Solida Sinica2006，19，3： | 6 |
| 8 | Effect of Jinlong capsule on proliferation and apoptosis of human pancreatic cancer cells BxPC-3显示文摘OBJECTIVE:To study the possible roles of Jinlong capsule(JLC) on the proliferation and apoptosis of human pancreatic cancer cells BxPC-3.METHODS:The human pancreatic cancer cells BxPC-3 were treated with JLC at the concentration of 0.05-1.00 mg/mL for 24-120 h.The inhibition rate of JLC on human pancreatic cancer cells BxPC-3 was detected by 3-(4,5-dimethiylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT) assay.Flow cytometry was employed to measure cell apoptosis using Annexin V-FITC/Propidium iodide(AV-FITC/PI) method.Cell cycles were determined by PI staining.The expression of S100 Calcium binding protein A4(S100A4) in cell matrix was measured by enzyme-linked immunosorbent assay(ELISA).The expression levels of apoptosis-related protein such as BCL2/adenovirus E1B 19 kDa interacting protein 3(BNIP3),B-cell lymphoma/leukemia-2(Bcl-2) and Cys-teinylaspartate specific proteinase 3(Caspase-3) were detected byWestern blotting.RESULTS:JLC significantly inhibited the proliferation of human pancreatic cancer cells BxPC-3 in a dose-dependent and time-dependent manner.JLC promoted cell apoptosis and maintained cell cycle in S and G 2 /M phase rather than G 1 /G 0 phase.The expression of S100A4 in the cell matrix was reduced.The expression of cell apoptotic protein BNIP3 was increased while Bcl-2 was decreased.CONCLUSION:JLC can inhibit the proliferation of human pancreatic cancer cells BxPC-3 by stimulating cell apoptosis,arresting the cell cycle at S and G 2 /M phase which blocks the circulation of normal cell cycle and reducing the expression of S100A4 protein.Higher pro-apoptosis protein BNIP3 and lower anti-apoptosis protein Bcl-2 levels were found,which may be related to the apoptotic effects of JLC. | Yaoyuan Li Jieqing Hu Hui Huang Yonghe He | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 6 |
| 9 | Architectural Units and Groundwater Resource Quantity Evaluation of Cretaceous Sandstones in the Ordos Basin,China显示文摘Sandstone is a common lithology in a number of groundwater reservoirs. Studying the skeleton sandstone architectural units, therefore, lays the basis for characterizing aquifer systems, groundwater quality, and resource evaluation. This comprehensive analysis of Cretaceous aquiferous sandstones in the Ordos basin, China, shows that there exists a basin-scale skeleton sandstone in the Luohe Formation which contains 11 isolated barrier beds, 12 small skeleton sandstone bodies in Huanhe Formation, and 3 in the Luohandong Formation. The spatial structure and superimposed relationship as well as the medium properties of these skeleton sandstones and isolated barrier beds can be shown by 3D visualization models. Simultaneously, resource quantity can be evaluated with the 3D inquiry functions. The comparison between property models and structural models indicates that the salinity of groundwater of the Luohe Formation has a close connection with the locations of isolated barrier beds that contain abundant gypsum. Through quantitative calculation, groundwater resource of the Cretaceous Luohe and Luohandong formations is estimated to be 1.6×10^(12) m^3, and the total groundwater resource of the Cretaceous system in the Ordos basin is more than 2×10^(12) m^3. | WU Liqun JIAO Yangquan ZHU Peimin LEI Xinrong WANG Yonghe | 2017 | Acta Geologica Sinica(English Edition)2017，91，1： | 5 |
| 10 | Calcium-mineralized polypeptide nanoparticle for intracellular drug delivery in osteosarcoma chemotherapy显示文摘The acidic microenvironments of tumor tissue and cells provide an opportunity for the development of pHresponsive drug delivery systems in cancer therapy.In this work,we designed a calcium carbonate(CaCO3)-corecrosslinked nanoparticle of methoxy poly(ethylene glycol)-block-poly(L-glutamic acid)through mineralization for intracellular delivery of doxorubicin(DOX),referred to as CaNP/DOX.CaNP/DOX exhibited high drug loading capability,uniform nanoparticle size,and pH-dependent DOX release.In the meantime,the enhanced cell uptake,superior cytotoxicity toward mouse osteosarcoma K7 cells,extended circulation half-life,and improved accumulation of DOX in K7 allograft tumor from CaNP/DOX were also demonstrated.More interestingly,CaNP/DOX displayed improved antitumor effect and reduced side effects against the K7 osteosarcoma-allografted mouse model and the 143B orthotopic osteosarcoma mouse model.Given the superior properties of Ca-mineralized polypeptide nanoparticle for intracellular drug delivery,the smart drug delivery system showed strong competitiveness in clinical chemotherapy of cancers. | Ke Li Di Li Li Zhao Yonghe Chang Yi Zhang Yan Cui Zhiyu Zhang | 2020 | Bioactive Materials2020，5，3： | 4 |
| 11 | Effect of methotrexate combined with Sanhuang Yilong decoction on serum and synovial fluid aquaporin levels in rheumatoid arthritis dampness-heat blockage syndrome显示文摘OBJECTIVE:To study the effect of methotrexate(MTX) combined with Sanhuang Yilong decoction(SYD) on aquaporin(AQP) expression,and to explore the role of AQPs in the pathogenesis of rheumatoid arthritis(RA).METHODS:A total of 118 dampness-heat blockage type RA patients who were hospitalized in the General Chengdu Military Hospital between January2014 and December 2016 were selected as subjects in this study(30 patient of these patients with knee joint effusion were assigned to the RA synovial fluid group).For the pre-treatment controlgroups,30 healthy volunteers were recruited as the healthy control group and 30 osteoarthritis(OA) patients with knee joint effusion were included as OA synovial fluid control group.The RA dampnessheat blockage syndrome treatment groups were divided into 45 cases in the combined group and 45 cases in the MTX group.The combined group received MTX combined with SYD treatment while the MTX group received MTX alone.AQP1,AQP2 and AQP3 expressions were detected in the serum and synovial fluid.RESULTS:AQP1 had the highest expression,followed by AQP3,and AQP2.The serum levels of AQP1,AQP2 and AQP3 were all significantly lower than those in the healthy volunteers(P < 0.05),while the synovial fluid AQP1,AQP2 and AQP3 expression in the RA group were comparable to these in the OA groups(P > 0.05).After treatment for2 weeks,serum AQP1,AQP2,AQP3 were significantly increased and erythrocyte sedimentation rate,C-reactive protein,disease activity score of 28 joints were decreased in the combined group(P < 0.05).CONCLUSION:Abnormal expression of AQPs inhibits water metabolism in RA dampness-heat blockage syndrome,so liquid is accumulated at the joint,which may play an important role in the pathogenesis of RA.MTX combined with SYD for the treatment of RA can effectively increase AQP expression. | Liu Defang Yan Jiao Guo Mingyang Luo Yong Yang Mei Yang Min Zou Longfu Li Wan Zhong Xiaolong Liu Tao Hu Yonghe | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 12 | Preemptive Semi-Online Scheduling with Tightly-Grouped Processing Times显示文摘This paper investigates a preemptive semi-online scheduling problem on m identical parallel machines where m = 2, 3. It is assumed that all jobs have their processing times in between p and rp (p>0, r≥1). The goal is to minimize the makespan. Best possible algorithms are designed for any r≥1 when m = 2,3. | YongHe Yi-WeiJiang | 2004 | Journal of Computer Science & Technology2004，19，6： | 4 |
| 13 | Effect of Sanhuangyilong decoction plus methotrexate on tumor necrosis factor alpha and interferon gamma in serum and synovial fluid in rheumatoid arthritis patients with symptom pattern of damp heat obstruction显示文摘OBJECTIVE: To investigate the effect of Sanhuangyilong decoction plus methotrexate(MTX) on Interferon gamma(IFN-γ) and tumor necrosis factor alpha(TNF-α) in the serum and synovial fluid of rheumatoid arthritis(RA) patients with damp-heat-obstruction symptom pattern, Sanhuangyilong decoction and the role of TNF-α and IFN-γ in the development of RA.METHODS: RA inpatients with damp-heat-obstruction symptom pattern(partly with knee joint effusion) were selected as the research subjects. Before the treatment, healthy subjects and osteoarthritis(OA) patients with knee joint effusion were assigned to the serum control group and the synovial fluid control group, respectively; during the treatment, RA patients with damp-heat-obstruction symptom pattern were divided into two groups:one is combined group that was administered Sanhuangyilong decoction plus MTX; the other group was MTX group that received MTX only. The expression levels of TNF-α and IFN-γ in the serum and synovial fluid were measured with enzyme-linked immunosorbent assay(ELISA) before and after the treatment, and the peripheral blood levels of erythrocyte sedimentation rate(ESR), C-reactive protein(CRP) and disease activity score in 28 joints(DAS28)were determined.RESULTS: Before treatment, the serum levels of TNF-α and IFN-γ in the RA patients with dampheat-obstruction symptom pattern were higher than those in healthy control group(P < 0.05).The expression levels of TNF-α and IFN-γ in the synovial fluid of the RA patients were higher than those in the serum of the RA patients(P < 0.05). The expression levels of TNF-α and IFN-γ in the synovial fluid of the RA patients were higher than those of the sy-novial fluid of the osteoarthritis patients(P < 0.05).The expression of TNF-α and IFN-γ in the serum and synovial fluid of the RA patients had no correlation with the inflammatory activity index ESR, CRP,or DAS28(P > 0.05). After 2 weeks of treatment, the expression level of TNF-α and IFN-γ in the combined group had increased, although the difference was not statistically significant(P > 0.05); in contrast, ESR, CRP, and DAS28 decreased, and the difference was statistically significant(P < 0.01). After 4 weeks of therapy, TNF-alpha and IFN-γ, ESR,CRP, and DAS28 in the combined group decreased compared with the before-treatment levels(P <0.01). After 2 w of treatment, the differences in the TNF-α and IFN-γ expression levels in the combined group were not statistically significant(P > 0.05)compared with that in the MTX group, although there were statistically significant differences in the ESR, CRP, and DAS28(P < 0.05). After 4 weeks of treatment, differences in TNF-α, IFN-γ, ESR, CRP, and DAS28 in the combined group compared with MTX group were statistically significant(P < 0.01).CONCLUSION: TNF-α and IFN-γ might be involved in the development of RA. The RA patients with damp-heat-obstruction symptom pattern show better benefits from the treatment of Sanhuangyilong decoction plus MTX, and the treatment is superior to that of using MTX only. | Liu Defang Yan Jiao Yun Mingdong Yang Ming Luo Yong Zhang Jun Guo Mingyang Yang Mei Yuan Weili Zou Wei Li Hua Hu Yonghe | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 4 |
| 14 | Controllable and switchable capillary adhesion mechanism for bio-adhesive pads: Effect of micro patterns显示文摘Some insects and animals, such as bugs, grasshoppers and tree frogs, realize their efficient adhesion mechanism to glass surface, wall and ceiling by injecting a wetting liquid thin film into the pad-substrate contact area. Their ability to control adhesion (attaching or detaching from a surface) is in many cases connected to the contact geometry and surface patterns of their attachment pads. This paper focuses on the dependence of the capillary adhesion (wet adhesion) on the micro patterns of the bio-adhesive pads. The objective is to reveal the possible mechanism for a bio-adhesive pad to control capillary force through adjusting its micro-scale surface pattern and topography. A capillary adhesion force model is built up taking account of the combined role of micro-dimple geometry as well as the wetting behavior of the confined liquid thin film. Calculated results of the apparent contact angle on the regularly micro-dimpled surfaces are compared with and in good agreement with the experimental measurements. Simulation of the capillary adhesion force reveals that it is controllable in a large mag- nitude by adjusting a dimensionless surface pattern parameter k defined as a/(a+b), where a is the dia- meter of micro dimple, and (a+b) is the side length of one pattern cell. When adjusting the parameter k more than 0.75, the capillary adhesion force could be switchable from attractive to repulsive. This effect of micro patterns on the interfacial capillary force is proved to be dominant when the pad-substrate clearance decreases to the nano/micrometer scale. These results indicate that a controllable and switchable capillary adhesive mechanism might be utilized by a living insect or animal to realize its stable adhesion and quick releasing movement through adjusting the micro-pattern topography of its bio-adhesive pad. | ZHANG XiangJun LIU Yuan LIU YongHe AHMED S.I.-U. | 2009 | Chinese Science Bulletin2009，54，10： | 3 |
| 15 | Effect of hand-ear acupuncture on chronic low-back pain: a randomized controlled trial显示文摘OBJECTIVE: To evaluate the effect of hand-ear acupuncture on chronic low-back pain(cLBP).METHODS: This was an open, randomized and controlled trial in The General Hospital of Western Theater Command, Sichuan Province. The trial was registered with ClinicalTrials.gov, NCT02260284. All the 152 participates with cLBP were randomly assigned to hand-ear acupuncture(n = 54), standard acupuncture(n = 50), or usual care groups(n = 48).Eighteen treatments were provided over 7 weeks.Back-related dysfunction and symptom severity were assessed by the Roland-Morris Disability Questionnaire(RMDQ) and the Visual Analogue Scale(VAS), which were collected at baseline, 2 months and 6 months post to the treatment.RESULTS: At 6 months, the RMDQ scores improved by 7.74 points of hand-ear acupuncture group. Significant improvement of VAS and RMDQ was observed in hand-ear acupuncture group(P < 0.001),but no significant changes of RMDQ were observed in both standard acupuncture group and usual care group. We also observed an overall efficacy rate of 88.89% in hand-ear acupuncture group, as evaluated by Diagnosis and Curative Effect Standard for Symptom pattern of Traditional Chinese Medicine, which was much higher than 45.84% in the usual care group(H = 16.000, P < 0.001).CONCLUSION: Both of the hand-ear acupuncture and standard acupuncture modes have beneficial and persistent effectiveness against cLBP compared with the usual care. Furthermore, hand-ear acupuncture is significantly more effective than the standardized acupuncture, especially in the long term. | Luo Yong Yang Min Liu Tao Zhong Xiaolong Tang Wen Guo Mingyang Hu Yonghe | 2019 | Journal of Traditional Chinese Medicine2019，39，4： | 2 |
| 16 | Delay-dependent criteria for the robust stability of systems with time-varying delay显示文摘The problem of delay-dependent robust stability for systems with titne-varying delay has been considered. By using the S-procedure and the Park' s inequality in the recent issue, a delay-dependent robust stability criterion which is less conservative than the previous results has been derived for time-delay systems with time-varying structured uncertainties. The same idea has also been easily extended to the systems with nonlinear perturbations. Numerical examples illustrated the effectiveness and the improvement of the proposed approach. | MinWU YongHE JinhuaSHE | 2003 | 控制理论与应用(英文版)2003，1，1： | 2 |
| 17 | A contrast study of the traumatic condition between the wounded in 5.12 Wenchuan earthquake and 4.25 Nepal earthquake显示文摘 | Sheng Ding Yonghe Hu Zhongkui Zhang Ting Wang | 2015 | Chinese Journal of Traumatology2015，18，3： | 2 |
| 18 | Autocrine expression of hepatocyte growth factor and its cytoprotective effect on hepatocyte poisoning显示文摘AIM: To construct pEGFP-hepatocyte growth factor (HGF) expression vector, the to detect its expression in transfected human hepatocytes, and to investigate the influence of autocrine HGF expression on the proliferative potential and cytoprotective effects in human hepatocytes.METHODS: Human HGF cDNA was ligated to the pEGFP vector. Recombinant plasmid was transfected into human hepatocyte line QZG with liposome. Expression of HGF protein was observed by fluorescence microscopy and immunohistochemistry. Hepatic cells were collected 24, 48, and 72 h after transfection to detect the number of [^3H]-TdR uptake in DNA. DNA synthesis was observed by using PCNA stain immunohistochemistry.Acute liver cell damage was induced by carbon tetrachloride. Cytoprotective effect was observed by examining the survival rate of hepatocytes and leakage of intracellular alanine transaminase (ALT) and potassium ions.RESULTS: HGF identification of pEGFP-HGF by enzyme digestion showed that HGF fragment was cloned into BamH I and SalI sites of pEGFP-N3. Expression of GFP in transfected hepatocytes was observed with fluorescence microscopy. The [^3H]-TdR uptake became 7 times as many as in thecontrol group 96 h after transfection. After HGF transfection, the survival rate of hepatocytes poisoned by CCI4 significantly increased (83% vs 61%, P<0.05), and the leakage of intracellular alanine transaminase and potassium ions decreased (586 nkat/L vs 1089 nkat/L, P<0.01; and 5.59 mmol/L vs 6.02 mmol/L, P<0.01 respectively). Culture of transfected hepatic cells promoted the proliferation of other nontransfected cells.CONCLUSION: Transfected HGF is expressed in hepatic cells and has the activity of promoting cell division and protecting hepatic cells against poisoning. | YongHe JunZhou Ke-FengDou YongChen Qing-GuoYan Hai-lVlinLi | 2004 | World Journal of Gastroenterology2004，10，19： | 2 |
| 19 | New Occurrence of the Early Cambrian Chengjiang Fauna in Haikou, Kunming, Yunnan Province,and Study on Trilobitoidea显示文摘This paper gives a brief report on the new occurrence of the Early CambrianQiongzhusi’ an Chengjiang fauna in the Haikou area, Kunming and its assemblage feature andthe stratigraphic section of the horizon yielding these fossils. Eight genera and 8 species ofTrilobitoidea are described here, embracing Leanchoilia asiatica Luo et Hu (sp. nov.), Yohoiasinensis Luo et Hu (sp. nov.), Zhongxinia speciosa Luo et Hu (gen. et sp. nov.), Xandarellaspectuculum Hou et al., Dianchia mirabilis Luo et Hu (gen. et sp. nov.), Kuamaia lata Hou,Retifacies longispinus Luo et Hu (sp. nov.) and Sinoburius lunaris Hou et al. | Luo Huilin Hu Shixue Zhang Shishan and Tao Yonghe Yunnan Institute of Geological Sciences, Kunming Yunnan Kunyang Phosphorite Mine, Jinning, Yunnan | 1997 | Acta Geologica Sinica(English Edition)1997，71，2： | 2 |
| 20 | Fault Systems and their Control of Deep Gas Accumulations in Xujiaweizi Area显示文摘A study of faults and their control of deep gas accumulations has been made on the basis of dividing fault systems in the Xujiaweizi area. The study indicates two sets of fault systems are developed vertically in the Xujiaweizi area, including a lower fault system and an upper fault system. Formed in the period of the Huoshiling Formation to Yingcheng Formation, the lower fault system consists of five fault systems including Xuxi strike-slip extensional fault system, NE-trending extensional fault system, near-EW-trending regulating fault system, Xuzhong strike-slip fault system and Xudong strike-slip fault system. Formed in the period of Qingshankou Formation to Yaojia Formation, the upper fault system was affected mainly by the boundary conditions of the lower fault system, and thus plenty of multi-directionally distributed dense fault zones were formed in the T2 reflection horizon. The Xuxi fault controlled the formation and distribution of Shahezi coal-measure source rocks, and Xuzhong and Xudong faults controlled the formation and distribution of volcanic reservoirs of Y1 Member and Y3 Member, respectively. In the forming period of the upper fault system, the Xuzhong fault was of successive strong activities and directly connected gas source rock reservoirs and volcanic reservoirs, so it is a strongly-charged direct gas source fault. The volcanic reservoir development zones of good physical properties that may be found near the Xuzhong fault are the favorable target zones for the next exploration of deep gas accumulations in Xujiaweizi area. | SUN Yonghe KANG Lin BAI Haifeng FU Xiaofei HU Ming | 2012 | Acta Geologica Sinica(English Edition)2012，86，6： | 2 |
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